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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HNRNPLL (from a repository: Sat Dec 3 17:03:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)84 (22.22 %)
The number (and %) of affected PPIs28 (33.33 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.786
Assortativity coefficient-0.2920
The network average Clustering coefficient0.575
The number (and %) of a zero Clustering coefficients4 (14.29 %)
The number (and %) of a zero Betweenness Centrality10 (35.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HNRNPLL All fusions
: AA639110;
Proteins found in more fusions QKI (see 3 fusions); HDAC5 (see 1 fusions); VHL (see 1 fusions); ATXN1 (see 3 fusions); HNRNPLL (see 1 fusions); RBPMS (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HNRNPLLparental protein280.114531.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 ATXN1protein found in more fusions70.5336.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 BARD1suppressor200BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
4 BOLLinteractor21.0000NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 CCNB1oncoprotein40.6671.667Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 CCNB2interactor30.6670.667Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CDC5Linteractor100.41718.000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
8 CNOT3suppressor21.0000NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
Not3 (PF04065, IPR007207): Not1 N-terminal domain, CCR4-Not complex component
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
9 DAB1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
10 FAM188Asuppressor100DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
11 GSTM3interactor200GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
12 HDAC5protein found in more fusions50.5002.333Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
13 HNRNPKoncoprotein90.53610.900ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
14 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
15 MDFIinteractor31.0000MDFI (PF15316, IPR026134): MyoD family inhibitor
16 NTRK1oncoprotein100.44418.567I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PAXIP1interactor30.6670.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
18 PCBP1oncoprotein60.8670.900Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
19 PDIA6interactor30.6670.667FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
20 PSMA3interactor31.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 QKIprotein found in more fusions80.4769.333KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
22 RBPMSprotein found in more fusions70.4677.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
23 RCN1interactor21.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
24 RHOXF2interactor60.6003.667DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
25 SNW1protein found in more fusions70.8002.000SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
26 THAP1interactor40.6670.400THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
27 UBE2Iinteractor60.5004.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 VHLsuppressor50.5002.667Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

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