Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAP3K1 (from a repository: Wed Nov 23 19:32:23 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 130 The number (and %) of the onco-proteins 38 (29.23 %) The number (and %) of the tumor suppressors 16 (12.31 %) Total number of binary PPIs (saturation %) 616 (7.35 %) The number (and %) of affected PPIs 130 (21.10 %) The number of possible different fusions 23 PPI diameter 2 PPI radius 1 The average degree of PPI 8.554 Assortativity coefficient -0.3263 The network average Clustering coefficient 0.491 The number (and %) of a zero Clustering coefficients 13 (10.00 %) The number (and %) of a zero Betweenness Centrality 33 (25.38 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MAP3K1	All fusions : DL057152;
Proteins found in more fusions	YWHAG (see 1 fusions); UBE2G1 (see 1 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); HIPK2 (see 1 fusions); RNF114 (see 1 fusions); ACTN1 (see 3 fusions); GRB2 (see 1 fusions); MAPK9 (see 3 fusions); MAP3K1 (see 1 fusions); UBAP1 (see 2 fusions); UBQLN1 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2L6 (see 2 fusions); CD74 (see 12 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); IKBKB (see 2 fusions); UBE2E1 (see 2 fusions); ARHGAP4 (see 5 fusions); CDC37 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MAP3K1	parental protein	130	0.052	12757.626	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
2	ACTN1	protein found in more fusions	6	0.600	1.733	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
3	ALK	oncoprotein	6	0.467	5.852	MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
4	APEX2	interactor	2	1.000	0	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family zf-GRF (PF06839, IPR010666): GRF zinc finger
5	APPL1	interactor	5	0.500	0.800	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region PH (PF00169, IPR001849, SM00233): PH domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) BAR_3 (PF16746): BAR domain of APPL family
6	ARHGAP4	oncoprotein	2	0	0	DASH_Spc19 (PF08287, IPR013251): Spc19 FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7	ARRB1	interactor	17	0.301	60.658	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8	ARRB2	interactor	22	0.277	102.367	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9	ASCC2	interactor	2	1.000	0	CUE (PF02845, IPR003892, SM00546): CUE domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
10	ATXN3	interactor	7	0.467	4.833	Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11	AXIN1	suppressor	8	0.619	3.672	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
12	BAP1	suppressor	3	0.667	1.000	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
13	BRCA1	suppressor	20	0.205	107.253	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
14	C6orf106	interactor	2	1.000	0	UBA_4 (PF14555): UBA-like domain N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
15	CARD14	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain ZapB (PF06005, IPR009252): Cell division protein ZapB PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
16	CCDC69	interactor	1	0	0	NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein DUF2441 (PF10386, IPR018840): Protein of unknown function (DUF2441) Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
17	CD74	oncoprotein	2	0	0	MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
18	CDC37	protein found in more fusions	12	0.382	24.989	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
19	CEP85	interactor	3	0.667	0.500	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SlyX (PF04102, IPR007236): SlyX Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
20	CHUK	suppressor	12	0.491	12.301	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
21	CRELD1	interactor	2	1.000	0	DUF326 (PF03860, IPR005560): Domain of Unknown Function (DUF326) EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
22	CRTC1	oncoprotein	3	1.000	0	TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
23	CUEDC1	oncoprotein	2	1.000	0	CUE (PF02845, IPR003892, SM00546): CUE domain
24	DCAF7	interactor	9	0.472	12.933	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25	DCUN1D1	interactor	10	0.289	23.425	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
26	DCUN1D2	interactor	2	1.000	0	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
27	DENND6B	interactor	1	0	0	DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain SPA (PF08616): Stabilization of polarity axis Avl9 (PF09794, IPR018307): Transport protein Avl9
28	DNAJB2	interactor	5	0.500	3.500	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
29	DNAJB6	interactor	6	0.467	5.000	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
30	DTX1	interactor	8	0.333	5.854	WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger PRIMA1 (PF16101): Proline-rich membrane anchor 1
31	DVL2	interactor	11	0.333	20.389	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
32	DYRK1A	oncoprotein	7	0.733	2.467	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
33	DYRK1B	oncoprotein	6	0.500	3.667	Pkinase (PF00069, IPR000719): Protein kinase domain
34	EPHA1	suppressor	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
