Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins HNRNPL (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 107 The number (and %) of the onco-proteins 45 (42.06 %) The number (and %) of the tumor suppressors 5 (4.67 %) Total number of binary PPIs (saturation %) 1436 (25.32 %) The number (and %) of affected PPIs 107 (7.45 %) The number of possible different fusions 26 PPI diameter 2 PPI radius 1 The average degree of PPI 25.944 Assortativity coefficient -0.1963 The network average Clustering coefficient 0.548 The number (and %) of a zero Clustering coefficients 3 (2.80 %) The number (and %) of a zero Betweenness Centrality 7 (6.54 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HNRNPL	All fusions : AI800860;
Proteins found in more fusions	U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); IVNS1ABP (see 2 fusions); VHL (see 1 fusions); YWHAZ (see 1 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); UBC (see 1 fusions); RPA1 (see 1 fusions); NEDD4 (see 1 fusions); TP53 (see 3 fusions); PTBP1 (see 1 fusions); ABCC1 (see 1 fusions); PUF60 (see 2 fusions); SFPQ (see 6 fusions); VEGFA (see 1 fusions); HNRNPL (see 2 fusions); HNRNPD (see 1 fusions); PCBP2 (see 3 fusions); SF1 (see 1 fusions); MCM2 (see 1 fusions); CSNK2A1 (see 1 fusions); DDX17 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	HNRNPL	parental protein	107	0.230	3241.922	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2	ABCC1	oncoprotein	7	0.600	3.709	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304) DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
3	ACTR3	interactor	8	0.536	1.219	Actin (PF00022, IPR004000, SM00268): Actin
4	APEX1	interactor	10	0.556	5.216	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
5	ATP6V1F	interactor	4	0.500	2.333	ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
6	CAND1	interactor	43	0.573	70.227	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7	CCDC8	interactor	32	0.484	35.129	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
8	COPS5	protein found in more fusions	44	0.529	69.793	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9	CRY1	interactor	17	0.542	5.154	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
10	CSE1L	oncoprotein	14	0.451	6.275	CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
11	CSNK2A1	oncoprotein	26	0.443	47.195	Pkinase (PF00069, IPR000719): Protein kinase domain
12	CUL1	oncoprotein	43	0.599	50.041	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	CUL3	protein found in more fusions	46	0.497	91.987	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14	CUL7	protein found in more fusions	47	0.430	102.307	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
15	DAB2	oncoprotein	2	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
16	DDX17	protein found in more fusions	47	0.476	103.962	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17	DHX15	interactor	31	0.548	27.982	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
18	DOCK4	interactor	4	0.833	0.133	DHR-2 (PF06920, IPR010703): Dock homology region 2 SH3_2 (PF07653, IPR011511): Variant SH3 domain DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
19	DPH5	interactor	2	1.000	0	TP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) Methylases
20	DYNC1H1	interactor	18	0.510	7.210	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5
21	EED	suppressor	36	0.523	41.047	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
22	EEF1A1	oncoprotein	42	0.406	120.263	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
23	EEF2	interactor	27	0.530	30.373	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
24	EIF2B1	interactor	6	1.000	0	IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
25	EIF4A3	interactor	34	0.572	48.439	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
26	EIF4H	interactor	12	0.682	2.614	eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27	ELAVL1	oncoprotein	41	0.441	118.308	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
28	FBXO6	interactor	27	0.456	31.014	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
29	FGFR3	oncoprotein	2	0	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
30	FN1	oncoprotein	52	0.354	233.662	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
31	FOXE1	oncoprotein	2	1.000	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
32	FUS	oncoprotein	47	0.501	122.748	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
33	GCN1	interactor	13	0.436	3.825	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat CLASP_N (PF12348, IPR024395): CLASP N terminal MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
34	HDAC5	protein found in more fusions	29	0.434	33.247	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
35	HIST1H3E	interactor	9	0.722	0.990	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
36	HIST3H3	interactor	14	0.714	3.378	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
37	HMG20B	interactor	1	0	0	IncA (PF04156, IPR007285): IncA protein NEMP (PF10225, IPR019358): NEMP family HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
38	HMGA1	oncoprotein	14	0.571	16.976	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
39	HNRNPA0	interactor	37	0.598	49.501	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
40	HNRNPA1	interactor	63	0.471	221.065	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
41	HNRNPA2B1	oncoprotein	44	0.485	98.354	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
42	HNRNPA3	oncoprotein	46	0.536	86.644	IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
43	HNRNPD	oncoprotein	48	0.476	146.509	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
44	HNRNPDL	interactor	45	0.470	137.799	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
45	HNRNPH1	oncoprotein	51	0.505	115.018	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
46	HNRNPK	oncoprotein	60	0.430	244.041	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
47	HNRNPM	interactor	39	0.494	66.102	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
48	HNRNPR	interactor	50	0.463	155.030	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
49	HNRNPU	interactor	54	0.452	181.574	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
50	HSPA5	oncoprotein	42	0.488	113.930	HSP70 (PF00012, IPR013126): Hsp70 protein
