Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITSN2 (from a repository: Sat Nov 12 09:27:09 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 86 The number (and %) of the onco-proteins 32 (37.21 %) The number (and %) of the tumor suppressors 4 (4.65 %) Total number of binary PPIs (saturation %) 219 (5.99 %) The number (and %) of affected PPIs 86 (39.27 %) The number of possible different fusions 15 PPI diameter 2 PPI radius 1 The average degree of PPI 4.395 Assortativity coefficient -0.4291 The network average Clustering coefficient 0.542 The number (and %) of a zero Clustering coefficients 22 (25.58 %) The number (and %) of a zero Betweenness Centrality 48 (55.81 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ITSN2	All fusions
Proteins found in more fusions	KDM1A (see 2 fusions); ITSN2 (see 1 fusions); RABEP1 (see 1 fusions); AP2M1 (see 3 fusions); SYN1 (see 1 fusions); RBMX (see 3 fusions); KHDRBS1 (see 1 fusions); EZH2 (see 1 fusions); REPS1 (see 1 fusions); SH3KBP1 (see 1 fusions); EPS15 (see 1 fusions); SNAP29 (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ITSN2	parental protein	86	0.029	6466.815	C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain
2	AGT	interactor	1	0	0	Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3	AHDC1	interactor	1	0	0	DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
4	AMPH	oncoprotein	6	0.533	5.833	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
5	ANKRD17	interactor	1	0	0	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein Mucin (PF01456, IPR000458): Mucin-like glycoprotein DUF2536 (PF10750, IPR019686): Protein of unknown function (DUF2536) KH_1 (PF00013, IPR004088, SM00322): KH domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
6	AP2M1	protein found in more fusions	7	0.600	4.182	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7	BCCIP	interactor	3	0.667	1.000	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
8	CBL	suppressor	8	0.619	4.848	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
9	CCDC88C	interactor	1	0	0	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Fez1 (PF06818): Fez1 HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper HOOK (PF05622, IPR008636): HOOK protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
10	CHIC2	oncoprotein	1	0	0	Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
11	CPSF6	interactor	3	0.667	1.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
12	DLGAP1	oncoprotein	2	1.000	0	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein
13	DNM2	interactor	8	0.429	12.682	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
14	DST	oncoprotein	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11 DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain Laminin_II (PF06009, IPR010307): Laminin Domain II Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Phasin (PF05597, IPR008769): Poly(hydroxyalcanoate) granule associated protein (phasin) Spectrin (PF00435, IPR002017): Spectrin repeat Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal XhlA (PF10779, IPR019715): Haemolysin XhlA zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein Plectin (PF00681, IPR001101, SM00250): Plectin repeat DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 EF-hand_7 (PF13499, IPR011992): EF-hand domain pair DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) NYD-SP28 (PF14772): Sperm tail Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
15	EGFR	oncoprotein	18	0.184	96.233	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16	EPS15	oncoprotein	6	0.800	0.682	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
17	EPS15L1	oncoprotein	3	1.000	0	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
18	ERC1	oncoprotein	4	0.500	2.500	RBD-FIP (PF09457, IPR019018): FIP domain BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
19	EZH2	suppressor	7	0.333	9.400	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
20	FASLG	interactor	2	1.000	0	PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1
21	FBF1	interactor	5	0.400	4.733	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
22	FCHSD1	interactor	3	1.000	0	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding SH3_9 (PF14604, IPR001452): Variant SH3 domain
23	FCHSD2	interactor	6	0.600	3.333	Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) Rit1_C (PF17184): Rit1 N-terminal domain
24	FNBP4	oncoprotein	3	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pap_E4 (PF02711, IPR003861): E4 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) WW (PF00397, IPR001202, SM00456): WW domain DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
25	GAREM2	interactor	2	1.000	0	SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) CABIT (PF12736, IPR025946): Cell-cycle sustaining, positive selection
26	GOLGA2	interactor	4	0.500	3.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
27	GOLGA8A	interactor	1	0	0	Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
28	GOLGB1	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9 Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ZapB (PF06005, IPR009252): Cell division protein ZapB FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spectrin (PF00435, IPR002017): Spectrin repeat Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal Tup_N (PF08581, IPR013890): Tup N-terminal BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial SOGA (PF11365, IPR027881): Protein SOGA TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region Metal_resist (PF13801, IPR025961): Heavy-metal resistance GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase CT_C_D (PF02682): Carboxyltransferase domain, subdomain C and D
29	GOLT1B	interactor	3	0.667	1.000	Got1 (PF04178, IPR007305): Got1/Sft2-like family
30	GPNMB	oncoprotein	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PKD (PF00801, IPR000601, SM00089): PKD domain TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
31	HNRNPK	oncoprotein	6	0.600	3.667	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
32	HOOK2	interactor	3	1.000	0	HOOK (PF05622, IPR008636): HOOK protein
33	ITPKA	interactor	1	0	0	IPK (PF03770, IPR005522): Inositol polyphosphate kinase
34	ITSN1	interactor	23	0.173	167.967	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
35	KCTD10	interactor	2	1.000	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain
36	KDM1A	protein found in more fusions	7	0.333	10.000	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain SWIRM (PF04433, IPR007526): SWIRM domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
37	KHDRBS1	protein found in more fusions	10	0.361	19.500	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
38	KIAA1549	oncoprotein	2	1.000	0	DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
39	KXD1	interactor	1	0	0	KxDL (PF10241, IPR019371): Uncharacterized conserved protein
40	LARP6	interactor	1	0	0	La (PF05383, IPR006630, SM00715): La domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUZ-C (PF12901, IPR024642): SUZ-C motif
41	LSM8	interactor	1	0	0	LSM (PF01423, IPR001163): LSM domain
