1 |
HSP90AB1 | parental protein | 288 | 0.101 | 28827.178 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
2 |
AARS | interactor | 13 | 0.436 | 10.248 | DHHA1 (PF02272, IPR003156): DHHA1 domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain |
3 |
ACD | interactor | 16 | 0.417 | 17.573 | TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD |
4 |
ACTG1 | protein found in more fusions | 31 | 0.294 | 102.400 | Actin (PF00022, IPR004000, SM00268): Actin |
5 |
ACTN1 | protein found in more fusions | 23 | 0.459 | 28.743 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation |
6 |
AGO3 | interactor | 16 | 0.400 | 20.245 | ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain |
7 |
AGO4 | interactor | 10 | 0.556 | 5.172 | ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain |
8 |
AHSA1 | protein found in more fusions | 42 | 0.312 | 188.852 | Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein |
9 |
AIP | suppressor | 11 | 0.564 | 6.948 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat |
10 |
AIRE | interactor | 15 | 0.462 | 7.696 | PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain |
11 |
AKT1 | oncoprotein | 37 | 0.314 | 128.792 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
12 |
ALDOA | interactor | 29 | 0.508 | 30.978 | Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I |
13 |
ARRB2 | interactor | 47 | 0.282 | 188.421 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
14 |
ATP5A1 | protein found in more fusions | 56 | 0.327 | 269.611 | ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain |
15 |
ATP5B | interactor | 39 | 0.379 | 119.716 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain NACHT (PF05729): NACHT domain |
16 |
ATP6V1B2 | interactor | 11 | 0.509 | 3.149 | ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481) |
17 |
AURKA | oncoprotein | 39 | 0.343 | 128.809 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
18 |
AURKB | interactor | 33 | 0.385 | 91.298 | Pkinase (PF00069, IPR000719): Protein kinase domain |
19 |
AURKC | interactor | 6 | 0.867 | 0.276 | Pkinase (PF00069, IPR000719): Protein kinase domain |
20 |
BAG3 | oncoprotein | 43 | 0.217 | 243.472 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
21 |
BRAF | oncoprotein | 14 | 0.564 | 8.259 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
22 |
C12orf10 | interactor | 7 | 0.714 | 0.913 | UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160) |
23 |
CACYBP | interactor | 14 | 0.500 | 11.976 | CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal |
24 |
CALR | oncoprotein | 22 | 0.429 | 33.085 | Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain |
25 |
CAMKMT | interactor | 6 | 0.800 | 0.170 | Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase |
26 |
CAND1 | interactor | 69 | 0.386 | 290.238 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
27 |
CAP1 | interactor | 12 | 0.691 | 2.966 | CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator |
28 |
CCDC117 | interactor | 6 | 0.733 | 0.460 | CCDC117 (PF15810, IPR031630): Coiled-coil domain-containing protein 117 |
29 |
CCDC8 | interactor | 66 | 0.265 | 344.787 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
30 |
CCT2 | interactor | 54 | 0.315 | 234.729 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
31 |
CD4 | suppressor | 18 | 0.463 | 12.032 | ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region |
32 |
CDC37 | protein found in more fusions | 66 | 0.185 | 742.587 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
33 |
CDC37L1 | interactor | 14 | 0.484 | 19.608 | CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain |
34 |
CDC5L | interactor | 58 | 0.323 | 287.192 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
35 |
CDK13 | interactor | 16 | 0.458 | 15.631 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family |
36 |
CDK15 | interactor | 9 | 0.639 | 3.152 | Pkinase (PF00069, IPR000719): Protein kinase domain ACT_5 (PF13710): ACT domain |
37 |
CDK18 | oncoprotein | 14 | 0.396 | 18.832 | APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain |
38 |
CDK2 | oncoprotein | 84 | 0.216 | 808.732 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
39 |
CDK3 | interactor | 11 | 0.473 | 6.944 | Pkinase (PF00069, IPR000719): Protein kinase domain |
40 |
CDK4 | oncoprotein | 19 | 0.491 | 19.492 | Pkinase (PF00069, IPR000719): Protein kinase domain |
41 |
CDK5 | oncoprotein | 14 | 0.564 | 7.854 | Pkinase (PF00069, IPR000719): Protein kinase domain |
42 |
CDK7 | oncoprotein | 13 | 0.409 | 13.466 | Pkinase (PF00069, IPR000719): Protein kinase domain |
43 |
CDK9 | protein found in more fusions | 27 | 0.332 | 79.894 | Pkinase (PF00069, IPR000719): Protein kinase domain |
44 |
CDKL4 | interactor | 4 | 0.833 | 0.143 | Pkinase (PF00069, IPR000719): Protein kinase domain |
45 |
CDKN2A | oncoprotein | 28 | 0.434 | 45.265 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
46 |
CEP250 | interactor | 35 | 0.466 | 48.373 | ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
47 |
CEP76 | interactor | 15 | 0.429 | 13.153 | Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain |
48 |
CFTR | suppressor | 27 | 0.311 | 72.224 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
49 |
CHORDC1 | interactor | 16 | 0.495 | 18.012 | CHORD (PF04968, IPR007051): CHORD CS (PF04969, IPR007052): CS domain |
50 |
CLIC4 | oncoprotein | 9 | 0.583 | 3.740 | GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain |
51 |
COPS4 | interactor | 19 | 0.450 | 17.802 | DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat |
52 |
CRISPLD2 | interactor | 1 | 0 | 0 | LCCL (PF03815, IPR004043, SM00603): LCCL domain CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family |
53 |
CRK | oncoprotein | 24 | 0.395 | 49.776 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
54 |
CRY2 | protein found in more fusions | 28 | 0.333 | 33.942 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
55 |
CSNK2A1 | oncoprotein | 39 | 0.314 | 156.312 | Pkinase (PF00069, IPR000719): Protein kinase domain |
56 |
CTNNB1 | oncoprotein | 36 | 0.283 | 134.756 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
57 |
CUL1 | oncoprotein | 71 | 0.339 | 366.395 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
58 |
CUL2 | suppressor | 48 | 0.405 | 130.873 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
59 |
CUL3 | protein found in more fusions | 100 | 0.238 | 997.584 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
60 |
CUL4A | protein found in more fusions | 37 | 0.448 | 73.987 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
61 |
CUL4B | oncoprotein | 47 | 0.446 | 112.781 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
62 |
CUL5 | suppressor | 54 | 0.391 | 196.911 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
63 |
CUL7 | protein found in more fusions | 67 | 0.262 | 330.828 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
64 |
CYP17A1 | interactor | 1 | 0 | 0 | p450 (PF00067, IPR001128): Cytochrome P450 |
65 |
DBN1 | oncoprotein | 29 | 0.323 | 94.789 | Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c |
66 |
DCTN2 | interactor | 19 | 0.418 | 28.591 | Dynamitin (PF04912): Dynamitin |
67 |
DCUN1D1 | interactor | 36 | 0.460 | 75.325 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
68 |
DDOST | interactor | 18 | 0.379 | 30.632 | DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta |
69 |
DDX24 | interactor | 20 | 0.495 | 27.494 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tti2 (PF10521, IPR018870): Tti2 family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
70 |
DNAJA2 | interactor | 28 | 0.505 | 31.856 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
71 |
DNAJC7 | interactor | 25 | 0.457 | 44.013 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat |
72 |
EED | suppressor | 36 | 0.279 | 125.375 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
73 |
EEF2 | interactor | 56 | 0.415 | 202.551 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
74 |
EGFR | oncoprotein | 73 | 0.226 | 727.298 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
75 |
EIF3H | interactor | 13 | 0.564 | 7.176 | Androgen_recep (PF02166, IPR001103): Androgen receptor JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease NHS (PF15273, IPR024845): NHS-like |
76 |
EIF4A1 | interactor | 34 | 0.364 | 70.714 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
77 |
ERBB3 | oncoprotein | 19 | 0.588 | 13.434 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
78 |
ESRRB | suppressor | 19 | 0.538 | 10.247 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
79 |
FASN | interactor | 34 | 0.333 | 57.241 | Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain KR (PF08659, IPR013968, SM00130): KR domain L27 (PF02828, IPR014775, SM00569): L27 domain Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site Thioesterase (PF00975, IPR001031): Thioesterase domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension |
80 |
FBXO6 | interactor | 59 | 0.237 | 340.698 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
81 |
FCHSD2 | interactor | 6 | 0.600 | 0.967 | Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) Rit1_C (PF17184): Rit1 N-terminal domain |
82 |
