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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)47 (39.17 %)
The number (and %) of affected PPIs16 (34.04 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.625
Assortativity coefficient-0.4485
The network average Clustering coefficient0.648
The number (and %) of a zero Clustering coefficients3 (18.75 %)
The number (and %) of a zero Betweenness Centrality8 (50.00 %)


List of the fusions

PPI for parental proteins: KSR1 All fusions
: AA999960;
Proteins found in more fusions BRAF (see 3 fusions); NF2 (see 1 fusions); DCAF1 (see 1 fusions); MARK3 (see 1 fusions); HSP90AA1 (see 2 fusions); KSR1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 KSR1parental protein160.210142.333Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
2 BRAFoncoprotein80.7143.500Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
3 BRAPinteractor51.0000BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
4 DCAF1protein found in more fusions31.0000DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
5 HSP90AA1oncoprotein50.8330.500HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
6 LSP1interactor21.0000Caldesmon (PF02029, IPR006018): Caldesmon
7 MAP2K1oncoprotein80.6676.000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
8 MARK3protein found in more fusions41.0000KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
9 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
10 PRMT2interactor100PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
11 RAF1oncoprotein90.6436.333Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12 SDF4interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 XPO1interactor40.8330.500CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
15 YWHABinteractor60.8002.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
16 YWHAEoncoprotein70.6674.83314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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