Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins HIPK2 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 56 The number (and %) of the onco-proteins 33 (58.93 %) The number (and %) of the tumor suppressors 5 (8.93 %) Total number of binary PPIs (saturation %) 284 (18.44 %) The number (and %) of affected PPIs 56 (19.72 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 8.786 Assortativity coefficient -0.3700 The network average Clustering coefficient 0.556 The number (and %) of a zero Clustering coefficients 6 (10.71 %) The number (and %) of a zero Betweenness Centrality 12 (21.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HIPK2	All fusions : BI035539;
Proteins found in more fusions	RUNX1 (see 1 fusions); CREBBP (see 5 fusions); PAX6 (see 2 fusions); RANBP9 (see 2 fusions); SKI (see 1 fusions); HIPK2 (see 1 fusions); MYBL2 (see 4 fusions); SIAH2 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); SIAH1 (see 1 fusions); PML (see 4 fusions); SENP1 (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	HIPK2	parental protein	56	0.129	1780.602	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
2	AATF	oncoprotein	4	0.833	0.222	DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32 RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TRAUB (PF08164, IPR012617): Apoptosis-antagonizing transcription factor, C-terminal Vif (PF00559, IPR000475): Retroviral Vif (Viral infectivity) protein AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
3	ABL1	oncoprotein	6	0.700	3.000	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4	AXIN1	oncoprotein	8	0.619	3.586	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
5	BTRC	oncoprotein	10	0.611	6.660	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
6	CBX4	oncoprotein	2	0	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region CBX7_C (PF17218): CBX family C-terminal motif
7	CHMP4B	interactor	6	0.700	2.000	Snf7 (PF03357, IPR005024): Snf7
8	CREBBP	oncoprotein	23	0.307	112.194	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9	CUL1	oncoprotein	11	0.378	15.363	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10	CXCL1	oncoprotein	2	0	0	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
11	DAXX	oncoprotein	16	0.486	29.024	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
12	DCAF7	interactor	8	0.643	4.252	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
13	DYRK1A	oncoprotein	7	0.667	1.967	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
14	DYRK1B	oncoprotein	8	0.476	3.655	Pkinase (PF00069, IPR000719): Protein kinase domain
15	EP300	oncoprotein	21	0.332	74.287	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
16	FBXO3	interactor	4	0.667	0.452	DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525) Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A SMI1_KNR4 (PF09346, IPR018958, SM00860): SMI1 / KNR4 family (SUKH-1) F-box-like (PF12937, IPR001810): F-box-like PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
17	FBXW7	oncoprotein	5	0.500	1.167	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
18	HIST2H2BE	interactor	7	0.571	5.860	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19	MAP3K1	oncoprotein	8	0.524	4.852	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
20	MAP3K7	oncoprotein	4	0.667	0.333	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
21	MBP	interactor	2	1.000	0	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
22	MDM2	oncoprotein	17	0.500	31.037	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23	MECP2	interactor	4	0.500	2.167	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
24	MKNK1	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
25	MYB	oncoprotein	11	0.509	14.719	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
26	MYBL1	oncoprotein	3	1.000	0	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
27	MYBL2	oncoprotein	5	0.833	0.333	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
28	NKX2-1	oncoprotein	2	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
29	NLK	protein found in more fusions	11	0.400	17.540	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
30	PAX6	oncoprotein	7	0.667	2.002	PAX (PF00292, IPR001523, SM00351): 'Paired box' domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31	PML	oncoprotein	23	0.359	88.758	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32	RANBP9	suppressor	9	0.643	3.507	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
33	RGMA	interactor	1	0	0	RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
34	RUNX1	oncoprotein	9	0.750	3.952	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
35	SENP1	protein found in more fusions	8	0.714	1.955	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
36	SENP2	interactor	5	0.700	0.821	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
37	SIAH1	suppressor	6	0.800	1.067	Sina (PF03145, IPR018121): Seven in absentia protein family
38	SIAH1P1	interactor	1	0	0	NA
39	SIAH2	oncoprotein	7	0.667	3.167	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
40	SKI	oncoprotein	16	0.400	38.676	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
41	SMAD1	interactor	10	0.750	3.536	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
42	SMAD2	oncoprotein	12	0.691	6.026	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
43	SMAD3	oncoprotein	19	0.386	58.752	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
44	SP100	suppressor	9	0.786	2.007	Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
45	SUMO1	interactor	14	0.526	19.190	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
46	SUMO2	interactor	10	0.583	6.708	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
47	SUMO3	interactor	7	0.667	2.752	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
48	TP53	oncoprotein	26	0.330	129.816	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
49	TP53INP1	oncoprotein	2	1.000	0	DOR (PF14839, IPR029431): DOR family
50	TP63	suppressor	13	0.545	19.997	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
51	TP73	oncoprotein	13	0.545	14.284	P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
52	TRADD	interactor	2	0	0	Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat
53	UBE2I	interactor	21	0.400	64.853	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54	WSB1	interactor	1	0	0	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SOCS_box (PF07525, IPR001496): SOCS box
55	XAF1	oncoprotein	4	0.667	0.900	Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
56	ZBTB4	suppressor	2	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SPX (PF03105, IPR004331): SPX domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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