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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)138
The number (and %) of the onco-proteins51 (36.96 %)
The number (and %) of the tumor suppressors6 (4.35 %)
Total number of binary PPIs (saturation %)714 (7.55 %)
The number (and %) of affected PPIs138 (19.33 %)
The number of possible different fusions27
PPI diameter2
PPI radius1
The average degree of PPI9.638
Assortativity coefficient-0.2647
The network average Clustering coefficient0.519
The number (and %) of a zero Clustering coefficients14 (10.14 %)
The number (and %) of a zero Betweenness Centrality31 (22.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LRRK2 All fusions
Proteins found in more fusions TPM1 (see 2 fusions); YWHAG (see 1 fusions); TPM2/TPM3 (see 1 fusions); HSP90AA1/GNAI2 (see 1 fusions); HSP90AA1 (see 2 fusions); L3MBTL3 (see 1 fusions); SH3GL2 (see 1 fusions); TPM2/TPM1 (see 1 fusions); HSP90AB1 (see 1 fusions); RAC1 (see 1 fusions); DVL3 (see 1 fusions); YWHAH (see 2 fusions); MAPT (see 1 fusions); TPM2 (see 1 fusions); ACTB (see 2 fusions); PRKDC (see 3 fusions); RIPK1 (see 1 fusions); ACTG1 (see 4 fusions); YWHAZ (see 1 fusions); STUB1 (see 1 fusions); RALYL (see 1 fusions); LRRK2 (see 1 fusions); CDC37 (see 2 fusions); DAPK1 (see 1 fusions); STK3 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LRRK2parental protein1380.05714507.441Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
2 ACTA2interactor70.5713.945Actin (PF00022, IPR004000, SM00268): Actin
3 ACTBoncoprotein150.39635.034Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBL2interactor30.6670.286Actin (PF00022, IPR004000, SM00268): Actin
5 ACTG1protein found in more fusions150.38538.185Actin (PF00022, IPR004000, SM00268): Actin
6 ACTG2interactor100Actin (PF00022, IPR004000, SM00268): Actin
7 ACTR2interactor150.59018.848Actin (PF00022, IPR004000, SM00268): Actin
8 ACTR3interactor120.7277.249Actin (PF00022, IPR004000, SM00268): Actin
9 AGO1interactor40.8330.667ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
10 AGO2interactor40.6671.500ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
11 AKAP8interactor100AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
12 AKT1oncoprotein270.289141.931PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13 ARFGAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
14 ARHGEF7interactor50.4004.333Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
15 ARPC1Binteractor100.8002.932WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
16 ARPC2interactor140.62614.133P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
17 ARPC4interactor110.7644.944ARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
18 ARPC5interactor110.7097.117P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
19 ATP5Linteractor21.0000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
20 ATRXoncoprotein50.6002.733DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
21 BAG5interactor51.0000BAG (PF02179, IPR003103, SM00264): BAG domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
RRF (PF01765, IPR023584): Ribosome recycling factor
22 BAXoncoprotein80.4767.217Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
23 C17orf53interactor100DUF4539 (PF15072, IPR028045): Domain of unknown function (DUF4539)
24 CALM1interactor180.28176.319EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 CALM2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26 CALM3interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
27 CAPZA1interactor80.6076.225F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
28 CAPZA2interactor260.348117.132F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
29 CAPZBinteractor120.53015.266Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
30 CASP8oncoprotein90.50012.333DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
31 CDC37protein found in more fusions140.55116.792CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
32 CDC42oncoprotein120.25534.408Ras (PF00071, IPR001806, SM00173): Ras family
33 CHD1Linteractor21.0000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 CLTConcoprotein140.34143.705Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
35 CSE1Loncoprotein30.6670.333CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
36 DAPK1oncoprotein150.25352.581ABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
37 DBN1oncoprotein230.39967.756Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
38 DNAJA1interactor120.40922.365DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
39 DNM1Linteractor40.6670.667Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
40 DVL1interactor51.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
41 DVL2interactor80.4769.567DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
42 DVL3protein found in more fusions51.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
43 DYNC1H1interactor50.6001.821AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
44 EEF1A1oncoprotein190.38654.517GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
45 EFHD2interactor50.8000.508SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46 EIF4EBP1oncoprotein50.6002.833eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
47 EPRSinteractor40.6672.000GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
48 FADDsuppressor80.50011.167Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
49 GNA12oncoprotein21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
50 GNA13interactor21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
51 GNAI2oncoprotein60.4676.067G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
52 H3F3Aoncoprotein31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
53 HERC2interactor120.25535.067ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
54 HIST1H3Ainteractor90.50010.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55 HMMRinteractor30.6670.286APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
56 HSP90AA1oncoprotein320.219272.101HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
57 HSP90AB1oncoprotein230.35185.835HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
58 HSPA4interactor170.51528.572Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
59 HSPA8oncoprotein220.44664.363HSP70 (PF00012, IPR013126): Hsp70 protein
60 HSPA9oncoprotein110.58210.852HSP70 (PF00012, IPR013126): Hsp70 protein
61 HSPD1oncoprotein100.55611.827Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
62 IQGAP1interactor330.242261.015CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
63 ITCHinteractor100.30624.333C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
64 L3MBTL3protein found in more fusions200CDC45 (PF02724, IPR003874): CDC45-like protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain
MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
Calci_bind_CcbP (PF11535, IPR020994): Calcium binding
Apelin (PF15360, IPR026155): APJ endogenous ligand
65 LIMA1suppressor250.323116.875LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
66 LRP6interactor21.0000Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
