1 |
LRRK2 | parental protein | 138 | 0.057 | 14507.441 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
2 |
ACTA2 | interactor | 7 | 0.571 | 3.945 | Actin (PF00022, IPR004000, SM00268): Actin |
3 |
ACTB | oncoprotein | 15 | 0.396 | 35.034 | Actin (PF00022, IPR004000, SM00268): Actin |
4 |
ACTBL2 | interactor | 3 | 0.667 | 0.286 | Actin (PF00022, IPR004000, SM00268): Actin |
5 |
ACTG1 | protein found in more fusions | 15 | 0.385 | 38.185 | Actin (PF00022, IPR004000, SM00268): Actin |
6 |
ACTG2 | interactor | 1 | 0 | 0 | Actin (PF00022, IPR004000, SM00268): Actin |
7 |
ACTR2 | interactor | 15 | 0.590 | 18.848 | Actin (PF00022, IPR004000, SM00268): Actin |
8 |
ACTR3 | interactor | 12 | 0.727 | 7.249 | Actin (PF00022, IPR004000, SM00268): Actin |
9 |
AGO1 | interactor | 4 | 0.833 | 0.667 | ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain |
10 |
AGO2 | interactor | 4 | 0.667 | 1.500 | ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain |
11 |
AKAP8 | interactor | 1 | 0 | 0 | AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein |
12 |
AKT1 | oncoprotein | 27 | 0.289 | 141.931 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
13 |
ARFGAP1 | interactor | 2 | 1.000 | 0 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf |
14 |
ARHGEF7 | interactor | 5 | 0.400 | 4.333 | Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7 |
15 |
ARPC1B | interactor | 10 | 0.800 | 2.932 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
16 |
ARPC2 | interactor | 14 | 0.626 | 14.133 | P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain |
17 |
ARPC4 | interactor | 11 | 0.764 | 4.944 | ARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4) |
18 |
ARPC5 | interactor | 11 | 0.709 | 7.117 | P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc) |
19 |
ATP5L | interactor | 2 | 1.000 | 0 | ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit |
20 |
ATRX | oncoprotein | 5 | 0.600 | 2.733 | DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) |
21 |
BAG5 | interactor | 5 | 1.000 | 0 | BAG (PF02179, IPR003103, SM00264): BAG domain PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region RRF (PF01765, IPR023584): Ribosome recycling factor |
22 |
BAX | oncoprotein | 8 | 0.476 | 7.217 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family |
23 |
C17orf53 | interactor | 1 | 0 | 0 | DUF4539 (PF15072, IPR028045): Domain of unknown function (DUF4539) |
24 |
CALM1 | interactor | 18 | 0.281 | 76.319 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
25 |
CALM2 | interactor | 1 | 0 | 0 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
26 |
CALM3 | interactor | 1 | 0 | 0 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
27 |
CAPZA1 | interactor | 8 | 0.607 | 6.225 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
28 |
CAPZA2 | interactor | 26 | 0.348 | 117.132 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
29 |
CAPZB | interactor | 12 | 0.530 | 15.266 | Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit |
30 |
CASP8 | oncoprotein | 9 | 0.500 | 12.333 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
31 |
CDC37 | protein found in more fusions | 14 | 0.551 | 16.792 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
32 |
CDC42 | oncoprotein | 12 | 0.255 | 34.408 | Ras (PF00071, IPR001806, SM00173): Ras family |
33 |
CHD1L | interactor | 2 | 1.000 | 0 | ATP-synt_E (PF05680, IPR008386): ATP synthase E chain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
34 |
CLTC | oncoprotein | 14 | 0.341 | 43.705 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link |
35 |
CSE1L | oncoprotein | 3 | 0.667 | 0.333 | CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein |
36 |
DAPK1 | oncoprotein | 15 | 0.253 | 52.581 | ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
37 |
DBN1 | oncoprotein | 23 | 0.399 | 67.756 | Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c |
38 |
DNAJA1 | interactor | 12 | 0.409 | 22.365 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
39 |
DNM1L | interactor | 4 | 0.667 | 0.667 | Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain |
40 |
DVL1 | interactor | 5 | 1.000 | 0 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
41 |
DVL2 | interactor | 8 | 0.476 | 9.567 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
42 |
DVL3 | protein found in more fusions | 5 | 1.000 | 0 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
43 |
DYNC1H1 | interactor | 5 | 0.600 | 1.821 | AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5 |
44 |
EEF1A1 | oncoprotein | 19 | 0.386 | 54.517 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
45 |
EFHD2 | interactor | 5 | 0.800 | 0.508 | SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
46 |
EIF4EBP1 | oncoprotein | 5 | 0.600 | 2.833 | eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) |
47 |
EPRS | interactor | 4 | 0.667 | 2.000 | GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain |
48 |
FADD | suppressor | 8 | 0.500 | 11.167 | Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain |
49 |
GNA12 | oncoprotein | 2 | 1.000 | 0 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
50 |
GNA13 | interactor | 2 | 1.000 | 0 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
51 |
GNAI2 | oncoprotein | 6 | 0.467 | 6.067 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
52 |
H3F3A | oncoprotein | 3 | 1.000 | 0 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
53 |
