Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: HSP90AB1 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 288 The number (and %) of the onco-proteins 110 (38.19 %) The number (and %) of the tumor suppressors 18 (6.25 %) Total number of binary PPIs (saturation %) 4538 (10.98 %) The number (and %) of affected PPIs 288 (6.35 %) The number of possible different fusions 66 PPI diameter 2 PPI radius 1 The average degree of PPI 30.729 Assortativity coefficient -0.1689 The network average Clustering coefficient 0.454 The number (and %) of a zero Clustering coefficients 2 (0.69 %) The number (and %) of a zero Betweenness Centrality 9 (3.12 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HSP90AB1	All fusions
Proteins found in more fusions	GRK5 (see 2 fusions); U2AF2 (see 2 fusions); LGALS3BP (see 2 fusions); UBA1 (see 2 fusions); HDAC5 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); CUL4A (see 4 fusions); HUWE1 (see 2 fusions); RPS4X/AHSA1 (see 1 fusions); GTF2E2 (see 2 fusions); BAG3 (see 4 fusions); STUB1 (see 1 fusions); HSPB1 (see 2 fusions); SHC1 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions); TUBG1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CUL3 (see 1 fusions); IVNS1ABP (see 2 fusions); MAPRE1 (see 1 fusions); ACTG1 (see 4 fusions); ACTG1/MEPCE (see 1 fusions); HTT (see 1 fusions); UBC (see 1 fusions); TP53 (see 3 fusions); FUS/PKM (see 1 fusions); MCM7 (see 2 fusions); CRY2 (see 3 fusions); ACTN1 (see 3 fusions); NFKB1 (see 2 fusions); FN1/RPL6 (see 1 fusions); CDK9 (see 2 fusions); HSP90AA1/GNAI2 (see 1 fusions); NPM1 (see 1 fusions); HSF1 (see 3 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); PINK1 (see 3 fusions); LGALS3 (see 2 fusions); PRKDC (see 3 fusions); IKBKB (see 2 fusions); STAT1 (see 1 fusions); SNW1 (see 1 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); JAK2 (see 3 fusions); HSP90AB1 (see 1 fusions); LDHA/SKI (see 3 fusions); CALR (see 6 fusions); NTRK1/TPM3 (see 3 fusions); REV1 (see 1 fusions); ERBB3 (see 1 fusions); CSNK2A1 (see 1 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); PRKCE (see 3 fusions); TNNT1 (see 1 fusions); GAPDH (see 2 fusions); CUL7 (see 2 fusions); SKI (see 1 fusions); LRRK2 (see 1 fusions); ATP5A1/HUWE1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); BRAF (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	HSP90AB1	parental protein	288	0.101	28827.178	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
2	AARS	interactor	13	0.436	10.248	DHHA1 (PF02272, IPR003156): DHHA1 domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3	ACD	interactor	16	0.417	17.573	TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
4	ACTG1	protein found in more fusions	31	0.294	102.400	Actin (PF00022, IPR004000, SM00268): Actin
5	ACTN1	protein found in more fusions	23	0.459	28.743	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
6	AGO3	interactor	16	0.400	20.245	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
7	AGO4	interactor	10	0.556	5.172	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
8	AHSA1	protein found in more fusions	42	0.312	188.852	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
9	AIP	suppressor	11	0.564	6.948	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
10	AIRE	interactor	15	0.462	7.696	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
11	AKT1	oncoprotein	37	0.314	128.792	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
12	ALDOA	interactor	29	0.508	30.978	Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
13	ARRB2	interactor	47	0.282	188.421	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
14	ATP5A1	protein found in more fusions	56	0.327	269.611	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
15	ATP5B	interactor	39	0.379	119.716	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain NACHT (PF05729): NACHT domain
16	ATP6V1B2	interactor	11	0.509	3.149	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
17	AURKA	oncoprotein	39	0.343	128.809	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
18	AURKB	interactor	33	0.385	91.298	Pkinase (PF00069, IPR000719): Protein kinase domain
19	AURKC	interactor	6	0.867	0.276	Pkinase (PF00069, IPR000719): Protein kinase domain
20	BAG3	oncoprotein	43	0.217	243.472	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
21	BRAF	oncoprotein	14	0.564	8.259	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
22	C12orf10	interactor	7	0.714	0.913	UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
23	CACYBP	interactor	14	0.500	11.976	CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
24	CALR	oncoprotein	22	0.429	33.085	Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain
25	CAMKMT	interactor	6	0.800	0.170	Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
26	CAND1	interactor	69	0.386	290.238	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
27	CAP1	interactor	12	0.691	2.966	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
28	CCDC117	interactor	6	0.733	0.460	CCDC117 (PF15810, IPR031630): Coiled-coil domain-containing protein 117
29	CCDC8	interactor	66	0.265	344.787	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
