1 |
MAP3K1 | parental protein | 130 | 0.052 | 12757.626 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal |
2 |
ACTN1 | protein found in more fusions | 6 | 0.600 | 1.733 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation |
3 |
ALK | oncoprotein | 6 | 0.467 | 5.852 | MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site |
4 |
APEX2 | interactor | 2 | 1.000 | 0 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family zf-GRF (PF06839, IPR010666): GRF zinc finger |
5 |
APPL1 | interactor | 5 | 0.500 | 0.800 | ATP-synt_E (PF05680, IPR008386): ATP synthase E chain Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region PH (PF00169, IPR001849, SM00233): PH domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) BAR_3 (PF16746): BAR domain of APPL family |
6 |
ARHGAP4 | oncoprotein | 2 | 0 | 0 | DASH_Spc19 (PF08287, IPR013251): Spc19 FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
7 |
ARRB1 | interactor | 17 | 0.301 | 60.658 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
8 |
ARRB2 | interactor | 22 | 0.277 | 102.367 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
9 |
ASCC2 | interactor | 2 | 1.000 | 0 | CUE (PF02845, IPR003892, SM00546): CUE domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3 |
10 |
ATXN3 | interactor | 7 | 0.467 | 4.833 | Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
11 |
AXIN1 | suppressor | 8 | 0.619 | 3.672 | Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain |
12 |
BAP1 | suppressor | 3 | 0.667 | 1.000 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term |
13 |
BRCA1 | suppressor | 20 | 0.205 | 107.253 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
14 |
C6orf106 | interactor | 2 | 1.000 | 0 | UBA_4 (PF14555): UBA-like domain N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene |
15 |
CARD14 | interactor | 1 | 0 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain ZapB (PF06005, IPR009252): Cell division protein ZapB PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
16 |
CCDC69 | interactor | 1 | 0 | 0 | NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein DUF2441 (PF10386, IPR018840): Protein of unknown function (DUF2441) Ferlin_C (PF16165, IPR032362): Ferlin C-terminus |
17 |
CD74 | oncoprotein | 2 | 0 | 0 | MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat |
18 |
CDC37 | protein found in more fusions | 12 | 0.382 | 24.989 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
19 |
CEP85 | interactor | 3 | 0.667 | 0.500 | DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SlyX (PF04102, IPR007236): SlyX Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding |
20 |
CHUK | suppressor | 12 | 0.491 | 12.301 | Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
21 |
CRELD1 | interactor | 2 | 1.000 | 0 | DUF326 (PF03860, IPR005560): Domain of Unknown Function (DUF326) EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP cEGF (PF12662, IPR026823): Complement Clr-like EGF-like |
22 |
CRTC1 | oncoprotein | 3 | 1.000 | 0 | TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus |
23 |
CUEDC1 | oncoprotein | 2 | 1.000 | 0 | CUE (PF02845, IPR003892, SM00546): CUE domain |
24 |
DCAF7 | interactor | 9 | 0.472 | 12.933 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
25 |
DCUN1D1 | interactor | 10 | 0.289 | 23.425 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
26 |
DCUN1D2 | interactor | 2 | 1.000 | 0 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
27 |
DENND6B | interactor | 1 | 0 | 0 | DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain SPA (PF08616): Stabilization of polarity axis Avl9 (PF09794, IPR018307): Transport protein Avl9 |
28 |
DNAJB2 | interactor | 5 | 0.500 | 3.500 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
29 |
DNAJB6 | interactor | 6 | 0.467 | 5.000 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain |
30 |
DTX1 | interactor | 8 | 0.333 | 5.854 | WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
31 |
DVL2 | interactor | 11 | 0.333 | 20.389 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
32 |
DYRK1A | oncoprotein | 7 | 0.733 | 2.467 | DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X |
33 |
DYRK1B | oncoprotein | 6 | 0.500 | 3.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
34 |
EPHA1 | suppressor | 2 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
35 |
EPN1 | interactor | 5 | 0.700 | 2.667 | ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
36 |
FAF2 | interactor | 10 | 0.472 | 13.300 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
37 |
FAM184A | interactor | 2 | 1.000 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus DivIC (PF04977, IPR007060): Septum formation initiator DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) SlyX (PF04102, IPR007236): SlyX ApoO (PF09769, IPR019166): Apolipoprotein O KxDL (PF10241, IPR019371): Uncharacterized conserved protein TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding FAM184 (PF15665): Family with sequence similarity 184, A and B PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 |
38 |
FAM188A | suppressor | 2 | 1.000 | 0 | DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205) |
39 |
FKBP5 | interactor | 6 | 0.733 | 2.233 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain |
40 |
FKBP6 | interactor | 2 | 1.000 | 0 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat |
41 |
FLNB | oncoprotein | 5 | 0.500 | 3.500 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
42 |
FRAT1 | oncoprotein | 3 | 0.667 | 1.000 | GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding |
43 |
GGA2 | interactor | 3 | 0.667 | 0.333 | Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain |
44 |
GRB2 | oncoprotein | 16 | 0.295 | 56.219 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
45 |
GRIPAP1 | interactor | 1 | 0 | 0 | DivIC (PF04977, IPR007060): Septum formation initiator HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) Rab5-bind (PF09311, IPR015390): Rabaptin-like protein TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574) JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain |
46 |
GSK3B | suppressor | 13 | 0.348 | 27.663 | Pkinase (PF00069, IPR000719): Protein kinase domain |
47 |
GSTP1 | suppressor | 7 | 0.600 | 2.883 | GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain |
48 |
HBS1L | interactor | 3 | 1.000 | 0 | HBS1_N (PF08938, IPR015033): HBS1 N-terminus GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
49 |
HGS | interactor | 11 | 0.309 | 26.119 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo |
50 |
HIP1 | oncoprotein | 3 | 1.000 | 0 | ANTH (PF07651, IPR011417): ANTH domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
51 |
HIPK2 | suppressor | 8 | 0.524 | 6.667 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
52 |
HSP90AA2P | oncoprotein | 1 | 0 | 0 | DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain |
53 |
HSPA1L | interactor | 11 | 0.364 | 18.071 | HSP70 (PF00012, IPR013126): Hsp70 protein |
54 |
IKBKB | protein found in more fusions | 10 | 0.472 | 10.989 | FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
55 |
IMPACT | interactor | 2 | 1.000 | 0 | RWD (PF05773, IPR006575, SM00591): RWD domain UPF0029 (PF01205, IPR001498): Uncharacterized protein family UPF0029 |
56 |
JUN | oncoprotein | 15 | 0.396 | 33.236 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor |
57 |
KAT5 | suppressor | 8 | 0.476 | 8.667 | MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain |
58 |
KRT36 | interactor | 2 | 1.000 | 0 | Filament (PF00038, IPR001664): Intermediate filament protein |
59 |
LLGL2 | interactor | 4 | 0.667 | 1.000 | Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus |
60 |
MAP2K1 | oncoprotein | 10 | 0.528 | 7.160 | Pkinase (PF00069, IPR000719): Protein kinase domain DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216) |
61 |
MAP2K4 | suppressor | 12 | 0.509 | 17.521 | Pkinase (PF00069, IPR000719): Protein kinase domain |
62 |
MAP2K7 | interactor | 11 | 0.473 | 16.571 | Pkinase (PF00069, IPR000719): Protein kinase domain |
63 |
MAP4K2 | oncoprotein | 3 | 0.667 | 0.400 | CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain |
64 |
MAP4K4 | interactor | 4 | 0.667 | 0.900 | CNH (PF00780, IPR001180, SM00036): CNH domain FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Pkinase (PF00069, IPR000719): Protein kinase domain FAM165 (PF14981, IPR028023): FAM165 family SOBP (PF15279, IPR026092): Sine oculis-binding protein FAM60A (PF15396, IPR026065): Protein Family FAM60A |
65 |
MAPK1 | oncoprotein | 20 | 0.275 | 80.612 | Pkinase (PF00069, IPR000719): Protein kinase domain |
66 |
MAPK3 | oncoprotein | 13 | 0.409 | 19.456 | Pkinase (PF00069, IPR000719): Protein kinase domain |
67 |
MAPK8 | oncoprotein | 16 | 0.305 | 53.622 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
68 |
MAPK8IP3 | interactor | 9 | 0.500 | 9.422 | Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II |
69 |
MAPK9 | suppressor | 12 | 0.473 | 13.710 | Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like |
70 |
MCM2 | oncoprotein | 25 | 0.214 | 157.524 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
71 |
NEK10 | interactor | 1 | 0 | 0 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-cone (PF03477, IPR005144): ATP cone domain Pkinase (PF00069, IPR000719): Protein kinase domain |
72 |
NFKBIA | oncoprotein | 16 | 0.242 | 68.675 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
73 |
NOP56 | interactor | 6 | 0.733 | 1.686 | Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal |
74 |
NPLOC4 | interactor | 8 | 0.500 | 7.144 | NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4 |
75 |
NR4A1 | suppressor | 4 | 0.667 | 0.533 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
76 |
NTRK1 | oncoprotein | 35 | 0.139 | 402.015 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
77 |
ODF2 | interactor | 6 | 0.333 | 8.333 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 (PF09134, IPR015217): Invasin, domain 3 Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
78 |
PAK1 | oncoprotein | 6 | 0.500 | 3.333 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
79 |
PLEKHB2 | interactor | 3 | 0.667 | 0.667 | PH (PF00169, IPR001849, SM00233): PH domain |
80 |
PSMD4 | interactor | 8 | 0.500 | 8.167 | UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain |
81 |
RAB3IL1 | interactor | 3 | 1.000 | 0 | Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p |
82 |
RABEP2 | interactor | 3 | 0.667 | 1.000 | Rab5-bind (PF09311, IPR015390): Rabaptin-like protein Rabaptin (PF03528, IPR018514): Rabaptin |
83 |
RAD18 | interactor | 7 | 0.467 | 5.700 | PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47 SAP (PF02037, IPR003034, SM00513): SAP domain zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
