Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins KPNB1 (from a repository: Sat Dec 3 16:10:29 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 211 The number (and %) of the onco-proteins 63 (29.86 %) The number (and %) of the tumor suppressors 22 (10.43 %) Total number of binary PPIs (saturation %) 1864 (8.41 %) The number (and %) of affected PPIs 211 (11.32 %) The number of possible different fusions 36 PPI diameter 2 PPI radius 1 The average degree of PPI 16.900 Assortativity coefficient -0.2417 The network average Clustering coefficient 0.487 The number (and %) of a zero Clustering coefficients 5 (2.37 %) The number (and %) of a zero Betweenness Centrality 26 (12.32 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KPNB1	All fusions : BE897946; BQ212023;
Proteins found in more fusions	TAF8 (see 2 fusions); GRK5 (see 4 fusions); SMAD4 (see 2 fusions); STAU1 (see 2 fusions); RAN/CFTR (see 1 fusions); NUP214 (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); RUNX1T1 (see 1 fusions); RANGAP1 (see 2 fusions); MYC (see 1 fusions); SREBF2 (see 2 fusions); NUP153 (see 2 fusions); LGALS3 (see 2 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); UBC (see 1 fusions); SENP1 (see 1 fusions); RASSF5 (see 2 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); FAN1 (see 1 fusions); ILK (see 1 fusions); JAK2 (see 3 fusions); KPNB1 (see 2 fusions); HUWE1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); CHD3 (see 1 fusions); NLK (see 4 fusions); FGFR1 (see 2 fusions); NCL (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KPNB1	parental protein	211	0.072	26556.162	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
2	AAAS	interactor	9	0.583	2.177	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
3	ADRB2	interactor	16	0.248	37.495	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4	AHSA1	interactor	10	0.556	5.653	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5	AICDA	interactor	9	0.357	6.398	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
6	AIRE	interactor	11	0.333	6.215	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
7	ALDH3A2	interactor	5	0.700	0.413	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
8	AMFR	oncoprotein	13	0.379	23.723	CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
9	ARRB2	interactor	17	0.346	35.452	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10	BARD1	suppressor	17	0.275	56.775	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
11	BUB3	interactor	16	0.417	24.785	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
12	C11orf58	interactor	4	0.500	2.400	DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) SMAP (PF15477, IPR028124): Small acidic protein family
13	CAND1	interactor	39	0.353	169.462	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14	CCDC8	interactor	35	0.260	162.715	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
15	CCNK	interactor	4	0.833	0.333	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
16	CD4	suppressor	4	0.667	0.400	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
17	CD99	interactor	1	0	0	CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
18	CDC5L	interactor	48	0.276	341.908	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
19	CDCA2	interactor	3	1.000	0	PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding MRI (PF15325, IPR028278): Modulator of retrovirus infection
20	CDK11A	oncoprotein	3	0.667	0.286	DDHD (PF02862, IPR004177, SM01127): DDHD domain eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pkinase (PF00069, IPR000719): Protein kinase domain RIO1 (PF01163, IPR018934): RIO1 family DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) DHHW (PF14286, IPR025945): DHHW protein DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
21	CDK2	suppressor	31	0.299	129.914	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
22	CDT1	oncoprotein	7	0.857	0.411	CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
23	CEP192	interactor	3	1.000	0	Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
24	CEP55	interactor	5	0.667	1.000	DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) ZapB (PF06005, IPR009252): Cell division protein ZapB EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
25	CERS2	interactor	3	1.000	0	PDR_CDR (PF06422, IPR010929): CDR ABC transporter TRAM1 (PF08390, IPR013599): TRAM1-like protein TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
26	CFTR	suppressor	15	0.319	29.443	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
27	CHD3	oncoprotein	14	0.449	20.899	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
28	CHD8	oncoprotein	12	0.409	13.203	BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
29	CLK3	interactor	8	0.476	3.644	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
30	COMTD1	interactor	6	0.400	2.832	FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
31	COPS5	protein found in more fusions	37	0.313	186.667	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
32	CRY1	interactor	7	0.800	0.333	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
