1 |
KPNB1 | parental protein | 211 | 0.072 | 26556.162 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat |
2 |
AAAS | interactor | 9 | 0.583 | 2.177 | PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613) |
3 |
ADRB2 | interactor | 16 | 0.248 | 37.495 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
4 |
AHSA1 | interactor | 10 | 0.556 | 5.653 | Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein |
5 |
AICDA | interactor | 9 | 0.357 | 6.398 | APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain |
6 |
AIRE | interactor | 11 | 0.333 | 6.215 | PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain |
7 |
ALDH3A2 | interactor | 5 | 0.700 | 0.413 | Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family |
8 |
AMFR | oncoprotein | 13 | 0.379 | 23.723 | CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain |
9 |
ARRB2 | interactor | 17 | 0.346 | 35.452 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
10 |
BARD1 | suppressor | 17 | 0.275 | 56.775 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
11 |
BUB3 | interactor | 16 | 0.417 | 24.785 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
12 |
C11orf58 | interactor | 4 | 0.500 | 2.400 | DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) SMAP (PF15477, IPR028124): Small acidic protein family |
13 |
CAND1 | interactor | 39 | 0.353 | 169.462 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
14 |
CCDC8 | interactor | 35 | 0.260 | 162.715 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
15 |
CCNK | interactor | 4 | 0.833 | 0.333 | Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) |
16 |
CD4 | suppressor | 4 | 0.667 | 0.400 | ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region |
17 |
CD99 | interactor | 1 | 0 | 0 | CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2 |
18 |
CDC5L | interactor | 48 | 0.276 | 341.908 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
19 |
CDCA2 | interactor | 3 | 1.000 | 0 | PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding MRI (PF15325, IPR028278): Modulator of retrovirus infection |
20 |
CDK11A | oncoprotein | 3 | 0.667 | 0.286 | DDHD (PF02862, IPR004177, SM01127): DDHD domain eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pkinase (PF00069, IPR000719): Protein kinase domain RIO1 (PF01163, IPR018934): RIO1 family DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) DHHW (PF14286, IPR025945): DHHW protein DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) |
21 |
CDK2 | suppressor | 31 | 0.299 | 129.914 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
CDT1 | oncoprotein | 7 | 0.857 | 0.411 | CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain |
23 |
CEP192 | interactor | 3 | 1.000 | 0 | Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin |
24 |
CEP55 | interactor | 5 | 0.667 | 1.000 | DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) ZapB (PF06005, IPR009252): Cell division protein ZapB EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 |
25 |
CERS2 | interactor | 3 | 1.000 | 0 | PDR_CDR (PF06422, IPR010929): CDR ABC transporter TRAM1 (PF08390, IPR013599): TRAM1-like protein TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
26 |
CFTR | suppressor | 15 | 0.319 | 29.443 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
27 |
CHD3 | oncoprotein | 14 | 0.449 | 20.899 | CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family |
28 |
CHD8 | oncoprotein | 12 | 0.409 | 13.203 | BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Myb_DNA-bind_7 (PF15963): Myb DNA-binding like |
29 |
CLK3 | interactor | 8 | 0.476 | 3.644 | Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
30 |
COMTD1 | interactor | 6 | 0.400 | 2.832 | FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
31 |
COPS5 | protein found in more fusions | 37 | 0.313 | 186.667 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
32 |
CRY1 | interactor | 7 | 0.800 | 0.333 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
33 |
CSE1L | oncoprotein | 28 | 0.352 | 82.324 | CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein |
34 |
CUL2 | suppressor | 24 | 0.409 | 67.800 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
35 |
CUL3 | protein found in more fusions | 59 | 0.229 | 532.079 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
36 |
CUL4B | oncoprotein | 25 | 0.467 | 55.076 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
37 |
