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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)159
The number (and %) of the onco-proteins28 (17.61 %)
The number (and %) of the tumor suppressors13 (8.18 %)
Total number of binary PPIs (saturation %)448 (3.57 %)
The number (and %) of affected PPIs159 (35.49 %)
The number of possible different fusions18
PPI diameter2
PPI radius1
The average degree of PPI5.245
Assortativity coefficient-0.3458
The network average Clustering coefficient0.509
The number (and %) of a zero Clustering coefficients37 (23.27 %)
The number (and %) of a zero Betweenness Centrality76 (47.80 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LGALS3 All fusions
: BM969627; CN479124;
Proteins found in more fusions PTPRJ (see 2 fusions); LGALS3 (see 2 fusions); PTPN11 (see 1 fusions); CLCN3 (see 2 fusions); APP (see 4 fusions); PCBP2 (see 3 fusions); CKAP4 (see 5 fusions); PRPF19 (see 2 fusions); EGFR (see 2 fusions); KPNB1 (see 2 fusions); PARP1 (see 1 fusions); HSP90AB1 (see 1 fusions); SLC12A2 (see 1 fusions); SQSTM1 (see 5 fusions); LGALS3BP (see 2 fusions); NAP1L1 (see 3 fusions); LAMP2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LGALS3parental protein1590.02122433.456Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
2 ABCB1oncoprotein100ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
3 ABCC4interactor40.5002.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4 ACP2interactor30.6671.000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
5 ACTA1interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
6 ACTA2interactor50.4003.833Actin (PF00022, IPR004000, SM00268): Actin
7 ADCY3interactor100HNOBA (PF07701, IPR011645): Heme NO binding associated
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1)
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3810 (PF12725, IPR024294): Protein of unknown function (DUF3810)
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
8 ADCY6interactor100DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
PRA1 (PF03208, IPR004895): PRA1 family protein
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
9 ADCY9interactor100DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
10 AGPSinteractor100FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
11 AHCYinteractor200AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
12 ALCAMinteractor30.6670.222C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
13 APPprotein found in more fusions190.157121.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
14 ATG9Ainteractor31.0000APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
15 ATP13A3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
16 ATP1A1interactor80.39313.900Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
17 ATP2B4interactor60.4676.222Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
18 ATP5C1interactor70.5247.133ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
19 BARD1suppressor90.32113.400BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
20 BRCA1suppressor80.42911.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
21 BSGinteractor40.5002.333Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
22 C1GALT1C1interactor100NA
23 CADM1suppressor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Syndecan (PF01034, IPR027789): Syndecan domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
24 CAPN1interactor31.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
25 CCT3interactor70.2869.900Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
26 CD109oncoprotein31.0000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
Lipocalin_4 (PF13648, IPR024311): Lipocalin-like domain
27 CD58interactor40.6671.167Botulinum_HA-17 (PF05588, IPR008903): Clostridium botulinum HA-17 domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
YjgP_YjgQ (PF03739, IPR005495): Predicted permease YjgP/YjgQ family
28 CD63interactor40.8330.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
29 CD68oncoprotein21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
30 CDC5Linteractor150.19854.267OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
31 CFTRsuppressor100.25023.200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
32 CKAP4protein found in more fusions40.6671.000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
33 CLCN3protein found in more fusions40.6670.667CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
34 CLNS1Ainteractor40.8330.667Voldacs (PF03517): Regulator of volume decrease after cellular swelling
35 COASYinteractor21.0000CoaE (PF01121, IPR001977): Dephospho-CoA kinase
CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
36 COLEC12interactor50.4005.167Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
37 COX17interactor31.0000COX17 (PF05051, IPR007745): Cytochrome C oxidase copper chaperone (COX17)
38 CRIP1interactor40.8330.667LIM (PF00412, IPR001781, SM00132): LIM domain
39 CRYZinteractor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
40 CSPG4oncoprotein21.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
Cadherin_3 (PF16184): Cadherin-like
41 DBIinteractor31.0000ACBP (PF00887, IPR000582): Acyl CoA binding protein
JmjN (PF02375, IPR003349, SM00545): jmjN domain
42 DDOSTinteractor70.4767.400DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
43 ECE1interactor30.6671.000Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
44 EGFRoncoprotein220.162151.100Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
45 ELMOD1interactor100ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family
46 ELNoncoprotein21.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
