Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins HDAC4 (from a repository: Thu Nov 17 05:36:52 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 130 The number (and %) of the onco-proteins 57 (43.85 %) The number (and %) of the tumor suppressors 33 (25.38 %) Total number of binary PPIs (saturation %) 786 (9.37 %) The number (and %) of affected PPIs 130 (16.54 %) The number of possible different fusions 32 PPI diameter 2 PPI radius 1 The average degree of PPI 11.108 Assortativity coefficient -0.3065 The network average Clustering coefficient 0.506 The number (and %) of a zero Clustering coefficients 12 (9.23 %) The number (and %) of a zero Betweenness Centrality 24 (18.46 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HDAC4	All fusions
Proteins found in more fusions	CTBP1 (see 2 fusions); PPARD (see 1 fusions); APP (see 4 fusions); SYK (see 1 fusions); YWHAG (see 1 fusions); LZTR1 (see 2 fusions); MAPK1 (see 1 fusions); NUP214 (see 1 fusions); GSK3B (see 1 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); BCL6 (see 2 fusions); ATXN1 (see 3 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); YY1 (see 2 fusions); YWHAH (see 2 fusions); SP1 (see 1 fusions); IKZF1 (see 1 fusions); SF1 (see 1 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); MARK3 (see 1 fusions); CAMK2D (see 1 fusions); RXRA (see 2 fusions); HDAC5 (see 1 fusions); ZBTB16 (see 3 fusions); SUV39H1 (see 1 fusions); SENP1 (see 1 fusions); STAT1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	HDAC4	parental protein	130	0.072	10784.326	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
2	ACTA1	interactor	3	0.667	0.333	Actin (PF00022, IPR004000, SM00268): Actin
3	AHRR	suppressor	4	0.833	0.400	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold
4	ANKRA2	interactor	9	0.417	13.111	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
5	APP	protein found in more fusions	26	0.190	173.331	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6	AR	oncoprotein	22	0.371	56.901	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
7	ATF2	oncoprotein	15	0.330	33.920	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
8	ATF3	suppressor	13	0.455	20.845	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
9	ATRX	oncoprotein	1	0	0	DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
10	ATXN1	protein found in more fusions	9	0.393	13.667	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
11	BCL6	oncoprotein	15	0.429	20.939	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
12	BCOR	oncoprotein	9	0.714	2.756	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
13	BCORL1	suppressor	4	0.833	0.200	Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
14	BRMS1	suppressor	9	0.536	7.614	Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family Sds3 (PF08598, IPR013907): Sds3-like
15	CACNA1C	interactor	2	1.000	0	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain Ion_trans (PF00520, IPR005821): Ion transport protein Rer1 (PF03248, IPR004932): Rer1 family ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18 DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
16	CAMK1	interactor	6	0.467	3.858	Pkinase (PF00069, IPR000719): Protein kinase domain Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
17	CAMK2D	oncoprotein	3	1.000	0	CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain Pkinase (PF00069, IPR000719): Protein kinase domain
18	CAMK4	interactor	1	0	0	DUF1103 (PF06513, IPR009484): Repeat of unknown function (DUF1103) Pkinase (PF00069, IPR000719): Protein kinase domain
19	CCDC136	suppressor	2	1.000	0	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Sec34 (PF04136, IPR007265): Sec34-like family Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding FlxA (PF14282, IPR025577): FlxA-like protein PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
20	CDK5	oncoprotein	6	0.700	1.400	Pkinase (PF00069, IPR000719): Protein kinase domain
21	CDKN1A	suppressor	14	0.308	42.367	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
22	CDR2	interactor	2	0	0	DivIC (PF04977, IPR007060): Septum formation initiator SlyX (PF04102, IPR007236): SlyX Striatin (PF08232, IPR013258): Striatin family BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
23	CEBPD	suppressor	4	0.500	0.360	bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
24	CIITA	oncoprotein	8	0.464	9.202	NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
25	CSRP3	interactor	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
26	CTBP1	protein found in more fusions	20	0.310	71.823	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
27	CTNNB1	oncoprotein	25	0.263	116.757	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
28	CUL7	protein found in more fusions	19	0.301	73.211	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29	DNAJB5	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
30	DNAJB6	interactor	3	1.000	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
31	DNAJB8	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
