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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HLA-B, HLA-C (from a repository: Sat Nov 12 21:32:12 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)109
The number (and %) of the onco-proteins20 (18.35 %)
The number (and %) of the tumor suppressors6 (5.50 %)
Total number of binary PPIs (saturation %)303 (5.15 %)
The number (and %) of affected PPIs125 (41.25 %)
The number of possible different fusions12
PPI diameter3
PPI radius2
The average degree of PPI5.028
Assortativity coefficient-0.1915
The network average Clustering coefficient0.384
The number (and %) of a zero Clustering coefficients36 (33.03 %)
The number (and %) of a zero Betweenness Centrality43 (39.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HLA-C,HLA-B All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); HLA-B (see 2 fusions); VCP (see 4 fusions); EZR (see 2 fusions); TRIM28 (see 1 fusions); HTT (see 1 fusions); CUL7 (see 2 fusions); UBC (see 1 fusions); B2M (see 9 fusions); STAT1 (see 1 fusions); HLA-B/HLA-C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HLA-Cparental protein640.0476065.452Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
2 HLA-Bparental protein620.0325806.893MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
3 ADRB2interactor80.52453.7207tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AHCYinteractor50.16712.262AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
5 ARFGEF1interactor21.0000DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
6 ARFGEF2interactor40.5008.272DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
7 ARHGEF4oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 ARV1interactor21.0000Arv1 (PF04161, IPR007290): Arv1-like family
9 ATP12Ainteractor2013.512Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 ATP1A3interactor30.66713.512Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
11 ATP1B3interactor70.19070.108Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
12 B2Moncoprotein90.50083.047C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 BATF2suppressor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 C1orf112interactor100RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
UBN_AB (PF14075, IPR026947): Ubinuclein conserved middle domain
DUF4487 (PF14868, IPR027902): Domain of unknown function (DUF4487)
15 CCDC8interactor150.297170.047Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
16 CD8Ainteractor50.66714.605V-set (PF07686, IPR013106): Immunoglobulin V-set domain
17 CDC25Aoncoprotein3041.753M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
18 CISD2interactor21.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
19 CLTCL1oncoprotein100Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
20 CNNM1interactor30.6671.294CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
21 CUL7protein found in more fusions140.282180.618ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
22 CXCR4interactor30.33334.1677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
23 DNAJC1interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4234 (PF14018, IPR025328): Domain of unknown function (DUF4234)
24 DNAJC16interactor30.6670.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
25 EDEM1interactor21.0000Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
26 EIF2AK3interactor30.6670.500OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
27 ERAP1interactor30.33324.329Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
28 ERBB3oncoprotein50.6670.917Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
29 EZRprotein found in more fusions60.30019.549DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
30 FAF2interactor110.422109.672DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
31 FAM213Ainteractor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
AhpC-TSA_2 (PF13911, IPR032801): AhpC/TSA antioxidant enzyme
32 FAM3Cinteractor100ILEI (PF15711): Interleukin-like EMT inducer
33 FAM91A1interactor100FAM91_N (PF14647, IPR028091): FAM91 N-terminus
FAM91_C (PF14648, IPR028097): FAM91 C-terminus
34 FBXO6interactor150.124266.238FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
35 FCGRTinteractor21.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
36 GPR50interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF1218 (PF06749, IPR009606): Protein of unknown function (DUF1218)
SMBP (PF16785, IPR031877): Small metal-binding protein
37 HEATR1interactor50.40036.281BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
HEAT (PF02985, IPR000357): HEAT repeat
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
U3snoRNP10 (PF12397, IPR022125): U3 small nucleolar RNA-associated protein 10
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
38 HEATR6interactor100HEAT (PF02985, IPR000357): HEAT repeat
DUF3636 (PF12331, IPR022093): Protein of unknown function (DUF3636)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4042 (PF13251, IPR025283): Domain of unknown function (DUF4042)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
39 HLA-Aoncoprotein150.276174.800DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
40 HLA-Einteractor160.200354.469MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
41 HLA-Finteractor50.5002.833MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
42 HLA-Ginteractor70.3336.952MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
43 HLA-Hinteractor31.0000NA
44 HMOX1interactor200Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
45 HSPA5oncoprotein190.268356.721HSP70 (PF00012, IPR013126): Hsp70 protein
46 HTTprotein found in more fusions31.0000HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
47 IFI16suppressor30.33317.157HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
48 INTS4interactor30.6672.043Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
