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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins14 (32.56 %)
The number (and %) of the tumor suppressors4 (9.30 %)
Total number of binary PPIs (saturation %)131 (14.51 %)
The number (and %) of affected PPIs43 (32.82 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.302
Assortativity coefficient-0.4912
The network average Clustering coefficient0.480
The number (and %) of a zero Clustering coefficients13 (30.23 %)
The number (and %) of a zero Betweenness Centrality20 (46.51 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KDM5C All fusions
: BF327651;
Proteins found in more fusions CSNK2A1 (see 1 fusions); ACTN1 (see 3 fusions); PCNA (see 1 fusions); MBD2 (see 1 fusions); KDM5C (see 1 fusions); RING1 (see 1 fusions); SMAD3 (see 3 fusions); HDAC1/ZNF592 (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KDM5Cparental protein430.0841360.919ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
2 ACTN1protein found in more fusions200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ARHGAP25oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
4 CALM1interactor60.6673.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 CBX3interactor60.9000.400Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
6 CENPKinteractor100CENP-K (PF11802, IPR020993): Centromere-associated protein K
7 CNOT4interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
8 CSNK2A1oncoprotein110.55612.700Pkinase (PF00069, IPR000719): Protein kinase domain
9 CSNK2Binteractor80.7622.067CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
10 E2F6oncoprotein80.6794.486BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
11 FOXJ2interactor40.8330.286SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
12 HDAC1suppressor160.34353.052FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
13 HDAC2suppressor100.52811.352Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
14 HIST2H3Ainteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HLA-Finteractor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
16 IER2oncoprotein100IER (PF05760, IPR008653): Immediate early response protein (IER)
MAGI_u1 (PF16663): Unstructured region on MAGI
17 LHX6suppressor100BON (PF04972, IPR007055, SM00749): BON domain
LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
18 LSM2interactor100LSM (PF01423, IPR001163): LSM domain
19 MAXsuppressor70.6004.167ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
20 MBD2oncoprotein51.0000API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
21 MGAinteractor70.7142.919AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
T-box (PF00907, IPR001699, SM00425): T-box
DUF4801 (PF16059, IPR032060): Domain of unknown function (DUF4801)
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
22 NCOR1oncoprotein30.6670.400BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
23 NXF1interactor80.5716.733NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 PCNAoncoprotein40.6671.000PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25 PITHD1interactor100PITH (PF06201, IPR010400): PITH domain
26 RESToncoprotein50.7002.000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Presenilin (PF01080, IPR001108): Presenilin
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
27 RING1protein found in more fusions80.7143.133zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
28 RNF2interactor170.34259.800zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
29 SCML4interactor100SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SLED (PF12140, IPR021987): SLED domain
RBR (PF17208): RNA binding Region
30 SEToncoprotein40.6670.333NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
31 SLC25A22interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
32 SMAD3oncoprotein40.6670.400MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
33 SPTBN2interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Spectrin (PF00435, IPR002017): Spectrin repeat
Mating_N (PF12731, IPR024333): Mating-type protein beta 1
DUF4110 (PF13422, IPR025183): Domain of unknown function (DUF4110)
PH_9 (PF15410): Pleckstrin homology domain
34 THTPAinteractor21.0000CYTH (PF01928, IPR023577, SM01118): CYTH domain
35 TOX4interactor200Extensin_2 (PF04554, IPR006706): Extensin-like region
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
YABBY (PF04690, IPR006780): YABBY protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
36 TSPYL2interactor31.0000Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
C_Hendra (PF16821, IPR031812): C protein from hendra and measles viruses
37 USP5interactor40.5003.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
38 VPS41interactor100Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39 XPO1interactor90.44415.900CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
40 ZMYND8oncoprotein110.38226.667DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
TCP (PF03634, IPR005333): TCP family transcription factor
zf-MYND (PF01753, IPR002893): MYND finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3544 (PF12064, IPR021931): Domain of unknown function (DUF3544)
CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
41 ZNF532interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
Fer4_9 (PF13187, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
42 ZNF592protein found in more fusions41.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
43 ZNF687interactor60.6673.286PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Fer4_21 (PF14697): 4Fe-4S dicluster domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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