30	CCT2	interactor	54	0.315	234.729	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
31	CD4	suppressor	18	0.463	12.032	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
32	CDC37	protein found in more fusions	66	0.185	742.587	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
33	CDC37L1	interactor	14	0.484	19.608	CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
34	CDC5L	interactor	58	0.323	287.192	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
35	CDK13	interactor	16	0.458	15.631	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
36	CDK15	interactor	9	0.639	3.152	Pkinase (PF00069, IPR000719): Protein kinase domain ACT_5 (PF13710): ACT domain
37	CDK18	oncoprotein	14	0.396	18.832	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
38	CDK2	oncoprotein	84	0.216	808.732	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
39	CDK3	interactor	11	0.473	6.944	Pkinase (PF00069, IPR000719): Protein kinase domain
40	CDK4	oncoprotein	19	0.491	19.492	Pkinase (PF00069, IPR000719): Protein kinase domain
41	CDK5	oncoprotein	14	0.564	7.854	Pkinase (PF00069, IPR000719): Protein kinase domain
42	CDK7	oncoprotein	13	0.409	13.466	Pkinase (PF00069, IPR000719): Protein kinase domain
43	CDK9	protein found in more fusions	27	0.332	79.894	Pkinase (PF00069, IPR000719): Protein kinase domain
44	CDKL4	interactor	4	0.833	0.143	Pkinase (PF00069, IPR000719): Protein kinase domain
45	CDKN2A	oncoprotein	28	0.434	45.265	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
46	CEP250	interactor	35	0.466	48.373	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
47	CEP76	interactor	15	0.429	13.153	Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
48	CFTR	suppressor	27	0.311	72.224	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
49	CHORDC1	interactor	16	0.495	18.012	CHORD (PF04968, IPR007051): CHORD CS (PF04969, IPR007052): CS domain
50	CLIC4	oncoprotein	9	0.583	3.740	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
51	COPS4	interactor	19	0.450	17.802	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
52	CRISPLD2	interactor	1	0	0	LCCL (PF03815, IPR004043, SM00603): LCCL domain CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
53	CRK	oncoprotein	24	0.395	49.776	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
54	CRY2	protein found in more fusions	28	0.333	33.942	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
55	CSNK2A1	oncoprotein	39	0.314	156.312	Pkinase (PF00069, IPR000719): Protein kinase domain
56	CTNNB1	oncoprotein	36	0.283	134.756	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
57	CUL1	oncoprotein	71	0.339	366.395	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
58	CUL2	suppressor	48	0.405	130.873	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
59	CUL3	protein found in more fusions	100	0.238	997.584	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
60	CUL4A	protein found in more fusions	37	0.448	73.987	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
61	CUL4B	oncoprotein	47	0.446	112.781	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
62	CUL5	suppressor	54	0.391	196.911	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
63	CUL7	protein found in more fusions	67	0.262	330.828	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
64	CYP17A1	interactor	1	0	0	p450 (PF00067, IPR001128): Cytochrome P450
65	DBN1	oncoprotein	29	0.323	94.789	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
66	DCTN2	interactor	19	0.418	28.591	Dynamitin (PF04912): Dynamitin
67	DCUN1D1	interactor	36	0.460	75.325	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
68	DDOST	interactor	18	0.379	30.632	DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
69	DDX24	interactor	20	0.495	27.494	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tti2 (PF10521, IPR018870): Tti2 family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
70	DNAJA2	interactor	28	0.505	31.856	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
71	DNAJC7	interactor	25	0.457	44.013	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
72	EED	suppressor	36	0.279	125.375	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
73	EEF2	interactor	56	0.415	202.551	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
74	EGFR	oncoprotein	73	0.226	727.298	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
75	EIF3H	interactor	13	0.564	7.176	Androgen_recep (PF02166, IPR001103): Androgen receptor JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease NHS (PF15273, IPR024845): NHS-like
76	EIF4A1	interactor	34	0.364	70.714	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
77	ERBB3	oncoprotein	19	0.588	13.434	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
78	ESRRB	suppressor	19	0.538	10.247	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
79	FASN	interactor	34	0.333	57.241	Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain KR (PF08659, IPR013968, SM00130): KR domain L27 (PF02828, IPR014775, SM00569): L27 domain Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site Thioesterase (PF00975, IPR001031): Thioesterase domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
