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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)130
The number (and %) of the onco-proteins38 (29.23 %)
The number (and %) of the tumor suppressors16 (12.31 %)
Total number of binary PPIs (saturation %)616 (7.35 %)
The number (and %) of affected PPIs130 (21.10 %)
The number of possible different fusions23
PPI diameter2
PPI radius1
The average degree of PPI8.554
Assortativity coefficient-0.3263
The network average Clustering coefficient0.491
The number (and %) of a zero Clustering coefficients13 (10.00 %)
The number (and %) of a zero Betweenness Centrality33 (25.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K1 All fusions
: DL057152;
Proteins found in more fusions YWHAG (see 1 fusions); UBE2G1 (see 1 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); HIPK2 (see 1 fusions); RNF114 (see 1 fusions); ACTN1 (see 3 fusions); GRB2 (see 1 fusions); MAPK9 (see 3 fusions); MAP3K1 (see 1 fusions); UBAP1 (see 2 fusions); UBQLN1 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2L6 (see 2 fusions); CD74 (see 12 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); IKBKB (see 2 fusions); UBE2E1 (see 2 fusions); ARHGAP4 (see 5 fusions); CDC37 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP3K1parental protein1300.05212757.626zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
2 ACTN1protein found in more fusions60.6001.733CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ALKoncoprotein60.4675.852MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
4 APEX2interactor21.0000Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
zf-GRF (PF06839, IPR010666): GRF zinc finger
5 APPL1interactor50.5000.800ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
6 ARHGAP4oncoprotein200DASH_Spc19 (PF08287, IPR013251): Spc19
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 ARRB1interactor170.30160.658Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8 ARRB2interactor220.277102.367Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9 ASCC2interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
10 ATXN3interactor70.4674.833Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 AXIN1suppressor80.6193.672Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
12 BAP1suppressor30.6671.000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
13 BRCA1suppressor200.205107.253BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
14 C6orf106interactor21.0000UBA_4 (PF14555): UBA-like domain
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
15 CARD14interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
ZapB (PF06005, IPR009252): Cell division protein ZapB
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
16 CCDC69interactor100NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
DUF2441 (PF10386, IPR018840): Protein of unknown function (DUF2441)
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
17 CD74oncoprotein200MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
18 CDC37protein found in more fusions120.38224.989CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
19 CEP85interactor30.6670.500DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
20 CHUKsuppressor120.49112.301Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
21 CRELD1interactor21.0000DUF326 (PF03860, IPR005560): Domain of Unknown Function (DUF326)
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
22 CRTC1oncoprotein31.0000TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
23 CUEDC1oncoprotein21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
24 DCAF7interactor90.47212.933WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25 DCUN1D1interactor100.28923.425Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
26 DCUN1D2interactor21.0000Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
27 DENND6Binteractor100DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
SPA (PF08616): Stabilization of polarity axis
Avl9 (PF09794, IPR018307): Transport protein Avl9
28 DNAJB2interactor50.5003.500DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
29 DNAJB6interactor60.4675.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
30 DTX1interactor80.3335.854WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
31 DVL2interactor110.33320.389DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
32 DYRK1Aoncoprotein70.7332.467DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
33 DYRK1Boncoprotein60.5003.667Pkinase (PF00069, IPR000719): Protein kinase domain
34 EPHA1suppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
35 EPN1interactor50.7002.667ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
36 FAF2interactor100.47213.300DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
37 FAM184Ainteractor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DivIC (PF04977, IPR007060): Septum formation initiator
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
SlyX (PF04102, IPR007236): SlyX
ApoO (PF09769, IPR019166): Apolipoprotein O
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
FAM184 (PF15665): Family with sequence similarity 184, A and B
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
38 FAM188Asuppressor21.0000DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
39 FKBP5interactor60.7332.233FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
40 FKBP6interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
41 FLNBoncoprotein50.5003.500CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
42 FRAT1oncoprotein30.6671.000GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding
43 GGA2interactor30.6670.333Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
44 GRB2oncoprotein160.29556.219SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
45 GRIPAP1interactor100DivIC (PF04977, IPR007060): Septum formation initiator
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
46 GSK3Bsuppressor130.34827.663Pkinase (PF00069, IPR000719): Protein kinase domain
47 GSTP1suppressor70.6002.883GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
48 HBS1Linteractor31.0000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
49 HGSinteractor110.30926.119FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
50 HIP1oncoprotein31.0000ANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
51 HIPK2suppressor80.5246.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
52 HSP90AA2Poncoprotein100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
53 HSPA1Linteractor110.36418.071HSP70 (PF00012, IPR013126): Hsp70 protein
54 IKBKBprotein found in more fusions100.47210.989FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
55 IMPACTinteractor21.0000RWD (PF05773, IPR006575, SM00591): RWD domain
UPF0029 (PF01205, IPR001498): Uncharacterized protein family UPF0029
56 JUNoncoprotein150.39633.236bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
57 KAT5suppressor80.4768.667MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
