Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins KHDRBS1 (from a repository: Sun Dec 4 09:20:25 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 161 The number (and %) of the onco-proteins 59 (36.65 %) The number (and %) of the tumor suppressors 19 (11.80 %) Total number of binary PPIs (saturation %) 1117 (8.67 %) The number (and %) of affected PPIs 161 (14.41 %) The number of possible different fusions 39 PPI diameter 2 PPI radius 1 The average degree of PPI 12.832 Assortativity coefficient -0.2285 The network average Clustering coefficient 0.499 The number (and %) of a zero Clustering coefficients 17 (10.56 %) The number (and %) of a zero Betweenness Centrality 35 (21.74 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KHDRBS1	All fusions
Proteins found in more fusions	RBMX (see 3 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); TNFRSF1A (see 2 fusions); MPHOSPH8 (see 5 fusions); EWSR1 (see 2 fusions); DLG4 (see 1 fusions); ACTB (see 3 fusions); PIK3R1 (see 1 fusions); DDX5 (see 1 fusions); RPA1 (see 1 fusions); PACSIN2 (see 1 fusions); SNX9 (see 2 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions); ITSN2 (see 1 fusions); CRY2 (see 3 fusions); SFPQ (see 6 fusions); LYN (see 2 fusions); SRPK2 (see 1 fusions); LCK (see 1 fusions); GAS7 (see 1 fusions); CREBBP (see 6 fusions); STAT3 (see 2 fusions); CD2AP (see 1 fusions); RBFOX2 (see 2 fusions); KHDRBS1 (see 1 fusions); COPA (see 2 fusions); RIPK1 (see 1 fusions); SH3KBP1 (see 1 fusions); STUB1 (see 1 fusions); HNRNPC (see 1 fusions); DDX17 (see 3 fusions); EZH2 (see 1 fusions); TBL1X (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KHDRBS1	parental protein	161	0.069	17919.823	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
2	ABI2	suppressor	5	0.833	0.333	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region SH3_9 (PF14604, IPR001452): Variant SH3 domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3	ACTB	oncoprotein	26	0.243	148.038	Actin (PF00022, IPR004000, SM00268): Actin
4	AGO1	interactor	6	0.467	5.011	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
5	AHI1	oncoprotein	1	0	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6	AMPH	oncoprotein	3	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
7	APBB1	interactor	9	0.714	1.466	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) WW (PF00397, IPR001202, SM00456): WW domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
8	ARHGEF4	oncoprotein	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9	ARHGEF9	interactor	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10	ATXN2	interactor	12	0.545	9.036	LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Spt20 (PF12090, IPR021950): Spt20 family SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
11	ATXN2L	interactor	7	0.619	3.686	LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
12	AZIN1	interactor	1	0	0	Orn_Arg_deC_N (PF02784, IPR022644): Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC (PF00278, IPR022643): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
13	BAIAP2L1	interactor	2	1.000	0	IMD (PF08397, IPR013606): IRSp53/MIM homology domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c SH3_9 (PF14604, IPR001452): Variant SH3 domain
14	BANP	suppressor	3	1.000	0	DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845) BEN (PF10523, IPR018379, SM01025): BEN domain
15	BMI1	oncoprotein	21	0.221	90.889	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
16	BTK	suppressor	10	0.389	11.349	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17	CAND1	interactor	30	0.539	53.195	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
18	CASP8	suppressor	7	0.600	4.333	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
19	CBX6	interactor	4	0.667	1.667	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain CBX7_C (PF17218): CBX family C-terminal motif
20	CCDC8	interactor	23	0.424	74.550	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
21	CD2AP	protein found in more fusions	5	0.667	0.686	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
22	CD81	interactor	14	0.500	14.131	Tetraspannin (PF00335, IPR018499): Tetraspanin family
23	CDC5L	interactor	33	0.490	113.337	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
24	CIRBP	oncoprotein	11	0.673	3.647	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
25	CLK1	interactor	11	0.600	5.922	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
26	COPA	protein found in more fusions	17	0.450	24.434	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
27	CREB3L3	interactor	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
28	CREBBP	suppressor	16	0.333	42.191	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
29	CRK	oncoprotein	14	0.308	38.313	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30	CRKL	oncoprotein	7	0.429	6.222	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31	CRY1	interactor	7	0.600	1.379	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
32	CRY2	protein found in more fusions	13	0.409	15.870	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
