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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAPKAPK5 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins9 (47.37 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)45 (26.32 %)
The number (and %) of affected PPIs19 (42.22 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.579
Assortativity coefficient-0.5204
The network average Clustering coefficient0.421
The number (and %) of a zero Clustering coefficients7 (36.84 %)
The number (and %) of a zero Betweenness Centrality10 (52.63 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAPKAPK5 All fusions
: BP398174; BE169498; BU622192; BP398708;
Proteins found in more fusions HSPB1 (see 3 fusions); MAPKAPK5 (see 4 fusions); SRPK2 (see 1 fusions); MAPK9 (see 3 fusions); TP53 (see 3 fusions); MAPK1 (see 1 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAPKAPK5parental protein190.105246.167Pkinase (PF00069, IPR000719): Protein kinase domain
2 CDCA8interactor200Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
3 EIF4EBP1oncoprotein31.0000eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
4 HSPB1oncoprotein40.6670.500HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
5 HSPB2interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
6 LSRinteractor100LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
7 MAPK1oncoprotein60.7001.833Pkinase (PF00069, IPR000719): Protein kinase domain
8 MAPK14oncoprotein80.4769.500Pkinase (PF00069, IPR000719): Protein kinase domain
9 MAPK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
10 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
11 MAPK9oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
12 MAPKAPK2oncoprotein50.6671.333Pkinase (PF00069, IPR000719): Protein kinase domain
13 RPL13interactor30.6670.667Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
14 SRPK1interactor40.6671.667FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
15 SRPK2oncoprotein40.6670.667DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
16 TAB1interactor21.0000PP2C (PF00481, IPR001932): Protein phosphatase 2C
17 TP53oncoprotein80.38111.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
18 ZNF282interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
19 ZNF576interactor100Opy2 (PF09463, IPR018571): Opy2 protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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