Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins LRRK2 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 138 The number (and %) of the onco-proteins 51 (36.96 %) The number (and %) of the tumor suppressors 6 (4.35 %) Total number of binary PPIs (saturation %) 714 (7.55 %) The number (and %) of affected PPIs 138 (19.33 %) The number of possible different fusions 27 PPI diameter 2 PPI radius 1 The average degree of PPI 9.638 Assortativity coefficient -0.2647 The network average Clustering coefficient 0.519 The number (and %) of a zero Clustering coefficients 14 (10.14 %) The number (and %) of a zero Betweenness Centrality 31 (22.46 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: LRRK2	All fusions
Proteins found in more fusions	TPM1 (see 2 fusions); YWHAG (see 1 fusions); TPM2/TPM3 (see 1 fusions); HSP90AA1/GNAI2 (see 1 fusions); HSP90AA1 (see 2 fusions); L3MBTL3 (see 1 fusions); SH3GL2 (see 1 fusions); TPM2/TPM1 (see 1 fusions); HSP90AB1 (see 1 fusions); RAC1 (see 1 fusions); DVL3 (see 1 fusions); YWHAH (see 2 fusions); MAPT (see 1 fusions); TPM2 (see 1 fusions); ACTB (see 2 fusions); PRKDC (see 3 fusions); RIPK1 (see 1 fusions); ACTG1 (see 4 fusions); YWHAZ (see 1 fusions); STUB1 (see 1 fusions); RALYL (see 1 fusions); LRRK2 (see 1 fusions); CDC37 (see 2 fusions); DAPK1 (see 1 fusions); STK3 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	LRRK2	parental protein	138	0.057	14507.441	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
2	ACTA2	interactor	7	0.571	3.945	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTB	oncoprotein	15	0.396	35.034	Actin (PF00022, IPR004000, SM00268): Actin
4	ACTBL2	interactor	3	0.667	0.286	Actin (PF00022, IPR004000, SM00268): Actin
5	ACTG1	protein found in more fusions	15	0.385	38.185	Actin (PF00022, IPR004000, SM00268): Actin
6	ACTG2	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTR2	interactor	15	0.590	18.848	Actin (PF00022, IPR004000, SM00268): Actin
8	ACTR3	interactor	12	0.727	7.249	Actin (PF00022, IPR004000, SM00268): Actin
9	AGO1	interactor	4	0.833	0.667	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
10	AGO2	interactor	4	0.667	1.500	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
11	AKAP8	interactor	1	0	0	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
12	AKT1	oncoprotein	27	0.289	141.931	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13	ARFGAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
14	ARHGEF7	interactor	5	0.400	4.333	Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
15	ARPC1B	interactor	10	0.800	2.932	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
16	ARPC2	interactor	14	0.626	14.133	P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
17	ARPC4	interactor	11	0.764	4.944	ARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
18	ARPC5	interactor	11	0.709	7.117	P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
19	ATP5L	interactor	2	1.000	0	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
20	ATRX	oncoprotein	5	0.600	2.733	DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
21	BAG5	interactor	5	1.000	0	BAG (PF02179, IPR003103, SM00264): BAG domain PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region RRF (PF01765, IPR023584): Ribosome recycling factor
22	BAX	oncoprotein	8	0.476	7.217	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
23	C17orf53	interactor	1	0	0	DUF4539 (PF15072, IPR028045): Domain of unknown function (DUF4539)
24	CALM1	interactor	18	0.281	76.319	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25	CALM2	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26	CALM3	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
27	CAPZA1	interactor	8	0.607	6.225	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
28	CAPZA2	interactor	26	0.348	117.132	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
29	CAPZB	interactor	12	0.530	15.266	Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
30	CASP8	oncoprotein	9	0.500	12.333	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
31	CDC37	protein found in more fusions	14	0.551	16.792	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
32	CDC42	oncoprotein	12	0.255	34.408	Ras (PF00071, IPR001806, SM00173): Ras family
33	CHD1L	interactor	2	1.000	0	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34	CLTC	oncoprotein	14	0.341	43.705	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
35	CSE1L	oncoprotein	3	0.667	0.333	CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
36	DAPK1	oncoprotein	15	0.253	52.581	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
37	DBN1	oncoprotein	23	0.399	67.756	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
38	DNAJA1	interactor	12	0.409	22.365	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
39	DNM1L	interactor	4	0.667	0.667	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain
40	DVL1	interactor	5	1.000	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
41	DVL2	interactor	8	0.476	9.567	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
42	DVL3	protein found in more fusions	5	1.000	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
43	DYNC1H1	interactor	5	0.600	1.821	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5
44	EEF1A1	oncoprotein	19	0.386	54.517	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
