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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins5 (26.32 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)51 (29.82 %)
The number (and %) of affected PPIs19 (37.25 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI4.421
Assortativity coefficient-0.3422
The network average Clustering coefficient0.601
The number (and %) of a zero Clustering coefficients4 (21.05 %)
The number (and %) of a zero Betweenness Centrality10 (52.63 %)


List of the fusions

PPI for parental proteins: HOOK3 All fusions
: AA829758; AI825480; AI365359; AW298467;
Proteins found in more fusions CUL3 (see 1 fusions); HOOK3 (see 4 fusions); HOOK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 HOOK3parental protein190.157223.167HOOK (PF05622, IPR008636): HOOK protein
2 AKTIPinteractor80.6078.833UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 CCDC8interactor200Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
4 CEP63interactor21.0000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
5 COMTD1interactor100FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
6 CUL3protein found in more fusions40.6670.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 FAM160A2interactor41.0000RAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
8 FNTBinteractor21.0000Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
9 HOOK1protein found in more fusions80.7622.833HOOK (PF05622, IPR008636): HOOK protein
10 HOOK2interactor90.53611.667HOOK (PF05622, IPR008636): HOOK protein
11 IFT57interactor100IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
12 MRE11Aoncoprotein31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
13 NTRK1oncoprotein60.4005.667I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 SCFD1interactor21.0000Sec1 (PF00995, IPR001619): Sec1 family
15 SSX2IPinteractor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
16 TNFSF13Boncoprotein60.9000.500TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
17 VPS16interactor60.7333.667Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
18 VPS41interactor51.0000Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19 ZC4H2interactor100zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKTIPinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzymeAA829758, AI365359, AI825480, AW298467
2 FAM160A2interactorRAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like proteinAA829758, AI365359, AI825480, AW298467
3 HOOK3parental proteinHOOK (PF05622, IPR008636): HOOK proteinAA829758, AI365359, AI825480, AW298467
4 SCFD1interactorSec1 (PF00995, IPR001619): Sec1 familyAA829758, AI365359, AI825480, AW298467

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