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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)133
The number (and %) of the onco-proteins26 (19.55 %)
The number (and %) of the tumor suppressors12 (9.02 %)
Total number of binary PPIs (saturation %)726 (8.27 %)
The number (and %) of affected PPIs132 (18.18 %)
The number of possible different fusions23
PPI diameter5
PPI radius3
The average degree of PPI10.105
Assortativity coefficient-0.2781
The network average Clustering coefficient0.439
The number (and %) of a zero Clustering coefficients8 (6.02 %)
The number (and %) of a zero Betweenness Centrality18 (13.53 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: IMMT,HCST All fusions
: BM925115;
Proteins found in more fusions SFPQ (see 6 fusions); EEF1A1 (see 1 fusions); CUL7 (see 2 fusions); ATXN1 (see 3 fusions); PINK1 (see 3 fusions); HNRNPD (see 1 fusions); NDUFS3 (see 1 fusions); NDEL1 (see 1 fusions); IMMT (see 4 fusions); TCF3 (see 4 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); KDM1A (see 2 fusions); CHD3 (see 1 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); TNNT1 (see 1 fusions); SUZ12 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IMMTparental protein1290.06212169.410Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
2 HCSTparental protein30265.753DAP10 (PF07213, IPR009861): DAP10 membrane protein
3 ABCE1interactor110.48910.207ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ADCK1interactor200ABC1 (PF03109, IPR004147): ABC1 family
APH (PF01636, IPR002575): Phosphotransferase enzyme family
5 ADCK5interactor200ABC1 (PF03109, IPR004147): ABC1 family
APH (PF01636, IPR002575): Phosphotransferase enzyme family
6 ADRB2interactor130.36420.2987tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 AKTIPinteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
8 ALBinteractor60.4676.233Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
9 APOOLinteractor70.5335.567ApoO (PF09769, IPR019166): Apolipoprotein O
10 ARMCX3oncoprotein100Arm_2 (PF04826, IPR006911): Armadillo-like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
11 ASCC2interactor50.7001.333CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
12 ATF2oncoprotein110.40016.262bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
13 ATP5A1protein found in more fusions230.281103.683ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
14 ATP5C1interactor240.286121.358ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
15 ATXN1protein found in more fusions80.38112.638AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
16 BAG6interactor170.19281.824DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 BMI1oncoprotein140.21869.819zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
18 C10orf88interactor200DUF4506 (PF14958, IPR028043): Domain of unknown function (DUF4506)
19 C15orf48interactor100.55610.033B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
20 C19orf70interactor50.6003.302QIL1 (PF15884, IPR026769): Protein QIL1
21 C8orf33interactor31.0000DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
22 CALM1interactor80.32121.094EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 CCDC113interactor21.0000DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
DUF2808 (PF10989, IPR021256): Protein of unknown function (DUF2808)
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
24 CCDC8interactor170.32557.760Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
25 CCT5interactor110.23618.459Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
26 CD244interactor30.33330.049Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
27 CD81interactor90.5006.272Tetraspannin (PF00335, IPR018499): Tetraspanin family
28 CDC37protein found in more fusions110.33327.745CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
29 CDK9protein found in more fusions80.28614.124Pkinase (PF00069, IPR000719): Protein kinase domain
30 CHCHD10interactor50.6670.450CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
31 CHD3oncoprotein120.25534.370CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
32 CLN3interactor70.38122.113CLN3 (PF02487, IPR003492): CLN3 protein
33 CRY1interactor70.4002.344DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
34 CSTF2interactor70.4299.622RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
35 CUL7protein found in more fusions220.28189.230ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
36 DISC1interactor40.5003.000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
37 DNAJC11suppressor80.39314.176DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
38 ECSITinteractor40.6670.500ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
39 ECT2suppressor40.6671.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
40 EEF1A1suppressor230.160146.979GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
41 EGFRoncoprotein220.238182.461Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
42 EIF3Fsuppressor110.38226.140JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
43 ELAVL1oncoprotein320.103736.492RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44 EP300oncoprotein130.21279.400Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
45 EXOSC10interactor50.6001.196DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
46 EZH2suppressor100.27835.552CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
47 FAM173Ainteractor30.6670.667Methyltransf_23 (PF13489): Methyltransferase domain
48 FBXO6interactor210.25293.096FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
49 FEZ1interactor100.36120.333FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
50 GOLT1Binteractor140.46233.390Got1 (PF04178, IPR007305): Got1/Sft2-like family
51 HAP1interactor180.176106.167HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
52 HIVEP1suppressor21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
53 HJURPinteractor100GAT (PF03127, IPR004152): GAT domain
Scm3 (PF10384, IPR018465): Centromere protein Scm3
HJURP_mid (PF12346, IPR021052): Holliday junction recognition protein-associated repeat
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
54 HMOX2interactor31.0000Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
55 HNRNPDoncoprotein130.45521.700CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
56 HNRNPRinteractor160.30848.923RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
57 HP1BP3interactor80.3218.541RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
58 IRAK1interactor80.4299.211Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
59 ITGA4interactor180.29441.495FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
60 KDM1Aprotein found in more fusions140.23144.570Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
61 KIF22interactor30.6671.000Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
62 KLRK1oncoprotein100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
63 KPNA2interactor100.28917.968Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
64 LGR4interactor80.3338.9007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
65 LRIF1interactor130.30337.841LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
