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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins23 (31.94 %)
The number (and %) of the tumor suppressors8 (11.11 %)
Total number of binary PPIs (saturation %)396 (15.49 %)
The number (and %) of affected PPIs72 (18.18 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI10.306
Assortativity coefficient-0.2341
The network average Clustering coefficient0.615
The number (and %) of a zero Clustering coefficients1 (1.39 %)
The number (and %) of a zero Betweenness Centrality12 (16.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HINT1 All fusions
: BQ775173; U51004; BG028183;
Proteins found in more fusions EWSR1 (see 2 fusions); GSTO2 (see 1 fusions); TKT (see 5 fusions); U2AF2 (see 2 fusions); KAT5 (see 3 fusions); HDAC7 (see 1 fusions); HINT1 (see 3 fusions); PRDX6 (see 1 fusions); OFD1 (see 1 fusions); SP1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HINT1parental protein720.1213146.534HIT (PF01230, IPR001310): HIT domain
2 ACTL6Ainteractor70.6195.833Actin (PF00022, IPR004000, SM00268): Actin
3 AKR1B1suppressor150.56220.372Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
4 AKR1B10interactor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 AKR1B15interactor80.7506.125Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
6 ARHGDIAinteractor90.4647.527Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
7 BTRConcoprotein100.30624.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
8 CDC16interactor100Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
9 CDC34oncoprotein50.6672.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
10 CDK9protein found in more fusions70.5335.733Pkinase (PF00069, IPR000719): Protein kinase domain
11 CTNNB1oncoprotein90.33321.333Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
12 DHX36interactor30.6670.333DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 DUTinteractor150.50526.194dUTPase (PF00692, IPR008180): dUTPase
14 ENO1oncoprotein250.41796.720Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 ENO2interactor240.53647.505Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
16 ENO3interactor200.66815.103Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 EWSR1oncoprotein120.43621.338RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FABP3suppressor40.8330.118Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
19 FABP5interactor150.7057.639Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
20 FABP7interactor60.6001.002Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
21 FKBP1Ainteractor220.46263.080FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
22 FKBP1Binteractor110.8182.200FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
23 FKBP2interactor130.7446.004FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
24 FKBP7interactor51.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 GPX4interactor180.51633.131GSHPx (PF00255, IPR000889): Glutathione peroxidase
26 GSTO2protein found in more fusions51.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
27 GSTT1suppressor21.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
28 HDAC7protein found in more fusions40.6670.500Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
29 HDAC9interactor31.0000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
30 HSPA4Linteractor70.7144.533HSP70 (PF00012, IPR013126): Hsp70 protein
31 HSPE1interactor210.45760.853Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
32 KAT5suppressor60.7002.333MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
33 LEF1oncoprotein40.6672.000CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
34 MIFoncoprotein60.7001.400MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
35 MITFoncoprotein21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
36 MTAPsuppressor40.6671.333PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
37 NME1-NME2interactor190.52635.048NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
38 NME2interactor180.52235.302NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
39 NUTF2interactor70.7330.673NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
40 OFD1protein found in more fusions60.5004.067APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
41 OXCT1interactor40.6671.000CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
42 PARK7suppressor80.4297.633DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
43 PFDN2interactor30.6671.000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
44 PIN1suppressor130.48725.475Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
45 PMP2interactor50.9000.154Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
46 PPIBinteractor110.6367.683Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
47 PRDX2interactor100.44414.144AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
48 PRDX5interactor90.44413.439Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
49 PRDX6protein found in more fusions90.46411.750AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
50 PTGR1interactor31.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
51 RAE1interactor50.7003.000Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52 RBX1oncoprotein41.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
53 RGNinteractor21.0000SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
54 RUVBL1oncoprotein110.40021.333TIP49 (PF06068, IPR010339): TIP49 C-terminus
55 RUVBL2oncoprotein80.5717.000TIP49 (PF06068, IPR010339): TIP49 C-terminus
56 SCLT1oncoprotein30.6670.500DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
57 SIN3Aoncoprotein40.5002.667Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
58 SP1protein found in more fusions60.6003.333zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
59 SPRinteractor110.45517.589adh_short (PF00106, IPR002198): short chain dehydrogenase
60 STILoncoprotein31.0000STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
61 STIP1interactor210.46260.869TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
62 TAGLNsuppressor180.51628.357Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
63 TAGLN2interactor330.303225.394Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
64 TAGLN3interactor190.52633.643Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
65 TKTprotein found in more fusions240.43968.457Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
66 TMEM189-UBE2V1interactor41.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
67 TXNoncoprotein170.41943.665Thioredoxin (PF00085, IPR013766): Thioredoxin
68 U2AF2protein found in more fusions140.42326.047RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
69 UBE2V1interactor60.6671.244UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
70 UCHL3interactor120.50912.523Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
71 UFC1interactor60.6002.733UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
72 UNKinteractor90.25020.833MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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