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Fusion ID: Protein names:	MAP3K3 PTPN21
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Visualization interactions

Cytoscape Web for: parental proteins MAP3K3, PTPN21 (from a repository: Fri Oct 4 03:08:56 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	52
The number (and %) of the onco-proteins	21 (40.38 %)
The number (and %) of the tumor suppressors	9 (17.31 %)
Total number of binary PPIs (saturation %)	215 (16.21 %)
The number (and %) of affected PPIs	51 (23.72 %)
The number of possible different fusions	16
PPI diameter	5
PPI radius	3
The average degree of PPI	7.154
Assortativity coefficient	-0.2542
The network average Clustering coefficient	0.471
The number (and %) of a zero Clustering coefficients	5 (9.62 %)
The number (and %) of a zero Betweenness Centrality	9 (17.31 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MAP3K3,PTPN21	All fusions
Proteins found in more fusions	NEDD4L (see 4 fusions); COPS5 (see 1 fusions); TRAF6 (see 1 fusions); MAP3K7 (see 7 fusions); SQSTM1 (see 5 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); YWHAG (see 1 fusions); MTOR (see 1 fusions); MAP3K2 (see 2 fusions); ZBTB16 (see 4 fusions); RIPK1 (see 1 fusions); HSP90AA1 (see 6 fusions); EGFR (see 2 fusions); NEDD4 (see 1 fusions);

List of the fusions

PPI for parental proteins: MAP3K3,PTPN21

All fusions

Proteins found in more fusions

NEDD4L (see 4 fusions); COPS5 (see 1 fusions); TRAF6 (see 1 fusions); MAP3K7 (see 7 fusions); SQSTM1 (see 5 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); YWHAG (see 1 fusions); MTOR (see 1 fusions); MAP3K2 (see 2 fusions); ZBTB16 (see 4 fusions); RIPK1 (see 1 fusions); HSP90AA1 (see 6 fusions); EGFR (see 2 fusions); NEDD4 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MAP3K3	parental protein	47	0.119	1471.997	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
2	PTPN21	parental protein	4	0.167	107.901	FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PRIMA1 (PF16101): Proline-rich membrane anchor 1
3	BIRC2	oncoprotein	7	0.600	2.748	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
4	BMX	interactor	4	0.667	38.654	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain PH_8 (PF15409): Pleckstrin homology domain
5	BRCA1	suppressor	8	0.333	11.301	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6	CDC37	protein found in more fusions	11	0.511	24.628	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7	CHUK	suppressor	13	0.500	33.323	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
8	COPS5	protein found in more fusions	9	0.429	17.173	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9	EGFR	oncoprotein	17	0.250	130.711	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10	FLNA	suppressor	6	0.400	21.881	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
11	FUS	suppressor	4	0.667	1.042	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
12	GAB1	oncoprotein	3	0.667	1.067	PH (PF00169, IPR001849, SM00233): PH domain
13	GLRX3	interactor	2	0	0	Glutaredoxin (PF00462, IPR002109): Glutaredoxin Thioredoxin (PF00085, IPR013766): Thioredoxin TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
14	GTF2I	interactor	3	0.667	0.500	GTF2I (PF02946, IPR004212): GTF2I-like repeat
15	HSP90AA1	oncoprotein	21	0.268	181.459	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
16	HSP90AA2P	oncoprotein	2	1.000	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
17	HSPA4	interactor	9	0.500	8.802	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
18	IP6K3	interactor	1	0	0	IPK (PF03770, IPR005522): Inositol polyphosphate kinase
19	IRAK1	interactor	11	0.600	8.621	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
20	KIF1C	interactor	3	0.333	26.269	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
21	KIFC3	oncoprotein	4	0.667	0.633	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
22	MAP2K3	interactor	5	0.500	2.867	Pkinase (PF00069, IPR000719): Protein kinase domain
23	MAP2K4	suppressor	8	0.381	12.382	Pkinase (PF00069, IPR000719): Protein kinase domain
24	MAP2K5	oncoprotein	5	0.667	1.375	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
25	MAP2K7	interactor	6	0.733	1.519	Pkinase (PF00069, IPR000719): Protein kinase domain
26	MAP3K2	protein found in more fusions	15	0.209	70.523	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
27	MAP3K7	oncoprotein	14	0.449	28.193	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28	MARK2	protein found in more fusions	7	0.467	7.716	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
29	MBP	interactor	2	1.000	0	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
30	MTOR	oncoprotein	10	0.528	7.723	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
31	NBR1	oncoprotein	4	0.667	1.000	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681) N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
32	NEDD4	suppressor	7	0.333	23.138	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
33	NEDD4L	suppressor	7	0.533	5.186	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
34	PARD6B	interactor	1	0	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
35	PDRG1	interactor	3	0.667	1.067	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
36	PFDN2	interactor	3	0.667	0.667	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
37	PPP2CA	suppressor	5	0.500	2.833	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38	PRKACA	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
39	RIPK1	protein found in more fusions	10	0.556	7.935	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
40	SMURF1	interactor	7	0.333	5.738	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
41	SPAG9	interactor	3	0.667	0.500	DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IncA (PF04156, IPR007285): IncA protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
42	SQSTM1	oncoprotein	13	0.318	35.548	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
43	SRC	oncoprotein	11	0.267	150.048	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44	TOM1L1	interactor	3	0.667	5.414	GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
45	TRAF6	protein found in more fusions	13	0.348	54.593	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46	TRAF7	oncoprotein	2	1.000	0	Sina (PF03145, IPR018121): Seven in absentia protein family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase WD40_like (PF17005, IPR031544): WD40-like domain
47	VWF	interactor	1	0	0	Antistasin (PF02822, IPR004094): Antistasin family C8 (PF08742, IPR014853, SM00832): C8 domain Metallothio_5 (PF02067, IPR000966): Metallothionein family 5 Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII) TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain VWA_N2 (PF16164, IPR032361): VWA N-terminal
48	XIAP	interactor	9	0.464	8.067	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
49	XPO1	interactor	15	0.352	55.554	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
50	YWHAE	oncoprotein	8	0.429	56.663	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
51	YWHAG	protein found in more fusions	9	0.464	59.043	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
52	ZBTB16	suppressor	2	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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