Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins IMMT (from a repository: Thu Nov 17 07:52:37 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 129 The number (and %) of the onco-proteins 23 (17.83 %) The number (and %) of the tumor suppressors 12 (9.30 %) Total number of binary PPIs (saturation %) 687 (8.32 %) The number (and %) of affected PPIs 129 (18.78 %) The number of possible different fusions 21 PPI diameter 2 PPI radius 1 The average degree of PPI 9.845 Assortativity coefficient -0.2713 The network average Clustering coefficient 0.471 The number (and %) of a zero Clustering coefficients 6 (4.65 %) The number (and %) of a zero Betweenness Centrality 20 (15.50 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: IMMT	All fusions : BU675384; BU685307; CB854254; BE159547;
Proteins found in more fusions	SFPQ (see 6 fusions); CUL7 (see 2 fusions); ATXN1 (see 3 fusions); PINK1 (see 3 fusions); HNRNPD (see 1 fusions); NDUFS3 (see 1 fusions); NDEL1 (see 1 fusions); IMMT (see 4 fusions); TCF3 (see 3 fusions); EGFR (see 2 fusions); KDM1A (see 2 fusions); CHD3 (see 1 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); TNNT1 (see 1 fusions); SUZ12 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	IMMT	parental protein	129	0.062	12152.568	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
2	ABCE1	interactor	11	0.489	10.018	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
3	ADCK1	interactor	2	0	0	ABC1 (PF03109, IPR004147): ABC1 family APH (PF01636, IPR002575): Phosphotransferase enzyme family
4	ADCK5	interactor	2	0	0	ABC1 (PF03109, IPR004147): ABC1 family APH (PF01636, IPR002575): Phosphotransferase enzyme family
5	ADRB2	interactor	13	0.364	20.845	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6	AKTIP	interactor	2	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
7	ALB	interactor	6	0.467	6.400	Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
8	APOOL	interactor	7	0.533	5.567	ApoO (PF09769, IPR019166): Apolipoprotein O
9	ARMCX3	oncoprotein	1	0	0	Arm_2 (PF04826, IPR006911): Armadillo-like Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
10	ASCC2	interactor	5	0.700	1.333	CUE (PF02845, IPR003892, SM00546): CUE domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
11	ATF2	oncoprotein	11	0.400	16.267	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
12	ATP5A1	protein found in more fusions	23	0.281	102.501	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
13	ATP5C1	interactor	24	0.286	118.866	ATP-synt (PF00231, IPR000131): ATP synthase ACT_4 (PF13291, IPR002912): ACT domain
14	ATXN1	protein found in more fusions	8	0.381	12.333	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
15	BAG6	interactor	17	0.192	76.180	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
16	BMI1	oncoprotein	13	0.227	43.800	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
17	C10orf88	interactor	2	0	0	DUF4506 (PF14958, IPR028043): Domain of unknown function (DUF4506)
18	C15orf48	interactor	10	0.556	9.898	B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
19	C19orf70	interactor	5	0.600	3.167	QIL1 (PF15884, IPR026769): Protein QIL1
20	C8orf33	interactor	3	1.000	0	DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
21	CALM1	interactor	7	0.286	12.250	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
22	CCDC113	interactor	2	1.000	0	DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) DUF2808 (PF10989, IPR021256): Protein of unknown function (DUF2808) KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
23	CCDC8	interactor	16	0.324	41.289	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
24	CCT5	interactor	11	0.236	18.446	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
25	CD244	interactor	2	1.000	0	Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4 WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Ig_2 (PF13895, IPR007110): Immunoglobulin domain
26	CD81	interactor	9	0.500	6.272	Tetraspannin (PF00335, IPR018499): Tetraspanin family
27	CDC37	protein found in more fusions	11	0.333	24.944	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
28	CDK9	protein found in more fusions	7	0.400	3.590	Pkinase (PF00069, IPR000719): Protein kinase domain
29	CHCHD10	interactor	5	0.667	0.450	CHCH (PF06747, IPR010625): CHCH domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
30	CHD3	oncoprotein	12	0.255	33.500	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
31	CLN3	interactor	6	0.400	6.733	CLN3 (PF02487, IPR003492): CLN3 protein
32	CRY1	interactor	7	0.400	2.344	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
33	CSTF2	interactor	7	0.429	9.067	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
34	CUL7	protein found in more fusions	21	0.274	71.106	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
35	DISC1	interactor	4	0.500	3.000	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
36	DNAJC11	suppressor	8	0.393	12.311	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
37	ECSIT	interactor	4	0.667	0.500	ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
38	ECT2	suppressor	4	0.667	1.067	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
39	EEF1A1	suppressor	23	0.160	137.297	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
40	EGFR	oncoprotein	21	0.258	96.591	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
41	EIF3F	suppressor	11	0.382	24.830	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
