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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)133
The number (and %) of the onco-proteins45 (33.83 %)
The number (and %) of the tumor suppressors21 (15.79 %)
Total number of binary PPIs (saturation %)802 (9.14 %)
The number (and %) of affected PPIs133 (16.58 %)
The number of possible different fusions29
PPI diameter2
PPI radius1
The average degree of PPI10.992
Assortativity coefficient-0.2702
The network average Clustering coefficient0.510
The number (and %) of a zero Clustering coefficients8 (6.02 %)
The number (and %) of a zero Betweenness Centrality23 (17.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K7 All fusions
: BF082260; BF082302; BF082281; BF082282; BF082284;
Proteins found in more fusions TAB2 (see 1 fusions); TRAF6 (see 1 fusions); SYK (see 1 fusions); MAGED1 (see 1 fusions); TNF (see 1 fusions); HSP90AA1 (see 2 fusions); HIPK2 (see 1 fusions); PINK1 (see 3 fusions); TNFRSF1A (see 2 fusions); STAT3 (see 2 fusions); MALT1 (see 1 fusions); EIF2AK2 (see 1 fusions); TRAF4 (see 1 fusions); RIPK1 (see 1 fusions); MCM2 (see 1 fusions); STUB1 (see 1 fusions); RACK1 (see 3 fusions); HSPB1 (see 4 fusions); COPS5 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); EZH2 (see 1 fusions); DAZAP2 (see 2 fusions); HCFC1 (see 2 fusions); MAP3K5 (see 1 fusions); CDC37 (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP3K7parental protein1330.06911773.532Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 ARRB2interactor190.29873.216Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3 ATMsuppressor80.4764.863FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 BBS10interactor30.6670.667Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
5 BCL10suppressor200.38655.263CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
6 BST2oncoprotein50.5002.286DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
7 CARD11oncoprotein160.43831.051CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
8 CARD8oncoprotein50.7003.000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
9 CARNMT1interactor31.0000N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
10 CDC37protein found in more fusions150.41829.837CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
11 CHUKsuppressor360.301199.858Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
12 CLTConcoprotein70.4765.536Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
13 COPS5protein found in more fusions180.27960.778JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
14 CYLDsuppressor130.43623.655CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
15 DAAM1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
16 DAZAP2protein found in more fusions50.6672.000DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
17 DR1interactor70.6196.333CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
18 ECSITinteractor50.5001.133ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
19 EDARADDinteractor51.0000Death (PF00531, IPR000488, SM00005): Death domain
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
20 EIF2AK2oncoprotein130.53013.388dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
21 ERC1oncoprotein70.5715.298RBD-FIP (PF09457, IPR019018): FIP domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
22 EZH2suppressor60.5002.833CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
23 FBXL17interactor100TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
24 FBXW5interactor40.6671.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
25 FYBinteractor41.0000PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
SH3_2 (PF07653, IPR011511): Variant SH3 domain
hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
DUF4651 (PF15513, IPR028105): Domain of unknown function (DUF4651)
26 HCFC1protein found in more fusions31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
27 HGSinteractor80.35714.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
28 HIPK2suppressor40.6671.000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
29 HSP90AA1oncoprotein350.225285.040HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
30 HSPA1Linteractor110.50910.848HSP70 (PF00012, IPR013126): Hsp70 protein
31 HSPB1oncoprotein150.41828.926HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
32 IKBKAPinteractor70.7332.333IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
33 IKBKBprotein found in more fusions320.312153.912FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
34 IKBKGinteractor410.260336.743CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
35 IL17RAinteractor41.0000SEFIR (PF08357, IPR013568): SEFIR domain
IL17R_fnIII_D1 (PF16556, IPR032356): Interleukin-17 receptor, fibronectin-III-like domain 1
IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
36 IL17RDsuppressor100SEFIR (PF08357, IPR013568): SEFIR domain
DUF2141 (PF09912, IPR018673): Uncharacterized protein conserved in bacteria (DUF2141)
DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
IL17R_D_N (PF16742, IPR031951): N-terminus of interleukin 17 receptor D
37 IRAK1interactor220.39064.362Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
38 ITCHinteractor170.32552.033C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
39 KAT2Ainteractor90.50013.000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
40 MAGED1protein found in more fusions90.4299.916MAGE (PF01454, IPR002190): MAGE family
41 MALT1oncoprotein150.50515.175Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
42 MAP2K4suppressor90.5007.900Pkinase (PF00069, IPR000719): Protein kinase domain
43 MAP2K6interactor90.33318.111Pkinase (PF00069, IPR000719): Protein kinase domain
44 MAP2K7interactor100.44416.975Pkinase (PF00069, IPR000719): Protein kinase domain
45 MAP3K14interactor150.52718.238Pkinase (PF00069, IPR000719): Protein kinase domain
46 MAP3K3oncoprotein140.44921.220PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
47 MAP3K5oncoprotein160.34345.238Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
48 MAP4K1suppressor50.8330.400CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
49 MAPK6oncoprotein100.25025.333Pkinase (PF00069, IPR000719): Protein kinase domain
50 MAPK8oncoprotein140.24445.183DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
51 MAPK8IP1oncoprotein70.5334.667PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
52 MAVSinteractor160.39041.606Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
53 MCM2oncoprotein150.36332.424AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
54 MED4interactor50.4004.567Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
55 MIB2oncoprotein50.7000.905Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
KOW (PF00467, IPR005824, SM00739): KOW motif
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
56 MYD88oncoprotein140.34633.010Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
57 NAIPinteractor21.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
Fer4_9 (PF13187, IPR017896): 4Fe-4S dicluster domain
58 NDFIP1interactor40.6671.067DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
59 NDUFS6interactor21.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
60 NFKBIAoncoprotein150.44826.960Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