84 |
RAD23A | oncoprotein | 11 | 0.311 | 23.100 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
85 |
RAD51AP1 | interactor | 1 | 0 | 0 | RAD51_interact (PF15696, IPR031419): RAD51 interacting motif |
86 |
RAF1 | oncoprotein | 16 | 0.343 | 41.463 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
87 |
RBCK1 | interactor | 11 | 0.267 | 25.121 | GAGA (PF09237, IPR015318): GAGA factor IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
88 |
RHOA | suppressor | 4 | 0.500 | 2.333 | Ras (PF00071, IPR001806, SM00173): Ras family |
89 |
RNF114 | protein found in more fusions | 10 | 0.278 | 12.987 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
90 |
RNF126 | interactor | 8 | 0.619 | 2.954 | Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zinc_ribbon_9 (PF14369): zinc-ribbon |
91 |
RNF141 | interactor | 1 | 0 | 0 | zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain |
92 |
RPL30 | interactor | 9 | 0.500 | 9.716 | NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3 |
93 |
RPL4 | interactor | 10 | 0.578 | 8.887 | Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain |
94 |
RPS13 | interactor | 10 | 0.556 | 8.002 | Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15 |
95 |
SPG20 | interactor | 1 | 0 | 0 | MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein |
96 |
STAM | interactor | 6 | 0.533 | 4.917 | GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
97 |
STAM2 | interactor | 11 | 0.273 | 26.935 | GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
98 |
STK38 | interactor | 4 | 1.000 | 0 | MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
99 |
TAB1 | interactor | 8 | 0.571 | 5.851 | PP2C (PF00481, IPR001932): Protein phosphatase 2C |
100 |
TNIP1 | interactor | 5 | 0.500 | 1.417 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
101 |
TOM1 | oncoprotein | 4 | 0.667 | 0.686 | GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain |
102 |
TOM1L2 | suppressor | 2 | 1.000 | 0 | GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain |
103 |
TP53 | suppressor | 30 | 0.143 | 250.846 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
104 |
TRAF2 | interactor | 19 | 0.176 | 97.133 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger) |
105 |
TRIM5 | interactor | 9 | 0.393 | 7.759 | Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
106 |
UBAC1 | interactor | 4 | 0.667 | 1.000 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain HEAT_2 (PF13646): HEAT repeats Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like |
107 |
UBAP1 | protein found in more fusions | 3 | 1.000 | 0 | MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054 |
108 |
UBASH3B | interactor | 8 | 0.381 | 6.230 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
109 |
UBE2D1 | interactor | 19 | 0.229 | 72.036 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
110 |
UBE2D2 | oncoprotein | 19 | 0.275 | 62.425 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
111 |
UBE2D3 | interactor | 12 | 0.200 | 17.802 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
112 |
UBE2D4 | interactor | 8 | 0.333 | 5.067 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
113 |
UBE2E1 | protein found in more fusions | 7 | 0.400 | 3.950 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
114 |
UBE2G1 | protein found in more fusions | 3 | 1.000 | 0 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
115 |
UBE2I | interactor | 18 | 0.257 | 69.541 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
116 |
UBE2K | interactor | 9 | 0.500 | 10.050 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
117 |
UBE2L6 | protein found in more fusions | 4 | 0.667 | 0.333 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
118 |
UBE2V1 | interactor | 9 | 0.389 | 15.233 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
119 |
UBE2W | interactor | 4 | 0.667 | 0.250 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
120 |
UBQLN1 | protein found in more fusions | 13 | 0.318 | 31.000 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X |
121 |
UBXN7 | interactor | 9 | 0.417 | 13.300 | UBX (PF00789, IPR001012, SM00166): UBX domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
122 |
UCHL5 | oncoprotein | 7 | 0.533 | 5.400 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 |
123 |
UFD1L | interactor | 8 | 0.429 | 12.186 | UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1 |
124 |
USP28 | interactor | 5 | 0.500 | 2.667 | TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif UBA_4 (PF14555): UBA-like domain DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769) |
125 |
XPO1 | interactor | 36 | 0.129 | 447.717 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
126 |
YWHAE | oncoprotein | 17 | 0.397 | 43.676 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
127 |
YWHAG | protein found in more fusions | 16 | 0.419 | 38.200 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
128 |
YWHAQ | interactor | 11 | 0.582 | 10.312 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
129 |
ZFAND3 | interactor | 1 | 0 | 0 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger |
130 |
ZFAND5 | interactor | 1 | 0 | 0 | zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger FAM53 (PF15242, IPR029356): Family of FAM53 |