49 INTS5interactor21.0000INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus
INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
50 IPO13interactor100IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
51 ITFG1interactor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
K1 (PF02960, IPR004121): K1 glycoprotein
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
52 ITGA6oncoprotein30.6671.294FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
53 KIR2DL1interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
54 KIR2DL2interactor2034.791DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
55 KIR2DL3interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
56 KIR2DS2interactor4050.342ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
57 KIR3DS1interactor2032.733ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
58 LILRB1interactor50.50029.659Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
59 LILRB2interactor40.50028.400Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
60 LRFN3interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
61 LTN1interactor40.16731.266zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
62 MAD2L2interactor200HORMA (PF02301, IPR003511): HORMA domain
63 MAPK8IP2interactor40.6674.937BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
64 MMS19interactor50.50057.937DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
65 MR1interactor40.50019.062MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
66 MSNoncoprotein70.40015.331DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
67 NCAPH2interactor200CNDH2_N (PF06278, IPR009378): Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
CNDH2_C (PF16858, IPR031737): Condensin II complex subunit CAP-H2 or CNDH2, C-term
CNDH2_M (PF16869): PF16858
68 NDUFA9interactor40.16737.644Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
69 NEK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
70 NETO2interactor30.6671.250CUB (PF00431, IPR000859, SM00042): CUB domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
71 NSDHLinteractor30.6670.6673Beta_HSD (PF01073, IPR002225): 3-beta hydroxysteroid dehydrogenase/isomerase family
GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
72 PAICSinteractor31.0000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
73 PCK1interactor40.8333.951PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
74 PDK1interactor200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
75 PFASinteractor30.6671.000AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
76 PI4KAinteractor30.6674.706PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Ipi1_N (PF12333, IPR024679): Rix1 complex component involved in 60S ribosome maturation
Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
77 PLS3interactor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
78 POMGNT1interactor100GNT-I (PF03071, IPR004139): GNT-I family
ILEI (PF15711): Interleukin-like EMT inducer
79 PRRG4interactor100Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
80 PSMD1interactor40.6678.657PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
81 PTCH1suppressor70.28622.188Patched (PF02460, IPR003392): Patched family
82 RNF139oncoprotein21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
83 RUVBL1oncoprotein60.30019.605TIP49 (PF06068, IPR010339): TIP49 C-terminus
84 SCAPinteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
85 SCARB1oncoprotein30.6671.723CD36 (PF01130, IPR002159): CD36 family
86 SGSM3interactor100RUN (PF02759, IPR004012, SM00593): RUN domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
87 SIAEinteractor50.20072.921SASA (PF03629, IPR005181): Carbohydrate esterase, sialic acid-specific acetylesterase
88 SLC39A3interactor100Zip (PF02535, IPR003689): ZIP Zinc transporter
89 STAT1suppressor50.6675.360SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
90 TANKsuppressor200DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
91 TAP2oncoprotein60.6006.129ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
92 TARSinteractor204.944HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
93 TCTN2interactor110.27373.841DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
94 TMEM206interactor100TMEM206 (PF15122, IPR029366): TMEM206 protein family
95 TMEM223interactor100TMEM223 (PF14640): Transmembrane protein 223
96 TMEM30Ainteractor60.33328.118CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family
97 TMEM63Binteractor2023.261RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
98 TRIB3interactor2019.368Pkinase (PF00069, IPR000719): Protein kinase domain
99 TRIM28protein found in more fusions70.33323.539ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
100 TTC28interactor203.951HisKA_3 (PF07730, IPR011712): Histidine kinase
PUB (PF09409, IPR018997): PUB domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
CHAT (PF12770, IPR024983): CHAT domain
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
101 TUBGCP2interactor40.8333.951Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
102 UBCprotein found in more fusions170.250218.151ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103 UFSP2interactor100Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
104 UXS1interactor100UXS1_N (PF11803, IPR021761): UDP-glucuronate decarboxylase N-terminal
GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
105 VARSinteractor309.524Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
106 VCPprotein found in more fusions170.250187.026AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
107 WDFY3interactor21.0000Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
108 WDR11suppressor100PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
109 YBX1oncoprotein60.60022.388CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2

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