Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HECTD1 (from a repository: Mon Aug 9 02:08:44 2021)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins7 (15.22 %)
The number (and %) of the tumor suppressors5 (10.87 %)
Total number of binary PPIs (saturation %)116 (11.21 %)
The number (and %) of affected PPIs46 (39.66 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.391
Assortativity coefficient-0.4999
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients17 (36.96 %)
The number (and %) of a zero Betweenness Centrality24 (52.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HECTD1 All fusions
Proteins found in more fusions HECTD1 (see 1 fusions); HSPB1 (see 1 fusions); NIN (see 1 fusions); TPM2 (see 1 fusions); APC (see 1 fusions); TP53 (see 3 fusions); UBC (see 7 fusions); PRDX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HECTD1parental protein460.0571736.033Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
NOA36 (PF06524, IPR010531): NOA36 protein
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
2 AARSD1interactor30.6671.000tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 ANKRD28interactor40.6671.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 AP1M2interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 APCsuppressor100.30623.067APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 ATP6V1C2interactor100V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
7 BMP15interactor100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
8 BTF3L4interactor100NAC (PF01849, IPR002715): NAC domain
9 C9orf24interactor100SMRP1 (PF15181, IPR028195): Spermatid-specific manchette-related protein 1
10 CAMKMTinteractor100Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
11 DIRAS3suppressor21.0000ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
VirE (PF05272, IPR007936): Virulence-associated protein E
12 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
13 DYNLT1interactor30.6671.000Tctex-1 (PF03645, IPR005334): Tctex-1 family
14 ESR1suppressor110.53318.133Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
15 FBXW11interactor70.4006.833WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
17 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
18 HSPB1oncoprotein70.5335.833HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 IGSF1interactor200UEV (PF05743, IPR008883): UEV domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
20 NCAPD2oncoprotein70.8102.500Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
HEAT (PF02985, IPR000357): HEAT repeat
LrgA (PF03788, IPR005538): LrgA family
Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
21 NCAPGinteractor80.7146.300P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
Terminase_2 (PF03592, IPR005335): Terminase small subunit
UVR (PF02151, IPR001943): UvrB/uvrC motif
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
HEAT_2 (PF13646): HEAT repeats
22 NCAPHinteractor70.7625.000Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
23 NCAPH2interactor61.0000CNDH2_N (PF06278, IPR009378): Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
CNDH2_C (PF16858, IPR031737): Condensin II complex subunit CAP-H2 or CNDH2, C-term
CNDH2_M (PF16869): PF16858
24 NINoncoprotein31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
25 PCLAFinteractor100PAF (PF15715, IPR031444): PCNA-associated factor
26 PPP2R5Dinteractor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
27 PRDX1oncoprotein40.6671.000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
28 RASSF6oncoprotein100Phage_Orf51 (PF06194, IPR009338): Phage Conserved Open Reading Frame 51
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RecO_C (PF02565, IPR003717): Recombination protein O C terminal
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
29 RIOK2interactor100RIO1 (PF01163, IPR018934): RIO1 family
Rio2_N (PF09202, IPR015285): Rio2, N-terminal
30 RPGRIP1Linteractor40.6671.167bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
31 SEM1interactor21.0000CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
32 SETDB1interactor21.0000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
33 SIRT7interactor50.5004.000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
34 SMC2interactor70.9050.800SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
35 SMC4interactor80.7504.300SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
36 TCEAL4interactor21.0000BEX (PF04538, IPR021156): Brain expressed X-linked like family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
37 TP53suppressor100.27823.400DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
38 TPM2protein found in more fusions200DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
39 TTLL1interactor100TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
40 TUBGCP3interactor30.6670.667Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
41 UBCprotein found in more fusions90.32116.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 UBE2D3interactor40.6670.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
43 YWHAQinteractor60.4008.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 ZNF622interactor200S-antigen (PF05756, IPR008825): S-antigen protein
Stm1_N (PF09598, IPR019084): Stm1
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
45 ZNHIT3interactor100FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
zf-HIT (PF04438, IPR007529): HIT zinc finger
46 ZRANB1interactor40.8330.400Copper-fist (PF00649, IPR001083, SM01090): Copper fist DNA binding domain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

B a c k    t o    T o p ⇑