DUF4169 (PF13770, IPR025227): Domain of unknown function (DUF4169)
47 EMBinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
48 ENPP4interactor30.6670.667Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
49 FCGR2Ainteractor21.0000DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
50 FLT4interactor21.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
51 FN1oncoprotein270.151261.122fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
52 GEMIN4interactor80.33311.400NA
53 GLB1oncoprotein100Glyco_hydro_35 (PF01301, IPR001944): Glycosyl hydrolases family 35
BetaGal_dom4_5 (PF13364, IPR025300): Beta-galactosidase jelly roll domain
54 GOLGA2interactor40.5002.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
55 GPR35interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
56 GPR52interactor30.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
57 GPR55interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
58 GTF2Iinteractor50.5004.067GTF2I (PF02946, IPR004212): GTF2I-like repeat
59 HEG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Orthoreo_P10 (PF07204, IPR009854): Orthoreovirus membrane fusion protein p10
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
EGF_3 (PF12947, IPR024731): EGF domain
DUF4215 (PF13948, IPR011936): Domain of unknown function (DUF4215)
60 HRNRinteractor100DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
61 HSP90AB1oncoprotein100.33316.200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
62 IGBP1interactor70.38110.400TAP42 (PF04177, IPR007304): TAP42-like family
63 IPO5interactor80.5008.633HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
64 ITGA1interactor31.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
65 ITGA2interactor31.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
66 ITGB1suppressor100.33327.067EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
67 KIAA0319Linteractor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
PKD (PF00801, IPR000601, SM00089): PKD domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
DUF4625 (PF15418, IPR027829): Domain of unknown function (DUF4625)
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
68 KIAA1549oncoprotein21.0000DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
69 KPNB1protein found in more fusions80.5245.300Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
70 LAMA1interactor50.7002.000Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
71 LAMA4interactor21.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
72 LAMB1interactor40.6671.667Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
YscO (PF07321, IPR009929): Type III secretion protein YscO
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Ntox1 (PF15500, IPR029137): Putative RNase-like toxin, toxin_1
73 LAMC1interactor40.5002.667BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_I (PF06008, IPR009254): Laminin Domain I
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
74 LAMP1interactor100Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
75 LAMP2protein found in more fusions40.6671.000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
76 LGALS1interactor140.22063.400Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
77 LGALS3BPoncoprotein60.4003.300BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
78 LGALS9interactor410.072730.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
79 LGALS9Cinteractor150.24860.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
80 LNPEPoncoprotein21.0000Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
Dynactin (PF12455, IPR022157): Dynein associated protein
81 LPAR1oncoprotein60.3339.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
82 MAP1LC3Ainteractor50.6002.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
83 MAPK3oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
84 MCCC1interactor21.0000Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
85 MCCC2interactor40.6671.000Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
86 MFAP3interactor21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
87 MPZL1interactor31.0000Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2
FTR1 (PF03239, IPR004923): Iron permease FTR1 family
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
88 MRC2interactor21.0000Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
89 MYH10interactor30.6670.400IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
90 MYL12Binteractor100EF-hand_11 (PF08976, IPR015070): EF-hand domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
91 MYL6interactor31.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
92 MYO1Einteractor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
93 MYOCinteractor60.5004.400IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
94 NAP1L1protein found in more fusions31.0000NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
95 NCSTNinteractor60.3339.167Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
96 NID2interactor40.5002.667EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
97 NPTNinteractor21.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
98 OSTM1interactor21.0000OSTMP1 (PF09777, IPR019172): Osteopetrosis-associated transmembrane protein 1 precursor
99 P2RY12interactor30.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
100 PARP1suppressor70.4674.433BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
101 PAXIP1interactor80.46411.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
102 PCBP2protein found in more fusions80.4297.433Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
103 PCCAinteractor100Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit
104 PDHXinteractor1002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
105 PEBP1suppressor40.6671.667PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
106 PLIN3interactor60.7002.167Perilipin (PF03036, IPR004279): Perilipin family
107 PODXLinteractor21.0000CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
CC190 (PF15768, IPR031525): Coiled-coil domain-containing protein 190
108 PPIGinteractor100Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
109 PRPF19protein found in more fusions50.5002.200Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
110 PRR13interactor200DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
111 PTGFRNinteractor31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
112 PTPN11suppressor60.5004.222SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
113 PTPRJsuppressor40.6670.222fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Syndecan (PF01034, IPR027789): Syndecan domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
114 PTPRKsuppressor60.4676.889fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
115 PTPRZ1interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
116 PYHIN1suppressor100HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
117 RAB11Boncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
118 RAB7Asuppressor40.5003.000Ras (PF00071, IPR001806, SM00173): Ras family
119 RPL12interactor100.48916.200Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
120 RPL35interactor70.6195.500Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
121 RPL7Ainteractor80.5369.567Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
122 RPS20interactor80.5718.067Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
123 RRAGBinteractor60.6004.167Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
124 RRAGCinteractor50.8001.333Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
125 RTN4RL2interactor100LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
126 SCARA3interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
127 SDK1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
128 SDK2interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
129 SERINC2interactor100Serinc (PF03348, IPR005016): Serine incorporator (Serinc)
130 SERPINH1interactor40.5002.333Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
131 SLC12A2protein found in more fusions50.6670.889AA_permease (PF00324, IPR004841): Amino acid permease
AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SLC12 (PF03522, IPR018491): Solute carrier family 12
132 SLC12A4interactor31.0000AA_permease (PF00324, IPR004841): Amino acid permease
SLC12 (PF03522, IPR018491): Solute carrier family 12
133 SLC12A6interactor31.0000AA_permease (PF00324, IPR004841): Amino acid permease
SLC12 (PF03522, IPR018491): Solute carrier family 12
Wzy_C (PF04932, IPR007016): O-Antigen ligase
134 SLC12A7interactor31.0000AA_permease (PF00324, IPR004841): Amino acid permease
SLC12 (PF03522, IPR018491): Solute carrier family 12
135 SLC15A4interactor100PTR2 (PF00854, IPR000109): POT family
136 SLC17A5interactor21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
137 SLC1A3interactor100SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
138 SLC1A5interactor40.5001.889SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
139 SLC25A5interactor50.5005.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
140 SLC26A2interactor100Spore_YabQ (PF09578, IPR019074): Spore cortex protein YabQ (Spore_YabQ)
STAS (PF01740, IPR002645): STAS domain
Sulfate_transp (PF00916, IPR011547): Sulfate permease family
141 SLC30A1interactor100Cation_efflux (PF01545, IPR002524): Cation efflux family
ZT_dimer (PF16916, IPR027470): Dimerisation domain of Zinc Transporter
142 SLC38A9interactor31.0000Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
143 SLC3A2interactor50.6003.333Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
144 SLC46A3interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
145 SLC4A2interactor30.6671.000Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
146 SLC4A7interactor40.6671.333Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
DUF2628 (PF10947, IPR024399): Protein of unknown function (DUF2628)
FAM176 (PF14851): FAM176 family
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
147 SLC7A2interactor100IncA (PF04156, IPR007285): IncA protein
AA_permease_2 (PF13520, IPR002293): Amino acid permease
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
148 SLC9A6interactor21.0000Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
149 SOD1interactor90.39315.333Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
150 SPRinteractor50.6003.333adh_short (PF00106, IPR002198): short chain dehydrogenase
151 SQSTM1oncoprotein70.4008.000PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
152 SS18L1oncoprotein200DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313)
SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
153 TEX35interactor21.0000Tsc35 (PF15079, IPR027874): Testis-specific protein 35
154 TMEM179Binteractor21.0000DUF986 (PF06173, IPR009328): Protein of unknown function (DUF986)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
TMEM117 (PF15113, IPR029370): TMEM117 protein family
155 TMEM63Ainteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
156 TMPOinteractor40.6671.000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
157 TMSB10oncoprotein100CheR (PF01739, IPR022642): CheR methyltransferase, SAM binding domain
158 TXNoncoprotein40.5002.167Thioredoxin (PF00085, IPR013766): Thioredoxin
159 VIMsuppressor120.29133.200Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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