Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins L3MBTL1 (from a repository: Wed Nov 16 16:43:38 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins6 (30.00 %)
The number (and %) of the tumor suppressors4 (20.00 %)
Total number of binary PPIs (saturation %)70 (36.84 %)
The number (and %) of affected PPIs20 (28.57 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.800
Assortativity coefficient-0.2873
The network average Clustering coefficient0.749
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality5 (25.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: L3MBTL1 All fusions
Proteins found in more fusions VCP (see 4 fusions); SETD7 (see 2 fusions); MCM2 (see 1 fusions); ETV6 (see 1 fusions); MCM7 (see 2 fusions); PCNA (see 1 fusions); TP53 (see 3 fusions); L3MBTL1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 L3MBTL1parental protein200.228200.467MBT (PF02820, IPR004092, SM00561): mbt repeat
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
2 CBX3interactor50.8330.667Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
3 CBX5suppressor50.6672.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
4 CDC45interactor60.8671.000CDC45 (PF02724, IPR003874): CDC45-like protein
5 ETV6suppressor31.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
6 ETV7interactor21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
7 HIST1H1Einteractor50.7002.333Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
8 HIST2H4Ainteractor21.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
9 KMT5Ainteractor31.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
ERp29 (PF07749, IPR011679): Endoplasmic reticulum protein ERp29, C-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
10 MCM2oncoprotein110.46722.333AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
11 MCM3interactor70.9050.800MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
12 MCM4interactor90.7863.133MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
13 MCM5oncoprotein70.8102.667MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
14 MCM6interactor80.9050.800MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
15 MCM7protein found in more fusions100.6399.800MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
16 PCNAoncoprotein70.6005.667PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
17 RB1suppressor40.5002.667RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
18 SETD7protein found in more fusions31.0000MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
19 TP53suppressor70.4008.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
20 VCPprotein found in more fusions40.6671.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

B a c k    t o    T o p ⇑