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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins3 (11.54 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)66 (20.31 %)
The number (and %) of affected PPIs26 (39.39 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI4.462
Assortativity coefficient-0.4677
The network average Clustering coefficient0.536
The number (and %) of a zero Clustering coefficients6 (23.08 %)
The number (and %) of a zero Betweenness Centrality12 (46.15 %)


List of the fusions

PPI for parental proteins: HEXB All fusions
Proteins found in more fusions EZR (see 2 fusions); GRB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 HEXBparental protein260.110474.567Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
2 ABCE1interactor31.0000ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ALDH1B1interactor60.6673.733Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 BNIP2interactor200BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
5 CSNK2Binteractor200CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
6 EZRprotein found in more fusions70.4007.067DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
7 FBXO6interactor70.38111.500FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
8 FHsuppressor60.5335.833Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
9 GRB2oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
10 GTF3C4interactor60.5336.333TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
11 HK1interactor50.7002.333Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
12 HK2interactor31.0000Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
13 IPO5interactor50.6003.333HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
14 IPO9interactor30.6670.667IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
15 PDCD10interactor60.5335.167DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
16 PROSCinteractor50.7002.667Ala_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
17 RPL22oncoprotein21.0000Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
18 SMC6interactor200SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
19 SOD1interactor200Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
20 STIM1interactor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SSP160 (PF06933, IPR009701): Special lobe-specific silk protein SSP160
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
21 STIM2interactor21.0000DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
MAGSP (PF03082, IPR004315): Male accessory gland secretory protein
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
22 TATDN1interactor60.6674.067TatD_DNase (PF01026, IPR001130): TatD related DNase
23 TSNAXinteractor100Translin (PF01997, IPR002848): Translin family
24 TUFMinteractor60.5336.333GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
25 UBR7interactor50.9000.400PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
26 VCPKMTinteractor100Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase

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