HERC2 | interactor | 12 | 0.255 | 35.067 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain MIB_HERC2 (PF06701, IPR010606): Mib_herc2 RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
54 |
HIST1H3A | interactor | 9 | 0.500 | 10.667 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
55 |
HMMR | interactor | 3 | 0.667 | 0.286 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family ApoO (PF09769, IPR019166): Apolipoprotein O Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal |
56 |
HSP90AA1 | oncoprotein | 32 | 0.219 | 272.101 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
57 |
HSP90AB1 | oncoprotein | 23 | 0.351 | 85.835 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
58 |
HSPA4 | interactor | 17 | 0.515 | 28.572 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
59 |
HSPA8 | oncoprotein | 22 | 0.446 | 64.363 | HSP70 (PF00012, IPR013126): Hsp70 protein |
60 |
HSPA9 | oncoprotein | 11 | 0.582 | 10.852 | HSP70 (PF00012, IPR013126): Hsp70 protein |
61 |
HSPD1 | oncoprotein | 10 | 0.556 | 11.827 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
62 |
IQGAP1 | interactor | 33 | 0.242 | 261.015 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain |
63 |
ITCH | interactor | 10 | 0.306 | 24.333 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
64 |
L3MBTL3 | protein found in more fusions | 2 | 0 | 0 | CDC45 (PF02724, IPR003874): CDC45-like protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain MBT (PF02820, IPR004092, SM00561): mbt repeat SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type Calci_bind_CcbP (PF11535, IPR020994): Calcium binding Apelin (PF15360, IPR026155): APJ endogenous ligand |
65 |
LIMA1 | suppressor | 25 | 0.323 | 116.875 | LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain |
66 |
LRP6 | interactor | 2 | 1.000 | 0 | Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050) |
67 |
LRRK1 | interactor | 5 | 0.500 | 1.500 | Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
68 |
MAP1B | interactor | 3 | 0.667 | 0.667 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
69 |
MAP2K3 | interactor | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
70 |
MAP2K4 | oncoprotein | 6 | 0.400 | 5.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
71 |
MAP2K6 | interactor | 3 | 0.667 | 1.000 | Pkinase (PF00069, IPR000719): Protein kinase domain |
72 |
MAP2K7 | interactor | 3 | 0.667 | 0.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
73 |
MAPT | protein found in more fusions | 13 | 0.576 | 9.111 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
74 |
MBP | interactor | 4 | 0.500 | 1.400 | Myelin_MBP (PF01669, IPR000548): Myelin basic protein |
75 |
MDN1 | interactor | 1 | 0 | 0 | AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain AAA_16 (PF13191): AAA ATPase domain Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain |
76 |
MPC2 | interactor | 1 | 0 | 0 | MPC (PF03650, IPR005336): Uncharacterised protein family (UPF0041) |
77 |
MPRIP | interactor | 10 | 0.578 | 9.294 | Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 (PF06818): Fez1 FliT (PF05400, IPR008622): Flagellar protein FliT HalX (PF08663, IPR013971): HalX domain Mnd1 (PF03962, IPR005647): Mnd1 family OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57 YlqD (PF11068, IPR021297): YlqD protein DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015) Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
78 |
MYL12B | interactor | 3 | 1.000 | 0 | EF-hand_11 (PF08976, IPR015070): EF-hand domain EF-hand_6 (PF13405, IPR002048): EF-hand domain DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
79 |
MYL6 | interactor | 4 | 0.833 | 0.400 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
80 |
MYL9 | interactor | 1 | 0 | 0 | UPF0154 (PF03672, IPR005359): Uncharacterised protein family (UPF0154) EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
81 |
MYO1B | interactor | 7 | 0.810 | 1.269 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) AAA_23 (PF13476): AAA domain |
82 |
MYO1C | interactor | 14 | 0.527 | 18.778 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
83 |
MYO1D | interactor | 2 | 1.000 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
84 |
MYO1F | interactor | 1 | 0 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain |
85 |
NEURL4 | interactor | 4 | 0.833 | 0.333 | Neuralized (PF07177, IPR006573, SM00588): Neuralized |
86 |
NFATC2 | oncoprotein | 9 | 0.250 | 14.467 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
87 |
NRON | interactor | 1 | 0 | 0 | NA |
88 |
PARK2 | suppressor | 31 | 0.246 | 222.882 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
89 |
PLEC | oncoprotein | 6 | 0.600 | 4.233 | CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FUSC (PF04632, IPR006726): Fusaric acid resistance protein family RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 S10_plectin (PF03501, IPR005326): Plectin/S10 domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) Plectin (PF00681, IPR001101, SM00250): Plectin repeat YlqD (PF11068, IPR021297): YlqD protein Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) |
90 |
PPP1R12A | interactor | 9 | 0.722 | 5.619 | DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Mucin (PF01456, IPR000458): Mucin-like glycoprotein RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
91 |
PPP2R1A | oncoprotein | 15 | 0.276 | 59.108 | TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
92 |
PRKCZ | interactor | 13 | 0.394 | 27.253 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