80	FBXO6	interactor	59	0.237	340.698	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
81	FCHSD2	interactor	6	0.600	0.967	Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) Rit1_C (PF17184): Rit1 N-terminal domain
82	FGFR3	oncoprotein	7	0.800	0.331	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
83	FKBP4	interactor	22	0.420	37.390	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
84	FKBP5	interactor	38	0.206	267.913	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
85	FKBP6	interactor	8	0.464	6.469	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
86	FKBPL	interactor	6	0.600	0.629	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat
87	FLNA	suppressor	33	0.375	77.538	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
88	FN1	oncoprotein	82	0.238	612.881	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
89	FUS	oncoprotein	57	0.407	191.952	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
90	GAN	interactor	25	0.424	19.319	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
91	GAPDH	oncoprotein	54	0.365	177.085	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
92	GNAI2	oncoprotein	12	0.379	8.861	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
93	GPN1	interactor	12	0.424	12.038	ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein NB-ARC (PF00931, IPR002182): NB-ARC domain
94	GRB2	oncoprotein	48	0.359	209.881	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
95	GRK2	interactor	4	0.833	0.125	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
96	GRK5	protein found in more fusions	19	0.288	27.342	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
97	GRK6	interactor	3	0.667	0.047	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
98	GTF2E2	protein found in more fusions	6	0.500	1.201	TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
99	HADHB	interactor	18	0.405	16.348	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
100	HAX1	interactor	16	0.383	26.339	Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
101	HDAC5	protein found in more fusions	61	0.277	242.982	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
102	HDAC6	oncoprotein	35	0.351	101.742	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
103	HGH1	interactor	3	1.000	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383) DUF384 (PF04064, IPR007206): Domain of unknown function (DUF384)
104	HIF1A	suppressor	21	0.438	28.394	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
105	HLA-DRA	interactor	7	0.857	0.156	MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
106	HLA-DRB1	interactor	10	0.778	1.775	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
107	HLA-DRB3	interactor	6	0.800	0.156	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
108	HLA-DRB4	interactor	5	0.700	0.156	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
109	HLA-DRB5	interactor	8	0.679	2.516	MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
110	HNRNPA1	interactor	76	0.325	513.466	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
111	HSF1	protein found in more fusions	17	0.458	18.124	DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
112	HSP90AA1	oncoprotein	201	0.124	9227.218	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
113	HSP90AA2P	oncoprotein	10	0.622	4.698	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
114	HSP90AA5P	interactor	22	0.229	81.296	NA
115	HSPA1A	interactor	71	0.264	472.384	HSP70 (PF00012, IPR013126): Hsp70 protein
116	HSPA4	interactor	65	0.249	489.892	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
117	HSPA5	oncoprotein	101	0.247	1063.906	HSP70 (PF00012, IPR013126): Hsp70 protein
118	HSPA8	oncoprotein	114	0.200	1865.926	HSP70 (PF00012, IPR013126): Hsp70 protein
119	HSPB1	oncoprotein	53	0.337	240.556	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
120	HSPD1	oncoprotein	67	0.278	373.800	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
121	HSPE1	interactor	16	0.592	6.628	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
122	HSPH1	oncoprotein	23	0.486	31.158	HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
123	HTT	protein found in more fusions	15	0.571	6.499	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
124	HUWE1	oncoprotein	75	0.298	441.627	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
125	IARS2	interactor	6	0.733	1.175	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
126	IFIT1	interactor	4	0.667	0.600	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268) TPR_19 (PF14559): Tetratricopeptide repeat
127	IKBKB	protein found in more fusions	25	0.308	76.021	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
128	IKBKG	interactor	31	0.292	113.977	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
129	INPPL1	oncoprotein	19	0.573	14.207	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain
130	IP6K2	interactor	4	0.667	0.833	IPK (PF03770, IPR005522): Inositol polyphosphate kinase
131	IPO7	interactor	19	0.398	18.666	Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Xpo1 (PF08389, IPR013598): Exportin 1-like protein DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
132	IQGAP1	interactor	45	0.314	193.227	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
