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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITPA (from a repository: Mon Dec 5 03:35:56 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins13 (28.89 %)
The number (and %) of the tumor suppressors3 (6.67 %)
Total number of binary PPIs (saturation %)132 (13.33 %)
The number (and %) of affected PPIs45 (34.09 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI5.200
Assortativity coefficient-0.3091
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients10 (22.22 %)
The number (and %) of a zero Betweenness Centrality21 (46.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ITPA All fusions
: BM545059;
Proteins found in more fusions HSPB1 (see 4 fusions); ECHS1 (see 1 fusions); PDCD6 (see 1 fusions); TKT (see 5 fusions); SSNA1 (see 1 fusions); ITPA (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ITPAparental protein450.0771510.289Ham1p_like (PF01725, IPR002637): Ham1 family
2 C9orf64interactor100Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family
3 ECHS1protein found in more fusions60.6003.222ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
4 EGFRoncoprotein70.4675.567Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
5 ENO1oncoprotein80.35715.300Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
6 FKBP1Binteractor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
7 FKBP2interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
8 GALEinteractor31.0000GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
9 GGCTinteractor21.0000GGACT (PF06094, IPR009288): Gamma-glutamyl cyclotransferase, AIG2-like
AIG2_2 (PF13772): AIG2-like family
10 GLO1interactor90.38918.400Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
11 GRPEL1interactor70.6004.133GrpE (PF01025, IPR000740): GrpE
12 HNRNPA1interactor100.44413.422RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 HNRNPA2B1oncoprotein50.7001.733RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 HNRNPA3oncoprotein31.0000IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
15 HSPA9oncoprotein120.39428.156HSP70 (PF00012, IPR013126): Hsp70 protein
16 HSPB1oncoprotein120.41822.800HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
17 IMPA2interactor50.5002.333Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
18 MOV10interactor100.28920.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NSFL1Cinteractor100SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
20 NXF1interactor130.22738.067NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 PARK7suppressor50.5002.067DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
22 PDCD6oncoprotein70.5334.556EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 PDXKoncoprotein30.6670.222Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
24 PPA1interactor41.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
25 PPIHinteractor31.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
26 PSMG4interactor30.6670.667PAC4 (PF16093, IPR032157): Proteasome assembly chaperone 4
27 SERPINB1oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
28 SERPINB11interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
29 SERPINB2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
30 SERPINB5suppressor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
31 SERPINB6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
32 SERPINB8interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
33 SHMT1interactor31.0000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
34 SHMT2interactor40.6672.000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
36 STIP1interactor70.6194.500TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
37 TESsuppressor50.4004.022LIM (PF00412, IPR001781, SM00132): LIM domain
PET (PF06297, IPR010442): PET Domain
PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
38 TKTprotein found in more fusions100.41716.633Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
39 TMEM189-UBE2V1interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
40 TSHRoncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
41 UBE2V1interactor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UMPSinteractor50.4003.222OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
43 VPS4Binteractor30.6670.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
44 WDR1interactor90.25023.789eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45 WNT4interactor100MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family

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