CUL7 | protein found in more fusions | 46 | 0.281 | 219.100 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
38 |
DCAF8 | interactor | 5 | 0.700 | 0.564 | DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661) |
39 |
DERL1 | interactor | 7 | 0.467 | 4.032 | DER1 (PF04511, IPR007599): Der1-like family |
40 |
DIS3 | interactor | 9 | 0.389 | 6.814 | RNB (PF00773, SM00955): RNB domain rve (PF00665, IPR001584): Integrase core domain PIN_4 (PF13638, IPR002716): PIN domain Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain Rrp44_S1 (PF17215): S1 domain |
41 |
DLGAP5 | interactor | 2 | 1.000 | 0 | GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein |
42 |
DYRK1B | oncoprotein | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
43 |
ECT2 | suppressor | 10 | 0.333 | 9.064 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal |
44 |
EED | suppressor | 34 | 0.216 | 157.030 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
45 |
EGFR | oncoprotein | 41 | 0.167 | 414.036 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
46 |
ELAVL1 | oncoprotein | 54 | 0.173 | 713.329 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
47 |
ERBB2 | oncoprotein | 5 | 0.667 | 1.200 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
48 |
ETF1 | interactor | 3 | 0.667 | 0.500 | eRF1_1 (PF03463, IPR005140): eRF1 domain 1 eRF1_2 (PF03464, IPR005141): eRF1 domain 2 eRF1_3 (PF03465, IPR005142): eRF1 domain 3 |
49 |
EXO1 | interactor | 5 | 0.500 | 2.286 | XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain |
50 |
EXOSC2 | interactor | 11 | 0.400 | 14.339 | EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region KH_6 (PF15985, IPR004088): KH domain |
51 |
FAN1 | protein found in more fusions | 7 | 0.533 | 4.944 | VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TPR_12 (PF13424): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) |
52 |
FBXO6 | interactor | 26 | 0.212 | 88.233 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
53 |
FGFR1 | oncoprotein | 3 | 1.000 | 0 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
54 |
FN1 | oncoprotein | 31 | 0.256 | 125.273 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
55 |
FUS | suppressor | 26 | 0.480 | 36.548 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
56 |
GLE1 | interactor | 9 | 0.714 | 1.505 | DUF1906 (PF08924, IPR015020): Domain of unknown function (DUF1906) GLE1 (PF07817, IPR012476): GLE1-like protein Membralin (PF09746, IPR019144): Tumour-associated protein |
57 |
GRK5 | protein found in more fusions | 7 | 0.533 | 1.635 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
58 |
HADHB | interactor | 15 | 0.390 | 23.552 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
59 |
HDAC5 | protein found in more fusions | 26 | 0.263 | 95.245 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
60 |
HIST1H1C | oncoprotein | 14 | 0.516 | 11.099 | Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349) |
61 |
HSPA5 | oncoprotein | 43 | 0.276 | 257.940 | HSP70 (PF00012, IPR013126): Hsp70 protein |
62 |
HUWE1 | oncoprotein | 36 | 0.321 | 174.351 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
63 |
ILK | suppressor | 13 | 0.500 | 9.070 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
64 |
ING1 | suppressor | 8 | 0.500 | 4.752 | PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta |
65 |
IPO4 | interactor | 10 | 0.600 | 2.686 | HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis UME (PF08064, IPR012993, SM00802): UME (NUC010) domain HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
66 |
IPO5 | interactor | 32 | 0.308 | 142.933 | HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat AAA_30 (PF13604): AAA domain HEAT_2 (PF13646): HEAT repeats PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal |
67 |
IPO7 | interactor | 25 | 0.300 | 84.199 | Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Xpo1 (PF08389, IPR013598): Exportin 1-like protein DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730) |
68 |
IPO8 | interactor | 10 | 0.444 | 10.351 | BUD22 (PF09073, IPR015158): BUD22 Cse1 (PF08506, IPR013713): Cse1 HAND (PF09110, IPR015194): HAND IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein |
69 |
IPO9 | interactor | 18 | 0.386 | 39.429 | IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Xpo1 (PF08389, IPR013598): Exportin 1-like protein UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central HEAT_EZ (PF13513): HEAT-like repeat |