33	CSE1L	oncoprotein	28	0.352	82.324	CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
34	CUL2	suppressor	24	0.409	67.800	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
35	CUL3	protein found in more fusions	59	0.229	532.079	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
36	CUL4B	oncoprotein	25	0.467	55.076	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
37	CUL7	protein found in more fusions	46	0.281	219.100	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
38	DCAF8	interactor	5	0.700	0.564	DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
39	DERL1	interactor	7	0.467	4.032	DER1 (PF04511, IPR007599): Der1-like family
40	DIS3	interactor	9	0.389	6.814	RNB (PF00773, SM00955): RNB domain rve (PF00665, IPR001584): Integrase core domain PIN_4 (PF13638, IPR002716): PIN domain Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain Rrp44_S1 (PF17215): S1 domain
41	DLGAP5	interactor	2	1.000	0	GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein
42	DYRK1B	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
43	ECT2	suppressor	10	0.333	9.064	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
44	EED	suppressor	34	0.216	157.030	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45	EGFR	oncoprotein	41	0.167	414.036	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46	ELAVL1	oncoprotein	54	0.173	713.329	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
47	ERBB2	oncoprotein	5	0.667	1.200	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
48	ETF1	interactor	3	0.667	0.500	eRF1_1 (PF03463, IPR005140): eRF1 domain 1 eRF1_2 (PF03464, IPR005141): eRF1 domain 2 eRF1_3 (PF03465, IPR005142): eRF1 domain 3
49	EXO1	interactor	5	0.500	2.286	XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
50	EXOSC2	interactor	11	0.400	14.339	EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region KH_6 (PF15985, IPR004088): KH domain
51	FAN1	protein found in more fusions	7	0.533	4.944	VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TPR_12 (PF13424): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
52	FBXO6	interactor	26	0.212	88.233	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
53	FGFR1	oncoprotein	3	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
54	FN1	oncoprotein	31	0.256	125.273	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
55	FUS	suppressor	26	0.480	36.548	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
56	GLE1	interactor	9	0.714	1.505	DUF1906 (PF08924, IPR015020): Domain of unknown function (DUF1906) GLE1 (PF07817, IPR012476): GLE1-like protein Membralin (PF09746, IPR019144): Tumour-associated protein
57	GRK5	protein found in more fusions	7	0.533	1.635	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
58	HADHB	interactor	15	0.390	23.552	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
59	HDAC5	protein found in more fusions	26	0.263	95.245	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
60	HIST1H1C	oncoprotein	14	0.516	11.099	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
61	HSPA5	oncoprotein	43	0.276	257.940	HSP70 (PF00012, IPR013126): Hsp70 protein
62	HUWE1	oncoprotein	36	0.321	174.351	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
63	ILK	suppressor	13	0.500	9.070	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
64	ING1	suppressor	8	0.500	4.752	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
65	IPO4	interactor	10	0.600	2.686	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis UME (PF08064, IPR012993, SM00802): UME (NUC010) domain HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
66	IPO5	interactor	32	0.308	142.933	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat AAA_30 (PF13604): AAA domain HEAT_2 (PF13646): HEAT repeats PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
67	IPO7	interactor	25	0.300	84.199	Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Xpo1 (PF08389, IPR013598): Exportin 1-like protein DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
68	IPO8	interactor	10	0.444	10.351	BUD22 (PF09073, IPR015158): BUD22 Cse1 (PF08506, IPR013713): Cse1 HAND (PF09110, IPR015194): HAND IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
69	IPO9	interactor	18	0.386	39.429	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Xpo1 (PF08389, IPR013598): Exportin 1-like protein UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central HEAT_EZ (PF13513): HEAT-like repeat
70	ITCH	interactor	16	0.314	40.326	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
71	ITGA4	interactor	24	0.344	46.867	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
72	JAK2	oncoprotein	5	0.667	2.000	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
73	KIAA1429	interactor	6	0.667	1.521	Mpp10 (PF04006, IPR007151): Mpp10 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus VIR_N (PF15912, IPR031801): Virilizer, N-terminal
74	KIFC1	interactor	5	0.500	1.500	APG6 (PF04111, IPR007243): Autophagy protein Apg6 IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit Microtub_bd (PF16796, IPR031852): Microtubule binding