58 KRT36interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
59 LLGL2interactor40.6671.000Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
60 MAP2K1oncoprotein100.5287.160Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
61 MAP2K4suppressor120.50917.521Pkinase (PF00069, IPR000719): Protein kinase domain
62 MAP2K7interactor110.47316.571Pkinase (PF00069, IPR000719): Protein kinase domain
63 MAP4K2oncoprotein30.6670.400CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
64 MAP4K4interactor40.6670.900CNH (PF00780, IPR001180, SM00036): CNH domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM165 (PF14981, IPR028023): FAM165 family
SOBP (PF15279, IPR026092): Sine oculis-binding protein
FAM60A (PF15396, IPR026065): Protein Family FAM60A
65 MAPK1oncoprotein200.27580.612Pkinase (PF00069, IPR000719): Protein kinase domain
66 MAPK3oncoprotein130.40919.456Pkinase (PF00069, IPR000719): Protein kinase domain
67 MAPK8oncoprotein160.30553.622DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
68 MAPK8IP3interactor90.5009.422Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
69 MAPK9suppressor120.47313.710Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
70 MCM2oncoprotein250.214157.524AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
71 NEK10interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-cone (PF03477, IPR005144): ATP cone domain
Pkinase (PF00069, IPR000719): Protein kinase domain
72 NFKBIAoncoprotein160.24268.675Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
73 NOP56interactor60.7331.686Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
74 NPLOC4interactor80.5007.144NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
75 NR4A1suppressor40.6670.533zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
76 NTRK1oncoprotein350.139402.015I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77 ODF2interactor60.3338.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase
Invasin_D3 (PF09134, IPR015217): Invasin, domain 3
Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
78 PAK1oncoprotein60.5003.333PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
79 PLEKHB2interactor30.6670.667PH (PF00169, IPR001849, SM00233): PH domain
80 PSMD4interactor80.5008.167UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
81 RAB3IL1interactor31.0000Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
82 RABEP2interactor30.6671.000Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
83 RAD18interactor70.4675.700PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
84 RAD23Aoncoprotein110.31123.100UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85 RAD51AP1interactor100RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
86 RAF1oncoprotein160.34341.463Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87 RBCK1interactor110.26725.121GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
88 RHOAsuppressor40.5002.333Ras (PF00071, IPR001806, SM00173): Ras family
89 RNF114protein found in more fusions100.27812.987zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
90 RNF126interactor80.6192.954Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
91 RNF141interactor100zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
92 RPL30interactor90.5009.716NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
93 RPL4interactor100.5788.887Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
94 RPS13interactor100.5568.002Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
95 SPG20interactor100MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
96 STAMinteractor60.5334.917GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
97 STAM2interactor110.27326.935GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
98 STK38interactor41.0000MEKHLA (PF08670, IPR013978): MEKHLA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99 TAB1interactor80.5715.851PP2C (PF00481, IPR001932): Protein phosphatase 2C
100 TNIP1interactor50.5001.417ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
101 TOM1oncoprotein40.6670.686GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
102 TOM1L2suppressor21.0000GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
103 TP53suppressor300.143250.846DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
104 TRAF2interactor190.17697.133MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
105 TRIM5interactor90.3937.759Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0)
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
106 UBAC1interactor40.6671.000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
HEAT_2 (PF13646): HEAT repeats
Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like
107 UBAP1protein found in more fusions31.0000MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
108 UBASH3Binteractor80.3816.230His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
109 UBE2D1interactor190.22972.036UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
110 UBE2D2oncoprotein190.27562.425UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
111 UBE2D3interactor120.20017.802UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
112 UBE2D4interactor80.3335.067UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
113 UBE2E1protein found in more fusions70.4003.950UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
114 UBE2G1protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
115 UBE2Iinteractor180.25769.541UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116 UBE2Kinteractor90.50010.050UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
117 UBE2L6protein found in more fusions40.6670.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
118 UBE2V1interactor90.38915.233UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119 UBE2Winteractor40.6670.250UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120 UBQLN1protein found in more fusions130.31831.000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
121 UBXN7interactor90.41713.300UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
122 UCHL5oncoprotein70.5335.400Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
123 UFD1Linteractor80.42912.186UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
124 USP28interactor50.5002.667TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
125 XPO1interactor360.129447.717CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
126 YWHAEoncoprotein170.39743.67614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
127 YWHAGprotein found in more fusions160.41938.20014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
128 YWHAQinteractor110.58210.31214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
129 ZFAND3interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
130 ZFAND5interactor100zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
FAM53 (PF15242, IPR029356): Family of FAM53

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