70 |
ITCH | interactor | 16 | 0.314 | 40.326 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
71 |
ITGA4 | interactor | 24 | 0.344 | 46.867 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
72 |
JAK2 | oncoprotein | 5 | 0.667 | 2.000 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
73 |
KIAA1429 | interactor | 6 | 0.667 | 1.521 | Mpp10 (PF04006, IPR007151): Mpp10 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus VIR_N (PF15912, IPR031801): Virilizer, N-terminal |
74 |
KIFC1 | interactor | 5 | 0.500 | 1.500 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit Microtub_bd (PF16796, IPR031852): Microtubule binding |
75 |
KPNA1 | interactor | 30 | 0.278 | 164.761 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
76 |
KPNA2 | interactor | 50 | 0.204 | 540.748 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
77 |
KPNA3 | interactor | 15 | 0.457 | 25.282 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
78 |
KPNA4 | interactor | 20 | 0.300 | 61.849 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
79 |
KPNA5 | oncoprotein | 8 | 0.500 | 2.690 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
80 |
KPNA6 | interactor | 19 | 0.333 | 50.540 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
81 |
LCA5 | interactor | 6 | 0.467 | 2.161 | IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease |
82 |
LCOR | interactor | 2 | 1.000 | 0 | DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553) |
83 |
LGALS3 | oncoprotein | 8 | 0.524 | 4.221 | Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin |
84 |
LYST | interactor | 2 | 1.000 | 0 | Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4800 (PF16057): Domain of unknown function (DUF4800) |
85 |
MCM2 | oncoprotein | 42 | 0.246 | 304.805 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
86 |
MDC1 | suppressor | 19 | 0.392 | 43.511 | FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
87 |
MED24 | interactor | 3 | 1.000 | 0 | Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal |
88 |
MEPCE | interactor | 18 | 0.431 | 30.102 | Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7 |
89 |
MESDC2 | interactor | 1 | 0 | 0 | Mesd (PF10185, IPR019330): Chaperone for wingless signalling and trafficking of LDL receptor |
90 |
MGMT | interactor | 4 | 0.833 | 0.200 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
91 |
MLH1 | suppressor | 13 | 0.449 | 26.973 | DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus |
92 |
MORF4L1 | interactor | 12 | 0.545 | 8.581 | MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain |
93 |
MORF4L2 | interactor | 10 | 0.556 | 9.161 | MRG (PF05712, IPR026541): MRG |
94 |
MRGBP | interactor | 11 | 0.473 | 12.164 | Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7 |
95 |
MSL1 | interactor | 7 | 0.476 | 4.477 | Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein PEHE (PF15275, IPR029332): PEHE domain MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1 |
96 |
MYC | oncoprotein | 35 | 0.255 | 169.121 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
97 |
NCL | protein found in more fusions | 41 | 0.258 | 260.741 | DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1 |
98 |
NDC1 | interactor | 9 | 0.667 | 2.373 | Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup |
99 |
NDN | suppressor | 5 | 0.833 | 0.667 | MAGE (PF01454, IPR002190): MAGE family |
100 |
NEMP1 | interactor | 2 | 1.000 | 0 | NEMP (PF10225, IPR019358): NEMP family EloA-BP1 (PF15870, IPR031736): ElonginA binding-protein 1 |
101 |
NFATC1 | oncoprotein | 7 | 0.667 | 2.815 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
102 |
NFATC2 | suppressor | 4 | 0.667 | 0.200 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
103 |
NLK | protein found in more fusions | 7 | 0.533 | 1.641 | Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit |
104 |
NOP56 | interactor | 21 | 0.352 | 39.843 | Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal |
105 |
NOS2 | interactor | 8 | 0.524 | 3.857 | FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain |
106 |
NOTCH1 | suppressor | 10 | 0.389 | 8.106 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
107 |
NRIP1 | oncoprotein | 3 | 0.667 | 0.222 | ALMT (PF11744, IPR020966): Aluminium activated malate transporter NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3 NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4 |
108 |
