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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins7 (15.22 %)
The number (and %) of the tumor suppressors5 (10.87 %)
Total number of binary PPIs (saturation %)116 (11.21 %)
The number (and %) of affected PPIs46 (39.66 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.391
Assortativity coefficient-0.4999
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients17 (36.96 %)
The number (and %) of a zero Betweenness Centrality24 (52.17 %)


List of the fusions

PPI for parental proteins: HECTD1 All fusions
Proteins found in more fusions HECTD1 (see 1 fusions); HSPB1 (see 1 fusions); NIN (see 1 fusions); TPM2 (see 1 fusions); APC (see 1 fusions); TP53 (see 3 fusions); UBC (see 7 fusions); PRDX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 HECTD1parental protein460.0571736.033Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
NOA36 (PF06524, IPR010531): NOA36 protein
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
2 AARSD1interactor30.6671.000tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 ANKRD28interactor40.6671.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 AP1M2interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 APCsuppressor100.30623.067APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 ATP6V1C2interactor100V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
7 BMP15interactor100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
8 BTF3L4interactor100NAC (PF01849, IPR002715): NAC domain
9 C9orf24interactor100SMRP1 (PF15181, IPR028195): Spermatid-specific manchette-related protein 1
10 CAMKMTinteractor100Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
11 DIRAS3suppressor21.0000ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
VirE (PF05272, IPR007936): Virulence-associated protein E
12 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
13 DYNLT1interactor30.6671.000Tctex-1 (PF03645, IPR005334): Tctex-1 family
14 ESR1suppressor110.53318.133Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
15 FBXW11interactor70.4006.833WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
17 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
18 HSPB1oncoprotein70.5335.833HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 IGSF1interactor200UEV (PF05743, IPR008883): UEV domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
20 NCAPD2oncoprotein70.8102.500Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
HEAT (PF02985, IPR000357): HEAT repeat
LrgA (PF03788, IPR005538): LrgA family
Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
21 NCAPGinteractor80.7146.300P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
Terminase_2 (PF03592, IPR005335): Terminase small subunit
UVR (PF02151, IPR001943): UvrB/uvrC motif
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
HEAT_2 (PF13646): HEAT repeats
22 NCAPHinteractor70.7625.000Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
23 NCAPH2interactor61.0000CNDH2_N (PF06278, IPR009378): Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
CNDH2_C (PF16858, IPR031737): Condensin II complex subunit CAP-H2 or CNDH2, C-term
CNDH2_M (PF16869): PF16858
24 NINoncoprotein31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
25 PCLAFinteractor100PAF (PF15715, IPR031444): PCNA-associated factor
26 PPP2R5Dinteractor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
27 PRDX1oncoprotein40.6671.000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
28 RASSF6oncoprotein100Phage_Orf51 (PF06194, IPR009338): Phage Conserved Open Reading Frame 51
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RecO_C (PF02565, IPR003717): Recombination protein O C terminal
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
29 RIOK2interactor100RIO1 (PF01163, IPR018934): RIO1 family
Rio2_N (PF09202, IPR015285): Rio2, N-terminal
30 RPGRIP1Linteractor40.6671.167bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
31 SEM1interactor21.0000CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
32 SETDB1interactor21.0000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
33 SIRT7interactor50.5004.000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
34 SMC2interactor70.9050.800SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
35 SMC4interactor80.7504.300SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
36 TCEAL4interactor21.0000BEX (PF04538, IPR021156): Brain expressed X-linked like family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
37 TP53suppressor100.27823.400DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
38 TPM2protein found in more fusions200DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
39 TTLL1interactor100TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
40 TUBGCP3interactor30.6670.667Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
41 UBCprotein found in more fusions90.32116.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 UBE2D3interactor40.6670.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
43 YWHAQinteractor60.4008.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 ZNF622interactor200S-antigen (PF05756, IPR008825): S-antigen protein
Stm1_N (PF09598, IPR019084): Stm1
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
45 ZNHIT3interactor100FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
zf-HIT (PF04438, IPR007529): HIT zinc finger
46 ZRANB1interactor40.8330.400Copper-fist (PF00649, IPR001083, SM01090): Copper fist DNA binding domain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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