75	KPNA1	interactor	30	0.278	164.761	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
76	KPNA2	interactor	50	0.204	540.748	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
77	KPNA3	interactor	15	0.457	25.282	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
78	KPNA4	interactor	20	0.300	61.849	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
79	KPNA5	oncoprotein	8	0.500	2.690	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
80	KPNA6	interactor	19	0.333	50.540	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
81	LCA5	interactor	6	0.467	2.161	IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
82	LCOR	interactor	2	1.000	0	DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553)
83	LGALS3	oncoprotein	8	0.524	4.221	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
84	LYST	interactor	2	1.000	0	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4800 (PF16057): Domain of unknown function (DUF4800)
85	MCM2	oncoprotein	42	0.246	304.805	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
86	MDC1	suppressor	19	0.392	43.511	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
87	MED24	interactor	3	1.000	0	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
88	MEPCE	interactor	18	0.431	30.102	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
89	MESDC2	interactor	1	0	0	Mesd (PF10185, IPR019330): Chaperone for wingless signalling and trafficking of LDL receptor
90	MGMT	interactor	4	0.833	0.200	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
91	MLH1	suppressor	13	0.449	26.973	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
92	MORF4L1	interactor	12	0.545	8.581	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
93	MORF4L2	interactor	10	0.556	9.161	MRG (PF05712, IPR026541): MRG
94	MRGBP	interactor	11	0.473	12.164	Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
95	MSL1	interactor	7	0.476	4.477	Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein PEHE (PF15275, IPR029332): PEHE domain MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
96	MYC	oncoprotein	35	0.255	169.121	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
97	NCL	protein found in more fusions	41	0.258	260.741	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
98	NDC1	interactor	9	0.667	2.373	Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
99	NDN	suppressor	5	0.833	0.667	MAGE (PF01454, IPR002190): MAGE family
100	NEMP1	interactor	2	1.000	0	NEMP (PF10225, IPR019358): NEMP family EloA-BP1 (PF15870, IPR031736): ElonginA binding-protein 1
101	NFATC1	oncoprotein	7	0.667	2.815	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
102	NFATC2	suppressor	4	0.667	0.200	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
103	NLK	protein found in more fusions	7	0.533	1.641	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
104	NOP56	interactor	21	0.352	39.843	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
105	NOS2	interactor	8	0.524	3.857	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
106	NOTCH1	suppressor	10	0.389	8.106	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
107	NRIP1	oncoprotein	3	0.667	0.222	ALMT (PF11744, IPR020966): Aluminium activated malate transporter NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3 NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
108	NSF	interactor	12	0.418	10.075	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain ATPase (PF06745, IPR014774): KaiC AAA_19 (PF13245): Part of AAA domain
109	NTRK1	oncoprotein	75	0.174	1107.935	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
110	NUMA1	oncoprotein	21	0.343	48.519	Colicin (PF01024, IPR000293): Colicin pore forming domain Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tup_N (PF08581, IPR013890): Tup N-terminal CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
111	NUP107	interactor	48	0.296	314.093	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
112	NUP133	oncoprotein	17	0.522	15.109	Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
113	NUP153	protein found in more fusions	57	0.227	585.026	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
114	NUP155	interactor	22	0.333	48.503	Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
115	NUP160	interactor	17	0.618	9.771	Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
116	NUP188	interactor	16	0.467	14.474	Nup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34 Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
117	NUP205	interactor	21	0.376	30.294	Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
118	NUP210	interactor	14	0.341	10.903	Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2)
119	NUP214	oncoprotein	27	0.382	71.169	dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
120	NUP35	interactor	23	0.462	40.560	Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
121	NUP37	interactor	11	0.618	6.969	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
122	NUP43	interactor	14	0.670	7.936	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
123	NUP50	interactor	22	0.359	78.829	NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa) Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
