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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HECW1 (from a repository: Tue Dec 6 11:22:44 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins7 (31.82 %)
The number (and %) of the tumor suppressors1 (4.55 %)
Total number of binary PPIs (saturation %)62 (26.84 %)
The number (and %) of affected PPIs22 (35.48 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.273
Assortativity coefficient-0.2956
The network average Clustering coefficient0.624
The number (and %) of a zero Clustering coefficients3 (13.64 %)
The number (and %) of a zero Betweenness Centrality11 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HECW1 All fusions
: AW895684;
Proteins found in more fusions HECW1 (see 1 fusions); MPHOSPH8 (see 5 fusions); TP53 (see 3 fusions); UBC (see 1 fusions); UBE2D2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HECW1parental protein220.124314.633C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
2 CACNA1Ainteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
3 DVL1interactor200DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
4 FBXL15interactor21.0000LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
5 GFI1Boncoprotein100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 HECW2interactor70.3338.733C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
7 LDLRAD4interactor21.0000Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
8 MPHOSPH8protein found in more fusions200Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
9 RNF43oncoprotein60.5003.067IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
10 SCNN1Ainteractor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
11 SCNN1Boncoprotein21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
12 SOD1interactor50.6672.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
13 SSR4interactor21.0000TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
14 TNK2interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
15 TP53suppressor70.4006.900DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
16 UBCprotein found in more fusions100.36119.733ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
17 UBE2D1interactor50.8330.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D2oncoprotein60.7002.067UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 UBE2D3interactor60.5002.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2J2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
21 UBE2L3interactor70.4677.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
22 USP7oncoprotein50.8330.400MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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