133	ISG15	suppressor	33	0.261	91.610	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
134	ITGA4	interactor	64	0.280	281.009	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
135	IVNS1ABP	protein found in more fusions	8	0.714	0.619	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
136	JAK2	oncoprotein	10	0.722	3.248	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
137	KEAP1	oncoprotein	15	0.451	12.253	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
138	KHDRBS2	interactor	3	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
139	KPNA2	interactor	30	0.324	74.320	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
140	LATS1	oncoprotein	10	0.311	12.681	Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
141	LATS2	oncoprotein	11	0.422	7.974	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
142	LDHA	protein found in more fusions	36	0.331	92.482	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
143	LGALS3	oncoprotein	10	0.333	7.135	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
144	LGALS3BP	oncoprotein	40	0.444	90.498	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
145	LRRK2	oncoprotein	23	0.351	36.953	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
146	MAGED2	interactor	22	0.498	25.739	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
147	MAP3K11	interactor	9	0.750	1.472	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain
148	MAPK6	oncoprotein	17	0.225	33.810	Pkinase (PF00069, IPR000719): Protein kinase domain
149	MAPK7	oncoprotein	16	0.600	4.213	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
150	MAPRE1	oncoprotein	28	0.271	80.415	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
151	MCM2	oncoprotein	105	0.247	1114.954	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
152	MCM5	oncoprotein	37	0.374	99.904	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
153	MCM6	interactor	23	0.381	34.827	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
154	MCM7	protein found in more fusions	33	0.238	89.052	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
155	MDH1	interactor	11	0.545	3.398	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
156	MDM2	oncoprotein	45	0.288	242.196	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
157	MEPCE	protein found in more fusions	18	0.477	13.752	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
158	MET	oncoprotein	12	0.515	6.733	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain
159	METTL21B	interactor	14	0.571	4.822	Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
160	METTL22	interactor	4	1.000	0	Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
161	MGMT	interactor	12	0.470	8.672	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
162	MKNK1	interactor	4	0.667	0.381	Pkinase (PF00069, IPR000719): Protein kinase domain
163	MTHFD1	interactor	25	0.413	34.185	FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
164	MVP	oncoprotein	14	0.321	16.868	Vault (PF01505, IPR002499): Major Vault Protein repeat DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543) MVP_shoulder (PF11978, IPR021870): Shoulder domain
165	MYH9	oncoprotein	45	0.314	206.071	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
166	MYL6	interactor	15	0.419	15.835	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
167	MYLK4	interactor	4	0.833	0.133	Pkinase (PF00069, IPR000719): Protein kinase domain
168	MYO19	interactor	11	0.600	5.931	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
169	NANS	interactor	7	0.619	1.280	NeuB (PF03102, IPR013132): NeuB family SAF (PF08666, IPR013974, SM00858): SAF domain
170	NFKB1	oncoprotein	17	0.408	17.359	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
171	NOS2	interactor	32	0.391	44.078	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
172	NPHP4	interactor	13	0.449	17.982	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
173	NPM1	oncoprotein	90	0.342	599.752	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
174	NPM3	interactor	6	0.667	0.821	Nucleoplasmin (PF03066): Nucleoplasmin
175	NR4A1	suppressor	10	0.422	6.408	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
176	NTRK1	oncoprotein	139	0.178	2710.502	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
177	NUMA1	oncoprotein	18	0.379	22.777	Colicin (PF01024, IPR000293): Colicin pore forming domain Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tup_N (PF08581, IPR013890): Tup N-terminal CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
178	NUP107	interactor	13	0.526	7.101	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
179	NUP85	interactor	8	0.643	1.609	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
180	NXF1	interactor	57	0.225	409.262	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
181	OBSL1	protein found in more fusions	63	0.297	260.064	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
182	P4HB	interactor	28	0.501	29.848	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
183	PAN2	interactor	48	0.308	167.959	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
184	PARK2	suppressor	54	0.304	236.676	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
