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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HOOK1 (from a repository: Thu Nov 24 21:03:45 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins7 (29.17 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)57 (20.65 %)
The number (and %) of affected PPIs24 (42.11 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.917
Assortativity coefficient-0.4671
The network average Clustering coefficient0.503
The number (and %) of a zero Clustering coefficients9 (37.50 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HOOK1 All fusions
: AA188823;
Proteins found in more fusions VPS39 (see 1 fusions); VCP (see 4 fusions); HOOK3 (see 4 fusions); HOOK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HOOK1parental protein240.095430.833HOOK (PF05622, IPR008636): HOOK protein
2 AKTIPinteractor80.6795.833UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 CDC5Linteractor31.0000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
4 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
5 FAM160A2interactor41.0000RAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
6 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
7 HOOK2interactor90.53612.000HOOK (PF05622, IPR008636): HOOK protein
8 HOOK3oncoprotein80.7622.833HOOK (PF05622, IPR008636): HOOK protein
9 LMO2oncoprotein31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
10 LRRC29interactor100Glyco_tran_WecB (PF03808, IPR004629): Glycosyl transferase WecB/TagA/CpsF family
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Ste50p-SAM (PF09235, IPR015316): Ste50p, sterile alpha motif
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
11 RABGGTBoncoprotein100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
12 SYCE1interactor100CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
13 TBC1D7interactor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
14 TFIP11interactor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
15 TNFSF13Boncoprotein60.9000.500TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
16 TRAK2interactor100ZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Milton (PF12448, IPR022154): Kinesin associated protein
17 USP2interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
18 VCPprotein found in more fusions40.6671.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
19 VPS16interactor60.8671.000Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
20 VPS18interactor50.7003.000Pep3_Vps18 (PF05131, IPR007810): Pep3/Vps18/deep orange family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
21 VPS39protein found in more fusions200CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
22 VPS41interactor60.8671.000Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23 ZNF250interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
24 ZNF785interactor100ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Lar_restr_allev (PF14354): Restriction alleviation protein Lar

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