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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins9 (29.03 %)
The number (and %) of the tumor suppressors9 (29.03 %)
Total number of binary PPIs (saturation %)67 (14.41 %)
The number (and %) of affected PPIs31 (46.27 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI3.290
Assortativity coefficient-0.3656
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients9 (29.03 %)
The number (and %) of a zero Betweenness Centrality22 (70.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ID3 All fusions
Proteins found in more fusions SMURF2 (see 1 fusions); TCF12 (see 1 fusions); CBFA2T2 (see 1 fusions); PUF60 (see 2 fusions); MLX (see 1 fusions); TCF3 (see 3 fusions); MYOD1 (see 1 fusions); VHL (see 1 fusions); ID3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ID3parental protein310.048790.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
2 ATF3suppressor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
3 CBFA2T2protein found in more fusions40.6671.000NHR2 (PF08788, IPR014896): NHR2 domain like
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1
4 CDK2suppressor70.3339.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 CNOT3suppressor100NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
Not3 (PF04065, IPR007207): Not1 N-terminal domain, CCR4-Not complex component
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
6 CSKinteractor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 E2F4suppressor30.6670.667E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
8 FAM74A1interactor100NA
9 FHL2oncoprotein90.25020.667LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
10 GATA4suppressor21.0000Apidaecin (PF00807, IPR004828): Apidaecin
GATA-N (PF05349, IPR008013): GATA-type transcription activator, N-terminal
DUF2387 (PF09526, IPR012658): Probable metal-binding protein (DUF2387)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
11 GNB2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
12 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
13 MLXprotein found in more fusions200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3322 (PF11795, IPR024537): Uncharacterized protein conserved in bacteria N-term (DUF3322)
14 MYOD1oncoprotein41.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
15 NKX2-5oncoprotein21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
16 PAX5suppressor100PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
17 PRDM14interactor21.0000Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
18 PUF60protein found in more fusions40.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
19 RND1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
20 SAP30interactor100Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
21 SMURF2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
22 SREBF1interactor200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
23 TCEB1oncoprotein21.0000Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
24 TCF12oncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
25 TCF3suppressor50.8330.667CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
26 TCF4suppressor50.6003.667CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
27 UNKinteractor100MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
28 VHLsuppressor40.6671.000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
29 ZNF3interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
30 ZNF408interactor31.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
31 ZNF626interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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