33	CSK	interactor	10	0.422	16.369	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
34	CUL3	protein found in more fusions	45	0.326	342.742	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
35	CUL7	protein found in more fusions	29	0.526	65.953	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
36	DDX17	protein found in more fusions	37	0.422	126.182	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
37	DDX5	oncoprotein	38	0.429	133.203	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
38	DHX15	interactor	30	0.508	62.798	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
39	DHX9	oncoprotein	35	0.477	97.229	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
40	DLG1	suppressor	4	0.500	2.400	L27_1 (PF09058, IPR015143): L27_1 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037) MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
41	DLG2	interactor	2	1.000	0	Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein L27_1 (PF09058, IPR015143): L27_1 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
42	DLG3	interactor	3	0.667	1.000	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
43	DLG4	protein found in more fusions	6	0.400	5.667	L27_1 (PF09058, IPR015143): L27_1 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44	DNMBP	interactor	2	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat IncA (PF04156, IPR007285): IncA protein RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
45	DOCK2	oncoprotein	6	0.533	3.722	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins SH3_9 (PF14604, IPR001452): Variant SH3 domain DOCK_N (PF16172, IPR032376): DOCK N-terminus
46	DOCK3	interactor	2	1.000	0	DHR-2 (PF06920, IPR010703): Dock homology region 2 SH3_2 (PF07653, IPR011511): Variant SH3 domain MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
47	DROSHA	interactor	7	0.524	5.034	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
48	EFEMP1	interactor	1	0	0	EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
49	EMG1	interactor	5	0.700	0.335	EMG1 (PF03587, IPR005304): EMG1/NEP1 methyltransferase
50	ESR1	suppressor	35	0.310	203.066	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
51	EWSR1	oncoprotein	36	0.282	235.107	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
52	EZH2	suppressor	15	0.429	26.295	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
53	FADD	suppressor	5	0.800	1.000	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
54	FBXW11	interactor	13	0.530	8.586	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
55	FGR	oncoprotein	3	0.667	0.250	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
56	FNBP4	oncoprotein	5	0.500	3.233	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pap_E4 (PF02711, IPR003861): E4 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) WW (PF00397, IPR001202, SM00456): WW domain DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
57	FRK	suppressor	3	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
58	FYN	oncoprotein	18	0.250	70.071	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
59	GAS7	oncoprotein	4	0.667	0.667	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain WW (PF00397, IPR001202, SM00456): WW domain YscO (PF07321, IPR009929): Type III secretion protein YscO SH3_9 (PF14604, IPR001452): Variant SH3 domain WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
60	GLRX3	interactor	4	1.000	0	Glutaredoxin (PF00462, IPR002109): Glutaredoxin Thioredoxin (PF00085, IPR013766): Thioredoxin TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
61	GPHN	oncoprotein	4	0.667	1.000	MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain MoeA_C (PF03454, IPR005111): MoeA C-terminal region (domain IV) MoeA_N (PF03453, IPR005110): MoeA N-terminal region (domain I and II) Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
62	GRAP2	interactor	2	1.000	0	NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
63	GRB2	oncoprotein	31	0.239	213.099	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
64	HCK	oncoprotein	10	0.400	12.055	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
65	HDAC6	oncoprotein	7	0.400	6.654	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
66	HIST1H3E	interactor	4	0.833	0.400	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
67	HNRNPA1	interactor	39	0.505	94.638	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
68	HNRNPC	protein found in more fusions	25	0.536	38.241	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
69	HNRNPK	oncoprotein	51	0.278	520.531	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
70	HNRNPR	interactor	34	0.513	97.364	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
71	INSR	interactor	11	0.455	17.919	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
72	IRS1	interactor	7	0.476	5.350	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
73	ITK	oncoprotein	7	0.667	1.600	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
74	ITSN1	interactor	9	0.393	14.133	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
75	ITSN2	protein found in more fusions	10	0.361	17.408	C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain
