Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZAK (from a repository: Mon Dec 5 00:23:22 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 38 The number (and %) of the onco-proteins 9 (23.68 %) The number (and %) of the tumor suppressors 5 (13.16 %) Total number of binary PPIs (saturation %) 99 (14.08 %) The number (and %) of affected PPIs 38 (38.38 %) The number of possible different fusions 8 PPI diameter 2 PPI radius 1 The average degree of PPI 4.474 Assortativity coefficient -0.3622 The network average Clustering coefficient 0.579 The number (and %) of a zero Clustering coefficients 8 (21.05 %) The number (and %) of a zero Betweenness Centrality 20 (52.63 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MAP3K20	All fusions : AW629613;
Proteins found in more fusions	SMARCB1 (see 12 fusions); NEDD4L (see 3 fusions); YWHAZ (see 1 fusions); EZH2 (see 1 fusions); MYC (see 1 fusions); ZAK (see 2 fusions); SRPK2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ZAK	parental protein	38	0.072	1085.067	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
2	CCDC69	interactor	1	0	0	NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein DUF2441 (PF10386, IPR018840): Protein of unknown function (DUF2441) Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
3	CDC42	oncoprotein	7	0.533	6.333	Ras (PF00071, IPR001806, SM00173): Ras family
4	CRMP1	interactor	3	1.000	0	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
5	DDAH2	interactor	2	1.000	0	Amidinotransf (PF02274, IPR003198): Amidinotransferase
6	ELAVL1	oncoprotein	14	0.256	55.900	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7	EMC2	interactor	1	0	0	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_19 (PF14559): Tetratricopeptide repeat Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
8	EZH2	suppressor	5	0.667	2.000	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
9	IGHM	interactor	1	0	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
10	ITSN1	interactor	6	0.600	3.333	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
11	MAP2K7	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
12	MIDN	interactor	2	1.000	0	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
13	MPP1	oncoprotein	1	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
14	MYC	oncoprotein	7	0.667	3.400	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
15	NEDD4L	suppressor	7	0.667	3.233	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
16	PARD6A	interactor	4	0.667	2.000	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
17	RAB5A	oncoprotein	3	0.667	0.667	Ras (PF00071, IPR001806, SM00173): Ras family
18	RBX1	oncoprotein	4	1.000	0	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
19	RNF19A	interactor	2	1.000	0	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
20	RPL10	suppressor	2	1.000	0	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
21	RPS6KA5	interactor	10	0.222	34.667	Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
22	SFN	suppressor	5	0.667	2.000	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
23	SMARCB1	suppressor	5	0.667	1.667	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
24	SRPK2	oncoprotein	4	0.667	1.000	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
25	TGFBR1	oncoprotein	4	0.833	0.667	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
26	UNC119	interactor	4	0.833	0.667	GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
27	VPS33B	interactor	2	1.000	0	Sec1 (PF00995, IPR001619): Sec1 family
28	XPO1	interactor	8	0.464	12.333	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
29	XRCC1	interactor	2	1.000	0	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain SPX (PF03105, IPR004331): SPX domain XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
30	YWHAB	interactor	7	0.429	10.667	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
31	YWHAZ	protein found in more fusions	8	0.429	10.400	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32	ZFP2	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
33	ZNF33A	interactor	1	0	0	HNH (PF01844, IPR002711): HNH endonuclease KRAB (PF01352, IPR001909, SM00349): KRAB box XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zinc_ribbon_4 (PF13717): zinc-ribbon domain
34	ZNF567	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
35	ZNF593	interactor	2	1.000	0	DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073) zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
36	ZNF746	interactor	2	1.000	0	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3669 (PF12417, IPR022137): Zinc finger protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
37	ZNF775	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
38	ZWINT	interactor	2	0	0	Zwint (PF15556, IPR029092): ZW10 interactor

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