FGFR3 | oncoprotein | 7 | 0.800 | 0.331 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
83 |
FKBP4 | interactor | 22 | 0.420 | 37.390 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat |
84 |
FKBP5 | interactor | 38 | 0.206 | 267.913 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain |
85 |
FKBP6 | interactor | 8 | 0.464 | 6.469 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat |
86 |
FKBPL | interactor | 6 | 0.600 | 0.629 | BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat |
87 |
FLNA | suppressor | 33 | 0.375 | 77.538 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat |
88 |
FN1 | oncoprotein | 82 | 0.238 | 612.881 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
89 |
FUS | oncoprotein | 57 | 0.407 | 191.952 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
90 |
GAN | interactor | 25 | 0.424 | 19.319 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif |
91 |
GAPDH | oncoprotein | 54 | 0.365 | 177.085 | Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein |
92 |
GNAI2 | oncoprotein | 12 | 0.379 | 8.861 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
93 |
GPN1 | interactor | 12 | 0.424 | 12.038 | ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein NB-ARC (PF00931, IPR002182): NB-ARC domain |
94 |
GRB2 | oncoprotein | 48 | 0.359 | 209.881 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
95 |
GRK2 | interactor | 4 | 0.833 | 0.125 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
96 |
GRK5 | protein found in more fusions | 19 | 0.288 | 27.342 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
97 |
GRK6 | interactor | 3 | 0.667 | 0.047 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
98 |
GTF2E2 | protein found in more fusions | 6 | 0.500 | 1.201 | TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain VCX_VCY (PF15231, IPR026653): Variable charge X/Y family |
99 |
HADHB | interactor | 18 | 0.405 | 16.348 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
100 |
HAX1 | interactor | 16 | 0.383 | 26.339 | Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein |
101 |
HDAC5 | protein found in more fusions | 61 | 0.277 | 242.982 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
102 |
HDAC6 | oncoprotein | 35 | 0.351 | 101.742 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
103 |
HGH1 | interactor | 3 | 1.000 | 0 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383) DUF384 (PF04064, IPR007206): Domain of unknown function (DUF384) |
104 |
HIF1A | suppressor | 21 | 0.438 | 28.394 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 |
105 |
HLA-DRA | interactor | 7 | 0.857 | 0.156 | MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain |
106 |
HLA-DRB1 | interactor | 10 | 0.778 | 1.775 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
107 |
HLA-DRB3 | interactor | 6 | 0.800 | 0.156 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
108 |
HLA-DRB4 | interactor | 5 | 0.700 | 0.156 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
109 |
HLA-DRB5 | interactor | 8 | 0.679 | 2.516 | MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
110 |
HNRNPA1 | interactor | 76 | 0.325 | 513.466 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
111 |
HSF1 | protein found in more fusions | 17 | 0.458 | 18.124 | DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding |
112 |
HSP90AA1 | oncoprotein | 201 | 0.124 | 9227.218 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
113 |
HSP90AA2P | oncoprotein | 10 | 0.622 | 4.698 | DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain |
114 |
HSP90AA5P | interactor | 22 | 0.229 | 81.296 | NA |
115 |
HSPA1A | interactor | 71 | 0.264 | 472.384 | HSP70 (PF00012, IPR013126): Hsp70 protein |
116 |
HSPA4 | interactor | 65 | 0.249 | 489.892 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
117 |
HSPA5 | oncoprotein | 101 | 0.247 | 1063.906 | HSP70 (PF00012, IPR013126): Hsp70 protein |
118 |
HSPA8 | oncoprotein | 114 | 0.200 | 1865.926 | HSP70 (PF00012, IPR013126): Hsp70 protein |
119 |
HSPB1 | oncoprotein | 53 | 0.337 | 240.556 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
120 |
HSPD1 | oncoprotein | 67 | 0.278 | 373.800 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
121 |
HSPE1 | interactor | 16 | 0.592 | 6.628 | Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit |
122 |
HSPH1 | oncoprotein | 23 | 0.486 | 31.158 | HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain |
123 |
HTT | protein found in more fusions | 15 | 0.571 | 6.499 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
124 |
HUWE1 | oncoprotein | 75 | 0.298 | 441.627 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