51	HSPA9	oncoprotein	28	0.497	35.297	HSP70 (PF00012, IPR013126): Hsp70 protein
52	HSPBP1	interactor	5	0.700	1.087	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like HEAT_EZ (PF13513): HEAT-like repeat
53	IFIT2	interactor	9	0.722	1.621	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat HTH_WhiA (PF02650, IPR023054): WhiA C-terminal HTH domain TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
54	IFIT3	interactor	11	0.756	1.840	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
55	IL7R	interactor	16	0.583	4.996	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
56	ILF3	oncoprotein	48	0.380	182.124	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
57	ISG15	suppressor	15	0.438	17.748	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
58	ITCH	interactor	10	0.556	4.100	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
59	ITGA4	interactor	44	0.421	115.487	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
60	IVNS1ABP	protein found in more fusions	13	0.727	1.482	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
61	KHDRBS2	interactor	13	0.742	1.102	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
62	LGALS1	interactor	9	0.583	3.328	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
63	LPP	oncoprotein	8	0.536	5.050	LIM (PF00412, IPR001781, SM00132): LIM domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
64	LSM14A	interactor	9	0.750	0.911	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FDF (PF09532, IPR019050, SM01199): FDF domain GRP (PF07172, IPR010800): Glycine rich protein family LSM14 (PF12701, IPR025609): Scd6-like Sm domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
65	MAGOH	interactor	17	0.537	13.433	Mago_nashi (PF02792, IPR004023): Mago nashi protein
66	MATR3	interactor	39	0.605	44.725	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
67	MBNL1	interactor	8	0.893	0.169	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 (PF15663): Zinc-finger containing family
68	MCM2	oncoprotein	53	0.422	186.892	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
69	MPV17	interactor	4	0.500	1.792	Mpv17_PMP22 (PF04117, IPR007248): Mpv17 / PMP22 family
70	MRPL41	interactor	5	0.600	0.425	MRP-L27 (PF09809, IPR019189): Mitochondrial ribosomal protein L27
71	NAA50	interactor	5	0.700	0.530	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
72	NARS	interactor	6	0.800	0.313	tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
73	NEDD4	suppressor	8	0.857	0.571	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
74	NPLOC4	interactor	11	0.618	5.412	NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
75	NTRK1	oncoprotein	60	0.345	402.399	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
76	OBSL1	interactor	45	0.445	83.328	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
77	PCBP2	protein found in more fusions	28	0.513	33.592	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
78	PDHA1	interactor	7	0.857	0.195	E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
79	PLEC	oncoprotein	13	0.474	4.412	CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FUSC (PF04632, IPR006726): Fusaric acid resistance protein family RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 S10_plectin (PF03501, IPR005326): Plectin/S10 domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) Plectin (PF00681, IPR001101, SM00250): Plectin repeat YlqD (PF11068, IPR021297): YlqD protein Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
80	PTBP1	oncoprotein	48	0.502	103.468	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
81	PUF60	protein found in more fusions	22	0.595	28.488	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
82	RNF2	interactor	29	0.389	54.336	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
83	RPA1	suppressor	38	0.635	37.701	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
84	RPA2	oncoprotein	33	0.665	21.761	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
85	RPA3	interactor	33	0.663	22.479	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
86	SCARNA22	interactor	16	0.742	2.223	NA
87	SF1	protein found in more fusions	21	0.495	20.891	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
88	SFPQ	oncoprotein	39	0.484	98.190	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
89	SMARCAD1	interactor	14	0.725	2.312	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
90	SNU13	interactor	16	0.676	8.345	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
91	SRRM2	interactor	31	0.572	35.472	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
92	SYNCRIP	interactor	48	0.465	136.722	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
93	TOP1	oncoprotein	29	0.539	33.872	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
94	TOPORS	oncoprotein	9	0.667	1.175	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
95	TP53	oncoprotein	34	0.398	96.081	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
96	TP63	suppressor	11	0.578	3.869	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
97	TRIM68	interactor	1	0	0	GAGA (PF09237, IPR015318): GAGA factor SPRY (PF00622, IPR003877, SM00449): SPRY domain DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
98	TUFM	interactor	18	0.484	7.499	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
99	U2AF2	protein found in more fusions	48	0.515	90.696	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
100	UBC	protein found in more fusions	47	0.485	135.150	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
101	UBL4A	interactor	19	0.456	12.035	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
102	UNK	interactor	20	0.300	38.712	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
103	VCAM1	interactor	39	0.395	77.700	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
104	VEGFA	oncoprotein	5	0.500	0.209	PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 VEGF_C (PF14554, IPR027928): VEGF heparin-binding domain
105	VHL	oncoprotein	24	0.656	15.683	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
106	YWHAE	oncoprotein	24	0.438	20.866	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
107	YWHAZ	protein found in more fusions	22	0.490	11.459	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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