1 |
HIPK2 | parental protein | 56 | 0.129 | 1780.602 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
2 |
AATF | oncoprotein | 4 | 0.833 | 0.222 | DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32 RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TRAUB (PF08164, IPR012617): Apoptosis-antagonizing transcription factor, C-terminal Vif (PF00559, IPR000475): Retroviral Vif (Viral infectivity) protein AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor |
3 |
ABL1 | oncoprotein | 6 | 0.700 | 3.000 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
4 |
AXIN1 | oncoprotein | 8 | 0.619 | 3.586 | Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain |
5 |
BTRC | oncoprotein | 10 | 0.611 | 6.660 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
6 |
CBX4 | oncoprotein | 2 | 0 | 0 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region CBX7_C (PF17218): CBX family C-terminal motif |
7 |
CHMP4B | interactor | 6 | 0.700 | 2.000 | Snf7 (PF03357, IPR005024): Snf7 |
8 |
CREBBP | oncoprotein | 23 | 0.307 | 112.194 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
9 |
CUL1 | oncoprotein | 11 | 0.378 | 15.363 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
10 |
CXCL1 | oncoprotein | 2 | 0 | 0 | IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like |
11 |
DAXX | oncoprotein | 16 | 0.486 | 29.024 | Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) |
12 |
DCAF7 | interactor | 8 | 0.643 | 4.252 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
13 |
DYRK1A | oncoprotein | 7 | 0.667 | 1.967 | DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X |
14 |
DYRK1B | oncoprotein | 8 | 0.476 | 3.655 | Pkinase (PF00069, IPR000719): Protein kinase domain |
15 |
EP300 | oncoprotein | 21 | 0.332 | 74.287 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
16 |
FBXO3 | interactor | 4 | 0.667 | 0.452 | DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525) Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A SMI1_KNR4 (PF09346, IPR018958, SM00860): SMI1 / KNR4 family (SUKH-1) F-box-like (PF12937, IPR001810): F-box-like PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated |
17 |
FBXW7 | oncoprotein | 5 | 0.500 | 1.167 | Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like |
18 |
HIST2H2BE | interactor | 7 | 0.571 | 5.860 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
19 |
MAP3K1 | oncoprotein | 8 | 0.524 | 4.852 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal |
20 |
MAP3K7 | oncoprotein | 4 | 0.667 | 0.333 | Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
21 |
MBP | interactor | 2 | 1.000 | 0 | Myelin_MBP (PF01669, IPR000548): Myelin basic protein |
22 |
MDM2 | oncoprotein | 17 | 0.500 | 31.037 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
23 |
MECP2 | interactor | 4 | 0.500 | 2.167 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
24 |
MKNK1 | interactor | 2 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
25 |
MYB | oncoprotein | 11 | 0.509 | 14.719 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
26 |
MYBL1 | oncoprotein | 3 | 1.000 | 0 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
27 |
MYBL2 | oncoprotein | 5 | 0.833 | 0.333 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
28 |
NKX2-1 | oncoprotein | 2 | 1.000 | 0 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719) |
29 |
NLK | protein found in more fusions | 11 | 0.400 | 17.540 | Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit |
30 |
PAX6 | oncoprotein | 7 | 0.667 | 2.002 | PAX (PF00292, IPR001523, SM00351): 'Paired box' domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
31 |
PML | oncoprotein | 23 | 0.359 | 88.758 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
32 |
RANBP9 | suppressor | 9 | 0.643 | 3.507 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain |
33 |
RGMA | interactor | 1 | 0 | 0 | RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus |
34 |
RUNX1 | oncoprotein | 9 | 0.750 | 3.952 | Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037) |
35 |
SENP1 | protein found in more fusions | 8 | 0.714 | 1.955 | Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
36 |
SENP2 | interactor | 5 | 0.700 | 0.821 | Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
37 |
SIAH1 | suppressor | 6 | 0.800 | 1.067 | Sina (PF03145, IPR018121): Seven in absentia protein family |
38 |
SIAH1P1 | interactor | 1 | 0 | 0 | NA |
39 |
SIAH2 | oncoprotein | 7 | 0.667 | 3.167 | Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
40 |
SKI | oncoprotein | 16 | 0.400 | 38.676 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
41 |
SMAD1 | interactor | 10 | 0.750 | 3.536 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
42 |
SMAD2 | oncoprotein | 12 | 0.691 | 6.026 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
43 |
SMAD3 | oncoprotein | 19 | 0.386 | 58.752 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
44 |
SP100 | suppressor | 9 | 0.786 | 2.007 | Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
45 |
SUMO1 | interactor | 14 | 0.526 | 19.190 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
46 |
SUMO2 | interactor | 10 | 0.583 | 6.708 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
47 |
SUMO3 | interactor | 7 | 0.667 | 2.752 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
48 |
TP53 | oncoprotein | 26 | 0.330 | 129.816 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
49 |
TP53INP1 | oncoprotein | 2 | 1.000 | 0 | DOR (PF14839, IPR029431): DOR family |
50 |
TP63 | suppressor | 13 | 0.545 | 19.997 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
51 |
TP73 | oncoprotein | 13 | 0.545 | 14.284 | P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
52 |
TRADD | interactor | 2 | 0 | 0 | Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat |
53 |
UBE2I | interactor | 21 | 0.400 | 64.853 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
54 |
WSB1 | interactor | 1 | 0 | 0 | PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SOCS_box (PF07525, IPR001496): SOCS box |
55 |
XAF1 | oncoprotein | 4 | 0.667 | 0.900 | Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65 |
56 |
ZBTB4 | suppressor | 2 | 1.000 | 0 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SPX (PF03105, IPR004331): SPX domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type |