125 |
IARS2 | interactor | 6 | 0.733 | 1.175 | Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS |
126 |
IFIT1 | interactor | 4 | 0.667 | 0.600 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268) TPR_19 (PF14559): Tetratricopeptide repeat |
127 |
IKBKB | protein found in more fusions | 25 | 0.308 | 76.021 | FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
128 |
IKBKG | interactor | 31 | 0.292 | 113.977 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
129 |
INPPL1 | oncoprotein | 19 | 0.573 | 14.207 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
130 |
IP6K2 | interactor | 4 | 0.667 | 0.833 | IPK (PF03770, IPR005522): Inositol polyphosphate kinase |
131 |
IPO7 | interactor | 19 | 0.398 | 18.666 | Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Xpo1 (PF08389, IPR013598): Exportin 1-like protein DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730) |
132 |
IQGAP1 | interactor | 45 | 0.314 | 193.227 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain |
133 |
ISG15 | suppressor | 33 | 0.261 | 91.610 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
134 |
ITGA4 | interactor | 64 | 0.280 | 281.009 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
135 |
IVNS1ABP | protein found in more fusions | 8 | 0.714 | 0.619 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
136 |
JAK2 | oncoprotein | 10 | 0.722 | 3.248 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
137 |
KEAP1 | oncoprotein | 15 | 0.451 | 12.253 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
138 |
KHDRBS2 | interactor | 3 | 1.000 | 0 | KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68 |
139 |
KPNA2 | interactor | 30 | 0.324 | 74.320 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
140 |
LATS1 | oncoprotein | 10 | 0.311 | 12.681 | Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
141 |
LATS2 | oncoprotein | 11 | 0.422 | 7.974 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
142 |
LDHA | protein found in more fusions | 36 | 0.331 | 92.482 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
143 |
LGALS3 | oncoprotein | 10 | 0.333 | 7.135 | Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin |
144 |
LGALS3BP | oncoprotein | 40 | 0.444 | 90.498 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain |
145 |
LRRK2 | oncoprotein | 23 | 0.351 | 36.953 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
146 |
MAGED2 | interactor | 22 | 0.498 | 25.739 | CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) |
147 |
MAP3K11 | interactor | 9 | 0.750 | 1.472 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain |
148 |
MAPK6 | oncoprotein | 17 | 0.225 | 33.810 | Pkinase (PF00069, IPR000719): Protein kinase domain |
149 |
MAPK7 | oncoprotein | 16 | 0.600 | 4.213 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
150 |
MAPRE1 | oncoprotein | 28 | 0.271 | 80.415 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
151 |
MCM2 | oncoprotein | 105 | 0.247 | 1114.954 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
152 |
MCM5 | oncoprotein | 37 | 0.374 | 99.904 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
153 |
MCM6 | interactor | 23 | 0.381 | 34.827 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
154 |
MCM7 | protein found in more fusions | 33 | 0.238 | 89.052 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
155 |
MDH1 | interactor | 11 | 0.545 | 3.398 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
156 |
MDM2 | oncoprotein | 45 | 0.288 | 242.196 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
157 |
MEPCE | protein found in more fusions | 18 | 0.477 | 13.752 | Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7 |
158 |
MET | oncoprotein | 12 | 0.515 | 6.733 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain |
159 |
METTL21B | interactor | 14 | 0.571 | 4.822 | Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase |
160 |
METTL22 | interactor | 4 | 1.000 | 0 | Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase |
161 |
MGMT | interactor | 12 | 0.470 | 8.672 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
162 |
MKNK1 | interactor | 4 | 0.667 | 0.381 | Pkinase (PF00069, IPR000719): Protein kinase domain |
163 |
MTHFD1 | interactor | 25 | 0.413 | 34.185 | FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
164 |
MVP | oncoprotein | 14 | 0.321 | 16.868 | Vault (PF01505, IPR002499): Major Vault Protein repeat DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543) MVP_shoulder (PF11978, IPR021870): Shoulder domain |
165 |
MYH9 | oncoprotein | 45 | 0.314 | 206.071 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
