Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins IKBKB (from a repository: Wed Nov 16 17:42:47 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 131 The number (and %) of the onco-proteins 46 (35.11 %) The number (and %) of the tumor suppressors 29 (22.14 %) Total number of binary PPIs (saturation %) 897 (10.53 %) The number (and %) of affected PPIs 131 (14.60 %) The number of possible different fusions 32 PPI diameter 2 PPI radius 1 The average degree of PPI 12.519 Assortativity coefficient -0.2896 The network average Clustering coefficient 0.548 The number (and %) of a zero Clustering coefficients 7 (5.34 %) The number (and %) of a zero Betweenness Centrality 22 (16.79 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: IKBKB	All fusions : CA436493; CA436950;
Proteins found in more fusions	TAB2 (see 1 fusions); TRAF6 (see 1 fusions); TNF (see 1 fusions); HSP90AA1 (see 2 fusions); PRKCD (see 2 fusions); IKBKB/TRAPPC9 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); NFKB1 (see 2 fusions); FAF1 (see 2 fusions); MAPK14 (see 1 fusions); TNFRSF1A (see 2 fusions); CREBBP (see 5 fusions); NEDD4L (see 3 fusions); CD40 (see 2 fusions); EIF2AK2 (see 1 fusions); PRKDC (see 3 fusions); RIPK1 (see 1 fusions); HTT (see 1 fusions); HSPB1 (see 3 fusions); COPS5 (see 1 fusions); FANCA (see 1 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); CDC37 (see 2 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); PRKCE (see 3 fusions); HOMER3 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	IKBKB	parental protein	131	0.082	9430.723	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
2	AKT1	oncoprotein	31	0.274	165.464	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3	AURKA	oncoprotein	19	0.418	41.026	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
4	BCL10	suppressor	16	0.533	24.773	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
5	BCL2	oncoprotein	11	0.489	9.037	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
6	BIRC3	oncoprotein	16	0.552	17.478	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7	BRAP	interactor	6	0.400	3.833	BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2 DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
8	BTRC	oncoprotein	27	0.329	104.130	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
9	CASP8	suppressor	17	0.475	30.897	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
10	CD40	protein found in more fusions	8	0.714	3.583	Glycophorin_A (PF01102, IPR001195): Glycophorin A TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
11	CDC37	protein found in more fusions	19	0.444	32.968	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
12	CDKN2A	suppressor	10	0.556	6.872	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
13	CHUK	suppressor	79	0.143	1677.117	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
14	CLTC	oncoprotein	11	0.418	11.104	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
15	COMMD7	interactor	4	1.000	0	COMM_domain (PF07258): COMM domain
16	COPS3	interactor	12	0.591	8.955	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain
17	COPS4	interactor	9	0.667	3.287	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
18	COPS5	protein found in more fusions	27	0.286	127.206	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
19	COPS7A	interactor	7	0.810	1.383	PCI (PF01399, IPR000717, SM00088): PCI domain
20	CREBBP	suppressor	15	0.495	19.426	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
21	CSF2RA	interactor	1	0	0	IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
22	CSF2RB	interactor	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Tissue_fac (PF01108, IPR003961): Tissue factor
23	CSNK2B	interactor	11	0.422	10.590	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
24	CTNNB1	oncoprotein	22	0.307	88.380	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
25	CUEDC2	interactor	4	0.833	0.500	CUE (PF02845, IPR003892, SM00546): CUE domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
26	CUL1	suppressor	25	0.312	105.010	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27	CUL3	protein found in more fusions	30	0.204	198.801	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28	DHCR24	interactor	2	1.000	0	FAD_binding_4 (PF01565, IPR006094): FAD binding domain
29	DPP4	suppressor	2	1.000	0	DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
30	DUSP1	suppressor	4	0.667	1.154	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
31	EGLN3	suppressor	6	0.900	0.154	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
32	EIF2AK2	oncoprotein	13	0.470	14.528	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
33	ERC1	oncoprotein	8	0.500	6.870	RBD-FIP (PF09457, IPR019018): FIP domain BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
34	FAF1	protein found in more fusions	11	0.378	14.906	UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain
35	FANCA	oncoprotein	6	0.900	0.167	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
36	FKBP4	interactor	6	0.667	1.817	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
37	FKBP5	interactor	10	0.644	10.541	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
38	FLNC	interactor	3	0.667	0.400	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
39	FOXO3	suppressor	9	0.583	6.296	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
40	GLI1	suppressor	6	0.733	1.889	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
41	HNRNPU	interactor	11	0.527	11.084	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
42	HOMER3	protein found in more fusions	2	0	0	COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
43	HSP90AA1	oncoprotein	42	0.234	318.516	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
44	HSP90AB1	oncoprotein	25	0.308	95.699	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
45	HSPB1	oncoprotein	17	0.450	33.401	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
46	HTT	protein found in more fusions	12	0.491	9.959	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
47	IKBKAP	interactor	9	0.571	4.137	IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
48	IKBKE	interactor	16	0.448	25.750	IncA (PF04156, IPR007285): IncA protein Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
49	IKBKG	interactor	61	0.180	830.513	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
50	IRAK1	interactor	22	0.405	63.946	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
51	IRS1	interactor	8	0.571	6.119	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
52	ITCH	interactor	14	0.295	29.903	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
53	JUN	oncoprotein	13	0.364	18.373	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
54	KEAP1	oncoprotein	9	0.536	4.633	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
55	LATS2	suppressor	7	0.533	3.900	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
56	MACROD1	oncoprotein	5	0.500	1.956	DUF1108 (PF06531, IPR009494): Protein of unknown function (DUF1108) DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502) Macro (PF01661, IPR002589, SM00506): Macro domain
57	MAP3K1	oncoprotein	10	0.472	6.614	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
58	MAP3K11	interactor	10	0.694	2.517	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain
59	MAP3K13	interactor	3	1.000	0	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
60	MAP3K14	interactor	13	0.682	6.393	Pkinase (PF00069, IPR000719): Protein kinase domain
61	MAP3K7	oncoprotein	32	0.312	146.368	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
62	MAPK14	oncoprotein	18	0.265	55.971	Pkinase (PF00069, IPR000719): Protein kinase domain
63	MAVS	interactor	13	0.591	9.248	Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain
64	MEOX2	interactor	3	0.667	0.400	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
65	MTOR	oncoprotein	16	0.486	21.568	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
66	MUC1	oncoprotein	9	0.444	8.820	SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter
67	NAA20	interactor	1	0	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
68	NCOA3	oncoprotein	11	0.509	12.572	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
69	NEDD4L	suppressor	2	0	0	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
70	NFKB1	suppressor	19	0.431	37.649	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
71	NFKBIA	oncoprotein	26	0.314	104.268	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
72	NFKBIB	interactor	9	0.694	6.417	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
73	NGFR	suppressor	5	1.000	0	LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
74	NLRC5	interactor	2	1.000	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
75	NLRP2	oncoprotein	6	0.600	3.050	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat NACHT (PF05729): NACHT domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat
76	NLRX1	interactor	4	0.667	1.167	NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) AAA_16 (PF13191): AAA ATPase domain AAA_22 (PF13401, IPR003593): AAA domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat
77	PELI1	interactor	5	0.500	1.783	Pellino (PF04710, IPR006800): Pellino
78	PLK1	suppressor	10	0.400	11.382	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
79	PPARG	suppressor	13	0.424	17.989	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
80	PPM1B	interactor	7	0.619	3.736	PP2C (PF00481, IPR001932): Protein phosphatase 2C PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
81	PPP1CA	suppressor	15	0.352	35.341	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
82	PPP1R15A	interactor	5	0.700	1.619	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1 CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
83	PPP2CA	suppressor	17	0.338	46.709	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
84	PPP2R3C	interactor	2	1.000	0	DUF61 (PF01886, IPR002746): Protein of unknown function DUF61 EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