185	PCBP1	oncoprotein	37	0.302	112.560	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
186	PGK1	interactor	27	0.510	29.312	PGK (PF00162, IPR001576): Phosphoglycerate kinase
187	PHB	oncoprotein	36	0.379	83.824	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
188	PINK1	protein found in more fusions	14	0.577	4.471	Pkinase (PF00069, IPR000719): Protein kinase domain
189	PKM	oncoprotein	52	0.296	269.077	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
190	POT1	interactor	23	0.307	42.216	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
191	PPID	interactor	17	0.529	13.987	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
192	PPP5C	interactor	19	0.497	20.476	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
193	PPP6R3	interactor	12	0.439	14.234	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
194	PRKAA1	suppressor	15	0.571	8.434	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
195	PRKACA	interactor	14	0.363	17.611	Pkinase (PF00069, IPR000719): Protein kinase domain
196	PRKACB	interactor	8	0.714	1.872	Pkinase (PF00069, IPR000719): Protein kinase domain
197	PRKCE	suppressor	12	0.455	11.519	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
198	PRKDC	protein found in more fusions	52	0.216	340.041	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
199	PSAT1	interactor	10	0.511	6.222	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
200	PSKH2	interactor	5	0.800	0.276	Pkinase (PF00069, IPR000719): Protein kinase domain
201	PSMA2	interactor	23	0.472	27.482	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
202	PSMA3	interactor	44	0.368	128.898	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
203	PSMB5	interactor	16	0.492	9.765	Proteasome (PF00227, IPR001353): Proteasome subunit
204	PSMD1	interactor	26	0.471	32.235	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
205	PTEN	oncoprotein	35	0.269	127.247	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
206	PTGES3	interactor	28	0.313	83.750	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
207	RAD21	oncoprotein	28	0.344	56.833	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
208	REV1	protein found in more fusions	5	0.833	0.036	IMS (PF00817, IPR001126): impB/mucB/samB family Cdd1 (PF11731, IPR021725): Pathogenicity locus IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain REV1_C (PF16727, IPR031991): DNA repair protein REV1 C-terminal domain
209	RHOBTB2	oncoprotein	6	0.800	0.209	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ras (PF00071, IPR001806, SM00173): Ras family SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
210	RPAP3	interactor	15	0.429	23.872	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
211	RPL10A	interactor	45	0.617	36.858	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
212	RPL14	interactor	48	0.523	103.178	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
213	RPL17	interactor	37	0.623	48.190	Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
214	RPL3	interactor	47	0.562	84.311	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
215	RPL32	interactor	30	0.759	16.163	Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
216	RPL5	oncoprotein	51	0.548	77.221	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
217	RPL6	protein found in more fusions	53	0.510	104.078	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
218	RPL7	interactor	54	0.485	154.577	Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
219	RPL7A	protein found in more fusions	43	0.585	58.300	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
220	RPLP0	interactor	63	0.429	202.005	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
221	RPLP0P6	interactor	24	0.761	11.999	NA
222	RPS16	interactor	53	0.491	122.207	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
223	RPS2	interactor	59	0.405	199.166	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
224	RPS23	interactor	37	0.640	33.915	Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
225	RPS26	interactor	30	0.685	31.192	Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
226	RPS3A	interactor	56	0.515	94.936	Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
227	RPS4X	protein found in more fusions	69	0.404	246.186	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
228	RPS6	interactor	56	0.466	143.079	Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
229	RPS6KA1	oncoprotein	8	0.679	1.183	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
230	RPS6KB2	interactor	38	0.277	126.839	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
231	RPSA	interactor	49	0.462	172.785	Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
232	SCARNA22	interactor	9	0.500	3.661	NA
233	SENP3	interactor	22	0.485	25.009	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
234	SGTA	interactor	9	0.722	1.108	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
235	SHC1	oncoprotein	34	0.375	99.220	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
236	SKI	oncoprotein	23	0.312	34.956	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
237	SLC33A1	interactor	3	0.667	0.222	Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
238	SMYD3	oncoprotein	5	0.600	0.902	SET (PF00856, IPR001214, SM00317): SET domain