166 |
MYL6 | interactor | 15 | 0.419 | 15.835 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
167 |
MYLK4 | interactor | 4 | 0.833 | 0.133 | Pkinase (PF00069, IPR000719): Protein kinase domain |
168 |
MYO19 | interactor | 11 | 0.600 | 5.931 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
169 |
NANS | interactor | 7 | 0.619 | 1.280 | NeuB (PF03102, IPR013132): NeuB family SAF (PF08666, IPR013974, SM00858): SAF domain |
170 |
NFKB1 | oncoprotein | 17 | 0.408 | 17.359 | Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
171 |
NOS2 | interactor | 32 | 0.391 | 44.078 | FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain |
172 |
NPHP4 | interactor | 13 | 0.449 | 17.982 | Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein |
173 |
NPM1 | oncoprotein | 90 | 0.342 | 599.752 | Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
174 |
NPM3 | interactor | 6 | 0.667 | 0.821 | Nucleoplasmin (PF03066): Nucleoplasmin |
175 |
NR4A1 | suppressor | 10 | 0.422 | 6.408 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
176 |
NTRK1 | oncoprotein | 139 | 0.178 | 2710.502 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
177 |
NUMA1 | oncoprotein | 18 | 0.379 | 22.777 | Colicin (PF01024, IPR000293): Colicin pore forming domain Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tup_N (PF08581, IPR013890): Tup N-terminal CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
178 |
NUP107 | interactor | 13 | 0.526 | 7.101 | Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107 |
179 |
NUP85 | interactor | 8 | 0.643 | 1.609 | Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin |
180 |
NXF1 | interactor | 57 | 0.225 | 409.262 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
181 |
OBSL1 | protein found in more fusions | 63 | 0.297 | 260.064 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
182 |
P4HB | interactor | 28 | 0.501 | 29.848 | Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain |
183 |
PAN2 | interactor | 48 | 0.308 | 167.959 | RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain |
184 |
PARK2 | suppressor | 54 | 0.304 | 236.676 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
185 |
PCBP1 | oncoprotein | 37 | 0.302 | 112.560 | Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
186 |
PGK1 | interactor | 27 | 0.510 | 29.312 | PGK (PF00162, IPR001576): Phosphoglycerate kinase |
187 |
PHB | oncoprotein | 36 | 0.379 | 83.824 | Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290) |
188 |
PINK1 | protein found in more fusions | 14 | 0.577 | 4.471 | Pkinase (PF00069, IPR000719): Protein kinase domain |
189 |
PKM | oncoprotein | 52 | 0.296 | 269.077 | PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain |
190 |
POT1 | interactor | 23 | 0.307 | 42.216 | POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein |
191 |
PPID | interactor | 17 | 0.529 | 13.987 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat |
192 |
PPP5C | interactor | 19 | 0.497 | 20.476 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat |
193 |
PPP6R3 | interactor | 12 | 0.439 | 14.234 | SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein |
194 |
PRKAA1 | suppressor | 15 | 0.571 | 8.434 | Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase |
195 |
PRKACA | interactor | 14 | 0.363 | 17.611 | Pkinase (PF00069, IPR000719): Protein kinase domain |
196 |
PRKACB | interactor | 8 | 0.714 | 1.872 | Pkinase (PF00069, IPR000719): Protein kinase domain |
197 |
PRKCE | suppressor | 12 | 0.455 | 11.519 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
198 |
PRKDC | protein found in more fusions | 52 | 0.216 | 340.041 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
199 |
PSAT1 | interactor | 10 | 0.511 | 6.222 | Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V |
200 |
PSKH2 | interactor | 5 | 0.800 | 0.276 | Pkinase (PF00069, IPR000719): Protein kinase domain |
201 |
PSMA2 | interactor | 23 | 0.472 | 27.482 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
202 |
PSMA3 | interactor | 44 | 0.368 | 128.898 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
203 |
PSMB5 | interactor | 16 | 0.492 | 9.765 | Proteasome (PF00227, IPR001353): Proteasome subunit |
204 |
PSMD1 | interactor | 26 | 0.471 | 32.235 | PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats |
205 |
PTEN | oncoprotein | 35 | 0.269 | 127.247 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
206 |
PTGES3 | interactor | 28 | 0.313 | 83.750 | CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
207 |
RAD21 | oncoprotein | 28 | 0.344 | 56.833 | Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
208 |
