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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HERC1 (from a repository: Sat Nov 19 13:34:01 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins8 (27.59 %)
The number (and %) of the tumor suppressors5 (17.24 %)
Total number of binary PPIs (saturation %)53 (13.05 %)
The number (and %) of affected PPIs29 (54.72 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.828
Assortativity coefficient-0.3904
The network average Clustering coefficient0.446
The number (and %) of a zero Clustering coefficients13 (44.83 %)
The number (and %) of a zero Betweenness Centrality23 (79.31 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: HERC1 All fusions
: BF997527;
Proteins found in more fusions KCMF1 (see 3 fusions); ARF1 (see 2 fusions); ECHS1 (see 1 fusions); EP300 (see 1 fusions); HERC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HERC1parental protein290.034716.000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
2 ARF1suppressor31.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
3 ARHGAP29suppressor100Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
IncA (PF04156, IPR007285): IncA protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
tRNA_lig_kinase (PF08303, IPR015966): tRNA ligase kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
4 BAK1oncoprotein31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
5 BRCA1suppressor60.5005.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 BYSLinteractor21.0000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
7 CLTConcoprotein30.6671.000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
8 DFFAsuppressor21.0000CIDE-N (PF02017, IPR003508): CIDE-N domain
DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain
T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
9 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
10 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
11 EP300oncoprotein60.4006.000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
12 GRIPAP1interactor100DivIC (PF04977, IPR007060): Septum formation initiator
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
13 HERC2interactor41.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
14 KCMF1oncoprotein40.6671.000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
Ntox28 (PF15605, IPR028948): Bacterial toxin 28
15 MLF1oncoprotein100Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
16 MORC1interactor100FliJ (PF02050, IPR012823): Flagellar FliJ protein
p25-alpha (PF05517, IPR008907): p25-alpha
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
17 MYL12Ainteractor21.0000EF-hand_11 (PF08976, IPR015070): EF-hand domain
DUF2267 (PF10025, IPR018727): Uncharacterized conserved protein (DUF2267)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 NOS2interactor200FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
19 PKMoncoprotein21.0000PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
20 RAPSNinteractor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
21 RSPH10B2interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
p25-alpha (PF05517, IPR008907): p25-alpha
22 SOX9oncoprotein31.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
23 TFDP3interactor21.0000DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
24 TSC2suppressor100Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
Tuberin (PF03542, IPR018515): Tuberin
DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
25 TTLL1interactor100TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
26 UBE2D3interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
27 UBE2Sinteractor200ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UNKinteractor30.6671.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
29 USP18interactor100TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HERC1parental proteinMerozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
BF997527

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