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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCNIP3 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins5 (23.81 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)36 (17.14 %)
The number (and %) of affected PPIs21 (58.33 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.571
Assortativity coefficient-0.6604
The network average Clustering coefficient0.316
The number (and %) of a zero Clustering coefficients13 (61.90 %)
The number (and %) of a zero Betweenness Centrality19 (90.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KCNIP3 All fusions
: BC019877; AA666181;
Proteins found in more fusions CREB1 (see 2 fusions); KCNIP3 (see 2 fusions); CTBP1 (see 2 fusions); CTBP2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCNIP3parental protein210.037362.000SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
EF-hand_9 (PF14658): EF-hand domain
2 CALM2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 CD177interactor100UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
4 CLN3interactor100CLN3 (PF02487, IPR003492): CLN3 protein
5 CREB1oncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
6 CREMsuppressor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
7 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
8 CTBP2protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
9 GRK2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
10 GRK6interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
11 IGF1Rinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
12 IGLV3-25interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
13 IL6STinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
14 KCND2interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3399 (PF11879, IPR024587): Domain of unknown function (DUF3399)
15 MAVSinteractor200Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
16 PCBD2interactor100Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
17 PPP3CAinteractor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
18 PSEN1oncoprotein31.0000Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
19 PSEN2oncoprotein31.0000Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
20 TARBP2interactor200dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
21 UBE2Iinteractor60.6004.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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