66 MDC1suppressor110.32728.766FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
67 MINOS1interactor40.6671.500DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
68 MMGT1interactor80.64313.565MMgT (PF10270, IPR018937): Membrane magnesium transporter
69 MRPL44interactor40.5001.644dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
70 MRPL58interactor110.36415.717RF-1 (PF00472, IPR000352): RF-1 domain
71 MSMO1interactor40.50013.575FA_hydroxylase (PF04116, IPR006694): Fatty acid hydroxylase superfamily
DUF4886 (PF16227, IPR032616): Domain of unknown function (DUF4886)
72 MTX2interactor90.27823.651Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
73 MYH9suppressor110.25530.103IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
74 MYO19interactor40.6670.667IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
75 NCSTNinteractor70.52416.601Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
76 NDEL1protein found in more fusions40.6671.179HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
77 NDUFA10interactor130.43632.059dNK (PF01712, IPR002624): Deoxynucleoside kinase
78 NDUFA12interactor130.56416.650NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
79 NDUFA4interactor180.29459.469B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
80 NDUFA9interactor180.43857.910Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
81 NDUFB9interactor100.57815.298Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
82 NDUFS3protein found in more fusions240.277119.003Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
83 NEK2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
84 NIPSNAP3Ainteractor21.0000NIPSNAP (PF07978, IPR012577): NIPSNAP
85 NOS3interactor50.5007.674FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
86 NTRK1oncoprotein420.141624.503I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
87 OBSL1interactor220.238112.726BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
88 OCIAD1interactor100.41718.737OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
89 OTUB1interactor110.38222.839Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
90 PARP1suppressor150.36339.610BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
91 PDE4DIPoncoprotein80.28629.494ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
92 PFDN1interactor60.4006.048Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
93 PIAS4interactor70.42916.708CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
94 PIK3R1oncoprotein60.10082.543RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
95 PINK1protein found in more fusions50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
96 PLA2G15interactor21.0000LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
97 PPOXinteractor40.5002.667Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
98 PRRC2Ainteractor80.35713.516BAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
99 PTPMT1interactor60.7000.850DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
100 RAB5Concoprotein120.45514.629Ras (PF00071, IPR001806, SM00173): Ras family
101 RAB7Asuppressor90.47217.182Ras (PF00071, IPR001806, SM00173): Ras family
102 RER1interactor50.6003.377Rer1 (PF03248, IPR004932): Rer1 family
103 RNF126interactor50.6671.067Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
104 SDHAF2oncoprotein21.0000Sdh5 (PF03937, IPR005631): Flavinator of succinate dehydrogenase
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
Reovirus_cap (PF00979, IPR000153): Reovirus outer capsid protein, Sigma 3
105 SENP3interactor40.8330.250Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
106 SFPQoncoprotein180.35365.298GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
107 SGPL1interactor90.55614.681Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
108 SIRT7interactor140.23148.056DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
109 SLC25A1interactor120.25827.036Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
110 SLC25A12interactor70.4296.325Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
111 SLC25A13interactor140.24258.256Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
112 SLC33A1interactor21.0000Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
113 SMN1interactor120.25523.045SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
114 SNAPINinteractor21.0000Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
115 SRRTinteractor70.4296.159ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
116 STMN4interactor100Stathmin (PF00836, IPR000956): Stathmin family
Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
117 STX5interactor40.6671.167Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
118 SUZ12suppressor60.5008.791DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
119 TAF1Dinteractor50.7002.342TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
120 TCF3suppressor90.35718.776CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
121 TK1oncoprotein80.2868.689TK (PF00265, IPR001267, SM00203): Thymidine kinase
122 TNNT1protein found in more fusions40.6670.667Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
123 TOMM40interactor100.42216.089Porin_3 (PF01459, IPR027246): Eukaryotic porin
124 TRAF3IP1interactor40.5002.333MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
125 TUBGCP3interactor40.6676.667Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
126 TXNDC9interactor30.6670.500Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
127 UBQLN4interactor60.5003.389CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
128 UQCRQinteractor110.43616.645UcrQ (PF02939, IPR004205): UcrQ family
129 VAPAinteractor210.36765.918DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
130 VCAM1interactor190.29859.279C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
131 VDAC1interactor210.36765.270Porin_3 (PF01459, IPR027246): Eukaryotic porin
132 VDAC2interactor300.267230.590Porin_3 (PF01459, IPR027246): Eukaryotic porin
133 VDAC3interactor160.48328.137Porin_3 (PF01459, IPR027246): Eukaryotic porin

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALBinteractorSerum_albumin (PF00273, IPR014760, SM00103): Serum albumin familyBM925115
2 HCSTparental proteinDAP10 (PF07213, IPR009861): DAP10 membrane proteinBM925115
3 IMMTparental proteinMitofilin (PF09731, IPR019133): Mitochondrial inner membrane proteinBM925115
4 KLRK1oncoproteinLectin_C (PF00059, IPR001304, SM00034): Lectin C-type domainBM925115
5 NDUFB9interactorComplex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)BM925115
6 NIPSNAP3AinteractorNIPSNAP (PF07978, IPR012577): NIPSNAPBM925115
7 PFDN1interactorPrefoldin_2 (PF01920, IPR002777): Prefoldin subunitBM925115
8 PIK3R1oncoproteinRhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
BM925115
9 RAB5ConcoproteinRas (PF00071, IPR001806, SM00173): Ras familyBM925115
10 RAB7AsuppressorRas (PF00071, IPR001806, SM00173): Ras familyBM925115
11 RER1interactorRer1 (PF03248, IPR004932): Rer1 familyBM925115
12 SLC25A1interactorMito_carr (PF00153, IPR018108): Mitochondrial carrier proteinBM925115

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