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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KDELR1 (from a repository: Sat Nov 12 16:42:47 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)19 (34.55 %)
The number (and %) of affected PPIs11 (57.89 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.364
Assortativity coefficient-0.2775
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality9 (81.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KDELR1 All fusions
: AI826978; CN300933;
Proteins found in more fusions KDELR1 (see 2 fusions); MCM2 (see 1 fusions); ARF1 (see 2 fusions); COPB1 (see 2 fusions); SEC23B (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KDELR1parental protein110.06783.000ER_lumen_recept (PF00810, IPR000133): ER lumen protein retaining receptor
2 ARF1suppressor40.6671.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
3 ARFGAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
4 BZW1interactor100W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
5 COPB1protein found in more fusions31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
6 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
7 MCM2oncoprotein31.0000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
8 NEK6interactor200Pkinase (PF00069, IPR000719): Protein kinase domain
9 SEC23Bprotein found in more fusions31.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
10 SERINC3oncoprotein100Serinc (PF03348, IPR005016): Serine incorporator (Serinc)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
11 TCEAL9interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family

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