45	EFHD2	interactor	5	0.800	0.508	SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46	EIF4EBP1	oncoprotein	5	0.600	2.833	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
47	EPRS	interactor	4	0.667	2.000	GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
48	FADD	suppressor	8	0.500	11.167	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
49	GNA12	oncoprotein	2	1.000	0	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
50	GNA13	interactor	2	1.000	0	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
51	GNAI2	oncoprotein	6	0.467	6.067	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
52	H3F3A	oncoprotein	3	1.000	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
53	HERC2	interactor	12	0.255	35.067	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain MIB_HERC2 (PF06701, IPR010606): Mib_herc2 RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
54	HIST1H3A	interactor	9	0.500	10.667	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55	HMMR	interactor	3	0.667	0.286	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family ApoO (PF09769, IPR019166): Apolipoprotein O Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
56	HSP90AA1	oncoprotein	32	0.219	272.101	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
57	HSP90AB1	oncoprotein	23	0.351	85.835	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
58	HSPA4	interactor	17	0.515	28.572	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
59	HSPA8	oncoprotein	22	0.446	64.363	HSP70 (PF00012, IPR013126): Hsp70 protein
60	HSPA9	oncoprotein	11	0.582	10.852	HSP70 (PF00012, IPR013126): Hsp70 protein
61	HSPD1	oncoprotein	10	0.556	11.827	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
62	IQGAP1	interactor	33	0.242	261.015	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
63	ITCH	interactor	10	0.306	24.333	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
64	L3MBTL3	protein found in more fusions	2	0	0	CDC45 (PF02724, IPR003874): CDC45-like protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain MBT (PF02820, IPR004092, SM00561): mbt repeat SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type Calci_bind_CcbP (PF11535, IPR020994): Calcium binding Apelin (PF15360, IPR026155): APJ endogenous ligand
65	LIMA1	suppressor	25	0.323	116.875	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
66	LRP6	interactor	2	1.000	0	Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
67	LRRK1	interactor	5	0.500	1.500	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
68	MAP1B	interactor	3	0.667	0.667	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
69	MAP2K3	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
70	MAP2K4	oncoprotein	6	0.400	5.667	Pkinase (PF00069, IPR000719): Protein kinase domain
71	MAP2K6	interactor	3	0.667	1.000	Pkinase (PF00069, IPR000719): Protein kinase domain
72	MAP2K7	interactor	3	0.667	0.667	Pkinase (PF00069, IPR000719): Protein kinase domain
73	MAPT	protein found in more fusions	13	0.576	9.111	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
74	MBP	interactor	4	0.500	1.400	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
75	MDN1	interactor	1	0	0	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain AAA_16 (PF13191): AAA ATPase domain Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
76	MPC2	interactor	1	0	0	MPC (PF03650, IPR005336): Uncharacterised protein family (UPF0041)
77	MPRIP	interactor	10	0.578	9.294	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 (PF06818): Fez1 FliT (PF05400, IPR008622): Flagellar protein FliT HalX (PF08663, IPR013971): HalX domain Mnd1 (PF03962, IPR005647): Mnd1 family OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57 YlqD (PF11068, IPR021297): YlqD protein DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015) Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
78	MYL12B	interactor	3	1.000	0	EF-hand_11 (PF08976, IPR015070): EF-hand domain EF-hand_6 (PF13405, IPR002048): EF-hand domain DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
79	MYL6	interactor	4	0.833	0.400	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
80	MYL9	interactor	1	0	0	UPF0154 (PF03672, IPR005359): Uncharacterised protein family (UPF0154) EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
81	MYO1B	interactor	7	0.810	1.269	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) AAA_23 (PF13476): AAA domain
82	MYO1C	interactor	14	0.527	18.778	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
83	MYO1D	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
84	MYO1F	interactor	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain
85	NEURL4	interactor	4	0.833	0.333	Neuralized (PF07177, IPR006573, SM00588): Neuralized
86	NFATC2	oncoprotein	9	0.250	14.467	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
87	NRON	interactor	1	0	0	NA
88	PARK2	suppressor	31	0.246	222.882	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
89	PLEC	oncoprotein	6	0.600	4.233	CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FUSC (PF04632, IPR006726): Fusaric acid resistance protein family RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 S10_plectin (PF03501, IPR005326): Plectin/S10 domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) Plectin (PF00681, IPR001101, SM00250): Plectin repeat YlqD (PF11068, IPR021297): YlqD protein Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
