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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IMPDH2 (from a repository: Sat Nov 12 09:35:55 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins21 (24.14 %)
The number (and %) of the tumor suppressors13 (14.94 %)
Total number of binary PPIs (saturation %)391 (10.45 %)
The number (and %) of affected PPIs87 (22.25 %)
The number of possible different fusions19
PPI diameter2
PPI radius1
The average degree of PPI8.138
Assortativity coefficient-0.2477
The network average Clustering coefficient0.533
The number (and %) of a zero Clustering coefficients11 (12.64 %)
The number (and %) of a zero Betweenness Centrality26 (29.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: IMPDH2 All fusions
: BU675368;
Proteins found in more fusions IMPDH2 (see 2 fusions); CD2AP (see 1 fusions); MME (see 1 fusions); SH3KBP1 (see 1 fusions); MCM2 (see 1 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); COPS5 (see 1 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); CUL3 (see 1 fusions); PEX14 (see 1 fusions); GRB2 (see 1 fusions); RPA1 (see 1 fusions); OFD1 (see 1 fusions); VHL (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IMPDH2parental protein870.0735356.232IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
2 ADPRHL2interactor21.0000ADP_ribosyl_GH (PF03747, IPR005502): ADP-ribosylglycohydrolase
DUF4148 (PF13663, IPR025421): Domain of unknown function (DUF4148)
3 AHSA1interactor90.5837.417Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 AKT1oncoprotein70.4675.452PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ANKRD9interactor100Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
6 AP4M1interactor21.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 API5interactor21.0000API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
8 APIPinteractor200Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
9 ASUNinteractor21.0000DUF2151 (PF10221, IPR019355): Cell cycle and development regulator
10 ATG5interactor100APG5 (PF04106, IPR007239): Autophagy protein Apg5
11 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
12 CD2APprotein found in more fusions50.6671.333SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
13 CDK2suppressor170.40838.845Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
14 CETN2interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
15 CHMP4Binteractor31.0000Snf7 (PF03357, IPR005024): Snf7
16 CLK1interactor50.6672.000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
17 COPS5protein found in more fusions170.50029.735JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18 COPS6interactor140.52618.432DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
19 CRY1interactor60.5002.536DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
20 CTPS1interactor160.36241.238CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
21 CUL3protein found in more fusions260.273137.347Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
22 CUL7protein found in more fusions120.47319.375ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23 DDX3Xsuppressor230.332102.859DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
24 EIF2S3interactor40.6670.432eIF2_C (PF09173, IPR015256): Initiation factor eIF2 gamma, C terminal
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
25 EIF4Binteractor90.5366.055RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
26 EMC2interactor60.4675.554TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
27 ENOPH1interactor30.6670.500Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
28 FANCIinteractor40.6670.367DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
29 FBXO25suppressor40.5001.250Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
30 FBXO6interactor130.37219.729FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
31 FN1oncoprotein150.41029.894fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
32 FOLR1interactor21.0000Folate_rec (PF03024, IPR018143): Folate receptor family
33 GLMNoncoprotein30.6670.286Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
34 GMPSoncoprotein100.42211.068GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
GMP_synt_C (PF00958, IPR001674): GMP synthase C terminal domain
NAD_synthase (PF02540, IPR022310): NAD synthase
35 GRB2oncoprotein90.5367.547SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
36 HDAC5protein found in more fusions70.7331.638Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
37 HUWE1oncoprotein150.48425.636BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
38 IKBKEinteractor31.0000IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
39 IMPDH1interactor130.26943.974IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
40 MAPK10suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
41 MCM2oncoprotein220.37666.025AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
42 MMEsuppressor200Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
43 MMGT1interactor31.0000MMgT (PF10270, IPR018937): Membrane magnesium transporter
44 MYO1Cinteractor90.4179.874IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
45 NCBP1interactor100.48914.445MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
46 NEDD4suppressor50.6671.167Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
47 NESinteractor30.6670.167Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
48 NMD3interactor30.6670.286DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
49 NOP9interactor30.6670.500PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
50 NPM1suppressor290.315165.740Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
51 NTRK1oncoprotein360.207342.209I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
52 NUP50interactor41.0000NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
53 OFD1protein found in more fusions60.7002.333APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
54 PARK2suppressor60.6001.267IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55 PCID2interactor60.4677.067PCI (PF01399, IPR000717, SM00088): PCI domain
56 PEX14protein found in more fusions200HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
57 PIAS4interactor30.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
58 PPATinteractor40.6671.400Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
59 PRKAR2Ainteractor30.6670.500RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
60 PUSL1interactor100PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
61 RPA1suppressor150.53819.675Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
62 RPA2oncoprotein130.57717.903RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
63 RPA3interactor110.6675.337Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
64 RPL15interactor180.51029.904Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
65 RPLP0P6interactor60.6674.250NA
66 RPS6interactor160.35845.025Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
67 RSG1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
68 SEC16Ainteractor90.36114.914APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
69 SFNsuppressor90.4298.28314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
70 SH3KBP1protein found in more fusions70.4006.233Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
71 SIRT6suppressor50.6002.833SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
72 SIRT7interactor140.35230.979DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
73 SKP2suppressor70.5716.233LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
74 SLC25A44interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
75 SMCR8interactor21.0000Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
76 SNU13interactor100.5567.221Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
77 SNX2interactor90.33320.900PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
78 SNX6interactor31.0000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
79 SOX2oncoprotein40.6670.667HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
80 STKLD1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
81 TEPSINinteractor21.0000ENTH (PF01417, IPR001026, SM00273): ENTH domain
82 U2AF2protein found in more fusions130.6975.859RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
83 UBA6interactor50.5003.500ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
84 UBQLN4interactor200CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
85 UCHL3interactor50.6671.167Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
86 VHLsuppressor100.47212.405Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
87 XRCC3oncoprotein21.0000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

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