42	EP300	oncoprotein	12	0.255	26.772	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
43	EXOSC10	interactor	5	0.600	1.075	DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease HRDC (PF00570, IPR002121, SM00341): HRDC domain PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain Sec62 (PF03839, IPR004728): Translocation protein Sec62
44	EZH2	suppressor	9	0.321	14.900	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
45	FAM173A	interactor	3	0.667	0.667	Methyltransf_23 (PF13489): Methyltransferase domain
46	FBXO6	interactor	21	0.252	91.589	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
47	FEZ1	interactor	10	0.361	20.333	FEZ (PF07763, IPR011680): FEZ-like protein DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
48	GOLT1B	interactor	13	0.500	17.414	Got1 (PF04178, IPR007305): Got1/Sft2-like family
49	HAP1	interactor	18	0.176	106.167	HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
50	HIVEP1	suppressor	2	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_7 (PF15269): Zinc-finger
51	HJURP	interactor	1	0	0	GAT (PF03127, IPR004152): GAT domain Scm3 (PF10384, IPR018465): Centromere protein Scm3 HJURP_mid (PF12346, IPR021052): Holliday junction recognition protein-associated repeat HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
52	HMOX2	interactor	3	1.000	0	Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
53	HNRNPD	oncoprotein	13	0.455	20.349	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
54	HNRNPR	interactor	16	0.308	51.784	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
55	HP1BP3	interactor	8	0.321	9.988	RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal SDA1 (PF05285, IPR007949): SDA1 YL1 (PF05764, IPR008895): YL1 nuclear protein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
56	IRAK1	interactor	8	0.429	8.967	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
57	ITGA4	interactor	18	0.294	41.664	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
58	KDM1A	protein found in more fusions	14	0.231	45.227	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain SWIRM (PF04433, IPR007526): SWIRM domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
59	KIF22	interactor	3	0.667	1.000	Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain HHH_3 (PF12836): Helix-hairpin-helix motif
60	KPNA2	interactor	10	0.289	15.990	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
61	LGR4	interactor	8	0.333	8.900	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
62	LRIF1	interactor	13	0.303	36.733	LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
63	MDC1	suppressor	10	0.289	20.400	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
64	MINOS1	interactor	4	0.667	1.500	DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
65	MMGT1	interactor	7	0.762	2.686	MMgT (PF10270, IPR018937): Membrane magnesium transporter
66	MRPL44	interactor	4	0.500	1.600	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
67	MRPL58	interactor	11	0.364	15.784	RF-1 (PF00472, IPR000352): RF-1 domain
68	MSMO1	interactor	3	1.000	0	FA_hydroxylase (PF04116, IPR006694): Fatty acid hydroxylase superfamily DUF4886 (PF16227, IPR032616): Domain of unknown function (DUF4886)
69	MTX2	interactor	9	0.278	22.200	Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
70	MYH9	suppressor	11	0.255	28.999	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
71	MYO19	interactor	4	0.667	0.667	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
72	NCSTN	interactor	6	0.667	2.194	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
73	NDEL1	protein found in more fusions	4	0.667	1.000	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
74	NDUFA10	interactor	13	0.436	30.102	dNK (PF01712, IPR002624): Deoxynucleoside kinase
75	NDUFA12	interactor	13	0.564	16.157	NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
76	NDUFA4	interactor	18	0.294	60.136	B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
77	NDUFA9	interactor	17	0.463	27.752	Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
78	NDUFB9	interactor	10	0.578	14.747	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
79	NDUFS3	protein found in more fusions	24	0.277	113.230	Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
80	NEK2	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
81	NIPSNAP3A	interactor	2	1.000	0	NIPSNAP (PF07978, IPR012577): NIPSNAP
82	NOS3	interactor	4	0.667	0.667	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
83	NTRK1	oncoprotein	40	0.144	438.935	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
84	OBSL1	interactor	21	0.237	85.110	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
85	OCIAD1	interactor	9	0.500	5.219	OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
86	OTUB1	interactor	11	0.382	22.367	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
87	PARP1	suppressor	14	0.321	31.690	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
88	PDE4DIP	oncoprotein	7	0.333	10.067	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9 DivIC (PF04977, IPR007060): Septum formation initiator DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220) DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515) IncA (PF04156, IPR007285): IncA protein Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54 FAM76 (PF16046, IPR032017): FAM76 protein MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
