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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCTD9 (from a repository: Thu Jul 11 21:36:18 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins8 (25.00 %)
The number (and %) of the tumor suppressors2 (6.25 %)
Total number of binary PPIs (saturation %)96 (19.35 %)
The number (and %) of affected PPIs32 (33.33 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.875
Assortativity coefficient-0.3955
The network average Clustering coefficient0.550
The number (and %) of a zero Clustering coefficients4 (12.50 %)
The number (and %) of a zero Betweenness Centrality11 (34.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KCTD9 All fusions
Proteins found in more fusions KCTD9 (see 1 fusions); MVP (see 2 fusions); FAM208B (see 2 fusions); CUL3 (see 1 fusions); FBLN1 (see 3 fusions); RBPMS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCTD9parental protein320.101695.400BTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
2 AQP1interactor31.0000MIP (PF00230, IPR000425): Major intrinsic protein
3 CARD9interactor80.5247.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
4 CBX8interactor31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
5 CCDC33interactor30.6670.500C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
6 CRADDinteractor100CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Death (PF00531, IPR000488, SM00005): Death domain
7 CUL3protein found in more fusions70.4008.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 EHHADHinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
9 ELAVL1oncoprotein60.5004.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FAM124Binteractor40.6672.000FAM124 (PF15067, IPR029380): FAM124 family
11 FAM208Bprotein found in more fusions60.5005.000DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
12 FBLN1suppressor200ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
13 GEMinteractor30.6670.400Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
14 GORASP2interactor30.6671.000GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
15 KRT40interactor100.28929.167Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
16 LONRF1interactor60.4005.167LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DZR (PF12773, IPR025874): Double zinc ribbon
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
17 MAD2L2interactor31.0000HORMA (PF02301, IPR003511): HORMA domain
18 MVPoncoprotein50.6671.667Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
19 NUP35interactor100Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
20 PNKDinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
21 PPP1R16Boncoprotein21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
22 PPP1R18interactor50.6002.733Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
23 PSMA1interactor60.6003.400Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
24 PSMB2interactor21.0000Proteasome (PF00227, IPR001353): Proteasome subunit
25 RBPMSprotein found in more fusions50.5002.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 SDCBPinteractor40.6671.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
27 SKP1oncoprotein31.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
28 STX11interactor70.4008.000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
29 SYT6interactor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
30 TRIM27oncoprotein110.26730.833IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
31 TRIM32suppressor60.5004.667NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
32 TRIM42interactor100.36119.733CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger

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