Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCNAB2 (from a repository: Tue Dec 6 00:05:59 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 28 The number (and %) of the onco-proteins 5 (17.86 %) The number (and %) of the tumor suppressors 5 (17.86 %) Total number of binary PPIs (saturation %) 60 (15.87 %) The number (and %) of affected PPIs 28 (46.67 %) The number of possible different fusions 6 PPI diameter 2 PPI radius 1 The average degree of PPI 3.357 Assortativity coefficient -0.5833 The network average Clustering coefficient 0.489 The number (and %) of a zero Clustering coefficients 11 (39.29 %) The number (and %) of a zero Betweenness Centrality 20 (71.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KCNAB2	All fusions : AA833885;
Proteins found in more fusions	NEDD4 (see 1 fusions); ATXN1 (see 3 fusions); RPA1 (see 1 fusions); NEDD4L (see 3 fusions); KCNAB2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KCNAB2	parental protein	28	0.057	639.333	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2	ALDOA	interactor	3	1.000	0	Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
3	ATIC	oncoprotein	2	1.000	0	AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme MGS (PF02142, IPR011607, SM00851): MGS-like domain
4	ATXN1	protein found in more fusions	2	0	0	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5	BAG6	interactor	2	0	0	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
6	BCOR	oncoprotein	2	0	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
7	CCAR2	suppressor	6	0.533	7.000	DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DBC1 (PF14443, IPR025954, SM01122): DBC1 S1-like (PF14444, IPR025223): S1-like
8	GAPVD1	interactor	1	0	0	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
9	GRIA2	interactor	1	0	0	ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region Lig_chan (PF00060, IPR001320): Ligand-gated ion channel Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
10	HAO1	interactor	2	1.000	0	FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
11	KCNA2	interactor	5	0.833	0.667	Ion_trans (PF00520, IPR005821): Ion transport protein BTB_2 (PF02214, IPR003131): BTB/POZ domain Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
12	KCNA4	interactor	4	0.833	0.667	GRP (PF07172, IPR010800): Glycine rich protein family Ion_trans (PF00520, IPR005821): Ion transport protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain BTB_2 (PF02214, IPR003131): BTB/POZ domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
13	KCNA5	interactor	6	0.700	2.333	Ion_trans (PF00520, IPR005821): Ion transport protein BTB_2 (PF02214, IPR003131): BTB/POZ domain
14	KCNA6	interactor	1	0	0	FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2 Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain PRP9_N (PF16958, IPR031590): Pre-mRNA-splicing factor PRP9 N-terminus
15	KCNAB1	interactor	6	0.400	9.000	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
16	KCNAB3	interactor	2	1.000	0	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
17	MRPL50	interactor	1	0	0	Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
18	NASP	interactor	1	0	0	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) SlyX (PF04102, IPR007236): SlyX TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV) SHNi-TPR (PF10516, IPR019544): SHNi-TPR XhlA (PF10779, IPR019715): Haemolysin XhlA TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
19	NEDD4	suppressor	3	1.000	0	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20	NEDD4L	suppressor	4	0.667	1.000	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
21	NUTF2	interactor	2	0	0	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
22	PREP	interactor	2	1.000	0	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
23	RPA1	suppressor	5	1.000	0	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
24	RPA2	oncoprotein	4	1.000	0	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
25	RPA3	interactor	5	1.000	0	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
26	SIRT1	suppressor	5	0.667	2.000	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
27	SNX3	interactor	1	0	0	PX (PF00787, IPR001683, SM00312): PX domain
28	ZNF281	oncoprotein	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger GRP (PF07172, IPR010800): Glycine rich protein family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 zf-C2H2_4 (PF13894): C2H2-type zinc finger

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