93 |
PRKDC | protein found in more fusions | 13 | 0.318 | 36.361 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
94 |
PSMD11 | interactor | 6 | 0.667 | 2.619 | DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat |
95 |
PTPN23 | suppressor | 3 | 0.667 | 1.000 | BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase SOGA (PF11365, IPR027881): Protein SOGA ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV |
96 |
RAB11A | oncoprotein | 8 | 0.536 | 8.833 | Ras (PF00071, IPR001806, SM00173): Ras family |
97 |
RAB11B | oncoprotein | 6 | 0.667 | 3.667 | Ras (PF00071, IPR001806, SM00173): Ras family |
98 |
RAB5A | oncoprotein | 7 | 0.476 | 7.667 | Ras (PF00071, IPR001806, SM00173): Ras family |
99 |
RAB5B | oncoprotein | 8 | 0.429 | 11.833 | Ras (PF00071, IPR001806, SM00173): Ras family |
100 |
RAB7A | oncoprotein | 9 | 0.500 | 12.786 | Ras (PF00071, IPR001806, SM00173): Ras family |
101 |
RAC1 | oncoprotein | 10 | 0.444 | 13.938 | Ras (PF00071, IPR001806, SM00173): Ras family |
102 |
RAI14 | interactor | 10 | 0.622 | 8.861 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Fez1 (PF06818): Fez1 FliJ (PF02050, IPR012823): Flagellar FliJ protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_13 (PF13166, IPR026866): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
103 |
RALYL | protein found in more fusions | 2 | 0 | 0 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit |
104 |
RHOA | oncoprotein | 6 | 0.467 | 6.619 | Ras (PF00071, IPR001806, SM00173): Ras family |
105 |
RIPK1 | protein found in more fusions | 10 | 0.417 | 16.952 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
106 |
RIPK2 | interactor | 4 | 1.000 | 0 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
107 |
RPL23 | interactor | 3 | 0.667 | 1.000 | Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e |
108 |
RPS8 | interactor | 8 | 0.464 | 9.990 | Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e |
109 |
SCFD1 | interactor | 1 | 0 | 0 | Sec1 (PF00995, IPR001619): Sec1 family |
110 |
SH3GL1 | oncoprotein | 12 | 0.418 | 31.000 | BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
111 |
SH3GL2 | oncoprotein | 7 | 0.400 | 9.000 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain |
112 |
SH3GL3 | interactor | 5 | 0.833 | 0.667 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain |
113 |
SNCA | interactor | 20 | 0.404 | 62.459 | Synuclein (PF01387, IPR001058): Synuclein |
114 |
SRPK1 | interactor | 2 | 1.000 | 0 | FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
115 |
STK24 | interactor | 5 | 0.667 | 1.333 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain |
116 |
STK25 | interactor | 3 | 1.000 | 0 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain |
117 |
STK3 | protein found in more fusions | 7 | 0.400 | 6.722 | Pkinase (PF00069, IPR000719): Protein kinase domain Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1 DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) |
118 |
STRBP | interactor | 1 | 0 | 0 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936) DZF (PF07528, IPR006561, SM00572): DZF domain |
119 |
STUB1 | suppressor | 18 | 0.449 | 40.874 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
120 |
TAOK3 | interactor | 3 | 0.667 | 0.286 | Pkinase (PF00069, IPR000719): Protein kinase domain TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma) PKK (PF12474, IPR022165): Polo kinase kinase |
121 |
TK1 | oncoprotein | 6 | 0.500 | 3.786 | TK (PF00265, IPR001267, SM00203): Thymidine kinase |
122 |
TMOD3 | interactor | 9 | 0.694 | 4.319 | Tropomodulin (PF03250, IPR004934): Tropomodulin Usher (PF00577, IPR000015): Outer membrane usher protein LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
123 |
TNPO1 | interactor | 2 | 1.000 | 0 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
124 |
TPM1 | protein found in more fusions | 12 | 0.455 | 16.292 | Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
125 |
TPM2 | protein found in more fusions | 10 | 0.500 | 11.100 | DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
126 |
TPM3 | oncoprotein | 11 | 0.511 | 11.974 | Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
127 |
TRADD | interactor | 7 | 0.733 | 3.000 | Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat |
128 |
TRAF2 | interactor | 14 | 0.295 | 45.519 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger) |
129 |
TUBA1A | oncoprotein | 11 | 0.545 | 14.406 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
130 |
TUBA1C | interactor | 11 | 0.455 | 18.796 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
131 |
TUBB | interactor | 18 | 0.484 | 41.888 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
132 |
VIM | suppressor | 12 | 0.309 | 28.388 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region |
133 |
YWHAB | interactor | 18 | 0.353 | 57.795 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
134 |
YWHAE | oncoprotein | 20 | 0.379 | 63.850 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
135 |
YWHAG | protein found in more fusions | 15 | 0.462 | 29.655 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
136 |
YWHAH | protein found in more fusions | 9 | 0.786 | 1.948 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
137 |
YWHAQ | interactor | 32 | 0.224 | 247.469 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
138 |
YWHAZ | protein found in more fusions | 15 | 0.516 | 23.055 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |