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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UBE2R2, KRT1 (from a repository: Sun Dec 18 04:12:30 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)95
The number (and %) of the onco-proteins36 (37.89 %)
The number (and %) of the tumor suppressors10 (10.53 %)
Total number of binary PPIs (saturation %)685 (15.34 %)
The number (and %) of affected PPIs95 (13.87 %)
The number of possible different fusions27
PPI diameter4
PPI radius2
The average degree of PPI13.326
Assortativity coefficient-0.1541
The network average Clustering coefficient0.480
The number (and %) of a zero Clustering coefficients7 (7.37 %)
The number (and %) of a zero Betweenness Centrality11 (11.58 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: KRT1,UBE2R2 All fusions
: BC028294;
Proteins found in more fusions AP2M1 (see 3 fusions); CUL4A (see 4 fusions); YWHAG (see 1 fusions); EPS15 (see 1 fusions); CBL (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); DSP (see 4 fusions); CSTA (see 1 fusions); UBA1 (see 2 fusions); YWHAH (see 2 fusions); UBE2R2 (see 1 fusions); UBE2D2 (see 2 fusions); CDH1 (see 3 fusions); ARIH2 (see 2 fusions); EZR (see 2 fusions); GAN (see 1 fusions); COPS5 (see 1 fusions); FANCA (see 1 fusions); SHC1 (see 1 fusions); FN1/YWHAG (see 1 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); PRKCE (see 3 fusions); DTX3L (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KRT1parental protein630.1962130.288Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
2 UBE2R2parental protein320.0901684.039NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 ADRB2interactor110.48927.0347tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ALBinteractor120.48533.048Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 AP2M1protein found in more fusions190.53639.346Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6 APOA1interactor60.8001.224ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
7 APPBP2interactor40.66716.041TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
8 ARHGDIAinteractor60.20028.148Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
9 ARIH2protein found in more fusions60.70010.533IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
10 BTRConcoprotein150.40798.749WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
11 C9orf78interactor31.0000DHOR (PF06537, IPR010538): Di-haem oxidoreductase, putative peroxidase
Hep_59 (PF07052, IPR010756): Hepatocellular carcinoma-associated antigen 59
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
12 CAND1interactor220.64335.036Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
13 CBLsuppressor190.52360.221Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
14 CBLConcoprotein50.50028.163Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
15 CCNA2oncoprotein70.46719.455Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
16 CDH1suppressor50.50016.591Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
17 COPS5protein found in more fusions280.493140.344JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18 COPS6interactor240.518128.608DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
19 CRKoncoprotein200.484175.728SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 CSTAoncoprotein90.50014.103Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
21 CUL1suppressor260.507118.951Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 CUL2suppressor220.57190.122Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23 CUL3protein found in more fusions370.381362.889Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
24 CUL4Aprotein found in more fusions220.59081.033Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL4Boncoprotein200.68933.764Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
26 CUL5suppressor220.628136.637Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 DCUN1D1interactor220.67534.884Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
28 DRG2interactor100MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
29 DSPsuppressor140.41046.970APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
30 DTX3Lprotein found in more fusions31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
31 DZIP3interactor31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
32 EEDsuppressor110.5566.640WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
33 EIF4A3interactor190.53646.796DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 EPS15oncoprotein150.58260.249Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
35 ESR1suppressor170.40857.102Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
36 EZRprotein found in more fusions80.14382.251DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
37 FANCAoncoprotein40.33314.338Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
38 FANCConcoprotein21.0000Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
39 FBXW11interactor110.55632.909WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
40 FBXW5interactor40.50015.309WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
41 FN1oncoprotein210.424134.205fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
42 GANprotein found in more fusions90.42914.423BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
43 GNPDA1interactor40.5008.387Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
44 GRB2oncoprotein270.48697.224SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
45 HDGFinteractor50.400114.507PWWP (PF00855, IPR000313, SM00293): PWWP domain
46 HNRNPA1interactor300.424151.453RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
47 INF2interactor205.169Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
48 INPPL1oncoprotein150.6959.794Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
49 IQCB1interactor70.5711.994DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
50 ITGA4interactor190.52337.411FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
51 IVLinteractor70.6674.603Involucrin (PF00904, IPR000354): Involucrin repeat
Involucrin_N (PF10583, IPR019571): Involucrin of squamous epithelia N-terminus
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
52 KNG1interactor21.0000Bradykinin (PF06753, IPR009608): Bradykinin
Chorion_2 (PF03964, IPR005649): Chorion family 2
Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
53 KRASoncoprotein90.143111.417Ras (PF00071, IPR001806, SM00173): Ras family
54 KRT10interactor430.281402.187Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
55 KRT2interactor390.306302.958Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
56 KRT5interactor320.373134.455Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
57 KRT77interactor90.6675.150Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
58 KRT9interactor390.247318.418Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
59 LGR4interactor100.25054.8347tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
60 LORinteractor50.8330.667Loricrin (PF15847, IPR031700): Major keratinocyte cell envelope protein
61 MAGOHinteractor80.6071.219Mago_nashi (PF02792, IPR004023): Mago nashi protein
62 MBL2interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
63 MEOX1interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
64 NEDD8interactor250.536131.112ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65 NUBP2interactor40.6673.000ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
66 PAK2protein found in more fusions60.8000.800PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
67 PAN2interactor80.5368.093RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
68 PI3interactor31.0000WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core'
Cementoin (PF10511, IPR019541): Trappin protein transglutaminase binding domain
69 PIK3R2oncoprotein160.60035.709RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
70 PNPLA2interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
71 POU5F1oncoprotein70.6670.844Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
72 PRKCEsuppressor40.6670.667C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
73 PRSS1interactor50.7001.322Trypsin (PF00089, IPR001254, SM00020): Trypsin
74 RAD23Aoncoprotein90.28695.113UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
75 RBX1oncoprotein180.507116.401zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
76 RNF113Binteractor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
77 RPS6KB2interactor120.36436.547Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
78 SFNsuppressor130.394233.55914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
79 SHC1oncoprotein160.64839.648PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
80 SLC25A5interactor250.31798.164Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
81 TJP1interactor40.5004.864DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
82 UBA1protein found in more fusions120.30959.693ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
83 UBASH3Binteractor140.71825.597His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
84 UBCprotein found in more fusions360.225614.386ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85 UBE2D2oncoprotein160.257231.970UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
86 UBE3Aoncoprotein100.25043.916HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
87 UBR7interactor40.50051.298PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
88 UCHL5oncoprotein110.33368.780Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
89 USP7oncoprotein110.55617.239MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
90 VCAM1interactor150.54356.235C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
91 WDR4interactor3020.804WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
92 YWHAEoncoprotein190.322178.45714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
93 YWHAGprotein found in more fusions170.367124.54314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
94 YWHAHprotein found in more fusions110.51168.89814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
95 YWHAQinteractor190.43362.32214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARIH2interactorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
BC028294
2 DRG2interactorMMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
BC028294
3 DTX3LinteractorKH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
BC028294
4 DZIP3interactorDUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
BC028294
5 KRT1parental proteinFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
BC028294
6 NUBP2interactorParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPaseBC028294
7 PNPLA2interactorPatatin (PF01734, IPR002641): Patatin-like phospholipaseBC028294
8 RBX1oncoproteinzf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domainBC028294
9 RNF113Binteractorzf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
BC028294
10 UBA1interactorThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
BC028294
11 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin familyBC028294
12 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzymeBC028294
13 UBE2R2parental proteinNOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BC028294
14 UBR7interactorPHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
BC028294

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