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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HLA-H, HLA-C (from a repository: Fri Jul 12 01:59:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins13 (20.00 %)
The number (and %) of the tumor suppressors4 (6.15 %)
Total number of binary PPIs (saturation %)180 (8.65 %)
The number (and %) of affected PPIs67 (37.22 %)
The number of possible different fusions10
PPI diameter3
PPI radius2
The average degree of PPI4.985
Assortativity coefficient-0.3141
The network average Clustering coefficient0.444
The number (and %) of a zero Clustering coefficients18 (27.69 %)
The number (and %) of a zero Betweenness Centrality27 (41.54 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HLA-C,HLA-H All fusions
Proteins found in more fusions HLA-C (see 1 fusions); CUL7 (see 2 fusions); HLA-B (see 4 fusions); CUL3 (see 1 fusions); HLA-H/HLA-B (see 1 fusions); HLA-C/HLA-H (see 2 fusions); UBC (see 7 fusions); B2M (see 10 fusions); HLA-C/HLA-B (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HLA-Cparental protein640.0473419.511Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
2 HLA-Hparental protein40.50015.372NA
3 ADRB2interactor70.4677.4757tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ARV1interactor21.0000Arv1 (PF04161, IPR007290): Arv1-like family
5 ATP1A3interactor30.6670.667Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6 ATP1B3interactor50.4005.000Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
7 B2Moncoprotein70.7332.067C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
8 BATF2suppressor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
9 CCDC8interactor80.6196.162Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CD8Ainteractor50.6670.900V-set (PF07686, IPR013106): Immunoglobulin V-set domain
11 CDC25Aoncoprotein2010.378M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
12 CISD2interactor21.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
13 CNNM1interactor30.6670.500CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
14 CUL3protein found in more fusions80.19013.900Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 CUL7protein found in more fusions70.8001.400ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
16 DNAJC1interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4234 (PF14018, IPR025328): Domain of unknown function (DUF4234)
17 DNAJC16interactor30.6670.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
18 EIF2AK3interactor30.6670.500OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
19 FAF2interactor100.44429.040DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
20 FAM213Ainteractor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
AhpC-TSA_2 (PF13911, IPR032801): AhpC/TSA antioxidant enzyme
21 FAM3Cinteractor100ILEI (PF15711): Interleukin-like EMT inducer
22 FBXO6interactor70.47611.033FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
23 GPR50interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF1218 (PF06749, IPR009606): Protein of unknown function (DUF1218)
SMBP (PF16785, IPR031877): Small metal-binding protein
24 HLA-Aoncoprotein130.29548.276DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
25 HLA-Boncoprotein170.21784.180MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
26 HLA-Einteractor130.26951.974MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
27 HLA-Finteractor50.5002.833MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
28 HLA-Ginteractor70.3337.273MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
29 HMOX1interactor200Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
30 HSPA5oncoprotein150.31966.925HSP70 (PF00012, IPR013126): Hsp70 protein
31 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
32 ITFG1interactor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
K1 (PF02960, IPR004121): K1 glycoprotein
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
33 ITGA6oncoprotein30.6670.500FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
34 KIR2DL1interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
35 KIR2DL2interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
36 KIR2DL3interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
37 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
38 LILRB1interactor50.5002.467Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
39 LILRB2interactor40.5001.467Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
40 LRFN3interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
41 MAD2L2interactor200HORMA (PF02301, IPR003511): HORMA domain
42 MAPK8IP2interactor31.0000BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
43 MMS19interactor40.50013.769DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
44 MR1interactor30.6671.000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
45 NEK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
46 NETO2interactor30.6671.000CUB (PF00431, IPR000859, SM00042): CUB domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
47 NSDHLinteractor30.6670.6673Beta_HSD (PF01073, IPR002225): 3-beta hydroxysteroid dehydrogenase/isomerase family
GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
48 PCK1interactor40.8330.333PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
49 PI4KAinteractor30.6670.500PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Ipi1_N (PF12333, IPR024679): Rix1 complex component involved in 60S ribosome maturation
Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
50 POMGNT1interactor100GNT-I (PF03071, IPR004139): GNT-I family
ILEI (PF15711): Interleukin-like EMT inducer
51 PRRG4interactor100Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
52 PTCH1suppressor70.28614.278Patched (PF02460, IPR003392): Patched family
53 RNF139oncoprotein21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
54 SCAPinteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
55 SCARB1oncoprotein30.6670.667CD36 (PF01130, IPR002159): CD36 family
56 TANKsuppressor200DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
57 TAP2oncoprotein60.6004.500ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
58 TCTN2interactor110.27339.171DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
59 TMEM206interactor100TMEM206 (PF15122, IPR029366): TMEM206 protein family
60 TMEM223interactor100TMEM223 (PF14640): Transmembrane protein 223
61 TMEM30Ainteractor50.4005.667CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family
62 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
63 UBCprotein found in more fusions110.40033.729ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 UFSP2interactor100Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
65 YBX1oncoprotein60.60014.254CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2

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