35	EPN1	interactor	5	0.700	2.667	ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
36	FAF2	interactor	10	0.472	13.300	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
37	FAM184A	interactor	2	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus DivIC (PF04977, IPR007060): Septum formation initiator DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) SlyX (PF04102, IPR007236): SlyX ApoO (PF09769, IPR019166): Apolipoprotein O KxDL (PF10241, IPR019371): Uncharacterized conserved protein TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding FAM184 (PF15665): Family with sequence similarity 184, A and B PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
38	FAM188A	suppressor	2	1.000	0	DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
39	FKBP5	interactor	6	0.733	2.233	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
40	FKBP6	interactor	2	1.000	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
41	FLNB	oncoprotein	5	0.500	3.500	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
42	FRAT1	oncoprotein	3	0.667	1.000	GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding
43	GGA2	interactor	3	0.667	0.333	Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
44	GRB2	oncoprotein	16	0.295	56.219	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
45	GRIPAP1	interactor	1	0	0	DivIC (PF04977, IPR007060): Septum formation initiator HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) Rab5-bind (PF09311, IPR015390): Rabaptin-like protein TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574) JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
46	GSK3B	suppressor	13	0.348	27.663	Pkinase (PF00069, IPR000719): Protein kinase domain
47	GSTP1	suppressor	7	0.600	2.883	GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
48	HBS1L	interactor	3	1.000	0	HBS1_N (PF08938, IPR015033): HBS1 N-terminus GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
49	HGS	interactor	11	0.309	26.119	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
50	HIP1	oncoprotein	3	1.000	0	ANTH (PF07651, IPR011417): ANTH domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
51	HIPK2	suppressor	8	0.524	6.667	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
52	HSP90AA2P	oncoprotein	1	0	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
53	HSPA1L	interactor	11	0.364	18.071	HSP70 (PF00012, IPR013126): Hsp70 protein
54	IKBKB	protein found in more fusions	10	0.472	10.989	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
55	IMPACT	interactor	2	1.000	0	RWD (PF05773, IPR006575, SM00591): RWD domain UPF0029 (PF01205, IPR001498): Uncharacterized protein family UPF0029
56	JUN	oncoprotein	15	0.396	33.236	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
57	KAT5	suppressor	8	0.476	8.667	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
58	KRT36	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein
59	LLGL2	interactor	4	0.667	1.000	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
60	MAP2K1	oncoprotein	10	0.528	7.160	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
61	MAP2K4	suppressor	12	0.509	17.521	Pkinase (PF00069, IPR000719): Protein kinase domain
62	MAP2K7	interactor	11	0.473	16.571	Pkinase (PF00069, IPR000719): Protein kinase domain
63	MAP4K2	oncoprotein	3	0.667	0.400	CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain
64	MAP4K4	interactor	4	0.667	0.900	CNH (PF00780, IPR001180, SM00036): CNH domain FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Pkinase (PF00069, IPR000719): Protein kinase domain FAM165 (PF14981, IPR028023): FAM165 family SOBP (PF15279, IPR026092): Sine oculis-binding protein FAM60A (PF15396, IPR026065): Protein Family FAM60A
65	MAPK1	oncoprotein	20	0.275	80.612	Pkinase (PF00069, IPR000719): Protein kinase domain
66	MAPK3	oncoprotein	13	0.409	19.456	Pkinase (PF00069, IPR000719): Protein kinase domain
67	MAPK8	oncoprotein	16	0.305	53.622	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
68	MAPK8IP3	interactor	9	0.500	9.422	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
69	MAPK9	suppressor	12	0.473	13.710	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
70	MCM2	oncoprotein	25	0.214	157.524	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
71	NEK10	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-cone (PF03477, IPR005144): ATP cone domain Pkinase (PF00069, IPR000719): Protein kinase domain
72	NFKBIA	oncoprotein	16	0.242	68.675	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
73	NOP56	interactor	6	0.733	1.686	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
74	NPLOC4	interactor	8	0.500	7.144	NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
75	NR4A1	suppressor	4	0.667	0.533	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
76	NTRK1	oncoprotein	35	0.139	402.015	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77	ODF2	interactor	6	0.333	8.333	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 (PF09134, IPR015217): Invasin, domain 3 Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
78	PAK1	oncoprotein	6	0.500	3.333	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
79	PLEKHB2	interactor	3	0.667	0.667	PH (PF00169, IPR001849, SM00233): PH domain
