Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HLA-C (from a repository: Fri Jul 12 02:02:12 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins13 (20.31 %)
The number (and %) of the tumor suppressors4 (6.25 %)
Total number of binary PPIs (saturation %)172 (8.53 %)
The number (and %) of affected PPIs64 (37.21 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.844
Assortativity coefficient-0.2979
The network average Clustering coefficient0.468
The number (and %) of a zero Clustering coefficients18 (28.12 %)
The number (and %) of a zero Betweenness Centrality30 (46.88 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HLA-C All fusions
Proteins found in more fusions HLA-C (see 1 fusions); CUL7 (see 2 fusions); HLA-B/HLA-H (see 1 fusions); HLA-B (see 4 fusions); HLA-C/HLA-H (see 2 fusions); UBC (see 7 fusions); B2M (see 10 fusions); HLA-C/HLA-B (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HLA-Cparental protein640.0473360.133Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
2 ADRB2interactor70.4676.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 ARV1interactor21.0000Arv1 (PF04161, IPR007290): Arv1-like family
4 ATP1A3interactor30.6670.667Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 ATP1B3interactor50.4005.000Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
6 B2Moncoprotein70.7332.067C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
7 BATF2suppressor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CCDC8interactor80.6195.833Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
9 CD8Ainteractor50.6670.900V-set (PF07686, IPR013106): Immunoglobulin V-set domain
10 CDC25Aoncoprotein100M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
11 CISD2interactor21.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
12 CNNM1interactor30.6670.500CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
13 CUL7protein found in more fusions70.8001.500ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14 DNAJC1interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4234 (PF14018, IPR025328): Domain of unknown function (DUF4234)
15 DNAJC16interactor30.6670.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
16 EIF2AK3interactor30.6670.500OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
17 FAF2interactor90.50010.400DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
18 FAM213Ainteractor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
AhpC-TSA_2 (PF13911, IPR032801): AhpC/TSA antioxidant enzyme
19 FAM3Cinteractor100ILEI (PF15711): Interleukin-like EMT inducer
20 FBXO6interactor70.47610.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
21 GPR50interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF1218 (PF06749, IPR009606): Protein of unknown function (DUF1218)
SMBP (PF16785, IPR031877): Small metal-binding protein
22 HLA-Aoncoprotein130.29547.000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
23 HLA-Boncoprotein170.21781.500MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
24 HLA-Einteractor130.26950.567MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
25 HLA-Finteractor50.5002.833MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
26 HLA-Ginteractor70.3336.667MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
27 HLA-Hprotein found in more fusions31.0000NA
28 HMOX1interactor200Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
29 HSPA5oncoprotein140.33342.333HSP70 (PF00012, IPR013126): Hsp70 protein
30 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
31 ITFG1interactor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
K1 (PF02960, IPR004121): K1 glycoprotein
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
32 ITGA6oncoprotein30.6670.500FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
33 KIR2DL1interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
34 KIR2DL2interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
35 KIR2DL3interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
36 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
37 LILRB1interactor50.5002.467Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
38 LILRB2interactor40.5001.467Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
39 LRFN3interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
40 MAD2L2interactor200HORMA (PF02301, IPR003511): HORMA domain
41 MAPK8IP2interactor31.0000BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
42 MMS19interactor31.0000DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
43 MR1interactor30.6671.000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
44 NEK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
45 NETO2interactor30.6671.000CUB (PF00431, IPR000859, SM00042): CUB domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
46 NSDHLinteractor30.6670.6673Beta_HSD (PF01073, IPR002225): 3-beta hydroxysteroid dehydrogenase/isomerase family
GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
47 PCK1interactor40.8330.333PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
48 PI4KAinteractor30.6670.500PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Ipi1_N (PF12333, IPR024679): Rix1 complex component involved in 60S ribosome maturation
Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
49 POMGNT1interactor100GNT-I (PF03071, IPR004139): GNT-I family
ILEI (PF15711): Interleukin-like EMT inducer
50 PRRG4interactor100Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
51 PTCH1suppressor70.28613.333Patched (PF02460, IPR003392): Patched family
52 RNF139oncoprotein21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
53 SCAPinteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
54 SCARB1oncoprotein30.6670.667CD36 (PF01130, IPR002159): CD36 family
55 TANKsuppressor200DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
56 TAP2oncoprotein60.6004.500ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
57 TCTN2interactor110.27337.167DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
58 TMEM206interactor100TMEM206 (PF15122, IPR029366): TMEM206 protein family
59 TMEM223interactor100TMEM223 (PF14640): Transmembrane protein 223
60 TMEM30Ainteractor50.4005.667CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family
61 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
62 UBCprotein found in more fusions100.44415.667ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
63 UFSP2interactor100Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
64 YBX1oncoprotein50.8001.333CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2

B a c k    t o    T o p ⇑