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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCNAB2 (from a repository: Tue Dec 6 00:05:59 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins5 (17.86 %)
The number (and %) of the tumor suppressors5 (17.86 %)
Total number of binary PPIs (saturation %)60 (15.87 %)
The number (and %) of affected PPIs28 (46.67 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.357
Assortativity coefficient-0.5833
The network average Clustering coefficient0.489
The number (and %) of a zero Clustering coefficients11 (39.29 %)
The number (and %) of a zero Betweenness Centrality20 (71.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KCNAB2 All fusions
: AA833885;
Proteins found in more fusions NEDD4 (see 1 fusions); ATXN1 (see 3 fusions); RPA1 (see 1 fusions); NEDD4L (see 3 fusions); KCNAB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCNAB2parental protein280.057639.333Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2 ALDOAinteractor31.0000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
3 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5 BAG6interactor200DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 BCORoncoprotein200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
7 CCAR2suppressor60.5337.000DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DBC1 (PF14443, IPR025954, SM01122): DBC1
S1-like (PF14444, IPR025223): S1-like
8 GAPVD1interactor100RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
9 GRIA2interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
10 HAO1interactor21.0000FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
11 KCNA2interactor50.8330.667Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
12 KCNA4interactor40.8330.667GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
BTB_2 (PF02214, IPR003131): BTB/POZ domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
13 KCNA5interactor60.7002.333Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
14 KCNA6interactor100FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
PRP9_N (PF16958, IPR031590): Pre-mRNA-splicing factor PRP9 N-terminus
15 KCNAB1interactor60.4009.000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
16 KCNAB3interactor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
17 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
18 NASPinteractor100Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
19 NEDD4suppressor31.0000Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20 NEDD4Lsuppressor40.6671.000WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
21 NUTF2interactor200NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
22 PREPinteractor21.0000Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
23 RPA1suppressor51.0000Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
24 RPA2oncoprotein41.0000RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
25 RPA3interactor51.0000Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
26 SIRT1suppressor50.6672.000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
27 SNX3interactor100PX (PF00787, IPR001683, SM00312): PX domain
28 ZNF281oncoprotein100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
GRP (PF07172, IPR010800): Glycine rich protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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