239	SNRPD1	interactor	26	0.440	38.732	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain
240	SNW1	protein found in more fusions	48	0.345	206.673	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
241	SPTAN1	oncoprotein	33	0.314	123.749	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
242	SSR4	interactor	18	0.510	11.409	TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta) OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
243	STAT1	suppressor	20	0.316	38.783	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
244	STIP1	interactor	47	0.283	262.357	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
245	STK33	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain PARM (PF17061, IPR031431): PARM
246	STOML2	oncoprotein	13	0.705	1.896	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769) Band_7_C (PF16200, IPR032435): C-terminal region of band_7
247	STUB1	suppressor	44	0.309	215.430	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
248	SUGT1	interactor	21	0.338	58.670	CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
249	SUMO2	interactor	12	0.382	5.201	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
250	TAF10	interactor	7	0.333	4.334	TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
251	TAF1D	interactor	4	0.833	0.143	TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
252	TCP1	interactor	43	0.338	122.499	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
253	TERF1	interactor	39	0.223	186.545	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
254	TINF2	interactor	18	0.375	25.840	TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
255	TMOD4	interactor	3	1.000	0	Tropomodulin (PF03250, IPR004934): Tropomodulin LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
256	TNNT1	protein found in more fusions	4	0.667	0.133	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
257	TOMM34	interactor	19	0.374	32.485	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919)
258	TP53	oncoprotein	85	0.257	831.915	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
259	TP63	suppressor	15	0.440	8.804	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
260	TPM3	oncoprotein	30	0.325	88.727	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
261	TRAF2	interactor	16	0.305	32.853	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
262	TRAF3IP1	interactor	14	0.407	14.184	MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
263	TRIM8	interactor	4	1.000	0	dCache_2 (PF08269, IPR004010, SM01049): Cache domain CASP_C (PF08172, IPR012955): CASP C terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
264	TTC4	suppressor	13	0.474	22.532	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
265	TUBA1A	oncoprotein	51	0.256	288.005	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
266	TUBA1C	interactor	56	0.284	250.630	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
267	TUBB	interactor	82	0.253	657.296	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
268	TUBG1	protein found in more fusions	50	0.420	129.983	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
269	TUBGCP2	interactor	17	0.662	5.856	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
270	TUBGCP3	interactor	23	0.514	18.098	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
271	U2AF2	protein found in more fusions	53	0.353	201.319	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
272	UBA1	protein found in more fusions	26	0.343	39.379	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
273	UBA52	interactor	15	0.410	15.889	Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
274	UBASH3B	interactor	22	0.557	17.142	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
275	UBC	protein found in more fusions	78	0.236	737.398	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
276	UBE3A	oncoprotein	17	0.417	19.363	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
277	UBL4A	interactor	51	0.333	179.604	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
278	UNC45B	interactor	3	1.000	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central TPR_16 (PF13432): Tetratricopeptide repeat HEAT_2 (PF13646): HEAT repeats
279	UNK	interactor	31	0.239	111.314	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
280	UQCRC2	oncoprotein	19	0.538	15.128	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
281	USP50	interactor	6	0.733	0.303	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
282	VCAM1	interactor	64	0.275	266.661	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
283	VCP	protein found in more fusions	84	0.286	721.969	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
284	WASL	interactor	8	0.643	3.458	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
285	XPO1	interactor	73	0.216	830.430	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
286	XRCC3	oncoprotein	10	0.356	8.923	Rad51 (PF08423, IPR013632): Rad51 RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
287	YWHAB	interactor	32	0.347	86.566	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
288	YWHAE	oncoprotein	66	0.277	478.578	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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