85	PRDX3	interactor	8	0.429	9.400	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
86	PRKCA	interactor	10	0.472	8.609	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87	PRKCB	suppressor	10	0.611	8.694	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
88	PRKCD	suppressor	14	0.449	17.555	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
89	PRKCE	suppressor	6	0.900	0.286	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
90	PRKCI	interactor	8	0.607	5.843	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
91	PRKCQ	interactor	9	0.786	1.436	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
92	PRKDC	protein found in more fusions	13	0.545	9.918	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
93	PYCARD	suppressor	5	0.833	0.400	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
94	PYGL	interactor	3	1.000	0	Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
95	RAN	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
96	RELA	oncoprotein	27	0.283	133.718	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
97	RICTOR	interactor	10	0.467	10.858	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
98	RIPK1	protein found in more fusions	21	0.447	49.835	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
99	ROCK1	interactor	1	0	0	FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
100	RPTOR	protein found in more fusions	9	0.821	1.752	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
101	SASH1	suppressor	5	1.000	0	PGA2 (PF07543, IPR011431): Protein trafficking PGA2 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
102	SHARPIN	interactor	8	0.952	0.222	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
103	SLC25A13	interactor	2	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
104	SLC25A22	interactor	2	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
105	SRC	oncoprotein	16	0.495	19.671	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
106	STAP2	interactor	2	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain
107	STK26	interactor	5	0.500	1.583	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
108	TAB1	interactor	14	0.462	19.398	PP2C (PF00481, IPR001932): Protein phosphatase 2C
109	TAB2	oncoprotein	15	0.604	11.627	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
110	TFAP2C	interactor	2	1.000	0	TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
111	TNF	oncoprotein	16	0.581	14.914	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
112	TNFAIP3	suppressor	19	0.542	24.279	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
113	TNFRSF1A	oncoprotein	23	0.424	66.884	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
114	TNIP2	interactor	6	0.867	0.733	PCRF (PF03462, IPR005139, SM00937): PCRF domain EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_4 (PF13894): C2H2-type zinc finger CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
115	TP53	suppressor	41	0.195	381.987	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
116	TP63	suppressor	11	0.533	11.459	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
117	TP73	suppressor	8	0.619	3.037	P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
118	TPX2	interactor	5	0.700	0.754	Aurora-A_bind (PF09041, IPR015128): Aurora-A binding TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259) TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
119	TRAF1	oncoprotein	17	0.600	19.271	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
120	TRAF2	interactor	31	0.343	130.146	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
121	TRAF3IP2	interactor	10	0.778	2.600	SEFIR (PF08357, IPR013568): SEFIR domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
122	TRAF6	protein found in more fusions	33	0.284	201.275	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
123	TRAPPC9	protein found in more fusions	1	0	0	PMBR (PF09373, IPR018975): Pseudomurein-binding repeat TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core (PF09454, IPR017916): Vps23 core domain
124	TRIM21	interactor	6	0.400	4.067	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
125	TRIM27	oncoprotein	9	0.393	13.483	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
126	TRIM40	interactor	3	1.000	0	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger CRR7 (PF12095, IPR021954): Protein CHLORORESPIRATORY REDUCTION 7 Dzip-like_N (PF13815, IPR032714): Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
127	TRPC4AP	interactor	8	0.750	1.832	Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
128	TSC1	suppressor	5	0.667	0.667	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
129	TWIST1	oncoprotein	6	0.600	3.278	ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit PRR20 (PF15708, IPR031439): Proline-rich protein family 20 FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
130	USP18	interactor	6	0.933	0.182	TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
131	USP4	oncoprotein	11	0.444	17.611	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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