76	KHDRBS2	interactor	20	0.409	48.175	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
77	KHDRBS3	interactor	16	0.457	23.228	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
78	LCK	oncoprotein	8	0.381	8.217	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
79	LGR4	interactor	8	0.619	4.136	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
80	LYN	oncoprotein	14	0.333	28.406	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
81	MATR3	interactor	34	0.439	120.739	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
82	MIA2	suppressor	1	0	0	NESP55 (PF06390, IPR009434): Neuroendocrine-specific golgi protein P55 (NESP55) SH3_2 (PF07653, IPR011511): Variant SH3 domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
83	MPHOSPH8	protein found in more fusions	4	0.667	0.286	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_5 (PF13857): Ankyrin repeats (many copies) YqzE (PF14038, IPR025622): YqzE-like protein
84	MPP6	interactor	3	1.000	0	L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
85	MYO1C	interactor	11	0.436	14.078	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
86	MYO7A	interactor	1	0	0	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain
87	NCF1	interactor	3	1.000	0	p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
88	NCK1	oncoprotein	9	0.389	13.883	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
89	NCK2	interactor	10	0.306	17.289	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
90	NCKIPSD	oncoprotein	5	0.700	1.667	DUF2013 (PF09431, IPR018556): Protein of unknown function (DUF2013) Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
91	NCSTN	interactor	4	0.833	0.105	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
92	NPHP1	interactor	6	0.400	5.500	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FAM176 (PF14851): FAM176 family Speriolin_N (PF15058, IPR029385): Speriolin N terminus DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
93	NTRK1	oncoprotein	56	0.212	785.995	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
94	OBSL1	interactor	30	0.483	68.555	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
95	OSTF1	interactor	3	0.667	0.286	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
96	PACSIN1	interactor	6	0.600	3.333	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SH3_9 (PF14604, IPR001452): Variant SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
97	PACSIN2	oncoprotein	6	0.600	3.000	DegS (PF05384, IPR008595): Sensor protein DegS FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
98	PACSIN3	interactor	6	0.500	4.667	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain GrpE (PF01025, IPR000740): GrpE SH3_9 (PF14604, IPR001452): Variant SH3 domain
99	PIK3R1	oncoprotein	18	0.353	50.262	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
100	PIK3R3	interactor	11	0.473	14.586	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
101	PLCG1	oncoprotein	9	0.667	4.971	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
102	POT1	interactor	10	0.278	19.067	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
103	PPP1CB	interactor	14	0.374	34.309	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
104	PPP1R13B	interactor	3	0.667	0.250	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) IncA (PF04156, IPR007285): IncA protein RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
105	PRMT1	interactor	21	0.500	32.089	Methyltransf_25 (PF13649): Methyltransferase domain
106	PSTPIP1	interactor	2	1.000	0	ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
107	PTBP2	interactor	6	0.700	0.591	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
108	PTK6	interactor	3	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
109	RALY	interactor	24	0.587	35.494	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
110	RAPSN	interactor	1	0	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
111	RASA1	oncoprotein	12	0.379	28.540	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
112	RBFOX2	protein found in more fusions	14	0.654	5.645	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
113	RBM15	oncoprotein	13	0.538	8.064	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC (PF07744, IPR012921): SPOC domain Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
114	RBM7	interactor	8	0.714	1.590	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
115	RBMX	suppressor	32	0.477	83.028	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
116	RIPK1	protein found in more fusions	5	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
117	RNF2	interactor	21	0.542	31.283	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
118	RPA1	suppressor	31	0.469	86.115	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
119	RPA2	oncoprotein	25	0.483	48.338	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
120	RPA3	interactor	24	0.549	26.586	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
121	RUSC2	interactor	1	0	0	RUN (PF02759, IPR004012, SM00593): RUN domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
