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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IRF7 (from a repository: Wed Feb 13 07:27:12 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins8 (20.51 %)
The number (and %) of the tumor suppressors10 (25.64 %)
Total number of binary PPIs (saturation %)117 (15.79 %)
The number (and %) of affected PPIs39 (33.33 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.923
Assortativity coefficient-0.4072
The network average Clustering coefficient0.445
The number (and %) of a zero Clustering coefficients12 (30.77 %)
The number (and %) of a zero Betweenness Centrality19 (48.72 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: IRF7 All fusions
Proteins found in more fusions CREBBP (see 6 fusions); TRAF6 (see 1 fusions); SMAD2 (see 2 fusions); TRIM28 (see 1 fusions); EP300 (see 1 fusions); SMAD4 (see 2 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IRF7parental protein390.0831146.038IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
2 ACADSinteractor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
3 AIPsuppressor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
4 ALKoncoprotein100MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
5 ARAFoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 CCDC47interactor21.0000DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
7 CREBBPsuppressor90.7144.852Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
8 DEAF1interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
9 EP300oncoprotein90.6794.519Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
10 FADDsuppressor50.4004.333Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
11 GCLMinteractor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
12 HACE1suppressor200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
13 INSRinteractor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
14 IQSEC1interactor21.0000Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
15 IRAK1interactor70.4677.500Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
16 IRF3suppressor140.30849.186IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
17 LTN1interactor100zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
18 MAFBoncoprotein31.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
19 MAVSinteractor60.6002.233Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
20 MYD88oncoprotein60.5003.833Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
21 NMIinteractor31.0000IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
22 P4HA1interactor100P4Ha_N (PF08336, IPR013547): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
23 PALD1interactor100PTPlike_phytase (PF14566): Inositol hexakisphosphate
24 PIAS4interactor70.6193.852CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
25 SMAD2suppressor100.6678.638MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
26 SMAD3oncoprotein100.55611.619MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
27 SMAD4suppressor80.8570.905MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
28 SUMO2interactor60.4003.452Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
29 SUMO3interactor100Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
30 TANKsuppressor70.4675.352DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
31 TBK1interactor60.6002.333DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
32 TLK2interactor100IncA (PF04156, IPR007285): IncA protein
Phage_1_1 (PF08200, IPR013232): Bacteriophage 1.1 Protein
Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
33 TNFAIP3suppressor70.4007.233OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
34 TP53suppressor90.5719.119DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
35 TRAF6protein found in more fusions80.4768.167SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
36 TRIM21interactor50.5002.667DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
37 TRIM28protein found in more fusions60.5004.167ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
38 TRMT2Ainteractor100PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
tRNA_U5-meth_tr (PF05958, IPR010280): tRNA (Uracil-5-)-methyltransferase
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
Hepar_II_III_N (PF16889, IPR031680): Heparinase II/III N-terminus
39 TRMT61Binteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit

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