REV1 | protein found in more fusions | 5 | 0.833 | 0.036 | IMS (PF00817, IPR001126): impB/mucB/samB family Cdd1 (PF11731, IPR021725): Pathogenicity locus IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain REV1_C (PF16727, IPR031991): DNA repair protein REV1 C-terminal domain |
209 |
RHOBTB2 | oncoprotein | 6 | 0.800 | 0.209 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ras (PF00071, IPR001806, SM00173): Ras family SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
210 |
RPAP3 | interactor | 15 | 0.429 | 23.872 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat |
211 |
RPL10A | interactor | 45 | 0.617 | 36.858 | Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family |
212 |
RPL14 | interactor | 48 | 0.523 | 103.178 | KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family |
213 |
RPL17 | interactor | 37 | 0.623 | 48.190 | Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e |
214 |
RPL3 | interactor | 47 | 0.562 | 84.311 | Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3 |
215 |
RPL32 | interactor | 30 | 0.759 | 16.163 | Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32 |
216 |
RPL5 | oncoprotein | 51 | 0.548 | 77.221 | Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18 |
217 |
RPL6 | protein found in more fusions | 53 | 0.510 | 104.078 | Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain |
218 |
RPL7 | interactor | 54 | 0.485 | 154.577 | Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain |
219 |
RPL7A | protein found in more fusions | 43 | 0.585 | 58.300 | Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family |
220 |
RPLP0 | interactor | 63 | 0.429 | 202.005 | Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10 |
221 |
RPLP0P6 | interactor | 24 | 0.761 | 11.999 | NA |
222 |
RPS16 | interactor | 53 | 0.491 | 122.207 | Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16 |
223 |
RPS2 | interactor | 59 | 0.405 | 199.166 | Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain |
224 |
RPS23 | interactor | 37 | 0.640 | 33.915 | Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23 |
225 |
RPS26 | interactor | 30 | 0.685 | 31.192 | Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e |
226 |
RPS3A | interactor | 56 | 0.515 | 94.936 | Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family |
227 |
RPS4X | protein found in more fusions | 69 | 0.404 | 246.186 | KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus |
228 |
RPS6 | interactor | 56 | 0.466 | 143.079 | Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574) |
229 |
RPS6KA1 | oncoprotein | 8 | 0.679 | 1.183 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
230 |
RPS6KB2 | interactor | 38 | 0.277 | 126.839 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
231 |
RPSA | interactor | 49 | 0.462 | 172.785 | Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus |
232 |
SCARNA22 | interactor | 9 | 0.500 | 3.661 | NA |
233 |
SENP3 | interactor | 22 | 0.485 | 25.009 | Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
234 |
SGTA | interactor | 9 | 0.722 | 1.108 | TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA |
235 |
SHC1 | oncoprotein | 34 | 0.375 | 99.220 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
236 |
SKI | oncoprotein | 23 | 0.312 | 34.956 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
237 |
SLC33A1 | interactor | 3 | 0.667 | 0.222 | Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1 |
238 |
SMYD3 | oncoprotein | 5 | 0.600 | 0.902 | SET (PF00856, IPR001214, SM00317): SET domain |
239 |
SNRPD1 | interactor | 26 | 0.440 | 38.732 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain |
240 |
SNW1 | protein found in more fusions | 48 | 0.345 | 206.673 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
241 |
SPTAN1 | oncoprotein | 33 | 0.314 | 123.749 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
242 |
SSR4 | interactor | 18 | 0.510 | 11.409 | TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta) OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C |
243 |
STAT1 | suppressor | 20 | 0.316 | 38.783 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
244 |
STIP1 | interactor | 47 | 0.283 | 262.357 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP |
245 |
STK33 | interactor | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain PARM (PF17061, IPR031431): PARM |
246 |
STOML2 | oncoprotein | 13 | 0.705 | 1.896 | Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769) Band_7_C (PF16200, IPR032435): C-terminal region of band_7 |
247 |
STUB1 | suppressor | 44 | 0.309 | 215.430 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
248 |
SUGT1 | interactor | 21 | 0.338 | 58.670 | CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
249 |
SUMO2 | interactor | 12 | 0.382 | 5.201 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
250 |
TAF10 | interactor | 7 | 0.333 | 4.334 | TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit |
251 |
TAF1D | interactor | 4 | 0.833 | 0.143 | TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D |
252 |
TCP1 | interactor | 43 | 0.338 | 122.499 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
253 |
TERF1 | interactor | 39 | 0.223 | 186.545 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
254 |
TINF2 | interactor | 18 | 0.375 | 25.840 | TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus |
255 |
TMOD4 | interactor | 3 | 1.000 | 0 | Tropomodulin (PF03250, IPR004934): Tropomodulin LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
256 |
TNNT1 | protein found in more fusions | 4 | 0.667 | 0.133 | Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) |
257 |
TOMM34 | interactor | 19 | 0.374 | 32.485 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919) |
258 |
TP53 | oncoprotein | 85 | 0.257 | 831.915 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
259 |
TP63 | suppressor | 15 | 0.440 | 8.804 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
260 |
TPM3 | oncoprotein | 30 | 0.325 | 88.727 | Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
261 |
TRAF2 | interactor | 16 | 0.305 | 32.853 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger) |
262 |
TRAF3IP1 | interactor | 14 | 0.407 | 14.184 | MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 |
263 |
TRIM8 | interactor | 4 | 1.000 | 0 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain CASP_C (PF08172, IPR012955): CASP C terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
264 |
TTC4 | suppressor | 13 | 0.474 | 22.532 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat |
265 |
TUBA1A | oncoprotein | 51 | 0.256 | 288.005 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
266 |
TUBA1C | interactor | 56 | 0.284 | 250.630 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
267 |
TUBB | interactor | 82 | 0.253 | 657.296 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
268 |
TUBG1 | protein found in more fusions | 50 | 0.420 | 129.983 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
269 |
TUBGCP2 | interactor | 17 | 0.662 | 5.856 | Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger |
270 |
TUBGCP3 | interactor | 23 | 0.514 | 18.098 | Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family |
271 |
U2AF2 | protein found in more fusions | 53 | 0.353 | 201.319 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
272 |
UBA1 | protein found in more fusions | 26 | 0.343 | 39.379 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
273 |
UBA52 | interactor | 15 | 0.410 | 15.889 | Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
274 |
UBASH3B | interactor | 22 | 0.557 | 17.142 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
275 |
UBC | protein found in more fusions | 78 | 0.236 | 737.398 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
276 |
UBE3A | oncoprotein | 17 | 0.417 | 19.363 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A |
277 |
UBL4A | interactor | 51 | 0.333 | 179.604 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
278 |
UNC45B | interactor | 3 | 1.000 | 0 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central TPR_16 (PF13432): Tetratricopeptide repeat HEAT_2 (PF13646): HEAT repeats |
279 |
UNK | interactor | 31 | 0.239 | 111.314 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
280 |
UQCRC2 | oncoprotein | 19 | 0.538 | 15.128 | Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain |
281 |
USP50 | interactor | 6 | 0.733 | 0.303 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
282 |
VCAM1 | interactor | 64 | 0.275 | 266.661 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
283 |
VCP | protein found in more fusions | 84 | 0.286 | 721.969 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
284 |
WASL | interactor | 8 | 0.643 | 3.458 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins |
285 |
XPO1 | interactor | 73 | 0.216 | 830.430 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
286 |
XRCC3 | oncoprotein | 10 | 0.356 | 8.923 | Rad51 (PF08423, IPR013632): Rad51 RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain |
287 |
YWHAB | interactor | 32 | 0.347 | 86.566 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
288 |
YWHAE | oncoprotein | 66 | 0.277 | 478.578 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |