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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HIPK2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins33 (58.93 %)
The number (and %) of the tumor suppressors5 (8.93 %)
Total number of binary PPIs (saturation %)284 (18.44 %)
The number (and %) of affected PPIs56 (19.72 %)
The number of possible different fusions18
PPI diameter2
PPI radius1
The average degree of PPI8.786
Assortativity coefficient-0.3700
The network average Clustering coefficient0.556
The number (and %) of a zero Clustering coefficients6 (10.71 %)
The number (and %) of a zero Betweenness Centrality12 (21.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HIPK2 All fusions
: BI035539;
Proteins found in more fusions RUNX1 (see 1 fusions); CREBBP (see 5 fusions); PAX6 (see 2 fusions); RANBP9 (see 2 fusions); SKI (see 1 fusions); HIPK2 (see 1 fusions); MYBL2 (see 4 fusions); SIAH2 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); SIAH1 (see 1 fusions); PML (see 4 fusions); SENP1 (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HIPK2parental protein560.1291780.602Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
2 AATFoncoprotein40.8330.222DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TRAUB (PF08164, IPR012617): Apoptosis-antagonizing transcription factor, C-terminal
Vif (PF00559, IPR000475): Retroviral Vif (Viral infectivity) protein
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
3 ABL1oncoprotein60.7003.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 AXIN1oncoprotein80.6193.586Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
5 BTRConcoprotein100.6116.660WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 CBX4oncoprotein200Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
7 CHMP4Binteractor60.7002.000Snf7 (PF03357, IPR005024): Snf7
8 CREBBPoncoprotein230.307112.194Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9 CUL1oncoprotein110.37815.363Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 CXCL1oncoprotein200IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
11 DAXXoncoprotein160.48629.024Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
12 DCAF7interactor80.6434.252WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
13 DYRK1Aoncoprotein70.6671.967DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
14 DYRK1Boncoprotein80.4763.655Pkinase (PF00069, IPR000719): Protein kinase domain
15 EP300oncoprotein210.33274.287Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
16 FBXO3interactor40.6670.452DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
SMI1_KNR4 (PF09346, IPR018958, SM00860): SMI1 / KNR4 family (SUKH-1)
F-box-like (PF12937, IPR001810): F-box-like
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
17 FBXW7oncoprotein50.5001.167Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
18 HIST2H2BEinteractor70.5715.860Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 MAP3K1oncoprotein80.5244.852zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
20 MAP3K7oncoprotein40.6670.333Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
21 MBPinteractor21.0000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
22 MDM2oncoprotein170.50031.037Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23 MECP2interactor40.5002.167K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
24 MKNK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
25 MYBoncoprotein110.50914.719Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
26 MYBL1oncoprotein31.0000Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
27 MYBL2oncoprotein50.8330.333Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
28 NKX2-1oncoprotein21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
29 NLKprotein found in more fusions110.40017.540Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
30 PAX6oncoprotein70.6672.002PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 PMLoncoprotein230.35988.758zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32 RANBP9suppressor90.6433.507Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
33 RGMAinteractor100RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
34 RUNX1oncoprotein90.7503.952Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
35 SENP1protein found in more fusions80.7141.955Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
36 SENP2interactor50.7000.821Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
37 SIAH1suppressor60.8001.067Sina (PF03145, IPR018121): Seven in absentia protein family
38 SIAH1P1interactor100NA
39 SIAH2oncoprotein70.6673.167Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
40 SKIoncoprotein160.40038.676c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
41 SMAD1interactor100.7503.536MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
42 SMAD2oncoprotein120.6916.026MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
43 SMAD3oncoprotein190.38658.752MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
44 SP100suppressor90.7862.007Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain; Sp100 domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
45 SUMO1interactor140.52619.190Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
46 SUMO2interactor100.5836.708Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
47 SUMO3interactor70.6672.752Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
48 TP53oncoprotein260.330129.816DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
49 TP53INP1oncoprotein21.0000DOR (PF14839, IPR029431): DOR family
50 TP63suppressor130.54519.997Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
51 TP73oncoprotein130.54514.284P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
52 TRADDinteractor200Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
53 UBE2Iinteractor210.40064.853UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54 WSB1interactor100PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
SOCS_box (PF07525, IPR001496): SOCS box
55 XAF1oncoprotein40.6670.900Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
56 ZBTB4suppressor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SPX (PF03105, IPR004331): SPX domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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