124	NUP54	interactor	11	0.636	5.848	Regulator_TrmB (PF11495, IPR021586): Archaeal transcriptional regulator TrmB KRTAP (PF11759, IPR021743): Keratin-associated matrix Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54 SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
125	NUP62	interactor	21	0.516	26.179	Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
126	NUP85	interactor	20	0.516	25.197	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
127	NUP88	interactor	16	0.625	10.825	Nup88 (PF10168, IPR019321): Nuclear pore component
128	NUP93	oncoprotein	31	0.308	110.663	Nic96 (PF04097, IPR007231): Nup93/Nic96
129	NUP98	suppressor	24	0.384	74.866	Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head
130	NUPL2	interactor	7	0.714	1.565	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
131	NUSAP1	interactor	7	0.524	2.151	GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
132	NUTF2	interactor	8	0.667	1.850	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
133	NXF1	interactor	50	0.236	459.054	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
134	OBSL1	interactor	49	0.278	250.414	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
135	PAPOLA	interactor	5	0.700	0.658	PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain Macoilin (PF09726, IPR019130): Transmembrane protein
136	PIAS4	interactor	13	0.487	19.978	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
137	PLEKHA8	oncoprotein	2	1.000	0	GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP) PH (PF00169, IPR001849, SM00233): PH domain AKNA (PF12443, IPR022150): AT-hook-containing transcription factor
138	PMS2	oncoprotein	10	0.422	12.296	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
139	POM121C	interactor	4	1.000	0	T2SSC (PF11356): Type II secretion system protein C Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region POM121 (PF15229): POM121 family
140	POU5F1	oncoprotein	13	0.333	14.584	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
141	PPP2CA	suppressor	20	0.158	88.378	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
142	PTHLH	oncoprotein	2	1.000	0	Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region Parathyroid (PF01279, IPR001415, SM00087): Parathyroid hormone family
143	PTMA	oncoprotein	11	0.400	15.524	Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
144	PTN	oncoprotein	7	0.533	6.167	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
145	RAC1	oncoprotein	13	0.409	14.692	Ras (PF00071, IPR001806, SM00173): Ras family
146	RAD21	oncoprotein	13	0.372	14.199	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
147	RAE1	interactor	22	0.468	36.737	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
148	RAN	oncoprotein	42	0.226	329.226	Ras (PF00071, IPR001806, SM00173): Ras family
149	RANBP1	interactor	10	0.511	7.061	PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
150	RANBP2	oncoprotein	40	0.306	213.023	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
151	RANBP6	interactor	5	0.700	1.248	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats
152	RANGAP1	protein found in more fusions	30	0.369	115.754	RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
153	RAPGEF3	interactor	5	0.500	0.790	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain BAT (PF15915, IPR031803): GAF and HTH_10 associated domain
154	RASSF5	suppressor	4	0.667	0.500	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
155	RCC1	interactor	22	0.338	66.154	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
156	RGPD8	interactor	5	0.700	0.758	GRIP (PF01465, IPR000237, SM00755): GRIP domain HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat FlxA (PF14282, IPR025577): FlxA-like protein TPR_19 (PF14559): Tetratricopeptide repeat Rab_bind (PF16704, IPR032023): Rab binding domain
157	RNF113A	interactor	2	1.000	0	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8 zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
158	RPRD1B	interactor	4	0.667	0.800	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1 CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
159	RUNX1T1	oncoprotein	3	1.000	0	NHR2 (PF08788, IPR014896): NHR2 domain like TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF zf-MYND (PF01753, IPR002893): MYND finger DUF3731 (PF12531, IPR021030): DNA-K related protein
160	RUSC2	interactor	2	1.000	0	RUN (PF02759, IPR004012, SM00593): RUN domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
161	RUVBL1	oncoprotein	34	0.335	132.912	TIP49 (PF06068, IPR010339): TIP49 C-terminus
162	RUVBL2	oncoprotein	34	0.294	153.452	TIP49 (PF06068, IPR010339): TIP49 C-terminus
163	SAMHD1	interactor	10	0.472	10.322	HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
164	SEH1L	interactor	33	0.337	116.844	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
165	SELENOS	interactor	3	1.000	0	Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
166	SENP1	protein found in more fusions	12	0.491	7.822	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
167	SENP3	interactor	8	0.536	3.892	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