89	PFDN1	interactor	6	0.400	5.867	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
90	PIAS4	interactor	6	0.400	5.967	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
91	PINK1	protein found in more fusions	5	0.667	2.000	Pkinase (PF00069, IPR000719): Protein kinase domain
92	PLA2G15	interactor	2	1.000	0	LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
93	PPOX	interactor	4	0.500	2.667	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
94	PRRC2A	interactor	8	0.357	13.415	BAT2_N (PF07001, IPR009738): BAT2 N-terminus MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
95	PTPMT1	interactor	6	0.700	0.850	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
96	RAB5C	oncoprotein	12	0.455	15.769	Ras (PF00071, IPR001806, SM00173): Ras family
97	RAB7A	suppressor	8	0.536	6.271	Ras (PF00071, IPR001806, SM00173): Ras family
98	RER1	interactor	5	0.600	2.889	Rer1 (PF03248, IPR004932): Rer1 family
99	RNF126	interactor	5	0.667	1.067	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zinc_ribbon_9 (PF14369): zinc-ribbon
100	SDHAF2	oncoprotein	2	1.000	0	Sdh5 (PF03937, IPR005631): Flavinator of succinate dehydrogenase Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2 Reovirus_cap (PF00979, IPR000153): Reovirus outer capsid protein, Sigma 3
101	SENP3	interactor	4	0.833	0.286	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
102	SFPQ	oncoprotein	17	0.350	38.707	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
103	SGPL1	interactor	8	0.643	3.563	Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
104	SIRT7	interactor	13	0.218	33.952	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
105	SLC25A1	interactor	12	0.258	25.556	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
106	SLC25A12	interactor	7	0.429	6.325	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
107	SLC25A13	interactor	13	0.231	36.172	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
108	SLC33A1	interactor	2	1.000	0	Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
109	SMN1	interactor	12	0.255	25.512	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
110	SNAPIN	interactor	2	1.000	0	Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
111	SRRT	interactor	7	0.429	5.419	ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2 DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit Macoilin (PF09726, IPR019130): Transmembrane protein DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546) DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
112	STMN4	interactor	1	0	0	Stathmin (PF00836, IPR000956): Stathmin family Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
113	STX5	interactor	4	0.667	1.167	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus Syntaxin (PF00804, IPR006011, SM00503): Syntaxin SNARE (PF05739, IPR000727, SM00397): SNARE domain Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
114	SUZ12	suppressor	5	0.667	1.667	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
115	TAF1D	interactor	5	0.700	2.067	TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
116	TCF3	suppressor	8	0.381	9.383	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
117	TK1	oncoprotein	8	0.286	8.756	TK (PF00265, IPR001267, SM00203): Thymidine kinase
118	TNNT1	protein found in more fusions	4	0.667	0.667	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
119	TOMM40	interactor	10	0.422	16.275	Porin_3 (PF01459, IPR027246): Eukaryotic porin
120	TRAF3IP1	interactor	4	0.500	2.333	MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
121	TUBGCP3	interactor	3	1.000	0	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
122	TXNDC9	interactor	3	0.667	0.500	Thioredoxin (PF00085, IPR013766): Thioredoxin DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
123	UBQLN4	interactor	6	0.500	3.389	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
124	UQCRQ	interactor	11	0.436	16.911	UcrQ (PF02939, IPR004205): UcrQ family
125	VAPA	interactor	21	0.367	64.207	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
126	VCAM1	interactor	18	0.314	39.531	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
127	VDAC1	interactor	21	0.367	68.092	Porin_3 (PF01459, IPR027246): Eukaryotic porin
128	VDAC2	interactor	29	0.264	188.126	Porin_3 (PF01459, IPR027246): Eukaryotic porin
129	VDAC3	interactor	16	0.483	28.621	Porin_3 (PF01459, IPR027246): Eukaryotic porin

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List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ALB	interactor	Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family	BE159547, BU685307, CB854254
2	IMMT	parental protein	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein	BE159547, BU685307, CB854254
3	NDUFB9	interactor	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)	BE159547, BU685307, CB854254
4	NIPSNAP3A	interactor	NIPSNAP (PF07978, IPR012577): NIPSNAP	BE159547, BU685307, CB854254
5	PFDN1	interactor	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit	BE159547, BU685307, CB854254
6	RAB5C	oncoprotein	Ras (PF00071, IPR001806, SM00173): Ras family	BE159547, BU685307, CB854254
7	RAB7A	suppressor	Ras (PF00071, IPR001806, SM00173): Ras family	BE159547, BU685307, CB854254
8	RER1	interactor	Rer1 (PF03248, IPR004932): Rer1 family	BE159547, BU685307, CB854254
9	SLC25A1	interactor	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein	BE159547, BU685307, CB854254

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