1 |
IKBKB | parental protein | 131 | 0.082 | 9430.723 | FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
2 |
AKT1 | oncoprotein | 31 | 0.274 | 165.464 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
3 |
AURKA | oncoprotein | 19 | 0.418 | 41.026 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
4 |
BCL10 | suppressor | 16 | 0.533 | 24.773 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain |
5 |
BCL2 | oncoprotein | 11 | 0.489 | 9.037 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
6 |
BIRC3 | oncoprotein | 16 | 0.552 | 17.478 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
7 |
BRAP | interactor | 6 | 0.400 | 3.833 | BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2 DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH |
8 |
BTRC | oncoprotein | 27 | 0.329 | 104.130 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
9 |
CASP8 | suppressor | 17 | 0.475 | 30.897 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
10 |
CD40 | protein found in more fusions | 8 | 0.714 | 3.583 | Glycophorin_A (PF01102, IPR001195): Glycophorin A TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
11 |
CDC37 | protein found in more fusions | 19 | 0.444 | 32.968 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
12 |
CDKN2A | suppressor | 10 | 0.556 | 6.872 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
13 |
CHUK | suppressor | 79 | 0.143 | 1677.117 | Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
14 |
CLTC | oncoprotein | 11 | 0.418 | 11.104 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link |
15 |
COMMD7 | interactor | 4 | 1.000 | 0 | COMM_domain (PF07258): COMM domain |
16 |
COPS3 | interactor | 12 | 0.591 | 8.955 | RasGEF (PF00617, IPR001895, SM00147): RasGEF domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain |
17 |
COPS4 | interactor | 9 | 0.667 | 3.287 | DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat |
18 |
COPS5 | protein found in more fusions | 27 | 0.286 | 127.206 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
19 |
COPS7A | interactor | 7 | 0.810 | 1.383 | PCI (PF01399, IPR000717, SM00088): PCI domain |
20 |
CREBBP | suppressor | 15 | 0.495 | 19.426 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
21 |
CSF2RA | interactor | 1 | 0 | 0 | IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding |
22 |
CSF2RB | interactor | 3 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Tissue_fac (PF01108, IPR003961): Tissue factor |
23 |
CSNK2B | interactor | 11 | 0.422 | 10.590 | CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit |
24 |
CTNNB1 | oncoprotein | 22 | 0.307 | 88.380 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
25 |
CUEDC2 | interactor | 4 | 0.833 | 0.500 | CUE (PF02845, IPR003892, SM00546): CUE domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) |
26 |
CUL1 | suppressor | 25 | 0.312 | 105.010 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
27 |
CUL3 | protein found in more fusions | 30 | 0.204 | 198.801 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
28 |
DHCR24 | interactor | 2 | 1.000 | 0 | FAD_binding_4 (PF01565, IPR006094): FAD binding domain |
29 |
DPP4 | suppressor | 2 | 1.000 | 0 | DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family |
30 |
DUSP1 | suppressor | 4 | 0.667 | 1.154 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
31 |
EGLN3 | suppressor | 6 | 0.900 | 0.154 | 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily |
32 |
EIF2AK2 | oncoprotein | 13 | 0.470 | 14.528 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain |
33 |
ERC1 | oncoprotein | 8 | 0.500 | 6.870 | RBD-FIP (PF09457, IPR019018): FIP domain BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
34 |
FAF1 | protein found in more fusions | 11 | 0.378 | 14.906 | UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain |
35 |
FANCA | oncoprotein | 6 | 0.900 | 0.167 | Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus |
36 |
FKBP4 | interactor | 6 | 0.667 | 1.817 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat |
37 |
FKBP5 | interactor | 10 | 0.644 | 10.541 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain |
38 |
FLNC | interactor | 3 | 0.667 | 0.400 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
39 |
FOXO3 | suppressor | 9 | 0.583 | 6.296 | Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
40 |
GLI1 | suppressor | 6 | 0.733 | 1.889 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
41 |
HNRNPU | interactor | 11 | 0.527 | 11.084 | CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
42 |
HOMER3 | protein found in more fusions | 2 | 0 | 0 | COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper |
43 |
HSP90AA1 | oncoprotein | 42 | 0.234 | 318.516 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
44 |
HSP90AB1 | oncoprotein | 25 | 0.308 | 95.699 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
45 |
HSPB1 | oncoprotein | 17 | 0.450 | 33.401 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
46 |
HTT | protein found in more fusions | 12 | 0.491 | 9.959 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
