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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)104
The number (and %) of the onco-proteins36 (34.62 %)
The number (and %) of the tumor suppressors8 (7.69 %)
Total number of binary PPIs (saturation %)321 (5.99 %)
The number (and %) of affected PPIs104 (32.40 %)
The number of possible different fusions22
PPI diameter2
PPI radius1
The average degree of PPI5.365
Assortativity coefficient-0.3860
The network average Clustering coefficient0.536
The number (and %) of a zero Clustering coefficients21 (20.19 %)
The number (and %) of a zero Betweenness Centrality46 (44.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ITSN1 All fusions
Proteins found in more fusions ITSN2 (see 5 fusions); RABEP1 (see 1 fusions); AP2M1 (see 4 fusions); KHDRBS1 (see 1 fusions); RNF40 (see 2 fusions); SH3KBP1 (see 1 fusions); EPS15 (see 1 fusions); EEF1A1 (see 6 fusions); PDE4D (see 2 fusions); FCHSD2 (see 1 fusions); PIK3R1 (see 1 fusions); SH3GL2 (see 1 fusions); EPHB2 (see 1 fusions); TSG101 (see 2 fusions); RAB11FIP2 (see 1 fusions); FNBP1 (see 7 fusions); SPDL1 (see 3 fusions); ITSN1 (see 2 fusions); MAP3K20 (see 1 fusions); REPS1 (see 1 fusions); CBLB (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ITSN1parental protein1040.0349393.602C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
2 AGFG1interactor30.6670.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
3 AGFG2interactor30.6670.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
4 AMPHoncoprotein120.33331.600BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
5 AP2B1interactor80.6794.967Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
6 AP2M1protein found in more fusions150.37442.033Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 ARF6oncoprotein30.6671.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 ARFIP2interactor40.6671.000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
9 ARHGAP31interactor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
10 ASAP2interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
11 CBLsuppressor140.33342.567Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
12 CBLBoncoprotein60.9000.400Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 CCNOinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
14 CDC42oncoprotein90.32117.833Ras (PF00071, IPR001806, SM00173): Ras family
15 CEP85Linteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc42p (PF11544, IPR021611): Spindle pole body component Spc42p
16 CLIP2interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Sas10 (PF09368, IPR018972): Sas10 C-terminal domain
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
17 CLTConcoprotein140.35247.250Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
18 CSNK2Binteractor50.5003.000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
19 CYTH1interactor21.0000DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
PH (PF00169, IPR001849, SM00233): PH domain
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
20 DAB2suppressor60.8001.567PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
21 DESinteractor100Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
22 DISC1interactor100HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
23 DLGAP1oncoprotein21.0000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein
24 DNM1interactor80.6193.669Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
25 DNM2interactor120.36430.636Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
26 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
27 DTX3oncoprotein21.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
28 EEF1A1suppressor70.4008.667GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
29 EPHB2suppressor200EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
30 EPN2interactor21.0000ENTH (PF01417, IPR001026, SM00273): ENTH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
31 EPS15oncoprotein140.33342.300Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
32 EPS15L1oncoprotein70.3819.833CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
33 FCHSD2protein found in more fusions60.6003.333Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
Rit1_C (PF17184): Rit1 N-terminal domain
34 FNBP1oncoprotein60.5002.400FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Laminin_II (PF06009, IPR010307): Laminin Domain II
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
35 FNBP4oncoprotein31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pap_E4 (PF02711, IPR003861): E4 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
WW (PF00397, IPR001202, SM00456): WW domain
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
36 GAREM2interactor21.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
CABIT (PF12736, IPR025946): Cell-cycle sustaining, positive selection,
37 GCC1interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
38 GOLGA5oncoprotein21.0000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
39 HIP1oncoprotein40.6670.667ANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
40 IGBP1interactor100TAP42 (PF04177, IPR007304): TAP42-like family
41 ITCHinteractor70.4677.400C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
42 ITSN2protein found in more fusions230.173170.283C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
43 KHDRBS1protein found in more fusions90.39312.669KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
44 KIF16Binteractor100DivIC (PF04977, IPR007060): Septum formation initiator
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF2721 (PF11026, IPR021279): Protein of unknown function (DUF2721)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
VGCC_beta4Aa_N (PF12052, IPR000584): Voltage gated calcium channel subunit beta domain 4Aa N terminal
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
45 KIF5Ainteractor30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Microtub_bd (PF16796, IPR031852): Microtubule binding
46 LMO4interactor30.6671.000LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
47 MAP3K20protein found in more fusions60.6003.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