80	PSMD4	interactor	8	0.500	8.167	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
81	RAB3IL1	interactor	3	1.000	0	Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
82	RABEP2	interactor	3	0.667	1.000	Rab5-bind (PF09311, IPR015390): Rabaptin-like protein Rabaptin (PF03528, IPR018514): Rabaptin
83	RAD18	interactor	7	0.467	5.700	PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47 SAP (PF02037, IPR003034, SM00513): SAP domain zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
84	RAD23A	oncoprotein	11	0.311	23.100	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85	RAD51AP1	interactor	1	0	0	RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
86	RAF1	oncoprotein	16	0.343	41.463	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87	RBCK1	interactor	11	0.267	25.121	GAGA (PF09237, IPR015318): GAGA factor IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
88	RHOA	suppressor	4	0.500	2.333	Ras (PF00071, IPR001806, SM00173): Ras family
89	RNF114	protein found in more fusions	10	0.278	12.987	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
90	RNF126	interactor	8	0.619	2.954	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zinc_ribbon_9 (PF14369): zinc-ribbon
91	RNF141	interactor	1	0	0	zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
92	RPL30	interactor	9	0.500	9.716	NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
93	RPL4	interactor	10	0.578	8.887	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
94	RPS13	interactor	10	0.556	8.002	Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
95	SPG20	interactor	1	0	0	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
96	STAM	interactor	6	0.533	4.917	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
97	STAM2	interactor	11	0.273	26.935	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
98	STK38	interactor	4	1.000	0	MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99	TAB1	interactor	8	0.571	5.851	PP2C (PF00481, IPR001932): Protein phosphatase 2C
100	TNIP1	interactor	5	0.500	1.417	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
101	TOM1	oncoprotein	4	0.667	0.686	GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
102	TOM1L2	suppressor	2	1.000	0	GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
103	TP53	suppressor	30	0.143	250.846	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
104	TRAF2	interactor	19	0.176	97.133	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
105	TRIM5	interactor	9	0.393	7.759	Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
106	UBAC1	interactor	4	0.667	1.000	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain HEAT_2 (PF13646): HEAT repeats Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like
107	UBAP1	protein found in more fusions	3	1.000	0	MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
108	UBASH3B	interactor	8	0.381	6.230	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
109	UBE2D1	interactor	19	0.229	72.036	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
110	UBE2D2	oncoprotein	19	0.275	62.425	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
111	UBE2D3	interactor	12	0.200	17.802	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
112	UBE2D4	interactor	8	0.333	5.067	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
113	UBE2E1	protein found in more fusions	7	0.400	3.950	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
114	UBE2G1	protein found in more fusions	3	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
115	UBE2I	interactor	18	0.257	69.541	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116	UBE2K	interactor	9	0.500	10.050	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
117	UBE2L6	protein found in more fusions	4	0.667	0.333	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
118	UBE2V1	interactor	9	0.389	15.233	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119	UBE2W	interactor	4	0.667	0.250	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120	UBQLN1	protein found in more fusions	13	0.318	31.000	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
121	UBXN7	interactor	9	0.417	13.300	UBX (PF00789, IPR001012, SM00166): UBX domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
122	UCHL5	oncoprotein	7	0.533	5.400	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
123	UFD1L	interactor	8	0.429	12.186	UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
124	USP28	interactor	5	0.500	2.667	TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif UBA_4 (PF14555): UBA-like domain DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
125	XPO1	interactor	36	0.129	447.717	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
126	YWHAE	oncoprotein	17	0.397	43.676	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
127	YWHAG	protein found in more fusions	16	0.419	38.200	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
128	YWHAQ	interactor	11	0.582	10.312	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
129	ZFAND3	interactor	1	0	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
130	ZFAND5	interactor	1	0	0	zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger FAM53 (PF15242, IPR029356): Family of FAM53

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