61 NLKprotein found in more fusions60.4004.786Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
62 NOD2interactor100.6674.310CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
63 PDPK1interactor70.4006.000Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
64 PELI3interactor60.6671.413Pellino (PF04710, IPR006800): Pellino
65 PINK1protein found in more fusions70.8000.733Pkinase (PF00069, IPR000719): Protein kinase domain
66 POLE4interactor31.0000CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
67 PPM1Binteractor80.5365.379PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
68 PPM1Lsuppressor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
69 PPP2R1Aoncoprotein130.33334.489TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
70 PPP5Cinteractor50.7001.086Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
71 PPP6Cinteractor31.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
72 PRKAA1suppressor90.36117.919Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
73 PRKAB1oncoprotein30.6671.000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
74 PRKCQinteractor110.6009.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
75 PRMT2interactor31.0000PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
76 PSMC3interactor90.39314.852AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
77 RACK1suppressor110.35620.475WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 RBCK1interactor120.6186.877GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
79 RBM7interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
80 RBX1oncoprotein90.35712.567zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
81 RELAoncoprotein170.25860.675DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
82 RIPK1protein found in more fusions240.39564.099Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
83 RIPK2interactor180.49333.616CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
84 RNF19Ainteractor100IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
85 RNF4interactor60.7002.333Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
86 ROR2suppressor60.6002.733I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Kringle (PF00051, IPR000001): Kringle domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Fz (PF01392, IPR020067, SM00063): Fz domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
87 RUVBL1oncoprotein60.6002.917TIP49 (PF06068, IPR010339): TIP49 C-terminus
88 SASH1suppressor70.6674.733PGA2 (PF07543, IPR011431): Protein trafficking PGA2
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
89 SGF29interactor60.7334.000DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
90 SIK1suppressor40.6670.800Pkinase (PF00069, IPR000719): Protein kinase domain
91 SIK3oncoprotein50.5003.200GET2 (PF08690, IPR028143): GET complex subunit GET2
Pkinase (PF00069, IPR000719): Protein kinase domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
92 SIVA1interactor31.0000Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
93 SKILsuppressor60.5003.833c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
94 SMAD3oncoprotein170.21774.519MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
95 SMAD6interactor70.5246.852MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
96 SMAD7interactor120.34825.371MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
97 SOCS3suppressor80.32114.089SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
98 STAT3suppressor120.38219.929SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
99 STRADBinteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
ASXH (PF13919, IPR028020): Asx homology domain
100 STUB1suppressor190.36645.358U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
101 SYKsuppressor110.46715.426Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
102 TAB1interactor300.223229.871PP2C (PF00481, IPR001932): Protein phosphatase 2C
103 TAB2oncoprotein370.221327.728CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
104 TAB3oncoprotein120.56411.363CUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
105 TADA3interactor51.0000GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
106 TAOK1interactor100Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Pkinase (PF00069, IPR000719): Protein kinase domain
PKK (PF12474, IPR022165): Polo kinase kinase
TcdB_N (PF12918, IPR024772): TcdB toxin N-terminal helical domain
107 TAOK2interactor21.0000Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
Pkinase (PF00069, IPR000719): Protein kinase domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
108 TGFBR1oncoprotein120.40923.588Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
109 TGFBR2suppressor70.5245.567ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
110 TIRAPinteractor90.5717.475TIR_2 (PF13676, IPR000157): TIR domain
111 TLR3interactor80.5715.886LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
112 TNFoncoprotein140.6159.808TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
113 TNFRSF11Aoncoprotein70.7142.329Abi (PF02517, IPR003675): CAAX protease self-immunity
DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
KIX (PF02172, IPR003101): KIX domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
114 TNFRSF1Aoncoprotein170.53323.296Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
115 TRAF2interactor350.292209.188MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
116 TRAF3oncoprotein160.46723.579ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
117 TRAF3IP2interactor120.58210.186SEFIR (PF08357, IPR013568): SEFIR domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
118 TRAF4oncoprotein110.51111.125MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
119 TRAF5interactor140.52617.357Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
120 TRAF6protein found in more fusions510.182662.440SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
121 TRIM5interactor70.6671.626Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0)
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
122 TRIM8interactor50.5001.133dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
123 USP18interactor70.8570.651TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
124 USP2interactor120.47022.380UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
125 USP4oncoprotein90.6076.239UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
126 VRK2interactor50.7002.333Pkinase (PF00069, IPR000719): Protein kinase domain
VP_N-CPKC (PF11475, IPR021573): Virion protein N terminal domain
127 WDR34interactor60.6003.748GTF2I (PF02946, IPR004212): GTF2I-like repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
128 XIAPinteractor170.33347.835BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
129 XPO1interactor300.200247.841CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
130 YEATS2interactor80.50013.000YEATS (PF03366, IPR005033): YEATS family
131 YWHAEoncoprotein100.44414.10714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
132 ZNF593interactor100DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
133 ZNF746interactor100Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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