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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LIMK1 (from a repository: Sun Nov 13 16:16:22 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins15 (38.46 %)
The number (and %) of the tumor suppressors4 (10.26 %)
Total number of binary PPIs (saturation %)102 (13.77 %)
The number (and %) of affected PPIs39 (38.24 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI4.462
Assortativity coefficient-0.3359
The network average Clustering coefficient0.440
The number (and %) of a zero Clustering coefficients12 (30.77 %)
The number (and %) of a zero Betweenness Centrality20 (51.28 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LIMK1 All fusions
: AK125156;
Proteins found in more fusions ERBIN (see 4 fusions); FYN (see 1 fusions); PAK4 (see 1 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); MAPK14 (see 1 fusions); LIMK1 (see 1 fusions); APP (see 4 fusions); BRAF (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LIMK1parental protein390.0701155.133LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 APPprotein found in more fusions140.25652.900APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ARRB1interactor70.4298.733Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 ARRB2interactor50.6003.167Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 BADoncoprotein40.8330.500Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
6 BLMHinteractor31.0000Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
7 BMPR2suppressor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
8 BRAFoncoprotein50.6671.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
9 CDKN1Csuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
10 CFL1interactor50.5003.067Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11 ELAVL1oncoprotein70.3339.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 ERBINoncoprotein200LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 HIST1H1Ainteractor40.5002.667Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
15 HSP90AA1oncoprotein110.33324.733HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
16 HSPA4interactor41.0000Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
17 ITGA1interactor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
18 LAMTOR1interactor21.0000LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
19 LATS1suppressor21.0000Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
20 LIMK2interactor50.4005.167LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
21 MAPK14oncoprotein60.4005.000Pkinase (PF00069, IPR000719): Protein kinase domain
22 MAPKAPK2oncoprotein50.5002.333Pkinase (PF00069, IPR000719): Protein kinase domain
23 MBPinteractor30.6671.000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
24 MIIPinteractor100Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
MIIP (PF15734, IPR031466): Migration and invasion-inhibitory
25 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
26 OSBPL5interactor21.0000Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
27 PAK1oncoprotein60.7001.733PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
28 PAK4protein found in more fusions60.6003.667PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
29 PARK2suppressor80.5247.733IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 POLR2Dinteractor21.0000RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
31 RAD54Linteractor100Rad54_N (PF08658, IPR013967): Rad54 N terminal
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32 RRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
33 RTEL1oncoprotein100C1_2 (PF03107, IPR004146): C1 domain
DEAD_2 (PF06733, IPR010614): DEAD_2
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DZR (PF12773, IPR025874): Double zinc ribbon
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
34 SARNPoncoprotein100SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
35 SH3PXD2Binteractor100PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
36 SRPK1interactor60.4676.333FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37 TADA3interactor100GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
38 UXTinteractor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
39 YWHAZprotein found in more fusions90.39313.90014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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