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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins18 (37.50 %)
The number (and %) of the tumor suppressors3 (6.25 %)
Total number of binary PPIs (saturation %)168 (14.89 %)
The number (and %) of affected PPIs48 (28.57 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI6.167
Assortativity coefficient-0.4971
The network average Clustering coefficient0.562
The number (and %) of a zero Clustering coefficients15 (31.25 %)
The number (and %) of a zero Betweenness Centrality30 (62.50 %)


List of the fusions

PPI for parental proteins: MARK3 All fusions
: BF356202;
Proteins found in more fusions HDAC7 (see 1 fusions); KSR1 (see 1 fusions); HDAC5 (see 1 fusions); HDAC4 (see 1 fusions); MARK2 (see 2 fusions); YWHAG (see 1 fusions); CTBP2 (see 2 fusions); YWHAZ (see 1 fusions); YWHAH (see 2 fusions); MARK3 (see 1 fusions); MAPT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MARK3parental protein480.0931662.597KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2 ALYREFinteractor31.0000FYTT (PF07078, IPR009782): Forty-two-three protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
3 ASB13interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SOCS_box (PF07525, IPR001496): SOCS box
4 ATP6V0Cinteractor100ATP-synt_C (PF00137, IPR002379): ATP synthase subunit C
5 CAPZA1interactor50.9000.500F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
6 CAPZBinteractor41.0000Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
7 CASQ2interactor100Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
8 CDC25Concoprotein80.8930.564M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
9 CEP192interactor100Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like
MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
10 CHGBinteractor100Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
11 CNBPoncoprotein100zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
12 CPSF3interactor21.0000Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
RMMBL (PF07521, IPR011108): Zn-dependent metallo-hydrolase RNA specificity domain
Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
CPSF73-100_C (PF11718, IPR021718, SM01098): Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Lactamase_B_3 (PF13483): Beta-lactamase superfamily domain
13 CTBP2protein found in more fusions2002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
14 DLG5interactor21.0000Takusan (PF04822, IPR006907): Takusan
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
dbPDZ_assoc (PF16610): Unstructured region between two PDZ domains on Dlg5
15 HDAC4oncoprotein110.9330.564Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
16 HDAC5protein found in more fusions130.69713.197Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
17 HDAC7protein found in more fusions120.9090.986Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
18 HNRNPDLinteractor21.0000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 KSR1oncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
20 MAP2oncoprotein31.0000MAP2_projctn (PF08377, IPR013588): MAP2/Tau projection domain
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
RII_binding_1 (PF10522, IPR018459): RII binding domain
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
21 MAPTprotein found in more fusions61.0000Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
22 MARK2protein found in more fusions200.35789.253DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
23 MEX3Cinteractor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 MITFoncoprotein100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
25 MTCL1interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
SOGA (PF11365, IPR027881): Protein SOGA
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26 NTRK1oncoprotein180.35376.297I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
27 PIM1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
28 PKP2interactor60.6002.530Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
29 PMPCBinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
30 PNPLA2interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
31 PPP2CBsuppressor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 PRKAA1suppressor60.8670.422Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
33 RASGRF1oncoprotein21.0000HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
34 SAAL1interactor100NA
35 SFNsuppressor120.6735.50014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
36 TADA2Ainteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
37 TCEA2interactor100Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
38 TERF2interactor200Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
39 TMEM17interactor40.6670.733Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
40 TTRinteractor200Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
41 USP21interactor31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
42 VPS11interactor21.0000DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
43 YWHABinteractor170.50742.23314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
44 YWHAEoncoprotein150.62918.13314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
45 YWHAGprotein found in more fusions140.8332.93014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
46 YWHAHprotein found in more fusions150.64821.53314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
47 YWHAQinteractor150.69511.13014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
48 YWHAZprotein found in more fusions160.70510.89714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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