NSF | interactor | 12 | 0.418 | 10.075 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain ATPase (PF06745, IPR014774): KaiC AAA_19 (PF13245): Part of AAA domain |
109 |
NTRK1 | oncoprotein | 75 | 0.174 | 1107.935 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
110 |
NUMA1 | oncoprotein | 21 | 0.343 | 48.519 | Colicin (PF01024, IPR000293): Colicin pore forming domain Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tup_N (PF08581, IPR013890): Tup N-terminal CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
111 |
NUP107 | interactor | 48 | 0.296 | 314.093 | Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107 |
112 |
NUP133 | oncoprotein | 17 | 0.522 | 15.109 | Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal |
113 |
NUP153 | protein found in more fusions | 57 | 0.227 | 585.026 | Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region |
114 |
NUP155 | interactor | 22 | 0.333 | 48.503 | Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like |
115 |
NUP160 | interactor | 17 | 0.618 | 9.771 | Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 |
116 |
NUP188 | interactor | 16 | 0.467 | 14.474 | Nup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34 Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205 |
117 |
NUP205 | interactor | 21 | 0.376 | 30.294 | Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205 |
118 |
NUP210 | interactor | 14 | 0.341 | 10.903 | Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2) |
119 |
NUP214 | oncoprotein | 27 | 0.382 | 71.169 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 |
120 |
NUP35 | interactor | 23 | 0.462 | 40.560 | Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif |
121 |
NUP37 | interactor | 11 | 0.618 | 6.969 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
122 |
NUP43 | interactor | 14 | 0.670 | 7.936 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
123 |
NUP50 | interactor | 22 | 0.359 | 78.829 | NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa) Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain |
124 |
NUP54 | interactor | 11 | 0.636 | 5.848 | Regulator_TrmB (PF11495, IPR021586): Archaeal transcriptional regulator TrmB KRTAP (PF11759, IPR021743): Keratin-associated matrix Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54 SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
125 |
NUP62 | interactor | 21 | 0.516 | 26.179 | Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region |
126 |
NUP85 | interactor | 20 | 0.516 | 25.197 | Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin |
127 |
NUP88 | interactor | 16 | 0.625 | 10.825 | Nup88 (PF10168, IPR019321): Nuclear pore component |
128 |
NUP93 | oncoprotein | 31 | 0.308 | 110.663 | Nic96 (PF04097, IPR007231): Nup93/Nic96 |
129 |
NUP98 | suppressor | 24 | 0.384 | 74.866 | Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head |
130 |
NUPL2 | interactor | 7 | 0.714 | 1.565 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
131 |
NUSAP1 | interactor | 7 | 0.524 | 2.151 | GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein |
132 |
NUTF2 | interactor | 8 | 0.667 | 1.850 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain |
133 |
NXF1 | interactor | 50 | 0.236 | 459.054 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
134 |
OBSL1 | interactor | 49 | 0.278 | 250.414 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
135 |
PAPOLA | interactor | 5 | 0.700 | 0.658 | PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain Macoilin (PF09726, IPR019130): Transmembrane protein |
136 |
PIAS4 | interactor | 13 | 0.487 | 19.978 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain |
137 |
PLEKHA8 | oncoprotein | 2 | 1.000 | 0 | GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP) PH (PF00169, IPR001849, SM00233): PH domain AKNA (PF12443, IPR022150): AT-hook-containing transcription factor |
138 |
PMS2 | oncoprotein | 10 | 0.422 | 12.296 | DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase |
139 |
POM121C | interactor | 4 | 1.000 | 0 | T2SSC (PF11356): Type II secretion system protein C Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region POM121 (PF15229): POM121 family |
140 |
POU5F1 | oncoprotein | 13 | 0.333 | 14.584 | Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
141 |
PPP2CA | suppressor | 20 | 0.158 | 88.378 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
142 |