42	LTBP4	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain TB (PF00683, IPR017878): TB domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain
43	LUC7L3	interactor	3	1.000	0	LUC7 (PF03194, IPR004882): LUC7 N_terminus Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
44	MAP4K3	interactor	1	0	0	CNH (PF00780, IPR001180, SM00036): CNH domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain
45	MBNL1	interactor	2	1.000	0	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 (PF15663): Zinc-finger containing family
46	MRPL9	interactor	2	1.000	0	Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
47	NBR1	oncoprotein	2	0	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681) N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
48	NINL	interactor	3	0.667	1.000	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
49	NR2C2	suppressor	3	1.000	0	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50	PDCD6IP	interactor	8	0.381	10.515	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
51	PDE4DIP	oncoprotein	3	0.667	1.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9 DivIC (PF04977, IPR007060): Septum formation initiator DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220) DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515) IncA (PF04156, IPR007285): IncA protein Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54 FAM76 (PF16046, IPR032017): FAM76 protein MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
52	PIK3AP1	interactor	2	1.000	0	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) DBB (PF14545, IPR017893): Dof, BCAP, and BANK (DBB) motif
53	PIK3C2B	interactor	3	0.667	0.182	C2 (PF00168, IPR000008, SM00239): C2 domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PX (PF00787, IPR001683, SM00312): PX domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
54	PPP1CC	oncoprotein	3	0.667	1.000	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
55	PPP4R3A	interactor	2	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1 WH1 (PF00568, IPR000697, SM00461): WH1 domain DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
56	PSEN1	oncoprotein	2	0	0	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
57	PTN	oncoprotein	3	1.000	0	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
58	RABEP1	oncoprotein	4	0.667	1.000	Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major) Rab5-bind (PF09311, IPR015390): Rabaptin-like protein Rabaptin (PF03528, IPR018514): Rabaptin
59	RBMX	suppressor	5	0.667	2.000	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
60	REPS1	protein found in more fusions	5	0.833	0.667	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC) DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
61	RNF20	interactor	3	1.000	0	Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein Atrophin-1 (PF03154, IPR002951): Atrophin-1 family BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Sox_N (PF12444, IPR022151): Sox developmental protein N terminal DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
62	RNF41	interactor	2	0	0	Sina (PF03145, IPR018121): Seven in absentia protein family USP8_interact (PF08941, IPR015036): USP8 interacting zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
63	ROCK1	interactor	1	0	0	FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
64	RUFY1	interactor	3	1.000	0	DM (PF00751, IPR001275, SM00301): DM DNA binding domain FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger RUN (PF02759, IPR004012, SM00593): RUN domain Tektin (PF03148, IPR000435): Tektin family
65	SEMA6A	interactor	1	0	0	PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain
66	SH3GL1	oncoprotein	4	0.667	0.400	BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
67	SH3KBP1	protein found in more fusions	16	0.286	61.315	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
68	SNAP29	protein found in more fusions	4	0.667	1.000	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
69	SOS1	oncoprotein	5	0.900	0.182	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
70	SOS2	interactor	2	1.000	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
71	SRGAP2	interactor	5	0.500	5.000	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) KIP1 (PF07765, IPR011684): KIP1-like protein RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF2987 (PF11205, IPR021370): Protein of unknown function (DUF2987)
72	STX4	oncoprotein	3	1.000	0	Syntaxin (PF00804, IPR006011, SM00503): Syntaxin SNARE (PF05739, IPR000727, SM00397): SNARE domain DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
73	SYN1	protein found in more fusions	4	0.667	1.000	Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain Synapsin_N (PF10581, IPR019736): Synapsin N-terminal DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
74	SYNJ2	interactor	3	1.000	0	DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866) Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family Syja_N (PF02383, IPR002013): SacI homology domain TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
75	TACC1	oncoprotein	2	1.000	0	TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
76	TBL3	interactor	2	1.000	0	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
77	TM9SF4	interactor	1	0	0	EMP70 (PF02990, IPR004240): Endomembrane protein 70 DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
78	TMF1	interactor	1	0	0	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) NHase_beta (PF02211, IPR024690): Nitrile hydratase beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain PilW (PF16074, IPR032092): Type IV Pilus-assembly protein W BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
79	TRIO	oncoprotein	1	0	0	T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle GRP (PF07172, IPR010800): Glycine rich protein family I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pap_E4 (PF02711, IPR003861): E4 protein PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Spectrin (PF00435, IPR002017): Spectrin repeat CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain PH_10 (PF15411): Pleckstrin homology domain SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
80	WAS	oncoprotein	8	0.393	11.682	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif PRIMA1 (PF16101): Proline-rich membrane anchor 1
81	WASF2	oncoprotein	2	1.000	0	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase WH2 (PF02205, IPR003124, SM00246): WH2 motif WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
82	WASL	interactor	8	0.429	11.348	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
83	WIPF1	interactor	5	0.600	2.667	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GRP (PF07172, IPR010800): Glycine rich protein family WH2 (PF02205, IPR003124, SM00246): WH2 motif
84	WIPF2	interactor	4	0.667	0.667	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal WH2 (PF02205, IPR003124, SM00246): WH2 motif CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
85	YLPM1	interactor	3	0.667	1.000	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
86	YTHDF1	interactor	2	1.000	0	YTH (PF04146, IPR007275): YT521-B-like domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)

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