47 |
IKBKAP | interactor | 9 | 0.571 | 4.137 | IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis |
48 |
IKBKE | interactor | 16 | 0.448 | 25.750 | IncA (PF04156, IPR007285): IncA protein Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon |
49 |
IKBKG | interactor | 61 | 0.180 | 830.513 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
50 |
IRAK1 | interactor | 22 | 0.405 | 63.946 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain |
51 |
IRS1 | interactor | 8 | 0.571 | 6.119 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
52 |
ITCH | interactor | 14 | 0.295 | 29.903 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
53 |
JUN | oncoprotein | 13 | 0.364 | 18.373 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor |
54 |
KEAP1 | oncoprotein | 9 | 0.536 | 4.633 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
55 |
LATS2 | suppressor | 7 | 0.533 | 3.900 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
56 |
MACROD1 | oncoprotein | 5 | 0.500 | 1.956 | DUF1108 (PF06531, IPR009494): Protein of unknown function (DUF1108) DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502) Macro (PF01661, IPR002589, SM00506): Macro domain |
57 |
MAP3K1 | oncoprotein | 10 | 0.472 | 6.614 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal |
58 |
MAP3K11 | interactor | 10 | 0.694 | 2.517 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain |
59 |
MAP3K13 | interactor | 3 | 1.000 | 0 | DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
60 |
MAP3K14 | interactor | 13 | 0.682 | 6.393 | Pkinase (PF00069, IPR000719): Protein kinase domain |
61 |
MAP3K7 | oncoprotein | 32 | 0.312 | 146.368 | Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
62 |
MAPK14 | oncoprotein | 18 | 0.265 | 55.971 | Pkinase (PF00069, IPR000719): Protein kinase domain |
63 |
MAVS | interactor | 13 | 0.591 | 9.248 | Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain |
64 |
MEOX2 | interactor | 3 | 0.667 | 0.400 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
65 |
MTOR | oncoprotein | 16 | 0.486 | 21.568 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
66 |
MUC1 | oncoprotein | 9 | 0.444 | 8.820 | SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter |
67 |
NAA20 | interactor | 1 | 0 | 0 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family |
68 |
NCOA3 | oncoprotein | 11 | 0.509 | 12.572 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
69 |
NEDD4L | suppressor | 2 | 0 | 0 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
70 |
NFKB1 | suppressor | 19 | 0.431 | 37.649 | Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
71 |
NFKBIA | oncoprotein | 26 | 0.314 | 104.268 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
72 |
NFKBIB | interactor | 9 | 0.694 | 6.417 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
73 |
NGFR | suppressor | 5 | 1.000 | 0 | LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit |
74 |
NLRC5 | interactor | 2 | 1.000 | 0 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
75 |
NLRP2 | oncoprotein | 6 | 0.600 | 3.050 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat NACHT (PF05729): NACHT domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
76 |
NLRX1 | interactor | 4 | 0.667 | 1.167 | NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain AAA_22 (PF13401, IPR003593): AAA domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
77 |
PELI1 | interactor | 5 | 0.500 | 1.783 | Pellino (PF04710, IPR006800): Pellino |
78 |
PLK1 | suppressor | 10 | 0.400 | 11.382 | Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region |
79 |
PPARG | suppressor | 13 | 0.424 | 17.989 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region |
80 |
PPM1B | interactor | 7 | 0.619 | 3.736 | PP2C (PF00481, IPR001932): Protein phosphatase 2C PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain |
81 |
PPP1CA | suppressor | 15 | 0.352 | 35.341 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
82 |
PPP1R15A | interactor | 5 | 0.700 | 1.619 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1 CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A |
83 |
PPP2CA | suppressor | 17 | 0.338 | 46.709 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
84 |
PPP2R3C | interactor | 2 | 1.000 | 0 | DUF61 (PF01886, IPR002746): Protein of unknown function DUF61 EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
85 |
PRDX3 | interactor | 8 | 0.429 | 9.400 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
86 |
PRKCA | interactor | 10 | 0.472 | 8.609 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
87 |
PRKCB | suppressor | 10 | 0.611 | 8.694 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
88 |
PRKCD | suppressor | 14 | 0.449 | 17.555 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
89 |
PRKCE | suppressor | 6 | 0.900 | 0.286 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
90 |
PRKCI | interactor | 8 | 0.607 | 5.843 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
91 |
