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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HOMER3 (from a repository: Sun Dec 4 20:16:56 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins12 (36.36 %)
The number (and %) of the tumor suppressors3 (9.09 %)
Total number of binary PPIs (saturation %)70 (13.26 %)
The number (and %) of affected PPIs33 (47.14 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI3.273
Assortativity coefficient-0.3835
The network average Clustering coefficient0.569
The number (and %) of a zero Clustering coefficients10 (30.30 %)
The number (and %) of a zero Betweenness Centrality24 (72.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HOMER3 All fusions
Proteins found in more fusions PML (see 4 fusions); RUNX1T1 (see 1 fusions); PSMC5 (see 2 fusions); APP (see 4 fusions); IKBKB (see 2 fusions); YWHAH (see 2 fusions); SRPK2 (see 1 fusions); HOMER3 (see 1 fusions); TRPC4 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HOMER3parental protein330.044916.667COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
2 ABI1oncoprotein21.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 ABI2suppressor40.6671.000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 ABI3interactor50.5003.000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 APPprotein found in more fusions60.4006.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 DBN1oncoprotein30.6671.000Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
7 DYNLL2interactor200Dynein_light (PF01221, IPR001372): Dynein light chain type 1
8 EAF1suppressor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
9 EIF3Dinteractor100eIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
10 FRYLoncoprotein21.0000MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal
MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal
MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
11 HOMER1interactor70.33314.000WH1 (PF00568, IPR000697, SM00461): WH1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
12 IFT57interactor21.0000IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
13 IKBKBprotein found in more fusions200FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
14 MOSoncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
15 NEBLinteractor100Bac_small_YrzI (PF09501, IPR012655): Probable sporulation protein (Bac_small_yrzI)
Annexin (PF00191, IPR018502, SM00335): Annexin
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 PKN1interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
17 PMLsuppressor200zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
18 POM121interactor100Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
19 PPP1R18interactor21.0000Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
20 PSMA1interactor60.5005.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 PSMA2interactor41.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
22 PSMC5protein found in more fusions41.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
23 RUNX1T1oncoprotein31.0000NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
24 RYR1interactor21.0000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
MIR (PF02815, IPR016093, SM00472): MIR domain
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Urb2 (PF10441, IPR018849): Urb2/Npa2 family
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
25 SNRPFinteractor100LSM (PF01423, IPR001163): LSM domain
26 SOX17oncoprotein100SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox17_18_mid (PF12067, IPR021934): Sox 17/18 central domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
27 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
28 TRPC1interactor50.8330.667Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
29 TRPC4protein found in more fusions41.0000Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
IncA (PF04156, IPR007285): IncA protein
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
30 TRPC5interactor40.8330.667Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
31 USP2interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
32 WIPF1interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GRP (PF07172, IPR010800): Glycine rich protein family
WH2 (PF02205, IPR003124, SM00246): WH2 motif
33 YWHAHprotein found in more fusions31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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