Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins KAT8 (from a repository: Sun Nov 13 16:25:21 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 39 The number (and %) of the onco-proteins 12 (30.77 %) The number (and %) of the tumor suppressors 8 (20.51 %) Total number of binary PPIs (saturation %) 147 (19.84 %) The number (and %) of affected PPIs 39 (26.53 %) The number of possible different fusions 7 PPI diameter 2 PPI radius 1 The average degree of PPI 6.718 Assortativity coefficient -0.4105 The network average Clustering coefficient 0.669 The number (and %) of a zero Clustering coefficients 2 (5.13 %) The number (and %) of a zero Betweenness Centrality 15 (38.46 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KAT8	All fusions : AA159555;
Proteins found in more fusions	HCFC1 (see 2 fusions); PRKDC (see 3 fusions); KMT2A (see 16 fusions); KAT8 (see 1 fusions); YWHAZ (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KAT8	parental protein	39	0.132	931.494	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
2	ATM	suppressor	5	1.000	0	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
3	BAZ2A	interactor	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DDHD (PF02862, IPR004177, SM01127): DDHD domain DDT (PF02791, IPR004022, SM00571): DDT domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain PHD (PF00628, IPR019787, SM00249): PHD-finger RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat Bromodomain (PF00439, IPR001487, SM00297): Bromodomain WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
4	BRD4	oncoprotein	6	0.800	1.667	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
5	CCAR2	suppressor	5	0.500	4.000	DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DBC1 (PF14443, IPR025954, SM01122): DBC1 S1-like (PF14444, IPR025223): S1-like
6	DYRK1B	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
7	FOXP3	suppressor	3	1.000	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
8	H2AFX	suppressor	10	0.600	9.541	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
9	HCFC1	protein found in more fusions	7	0.667	4.000	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
10	HECW2	interactor	5	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
11	HIST1H2BG	oncoprotein	4	0.667	0.900	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12	HIST1H3A	interactor	15	0.363	38.900	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13	HIST1H4A	interactor	11	0.455	19.719	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
14	HNRNPA1	interactor	9	0.607	7.800	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
15	KANSL1	interactor	3	1.000	0	PEHE (PF15275, IPR029332): PEHE domain
16	KMT2A	oncoprotein	12	0.400	24.908	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
17	MCRS1	interactor	1	0	0	FHA (PF00498, IPR000253, SM00240): FHA domain MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
18	MORF4L1	interactor	3	1.000	0	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
19	MSL1	interactor	8	0.464	12.952	Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein PEHE (PF15275, IPR029332): PEHE domain MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
20	MSL2	interactor	8	0.571	7.186	MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2 zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
21	MSL3	interactor	9	0.472	14.019	GET2 (PF08690, IPR028143): GET complex subunit GET2 MRG (PF05712, IPR026541): MRG Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
22	MSL3P1	interactor	2	1.000	0	NA
23	OGT	interactor	3	1.000	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41 TPR_19 (PF14559): Tetratricopeptide repeat
24	PAF1	oncoprotein	6	0.733	1.686	Paf1 (PF03985, IPR007133): Paf1 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
25	PHF20	oncoprotein	4	0.667	0.508	GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
26	PHF20L1	interactor	1	0	0	MBT (PF02820, IPR004092, SM00561): mbt repeat PHD (PF00628, IPR019787, SM00249): PHD-finger U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776) CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537) PEHE (PF15275, IPR029332): PEHE domain EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
27	PLK1	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
28	PPP1CB	interactor	4	0.833	0.667	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29	PRKDC	protein found in more fusions	9	0.500	10.956	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
30	RBBP5	oncoprotein	8	0.571	7.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31	RNF2	interactor	8	0.667	4.067	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
32	SIRT1	suppressor	7	0.467	6.222	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
33	TCEB3	suppressor	3	1.000	0	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
34	TNK2	interactor	3	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
35	TP53	suppressor	18	0.272	80.100	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
36	TPR	oncoprotein	2	1.000	0	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
37	WDR5	interactor	9	0.500	13.056	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
38	YWHAE	oncoprotein	10	0.600	9.327	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
39	YWHAZ	protein found in more fusions	11	0.600	9.327	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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