Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITPA (from a repository: Mon Dec 5 03:35:56 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins13 (28.89 %)
The number (and %) of the tumor suppressors3 (6.67 %)
Total number of binary PPIs (saturation %)132 (13.33 %)
The number (and %) of affected PPIs45 (34.09 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI5.200
Assortativity coefficient-0.3091
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients10 (22.22 %)
The number (and %) of a zero Betweenness Centrality21 (46.67 %)


List of the fusions

PPI for parental proteins: ITPA All fusions
: BM545059;
Proteins found in more fusions HSPB1 (see 4 fusions); ECHS1 (see 1 fusions); PDCD6 (see 1 fusions); TKT (see 5 fusions); SSNA1 (see 1 fusions); ITPA (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ITPAparental protein450.0771510.289Ham1p_like (PF01725, IPR002637): Ham1 family
2 C9orf64interactor100Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family
3 ECHS1protein found in more fusions60.6003.222ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
4 EGFRoncoprotein70.4675.567Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
5 ENO1oncoprotein80.35715.300Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
6 FKBP1Binteractor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
7 FKBP2interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
8 GALEinteractor31.0000GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
9 GGCTinteractor21.0000GGACT (PF06094, IPR009288): Gamma-glutamyl cyclotransferase, AIG2-like
AIG2_2 (PF13772): AIG2-like family
10 GLO1interactor90.38918.400Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
11 GRPEL1interactor70.6004.133GrpE (PF01025, IPR000740): GrpE
12 HNRNPA1interactor100.44413.422RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 HNRNPA2B1oncoprotein50.7001.733RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 HNRNPA3oncoprotein31.0000IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
15 HSPA9oncoprotein120.39428.156HSP70 (PF00012, IPR013126): Hsp70 protein
16 HSPB1oncoprotein120.41822.800HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
17 IMPA2interactor50.5002.333Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
18 MOV10interactor100.28920.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NSFL1Cinteractor100SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
20 NXF1interactor130.22738.067NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 PARK7suppressor50.5002.067DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
22 PDCD6oncoprotein70.5334.556EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 PDXKoncoprotein30.6670.222Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
24 PPA1interactor41.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
25 PPIHinteractor31.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
26 PSMG4interactor30.6670.667PAC4 (PF16093, IPR032157): Proteasome assembly chaperone 4
27 SERPINB1oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
28 SERPINB11interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
29 SERPINB2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
30 SERPINB5suppressor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
31 SERPINB6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
32 SERPINB8interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
33 SHMT1interactor31.0000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
34 SHMT2interactor40.6672.000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
36 STIP1interactor70.6194.500TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
37 TESsuppressor50.4004.022LIM (PF00412, IPR001781, SM00132): LIM domain
PET (PF06297, IPR010442): PET Domain
PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
38 TKTprotein found in more fusions100.41716.633Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
39 TMEM189-UBE2V1interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
40 TSHRoncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
41 UBE2V1interactor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UMPSinteractor50.4003.222OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
43 VPS4Binteractor30.6670.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
44 WDR1interactor90.25023.789eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45 WNT4interactor100MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family

B a c k    t o    T o p ⇑