PTHLH | oncoprotein | 2 | 1.000 | 0 | Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region Parathyroid (PF01279, IPR001415, SM00087): Parathyroid hormone family |
143 |
PTMA | oncoprotein | 11 | 0.400 | 15.524 | Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family |
144 |
PTN | oncoprotein | 7 | 0.533 | 6.167 | PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain |
145 |
RAC1 | oncoprotein | 13 | 0.409 | 14.692 | Ras (PF00071, IPR001806, SM00173): Ras family |
146 |
RAD21 | oncoprotein | 13 | 0.372 | 14.199 | Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
147 |
RAE1 | interactor | 22 | 0.468 | 36.737 | Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
148 |
RAN | oncoprotein | 42 | 0.226 | 329.226 | Ras (PF00071, IPR001806, SM00173): Ras family |
149 |
RANBP1 | interactor | 10 | 0.511 | 7.061 | PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain |
150 |
RANBP2 | oncoprotein | 40 | 0.306 | 213.023 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
151 |
RANBP6 | interactor | 5 | 0.700 | 1.248 | HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats |
152 |
RANGAP1 | protein found in more fusions | 30 | 0.369 | 115.754 | RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
153 |
RAPGEF3 | interactor | 5 | 0.500 | 0.790 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain BAT (PF15915, IPR031803): GAF and HTH_10 associated domain |
154 |
RASSF5 | suppressor | 4 | 0.667 | 0.500 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
155 |
RCC1 | interactor | 22 | 0.338 | 66.154 | RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
156 |
RGPD8 | interactor | 5 | 0.700 | 0.758 | GRIP (PF01465, IPR000237, SM00755): GRIP domain HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat FlxA (PF14282, IPR025577): FlxA-like protein TPR_19 (PF14559): Tetratricopeptide repeat Rab_bind (PF16704, IPR032023): Rab binding domain |
157 |
RNF113A | interactor | 2 | 1.000 | 0 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8 zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
158 |
RPRD1B | interactor | 4 | 0.667 | 0.800 | CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1 CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour |
159 |
RUNX1T1 | oncoprotein | 3 | 1.000 | 0 | NHR2 (PF08788, IPR014896): NHR2 domain like TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF zf-MYND (PF01753, IPR002893): MYND finger DUF3731 (PF12531, IPR021030): DNA-K related protein |
160 |
RUSC2 | interactor | 2 | 1.000 | 0 | RUN (PF02759, IPR004012, SM00593): RUN domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
161 |
RUVBL1 | oncoprotein | 34 | 0.335 | 132.912 | TIP49 (PF06068, IPR010339): TIP49 C-terminus |
162 |
RUVBL2 | oncoprotein | 34 | 0.294 | 153.452 | TIP49 (PF06068, IPR010339): TIP49 C-terminus |
163 |
SAMHD1 | interactor | 10 | 0.472 | 10.322 | HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
164 |
SEH1L | interactor | 33 | 0.337 | 116.844 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein |
165 |
SELENOS | interactor | 3 | 1.000 | 0 | Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326) |
166 |
SENP1 | protein found in more fusions | 12 | 0.491 | 7.822 | Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
167 |
SENP3 | interactor | 8 | 0.536 | 3.892 | Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
168 |
SERPINB12 | interactor | 4 | 0.667 | 0.382 | Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor) |
169 |
SF3B3 | interactor | 22 | 0.429 | 34.334 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
170 |
SIRT7 | interactor | 40 | 0.238 | 221.124 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
171 |
SLC27A2 | interactor | 1 | 0 | 0 | AMP-binding (PF00501, IPR000873): AMP-binding enzyme AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain |
172 |
SMAD2 | suppressor | 19 | 0.373 | 47.272 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
173 |
SMAD3 | oncoprotein | 22 | 0.267 | 92.681 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
174 |
SMAD4 | suppressor | 15 | 0.297 | 35.291 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
175 |
SMC3 | oncoprotein | 24 | 0.308 | 76.040 | SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain |
176 |
SMN1 | interactor | 14 | 0.346 | 30.280 | SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) |
177 |
SMPD4 | interactor | 6 | 0.600 | 0.998 | mit_SMPDase (PF14724, IPR024129): Mitochondrial-associated sphingomyelin phosphodiesterase |
178 |