90	PPP1R12A	interactor	9	0.722	5.619	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Mucin (PF01456, IPR000458): Mucin-like glycoprotein RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
91	PPP2R1A	oncoprotein	15	0.276	59.108	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
92	PRKCZ	interactor	13	0.394	27.253	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
93	PRKDC	protein found in more fusions	13	0.318	36.361	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
94	PSMD11	interactor	6	0.667	2.619	DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat
95	PTPN23	suppressor	3	0.667	1.000	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase SOGA (PF11365, IPR027881): Protein SOGA ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
96	RAB11A	oncoprotein	8	0.536	8.833	Ras (PF00071, IPR001806, SM00173): Ras family
97	RAB11B	oncoprotein	6	0.667	3.667	Ras (PF00071, IPR001806, SM00173): Ras family
98	RAB5A	oncoprotein	7	0.476	7.667	Ras (PF00071, IPR001806, SM00173): Ras family
99	RAB5B	oncoprotein	8	0.429	11.833	Ras (PF00071, IPR001806, SM00173): Ras family
100	RAB7A	oncoprotein	9	0.500	12.786	Ras (PF00071, IPR001806, SM00173): Ras family
101	RAC1	oncoprotein	10	0.444	13.938	Ras (PF00071, IPR001806, SM00173): Ras family
102	RAI14	interactor	10	0.622	8.861	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Fez1 (PF06818): Fez1 FliJ (PF02050, IPR012823): Flagellar FliJ protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_13 (PF13166, IPR026866): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
103	RALYL	protein found in more fusions	2	0	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
104	RHOA	oncoprotein	6	0.467	6.619	Ras (PF00071, IPR001806, SM00173): Ras family
105	RIPK1	protein found in more fusions	10	0.417	16.952	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
106	RIPK2	interactor	4	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
107	RPL23	interactor	3	0.667	1.000	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
108	RPS8	interactor	8	0.464	9.990	Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
109	SCFD1	interactor	1	0	0	Sec1 (PF00995, IPR001619): Sec1 family
110	SH3GL1	oncoprotein	12	0.418	31.000	BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
111	SH3GL2	oncoprotein	7	0.400	9.000	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
112	SH3GL3	interactor	5	0.833	0.667	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
113	SNCA	interactor	20	0.404	62.459	Synuclein (PF01387, IPR001058): Synuclein
114	SRPK1	interactor	2	1.000	0	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
115	STK24	interactor	5	0.667	1.333	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
116	STK25	interactor	3	1.000	0	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
117	STK3	protein found in more fusions	7	0.400	6.722	Pkinase (PF00069, IPR000719): Protein kinase domain Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1 DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
118	STRBP	interactor	1	0	0	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936) DZF (PF07528, IPR006561, SM00572): DZF domain
119	STUB1	suppressor	18	0.449	40.874	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
120	TAOK3	interactor	3	0.667	0.286	Pkinase (PF00069, IPR000719): Protein kinase domain TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma) PKK (PF12474, IPR022165): Polo kinase kinase
121	TK1	oncoprotein	6	0.500	3.786	TK (PF00265, IPR001267, SM00203): Thymidine kinase
122	TMOD3	interactor	9	0.694	4.319	Tropomodulin (PF03250, IPR004934): Tropomodulin Usher (PF00577, IPR000015): Outer membrane usher protein LRR_6 (PF13516, IPR001611): Leucine Rich repeat
123	TNPO1	interactor	2	1.000	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
124	TPM1	protein found in more fusions	12	0.455	16.292	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
125	TPM2	protein found in more fusions	10	0.500	11.100	DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
126	TPM3	oncoprotein	11	0.511	11.974	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
127	TRADD	interactor	7	0.733	3.000	Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat
128	TRAF2	interactor	14	0.295	45.519	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
129	TUBA1A	oncoprotein	11	0.545	14.406	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
130	TUBA1C	interactor	11	0.455	18.796	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
131	TUBB	interactor	18	0.484	41.888	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
132	VIM	suppressor	12	0.309	28.388	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
133	YWHAB	interactor	18	0.353	57.795	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
134	YWHAE	oncoprotein	20	0.379	63.850	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
135	YWHAG	protein found in more fusions	15	0.462	29.655	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
136	YWHAH	protein found in more fusions	9	0.786	1.948	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
137	YWHAQ	interactor	32	0.224	247.469	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138	YWHAZ	protein found in more fusions	15	0.516	23.055	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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