48 MAPK6oncoprotein70.3338.833Pkinase (PF00069, IPR000719): Protein kinase domain
49 MAPK8IP2interactor31.0000BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
50 MRPL20interactor100Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
51 MTUS2suppressor40.6671.000DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
52 NECAP2interactor41.0000DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
53 PACSIN3interactor90.32110.433FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
GrpE (PF01025, IPR000740): GrpE
SH3_9 (PF14604, IPR001452): Variant SH3 domain
54 PAK3interactor31.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
55 PDCD6IPinteractor90.42912.833BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
56 PDE4Doncoprotein31.0000Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
57 PFDN5interactor100Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
58 PHGDHinteractor30.6671.0002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
59 PICALMoncoprotein90.6118.367ANTH (PF07651, IPR011417): ANTH domain
60 PIK3AP1interactor21.0000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DBB (PF14545, IPR017893): Dof, BCAP, and BANK (DBB) motif,
61 PIK3C2Binteractor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PX (PF00787, IPR001683, SM00312): PX domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
62 PIK3R1oncoprotein100.47214.233RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
63 PLK1suppressor60.3339.333Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
64 PPFIA2interactor200DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SlyX (PF04102, IPR007236): SlyX
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
65 PPLinteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FliT (PF05400, IPR008622): Flagellar protein FliT
M (PF02370, IPR003345): M protein repeat
Mnd1 (PF03962, IPR005647): Mnd1 family
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spectrin (PF00435, IPR002017): Spectrin repeat
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
66 PREX1oncoprotein100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
67 RAB11FIP2protein found in more fusions40.6670.400C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
68 RAB5Aoncoprotein50.5004.667Ras (PF00071, IPR001806, SM00173): Ras family
69 RABEP1oncoprotein40.6670.667Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
70 RAD18interactor40.6671.000PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
71 RAI14interactor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Fez1 (PF06818): Fez1
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_13 (PF13166, IPR026866): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
72 REPS1protein found in more fusions80.5247.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC)
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
73 RNASEH2Ainteractor21.0000RNase_HII (PF01351, IPR024567): Ribonuclease HII
74 RNF40protein found in more fusions200BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
75 RPS6KA5interactor40.6672.000Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
76 SCAMP1interactor50.5003.000SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
77 SCOCinteractor100DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
78 SETD3interactor21.0000Pertussis_S2S3 (PF02918, IPR020063): Pertussis toxin, subunit 2 and 3, C-terminal domain
Rubis-subs-bind (PF09273, IPR015353): Rubisco LSMT substrate-binding
SET (PF00856, IPR001214, SM00317): SET domain
Transposase_1 (PF01359, IPR001888): Transposase (partial DDE domain)
79 SF3B4interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
80 SGIP1interactor31.0000muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
81 SH3GL2oncoprotein100.52810.683BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
82 SH3KBP1protein found in more fusions210.232118.633Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
83 SKIV2Linteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516)
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
84 SMARCC2interactor21.0000GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
85 SNAP23interactor31.0000DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
86 SNAP25interactor21.0000SNAP-25 (PF00835, IPR000928): SNAP-25 family
Use1 (PF09753, IPR019150): Membrane fusion protein Use1
87 SNX5oncoprotein30.6671.000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
88 SOS1oncoprotein50.9000.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
89 SPDL1protein found in more fusions200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF2911 (PF11138, IPR021314): Protein of unknown function (DUF2911)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
90 SPRY2suppressor60.7001.352KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
91 STON2interactor60.8001.667Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Stonin2_N (PF12016, IPR022699): Stonin 2
92 SYNJ1interactor70.5245.669DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
YppG (PF14179, IPR025555): YppG-like protein
93 SYNJ2interactor31.0000DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
94 TFGoncoprotein50.6672.000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
95 TK1oncoprotein50.5003.000TK (PF00265, IPR001267, SM00203): Thymidine kinase
96 TRIM8interactor40.6671.000dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
97 TSG101suppressor70.4677.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
98 TTC37interactor21.0000DUF982 (PF06169, IPR010385): Protein of unknown function (DUF982)
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Retrotran_gag_2 (PF14223): gag-polypeptide of LTR copia-type
TPR_19 (PF14559): Tetratricopeptide repeat
99 UBE2Kinteractor30.6671.000UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
100 UNC119interactor60.4677.667GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
101 WASoncoprotein90.38915.300CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
102 WASLinteractor70.3817.252Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
103 WBP11interactor21.0000BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
104 ZFPM2interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

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