168	SERPINB12	interactor	4	0.667	0.382	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
169	SF3B3	interactor	22	0.429	34.334	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
170	SIRT7	interactor	40	0.238	221.124	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
171	SLC27A2	interactor	1	0	0	AMP-binding (PF00501, IPR000873): AMP-binding enzyme AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
172	SMAD2	suppressor	19	0.373	47.272	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
173	SMAD3	oncoprotein	22	0.267	92.681	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
174	SMAD4	suppressor	15	0.297	35.291	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
175	SMC3	oncoprotein	24	0.308	76.040	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
176	SMN1	interactor	14	0.346	30.280	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
177	SMPD4	interactor	6	0.600	0.998	mit_SMPDase (PF14724, IPR024129): Mitochondrial-associated sphingomyelin phosphodiesterase
178	SMURF1	interactor	15	0.352	28.030	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
179	SNUPN	interactor	4	0.667	1.105	mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain Snurportin1 (PF11538, IPR024721): Snurportin1
180	SNW1	protein found in more fusions	48	0.257	371.027	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
181	SP110	oncoprotein	2	1.000	0	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
182	SPG20	interactor	7	0.667	1.446	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
183	SREBF2	protein found in more fusions	6	0.500	1.152	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
184	SRY	interactor	2	1.000	0	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
185	STAU1	protein found in more fusions	23	0.463	34.846	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
186	SUMO1	interactor	17	0.533	18.350	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
187	TAF10	interactor	9	0.389	13.979	TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
188	TAF11	interactor	3	0.667	0.667	CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region
189	TAF3	interactor	3	1.000	0	Bromo_TP (PF07524, IPR006565): Bromodomain associated GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) FHIPEP (PF00771, IPR001712): FHIPEP family FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PHD (PF00628, IPR019787, SM00249): PHD-finger zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
190	TAF4B	interactor	2	1.000	0	TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
191	TAF8	protein found in more fusions	6	0.500	4.667	Bromo_TP (PF07524, IPR006565): Bromodomain associated TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term DUF3090 (PF11290, IPR021441): Protein of unknown function (DUF3090)
192	TERF1	interactor	13	0.348	19.736	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
193	TERF2	interactor	16	0.295	44.715	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
194	THOC2	interactor	12	0.318	20.545	Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
195	TMEM209	interactor	6	0.800	0.440	CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal
196	TMEM214	interactor	6	0.733	0.803	TMEM214 (PF10151, IPR019308): TMEM214, C-terminal, caspase 4 activator
197	TP53	suppressor	48	0.205	470.255	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
198	TP53BP1	suppressor	17	0.338	40.235	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
199	TPX2	interactor	3	0.667	0.133	Aurora-A_bind (PF09041, IPR015128): Aurora-A binding TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259) TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
200	TUBA1A	oncoprotein	26	0.268	119.285	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
201	U2AF2	protein found in more fusions	34	0.330	151.229	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
202	UBC	protein found in more fusions	51	0.220	501.651	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
203	UBE2I	interactor	38	0.237	260.869	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
204	UBL4A	interactor	14	0.484	11.340	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
205	UNK	interactor	16	0.242	28.811	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
206	UQCR10	interactor	1	0	0	UCR_UQCRX_QCR9 (PF05365, IPR008027): Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
207	VCAM1	interactor	22	0.299	43.956	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
208	YTHDC1	interactor	1	0	0	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family YTH (PF04146, IPR007275): YT521-B-like domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
209	YWHAE	oncoprotein	31	0.237	165.549	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
210	ZC3H14	interactor	8	0.500	7.402	PWI (PF01480, IPR002483, SM00311): PWI domain zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
211	ZNF207	interactor	5	0.500	2.380	MCPVI (PF02993, IPR004243): Minor capsid protein VI SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 (PF13894): C2H2-type zinc finger

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