122	SASH1	suppressor	2	1.000	0	PGA2 (PF07543, IPR011431): Protein trafficking PGA2 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
123	SCG5	interactor	1	0	0	Secretogranin_V (PF05281, IPR007945): Neuroendocrine protein 7B2 precursor (Secretogranin V)
124	SFPQ	oncoprotein	28	0.342	116.576	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
125	SH3GL1	oncoprotein	7	0.533	3.682	BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
126	SH3KBP1	protein found in more fusions	21	0.242	94.570	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
127	SH3PXD2A	interactor	3	1.000	0	DUF1604 (PF07713, IPR011666): Protein of unknown function (DUF1604) PX (PF00787, IPR001683, SM00312): PX domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
128	SH3YL1	interactor	1	0	0	Ysc84 (PF04366, IPR007461): Las17-binding protein actin regulator SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
129	SKAP2	interactor	6	0.600	1.452	PH (PF00169, IPR001849, SM00233): PH domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_9 (PF15410): Pleckstrin homology domain PH_13 (PF16652, IPR001849): Pleckstrin homology domain
130	SMAD2	suppressor	9	0.393	11.244	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
131	SMARCA2	suppressor	6	0.600	1.942	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
132	SMARCAD1	interactor	11	0.927	0.388	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
133	SNW1	protein found in more fusions	34	0.460	112.997	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
134	SNX30	interactor	1	0	0	BAR (PF03114, IPR004148, SM00721): BAR domain PX (PF00787, IPR001683, SM00312): PX domain
135	SNX9	protein found in more fusions	7	0.467	5.180	PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
136	SORBS1	interactor	6	0.467	5.286	SH3_2 (PF07653, IPR011511): Variant SH3 domain Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein
137	SPATA13	interactor	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
138	SRC	oncoprotein	26	0.270	142.602	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
139	SRPK2	oncoprotein	24	0.431	71.060	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
140	SRRM1	interactor	18	0.634	14.014	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
141	SRSF3	oncoprotein	24	0.493	40.789	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
142	SSFA2	interactor	4	0.667	0.733	KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
143	STAT3	suppressor	14	0.410	26.155	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
144	STUB1	suppressor	8	0.381	9.067	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
145	SUZ12	suppressor	17	0.492	21.684	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
146	SYNCRIP	interactor	33	0.413	134.554	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
147	TBL1X	protein found in more fusions	2	0	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
148	TJP1	interactor	8	0.500	4.192	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
149	TNFRSF1A	oncoprotein	11	0.489	17.452	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
150	TSPOAP1	oncoprotein	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain ZapB (PF06005, IPR009252): Cell division protein ZapB fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SlyX (PF04102, IPR007236): SlyX DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding SH3_9 (PF14604, IPR001452): Variant SH3 domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
151	TUBB3	interactor	8	0.536	5.490	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
152	U2AF2	protein found in more fusions	35	0.535	73.818	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
153	UBASH3B	interactor	9	0.536	6.656	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
154	USO1	interactor	4	1.000	0	Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain MutS_III (PF05192, IPR007696, SM00533): MutS domain III ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
155	VAV1	oncoprotein	11	0.364	22.763	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
156	WBP11	interactor	14	0.341	33.826	BUD22 (PF09073, IPR015158): BUD22 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SspB (PF04386, IPR007481): Stringent starvation protein B Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
157	WBP4	interactor	6	0.533	1.058	CDC45 (PF02724, IPR003874): CDC45-like protein WW (PF00397, IPR001202, SM00456): WW domain zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger TMCO5 (PF14992, IPR026617): TMCO5 family
158	YES1	oncoprotein	5	0.400	4.119	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
159	YTHDC1	interactor	10	0.600	7.486	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family YTH (PF04146, IPR007275): YT521-B-like domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
160	ZBTB7A	interactor	2	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain GAGA (PF09237, IPR015318): GAGA factor zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
161	ZDHHC6	interactor	1	0	0	SH3_2 (PF07653, IPR011511): Variant SH3 domain zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase

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