67 LRRK1interactor50.5001.500Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
68 MAP1Binteractor30.6670.667DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
69 MAP2K3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
70 MAP2K4oncoprotein60.4005.667Pkinase (PF00069, IPR000719): Protein kinase domain
71 MAP2K6interactor30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
72 MAP2K7interactor30.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
73 MAPTprotein found in more fusions130.5769.111Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
74 MBPinteractor40.5001.400Myelin_MBP (PF01669, IPR000548): Myelin basic protein
75 MDN1interactor100AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain
AAA_16 (PF13191): AAA ATPase domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
76 MPC2interactor100MPC (PF03650, IPR005336): Uncharacterised protein family (UPF0041)
77 MPRIPinteractor100.5789.294Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Fez1 (PF06818): Fez1
FliT (PF05400, IPR008622): Flagellar protein FliT
HalX (PF08663, IPR013971): HalX domain
Mnd1 (PF03962, IPR005647): Mnd1 family
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
YlqD (PF11068, IPR021297): YlqD protein
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
78 MYL12Binteractor31.0000EF-hand_11 (PF08976, IPR015070): EF-hand domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
79 MYL6interactor40.8330.400EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
80 MYL9interactor100UPF0154 (PF03672, IPR005359): Uncharacterised protein family (UPF0154)
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
81 MYO1Binteractor70.8101.269IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
AAA_23 (PF13476): AAA domain
82 MYO1Cinteractor140.52718.778IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
83 MYO1Dinteractor21.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
84 MYO1Finteractor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
85 NEURL4interactor40.8330.333Neuralized (PF07177, IPR006573, SM00588): Neuralized
86 NFATC2oncoprotein90.25014.467RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
87 NRONinteractor100NA
88 PARK2suppressor310.246222.882IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
89 PLEConcoprotein60.6004.233CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
S10_plectin (PF03501, IPR005326): Plectin/S10 domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
YlqD (PF11068, IPR021297): YlqD protein
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
90 PPP1R12Ainteractor90.7225.619DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
91 PPP2R1Aoncoprotein150.27659.108TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
92 PRKCZinteractor130.39427.253PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
93 PRKDCprotein found in more fusions130.31836.361FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
94 PSMD11interactor60.6672.619DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
95 PTPN23suppressor30.6671.000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SOGA (PF11365, IPR027881): Protein SOGA
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
96 RAB11Aoncoprotein80.5368.833Ras (PF00071, IPR001806, SM00173): Ras family
97 RAB11Boncoprotein60.6673.667Ras (PF00071, IPR001806, SM00173): Ras family
98 RAB5Aoncoprotein70.4767.667Ras (PF00071, IPR001806, SM00173): Ras family
99 RAB5Boncoprotein80.42911.833Ras (PF00071, IPR001806, SM00173): Ras family
100 RAB7Aoncoprotein90.50012.786Ras (PF00071, IPR001806, SM00173): Ras family
101 RAC1oncoprotein100.44413.938Ras (PF00071, IPR001806, SM00173): Ras family
102 RAI14interactor100.6228.861Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Fez1 (PF06818): Fez1
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_13 (PF13166, IPR026866): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
103 RALYLprotein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
104 RHOAoncoprotein60.4676.619Ras (PF00071, IPR001806, SM00173): Ras family
105 RIPK1protein found in more fusions100.41716.952Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
106 RIPK2interactor41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
107 RPL23interactor30.6671.000Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
108 RPS8interactor80.4649.990Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
109 SCFD1interactor100Sec1 (PF00995, IPR001619): Sec1 family
110 SH3GL1oncoprotein120.41831.000BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
111 SH3GL2oncoprotein70.4009.000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
112 SH3GL3interactor50.8330.667BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
113 SNCAinteractor200.40462.459Synuclein (PF01387, IPR001058): Synuclein
114 SRPK1interactor21.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
115 STK24interactor50.6671.333DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
116 STK25interactor31.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
117 STK3protein found in more fusions70.4006.722Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
118 STRBPinteractor100dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DZF (PF07528, IPR006561, SM00572): DZF domain
119 STUB1suppressor180.44940.874U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
120 TAOK3interactor30.6670.286Pkinase (PF00069, IPR000719): Protein kinase domain
TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
PKK (PF12474, IPR022165): Polo kinase kinase
121 TK1oncoprotein60.5003.786TK (PF00265, IPR001267, SM00203): Thymidine kinase
122 TMOD3interactor90.6944.319Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
123 TNPO1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
124 TPM1protein found in more fusions120.45516.292Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
125 TPM2protein found in more fusions100.50011.100DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
126 TPM3oncoprotein110.51111.974Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
127 TRADDinteractor70.7333.000Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
128 TRAF2interactor140.29545.519MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
129 TUBA1Aoncoprotein110.54514.406Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
130 TUBA1Cinteractor110.45518.796Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
131 TUBBinteractor180.48441.888Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
132 VIMsuppressor120.30928.388Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
133 YWHABinteractor180.35357.79514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
134 YWHAEoncoprotein200.37963.85014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
135 YWHAGprotein found in more fusions150.46229.65514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
136 YWHAHprotein found in more fusions90.7861.94814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
137 YWHAQinteractor320.224247.46914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138 YWHAZprotein found in more fusions150.51623.05514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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