SMURF1 | interactor | 15 | 0.352 | 28.030 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
179 |
SNUPN | interactor | 4 | 0.667 | 1.105 | mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain Snurportin1 (PF11538, IPR024721): Snurportin1 |
180 |
SNW1 | protein found in more fusions | 48 | 0.257 | 371.027 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
181 |
SP110 | oncoprotein | 2 | 1.000 | 0 | Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain |
182 |
SPG20 | interactor | 7 | 0.667 | 1.446 | MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein |
183 |
SREBF2 | protein found in more fusions | 6 | 0.500 | 1.152 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit |
184 |
SRY | interactor | 2 | 1.000 | 0 | DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
185 |
STAU1 | protein found in more fusions | 23 | 0.463 | 34.846 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
186 |
SUMO1 | interactor | 17 | 0.533 | 18.350 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
187 |
TAF10 | interactor | 9 | 0.389 | 13.979 | TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit |
188 |
TAF11 | interactor | 3 | 0.667 | 0.667 | CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region |
189 |
TAF3 | interactor | 3 | 1.000 | 0 | Bromo_TP (PF07524, IPR006565): Bromodomain associated GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) FHIPEP (PF00771, IPR001712): FHIPEP family FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PHD (PF00628, IPR019787, SM00249): PHD-finger zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824) |
190 |
TAF4B | interactor | 2 | 1.000 | 0 | TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
191 |
TAF8 | protein found in more fusions | 6 | 0.500 | 4.667 | Bromo_TP (PF07524, IPR006565): Bromodomain associated TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term DUF3090 (PF11290, IPR021441): Protein of unknown function (DUF3090) |
192 |
TERF1 | interactor | 13 | 0.348 | 19.736 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
193 |
TERF2 | interactor | 16 | 0.295 | 44.715 | Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif |
194 |
THOC2 | interactor | 12 | 0.318 | 20.545 | Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus |
195 |
TMEM209 | interactor | 6 | 0.800 | 0.440 | CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal |
196 |
TMEM214 | interactor | 6 | 0.733 | 0.803 | TMEM214 (PF10151, IPR019308): TMEM214, C-terminal, caspase 4 activator |
197 |
TP53 | suppressor | 48 | 0.205 | 470.255 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
198 |
TP53BP1 | suppressor | 17 | 0.338 | 40.235 | 53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
199 |
TPX2 | interactor | 3 | 0.667 | 0.133 | Aurora-A_bind (PF09041, IPR015128): Aurora-A binding TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259) TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) |
200 |
TUBA1A | oncoprotein | 26 | 0.268 | 119.285 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
201 |
U2AF2 | protein found in more fusions | 34 | 0.330 | 151.229 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
202 |
UBC | protein found in more fusions | 51 | 0.220 | 501.651 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
203 |
UBE2I | interactor | 38 | 0.237 | 260.869 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
204 |
UBL4A | interactor | 14 | 0.484 | 11.340 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
205 |
UNK | interactor | 16 | 0.242 | 28.811 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
206 |
UQCR10 | interactor | 1 | 0 | 0 | UCR_UQCRX_QCR9 (PF05365, IPR008027): Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like |
207 |
VCAM1 | interactor | 22 | 0.299 | 43.956 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
208 |
YTHDC1 | interactor | 1 | 0 | 0 | DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family YTH (PF04146, IPR007275): YT521-B-like domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH |
209 |
YWHAE | oncoprotein | 31 | 0.237 | 165.549 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
210 |
ZC3H14 | interactor | 8 | 0.500 | 7.402 | PWI (PF01480, IPR002483, SM00311): PWI domain zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger |
211 |
ZNF207 | interactor | 5 | 0.500 | 2.380 | MCPVI (PF02993, IPR004243): Minor capsid protein VI SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 (PF13894): C2H2-type zinc finger |