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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)101
The number (and %) of the onco-proteins32 (31.68 %)
The number (and %) of the tumor suppressors15 (14.85 %)
Total number of binary PPIs (saturation %)456 (9.03 %)
The number (and %) of affected PPIs99 (21.71 %)
The number of possible different fusions21
PPI diameter5
PPI radius3
The average degree of PPI8.139
Assortativity coefficient-0.2658
The network average Clustering coefficient0.443
The number (and %) of a zero Clustering coefficients17 (16.83 %)
The number (and %) of a zero Betweenness Centrality21 (20.79 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions HSPB1/OBSL1 (see 1 fusions); KIF11 (see 1 fusions); SMAD4 (see 2 fusions); PRKDC (see 3 fusions); TOPBP1 (see 2 fusions); VCP (see 4 fusions); HMG20A (see 2 fusions); HDAC1 (see 1 fusions); KDM1A (see 2 fusions); HSPB1 (see 4 fusions); CSNK2A1 (see 1 fusions); COPS5 (see 1 fusions); CSNK2A1/ELAVL1 (see 1 fusions); S100A10 (see 1 fusions); SUV39H1 (see 1 fusions); VPS26A (see 1 fusions); RCOR1 (see 2 fusions); KCMF1 (see 4 fusions); VPS35 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HDLBPparental protein700.0814598.577BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
2 PHF21Aparental protein290.1031479.141AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
PHD (PF00628, IPR019787, SM00249): PHD-finger
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
3 ACTL6Ainteractor50.50010.941Actin (PF00022, IPR004000, SM00268): Actin
4 ADARinteractor80.42936.103dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
5 AKTIPinteractor100UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
6 ARRB1interactor50.50030.965Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATP6V1B2interactor40.33332.786ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
8 BANPsuppressor31.0000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
9 BPGMinteractor100Exc (PF07825, IPR012884): Excisionase-like protein
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
10 CBX5suppressor70.26787.516Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
11 CCDC8interactor120.41841.328Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
12 CD14interactor100LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 CDC5Linteractor180.404100.810OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
14 CDK2suppressor170.38382.816Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 CLUHinteractor40.6670.821DUF727 (PF05303, IPR007967): Protein of unknown function (DUF727)
eIF3_p135 (PF12807): Translation initiation factor eIF3 subunit 135
CLU (PF13236, IPR025697): Clustered mitochondria
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
CLU_N (PF15044, IPR028275): Mitochondrial function, CLU-N-term
16 COPS5protein found in more fusions180.368121.499JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
17 CSNK2A1oncoprotein160.381236.865Pkinase (PF00069, IPR000719): Protein kinase domain
18 CYP1A1oncoprotein30.33310.443p450 (PF00067, IPR001128): Cytochrome P450
19 DDX43oncoprotein100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
20 DHX9oncoprotein150.46740.601DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
22 EIF2Ainteractor50.5006.562Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
23 ELAVL1oncoprotein290.167941.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 ERBB2oncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ESCO2interactor60.8677.768Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
26 ESR1suppressor200.257259.528Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
27 FAM46Ainteractor30.3335.562NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
28 FAUinteractor30.6671.295Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
29 FHL3interactor50.33317.695LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
30 GLMNoncoprotein21.0000Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
31 GTF2Iinteractor90.389125.611GTF2I (PF02946, IPR004212): GTF2I-like repeat
32 HDAC1suppressor160.352227.490FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
33 HDAC2suppressor210.311354.682Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
34 HIST2H3Cinteractor30.6674.078Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
35 HIST3H3interactor60.46741.920Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
36 HMG20Aprotein found in more fusions90.64329.938DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
37 HMG20Binteractor80.6799.956IncA (PF04156, IPR007285): IncA protein
NEMP (PF10225, IPR019358): NEMP family
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
38 HSPB1oncoprotein150.319153.028HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
39 IKBKGinteractor90.179205.026CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40 IP6K3interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
41 KCMF1oncoprotein70.40013.070zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
Ntox28 (PF15605, IPR028948): Bacterial toxin 28
42 KDM1Aprotein found in more fusions190.307281.896Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
43 KIF11protein found in more fusions70.6676.344Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
44 KIF22interactor204.078Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
45 KRT40interactor3031.945Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
46 LGR4interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 LLGL2interactor200Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
48 LPXNinteractor209.923LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
49 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
50 MLH1suppressor50.8002.933DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
51 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
52 NAF1interactor204.623AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
53 NTRK1oncoprotein350.191651.022I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
54 NUP58interactor60.40033.036Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
55 NUP62interactor50.66717.618Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
56 OBSL1protein found in more fusions210.274439.915BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
57 PLAURoncoprotein202.634Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
58 PRKDCprotein found in more fusions200.427114.942FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
59 PSMD12interactor60.6003.337Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
60 PTCRAoncoprotein21.0000PTCRA (PF15028, IPR027834): Pre-T-cell antigen receptor
61 RBPJinteractor80.42962.496BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
62 RCOR1protein found in more fusions100.66710.612DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
63 S100A10oncoprotein302.634S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
64 S100A11suppressor200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
65 SAC3D1interactor51.0000SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
66 SCARNA22interactor60.7331.269NA
67 SCLT1oncoprotein60.26751.406DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
68 SERPINB3oncoprotein30.6670.286Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
69 SERPINB5suppressor80.250155.752Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
70 SIRT7interactor140.297117.290DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
71 SMAD4suppressor80.286110.013MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
72 SMSinteractor40.8332.634Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
73 SNW1protein found in more fusions220.248423.879SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
74 SOD1interactor3012.060Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
75 SOS1oncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
76 SUV39H1protein found in more fusions90.429109.916Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
77 TAF10interactor30.6676.306TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
78 TMEM171interactor21.0000TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
79 TOPBP1protein found in more fusions31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
80 TRAF1oncoprotein60.30029.373HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
81 TTC4suppressor90.63912.493TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
82 TTKinteractor80.7143.903Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
83 TYRO3oncoprotein40.33340.035fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
84 UBA6interactor80.46418.950ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
85 UBE2Ainteractor50.5003.644UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
86 UBE4Bsuppressor130.53035.387DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
87 UPF1interactor120.37988.470UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
88 VCPprotein found in more fusions180.294238.857AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
89 VPS25interactor61.0000ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
90 VPS26Aprotein found in more fusions110.66732.693Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
91 VPS29interactor80.8212.100Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
92 VPS35protein found in more fusions130.54546.614FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
93 VPS36interactor100.66721.944EAP30 (PF04157, IPR007286): EAP30/Vps36 family
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
94 WWOXsuppressor100.26769.831adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
95 XPOTinteractor40.5002.043DUF310 (PF03750, IPR010149): Protein of unknown function (DUF310)
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
96 XRCC5suppressor140.47426.924Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
97 YBX1oncoprotein90.5838.343CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
98 ZCCHC7interactor202.634zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
zf-CCHC_3 (PF13917): Zinc knuckle
99 ZNF598interactor30.6670.363Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
100 ZW10interactor21.0000Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
101 ZYXsuppressor50.10069.117DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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