PRKCQ | interactor | 9 | 0.786 | 1.436 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
92 |
PRKDC | protein found in more fusions | 13 | 0.545 | 9.918 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
93 |
PYCARD | suppressor | 5 | 0.833 | 0.400 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain |
94 |
PYGL | interactor | 3 | 1.000 | 0 | Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase |
95 |
RAN | oncoprotein | 1 | 0 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
96 |
RELA | oncoprotein | 27 | 0.283 | 133.718 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
97 |
RICTOR | interactor | 10 | 0.467 | 10.858 | RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5 |
98 |
RIPK1 | protein found in more fusions | 21 | 0.447 | 49.835 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
99 |
ROCK1 | interactor | 1 | 0 | 0 | FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
100 |
RPTOR | protein found in more fusions | 9 | 0.821 | 1.752 | HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain |
101 |
SASH1 | suppressor | 5 | 1.000 | 0 | PGA2 (PF07543, IPR011431): Protein trafficking PGA2 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein |
102 |
SHARPIN | interactor | 8 | 0.952 | 0.222 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Sharpin_PH (PF16764, IPR031912): Sharpin PH domain |
103 |
SLC25A13 | interactor | 2 | 1.000 | 0 | Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
104 |
SLC25A22 | interactor | 2 | 1.000 | 0 | Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257) |
105 |
SRC | oncoprotein | 16 | 0.495 | 19.671 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
106 |
STAP2 | interactor | 2 | 1.000 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
107 |
STK26 | interactor | 5 | 0.500 | 1.583 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain |
108 |
TAB1 | interactor | 14 | 0.462 | 19.398 | PP2C (PF00481, IPR001932): Protein phosphatase 2C |
109 |
TAB2 | oncoprotein | 15 | 0.604 | 11.627 | CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others |
110 |
TFAP2C | interactor | 2 | 1.000 | 0 | TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2 |
111 |
TNF | oncoprotein | 16 | 0.581 | 14.914 | TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family |
112 |
TNFAIP3 | suppressor | 19 | 0.542 | 24.279 | OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain |
113 |
TNFRSF1A | oncoprotein | 23 | 0.424 | 66.884 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
114 |
TNIP2 | interactor | 6 | 0.867 | 0.733 | PCRF (PF03462, IPR005139, SM00937): PCRF domain EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_4 (PF13894): C2H2-type zinc finger CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
115 |
TP53 | suppressor | 41 | 0.195 | 381.987 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
116 |
TP63 | suppressor | 11 | 0.533 | 11.459 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
117 |
TP73 | suppressor | 8 | 0.619 | 3.037 | P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
118 |
TPX2 | interactor | 5 | 0.700 | 0.754 | Aurora-A_bind (PF09041, IPR015128): Aurora-A binding TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259) TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) |
119 |
TRAF1 | oncoprotein | 17 | 0.600 | 19.271 | HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain |
120 |
TRAF2 | interactor | 31 | 0.343 | 130.146 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger) |
121 |
TRAF3IP2 | interactor | 10 | 0.778 | 2.600 | SEFIR (PF08357, IPR013568): SEFIR domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) |
122 |
TRAF6 | protein found in more fusions | 33 | 0.284 | 201.275 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
123 |
TRAPPC9 | protein found in more fusions | 1 | 0 | 0 | PMBR (PF09373, IPR018975): Pseudomurein-binding repeat TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core (PF09454, IPR017916): Vps23 core domain |
124 |
TRIM21 | interactor | 6 | 0.400 | 4.067 | DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
125 |
TRIM27 | oncoprotein | 9 | 0.393 | 13.483 | IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease |
126 |
TRIM40 | interactor | 3 | 1.000 | 0 | Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger CRR7 (PF12095, IPR021954): Protein CHLORORESPIRATORY REDUCTION 7 Dzip-like_N (PF13815, IPR032714): Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
127 |
TRPC4AP | interactor | 8 | 0.750 | 1.832 | Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689) |
128 |
TSC1 | suppressor | 5 | 0.667 | 0.667 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein |
129 |
TWIST1 | oncoprotein | 6 | 0.600 | 3.278 | ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit PRR20 (PF15708, IPR031439): Proline-rich protein family 20 FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2 |
130 |
USP18 | interactor | 6 | 0.933 | 0.182 | TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
131 |
USP4 | oncoprotein | 11 | 0.444 | 17.611 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain |