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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PAX3, MAML3 (from a repository: Tue Mar 7 12:27:52 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins6 (20.00 %)
The number (and %) of the tumor suppressors4 (13.33 %)
Total number of binary PPIs (saturation %)56 (12.87 %)
The number (and %) of affected PPIs28 (50.00 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI3.133
Assortativity coefficient-0.4395
The network average Clustering coefficient0.434
The number (and %) of a zero Clustering coefficients11 (36.67 %)
The number (and %) of a zero Betweenness Centrality19 (63.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: MAML3,PAX3 All fusions
: KF727276; KF727277;
Proteins found in more fusions TRIM28 (see 1 fusions); MSX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAML3parental protein90.083229.900Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
MamL-1 (PF09596, IPR019082): MamL-1 domain
DUF2459 (PF09601, IPR011727): Protein of unknown function (DUF2459)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SprA-related (PF12118, IPR021973): SprA-related family
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM70 (PF14967, IPR028014): FAM70 protein
2 PAX3parental protein190.064532.367PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax7 (PF12360, IPR022106): Paired box protein 7
3 DAXXoncoprotein50.33370.467Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
4 FOXE1oncoprotein100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
5 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 HDAC1suppressor60.40055.467FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
7 HDAC10interactor21.0000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
8 IPO13interactor100IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
9 MAML1interactor31.0000MamL-1 (PF09596, IPR019082): MamL-1 domain
Kri1 (PF05178, IPR018034): KRI1-like family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 MEOX1interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
11 MEOX2interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
12 MSX1protein found in more fusions31.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
13 NFX1interactor100R3H (PF01424, IPR001374, SM00393): R3H domain
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
14 NOTCH1suppressor60.40090.867Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
15 PCTPinteractor100START (PF01852, IPR002913, SM00234): START domain
16 POU3F2interactor40.6674.167Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
17 PSMD4interactor21.0000UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
18 RAD23Bsuppressor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
19 RAI1interactor2044.233Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
20 RBPJinteractor40.50083.233BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
21 SCMH1interactor200MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SLED (PF12140, IPR021987): SLED domain
RBR (PF17208): RNA binding Region
22 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 SOX10oncoprotein21.0000Beta-lactamase (PF00144, IPR001466): Beta-lactamase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
24 SPIN1interactor100Spin-Ssty (PF02513, IPR003671): Spin/Ssty Family
25 SUPT5Hinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
26 TAF1oncoprotein21.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
27 TBPinteractor70.267109.400TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
28 TRIM28protein found in more fusions60.300117.733ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
29 ZBTB1interactor2032.167BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
30 ZZZ3interactor100Cript (PF10235, IPR019367): Microtubule-associated protein CRIPT
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MAML3parental proteinDrf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
MamL-1 (PF09596, IPR019082): MamL-1 domain
DUF2459 (PF09601, IPR011727): Protein of unknown function (DUF2459)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SprA-related (PF12118, IPR021973): SprA-related family
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM70 (PF14967, IPR028014): FAM70 protein
KF727276, KF727277
2 PAX3parental proteinPAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax7 (PF12360, IPR022106): Paired box protein 7
KF727276, KF727277
3 PCTPinteractorSTART (PF01852, IPR002913, SM00234): START domainKF727277
4 SOX10oncoproteinBeta-lactamase (PF00144, IPR001466): Beta-lactamase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
KF727277
5 SPIN1interactorSpin-Ssty (PF02513, IPR003671): Spin/Ssty FamilyKF727277

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