Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LIMD1 (from a repository: Fri Jul 12 01:14:46 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins11 (28.95 %)
The number (and %) of the tumor suppressors5 (13.16 %)
Total number of binary PPIs (saturation %)113 (16.07 %)
The number (and %) of affected PPIs38 (33.63 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.158
Assortativity coefficient-0.2253
The network average Clustering coefficient0.592
The number (and %) of a zero Clustering coefficients3 (7.89 %)
The number (and %) of a zero Betweenness Centrality10 (26.32 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LIMD1 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); RHOBTB3 (see 1 fusions); TRAF6 (see 1 fusions); RARA (see 1 fusions); LIMD1 (see 1 fusions); PYGB (see 1 fusions); APP (see 5 fusions); VHL (see 1 fusions); SQSTM1 (see 5 fusions); AURKA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LIMD1parental protein380.0921053.067LIM (PF00412, IPR001781, SM00132): LIM domain
2 APPprotein found in more fusions120.21841.167APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 AURKAoncoprotein70.5335.833Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 C1orf105interactor21.0000DUF4548 (PF15081, IPR027845): Domain of unknown function (DUF4548)
5 C9orf78interactor40.6671.667DHOR (PF06537, IPR010538): Di-haem oxidoreductase, putative peroxidase
Hep_59 (PF07052, IPR010756): Hepatocellular carcinoma-associated antigen 59
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
6 CEP170interactor40.8330.500FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
7 CNTROBinteractor60.6003.667DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
8 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
9 EGLN1suppressor60.5005.000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
10 EGLN2interactor40.6671.0002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
11 EGLN3suppressor50.5003.0002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
12 EHD1interactor60.6003.667Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
13 FKBP9interactor60.5336.000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14 GOLGA4interactor40.6671.667ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fez1 (PF06818): Fez1
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
Mnd1 (PF03962, IPR005647): Mnd1 family
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
XhlA (PF10779, IPR019715): Haemolysin XhlA
YlqD (PF11068, IPR021297): YlqD protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
TetR_C_13 (PF16925, IPR011075): Bacterial transcriptional repressor C-terminal
15 GTF3C4interactor40.6671.667TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
16 HIPK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
17 IGBP1interactor21.0000TAP42 (PF04177, IPR007304): TAP42-like family
18 LATS1suppressor50.6002.400Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
19 LATS2suppressor70.5335.567Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
20 LGALS12interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
21 ODF2interactor50.6002.833ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase
Invasin_D3 (PF09134, IPR015217): Invasin, domain 3
Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
22 PHYHIPinteractor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
23 PLCG1oncoprotein40.6671.667C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
24 PPP2R1Aoncoprotein30.6671.000TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
25 PYGBprotein found in more fusions50.6671.667Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
26 RARAoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
27 RFPL4Binteractor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
28 RHOBTB3protein found in more fusions41.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
29 SQSTM1oncoprotein60.4006.000PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
30 SSX2IPprotein found in more fusions80.4768.000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
31 STACinteractor30.6670.667SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
32 STILoncoprotein31.0000STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
33 TRAF6protein found in more fusions40.6671.000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
34 TRIP6interactor100.33327.067DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
35 UBA6interactor40.6671.667ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
36 UBR7interactor60.4677.000PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
37 VHLsuppressor70.5336.667Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
38 XPO1interactor70.4768.900CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