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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCMF1 (from a repository: Sat Nov 19 13:29:06 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins16 (26.67 %)
The number (and %) of the tumor suppressors1 (1.67 %)
Total number of binary PPIs (saturation %)224 (12.66 %)
The number (and %) of affected PPIs60 (26.79 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI6.867
Assortativity coefficient-0.3302
The network average Clustering coefficient0.657
The number (and %) of a zero Clustering coefficients6 (10.00 %)
The number (and %) of a zero Betweenness Centrality27 (45.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KCMF1 All fusions
: AW803556; CN478588; CB241984;
Proteins found in more fusions HSPB1 (see 3 fusions); UBE2D2 (see 2 fusions); GRK5 (see 3 fusions); UBC (see 1 fusions); VCP (see 4 fusions); PSMC5 (see 2 fusions); HERC1 (see 1 fusions); KCMF1 (see 3 fusions); NUP214 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCMF1parental protein600.0862640.300zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
Ntox28 (PF15605, IPR028948): Bacterial toxin 28
2 ABHD10interactor31.0000Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 ACOT9interactor40.6671.3334HBT (PF03061, IPR006683): Thioesterase superfamily
4 BYSLinteractor50.7003.000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
5 CD96interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
6 CEP85interactor21.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
7 CHIAinteractor21.0000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
Serglycin (PF04360, IPR007455): Serglycin
CBM_14 (PF01607, IPR002557, SM00494): Chitin binding Peritrophin-A domain
8 CST9interactor21.0000Cathelicidins (PF00666, IPR001894): Cathelicidin
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
9 EDAinteractor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
10 EIF3Linteractor31.0000Paf67 (PF10255, IPR019382): RNA polymerase I-associated factor PAF67
11 FLNCinteractor51.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
12 GRK5protein found in more fusions41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
13 HDLBPoncoprotein60.4005.133BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
14 HERC1protein found in more fusions40.6671.000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
15 HSPB1oncoprotein120.40027.300HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
16 IDH2oncoprotein100Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
17 IKBKGinteractor40.6670.333CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
18 KRASoncoprotein60.4005.667Ras (PF00071, IPR001806, SM00173): Ras family
19 MED20interactor100Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
20 MRS2interactor100CcmB (PF03379, IPR003544): CcmB protein
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
21 NIPSNAP1interactor50.5003.300NIPSNAP (PF07978, IPR012577): NIPSNAP
22 NIPSNAP3Ainteractor31.0000NIPSNAP (PF07978, IPR012577): NIPSNAP
23 NUP188interactor21.0000Nup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34
Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
24 NUP214oncoprotein41.0000dCache_2 (PF08269, IPR004010, SM01049): Cache domain
HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1
NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
25 NUP93oncoprotein40.5002.667Nic96 (PF04097, IPR007231): Nup93/Nic96
26 OGTinteractor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
27 PNO1interactor70.5716.900KH_1 (PF00013, IPR004088, SM00322): KH domain
28 POGLUT1interactor21.0000Glyco_transf_90 (PF05686, IPR006598, SM00672): Glycosyl transferase family 90
29 POU5F1oncoprotein80.42910.667Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30 PRCPinteractor21.0000Peptidase_S28 (PF05577, IPR008758): Serine carboxypeptidase S28
31 PSMC1interactor150.62920.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
32 PSMC5protein found in more fusions140.70510.089AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
33 PSMD11interactor110.8185.756DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
34 PSMD12interactor150.62624.967Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
35 PSMD13interactor130.66713.944Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
36 PSMD3interactor130.67913.378Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
37 PSMD7interactor120.8333.767JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
38 PSMD8interactor110.9270.867CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
39 PYM1interactor50.9000.500CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Mago-bind (PF09282, IPR015362): Mago binding
AAA_23 (PF13476): AAA domain
40 QARSinteractor21.0000tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
41 RASSF10suppressor100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
42 RASSF9interactor31.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087)
43 RPS13interactor100.48919.300Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
44 SARS2interactor31.0000tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
45 SOX2oncoprotein90.35715.833HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
46 SSBP1interactor41.0000SSB (PF00436, IPR000424): Single-strand binding protein family
47 TESPA1interactor100PUB (PF09409, IPR018997): PUB domain
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain
48 TFDP3interactor30.6671.000DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
49 TJP2oncoprotein31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
50 TXNL1interactor110.7645.822PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
51 UBCprotein found in more fusions180.39066.478ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
52 UBE2Ainteractor120.34525.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53 UBE2Binteractor110.40017.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54 UBE2D2oncoprotein31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
55 UBR4interactor160.20090.600CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
RecR (PF02132, IPR023628): RecR protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
DZR (PF12773, IPR025874): Double zinc ribbon
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
FAM176 (PF14851): FAM176 family
56 UCHL5oncoprotein130.8333.900Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
57 VCPprotein found in more fusions110.44416.367AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
58 VEGFDinteractor21.0000CXCXC (PF03128, IPR004153): CXCXC repeat
PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
59 WDR26interactor40.5001.833eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
60 XPO1interactor140.25363.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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