32	EFEMP2	interactor	2	1.000	0	EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Adipogenin (PF15202, IPR027938): Adipogenin
33	ELAVL1	oncoprotein	21	0.195	99.302	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34	ESCO2	interactor	2	1.000	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
35	ESR1	suppressor	32	0.286	180.888	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
36	FOXP3	suppressor	9	0.306	14.898	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
37	GATA1	oncoprotein	6	0.733	0.829	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
38	GATA3	oncoprotein	5	0.600	1.778	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
39	GCM1	interactor	6	0.533	3.817	DUF1272 (PF06906, IPR010696): Protein of unknown function (DUF1272) GCM (PF03615, IPR003902): GCM motif protein
40	GNB1	interactor	4	0.667	0.440	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41	GOLGA2	interactor	5	0.800	0.800	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
42	GSK3B	suppressor	12	0.436	13.826	Pkinase (PF00069, IPR000719): Protein kinase domain
43	HDAC3	suppressor	46	0.194	483.585	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
44	HDAC5	protein found in more fusions	59	0.155	971.846	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
45	HDAC7	protein found in more fusions	32	0.305	170.679	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
46	HDAC9	interactor	19	0.229	65.517	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein
47	HIC1	suppressor	8	0.619	2.578	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
48	HIF1A	suppressor	12	0.606	6.890	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
49	HNF4A	suppressor	13	0.515	11.430	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50	IFRD1	interactor	4	0.667	0.333	IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
51	IKZF1	suppressor	14	0.577	12.049	Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
52	IKZF2	suppressor	7	0.867	0.556	ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
53	IKZF3	suppressor	12	0.491	16.394	C1_2 (PF03107, IPR004146): C1 domain Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_7 (PF15269): Zinc-finger
54	IKZF4	interactor	10	0.611	5.775	ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
55	JDP2	suppressor	5	0.500	0.687	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
56	KDM5B	interactor	7	0.667	1.875	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Rubredoxin (PF00301, IPR024935): Rubredoxin zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
57	KRT31	interactor	3	0.667	0.500	Filament (PF00038, IPR001664): Intermediate filament protein
58	KRT38	interactor	1	0	0	Filament (PF00038, IPR001664): Intermediate filament protein
59	KRT40	interactor	3	0.667	1.000	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
60	LCOR	interactor	6	0.600	2.263	DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553)
61	LDOC1	oncoprotein	4	0.667	0.286	DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
62	LZTR1	oncoprotein	3	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3 Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
63	MAP1S	interactor	1	0	0	Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
64	MAPK1	oncoprotein	19	0.307	57.384	Pkinase (PF00069, IPR000719): Protein kinase domain
65	MAPK3	oncoprotein	10	0.444	11.950	Pkinase (PF00069, IPR000719): Protein kinase domain
66	MARK3	protein found in more fusions	11	0.933	0.786	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
67	MECOM	oncoprotein	8	0.571	4.357	SET (PF00856, IPR001214, SM00317): SET domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
68	MEF2A	oncoprotein	10	0.533	13.143	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
69	MEF2C	oncoprotein	10	0.444	12.054	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
70	MEF2D	oncoprotein	7	0.571	2.999	DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
71	MIF4GD	interactor	2	1.000	0	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
72	MORC2	interactor	1	0	0	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit zf-CW (PF07496, IPR011124): CW-type Zinc Finger EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
73	MTUS2	suppressor	2	0	0	DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496) RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat FAM184 (PF15665): Family with sequence similarity 184, A and B
74	NACC1	interactor	9	0.321	11.700	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain
75	NCOR1	oncoprotein	28	0.365	110.089	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
76	NCOR2	oncoprotein	28	0.368	112.023	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
77	NFATC1	oncoprotein	8	0.571	5.683	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
78	NFKB1	suppressor	19	0.392	49.088	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
79	NFKBIA	oncoprotein	10	0.622	7.615	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
80	NFKBIE	oncoprotein	5	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
81	NPPB	interactor	2	1.000	0	ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide
82	NR1H2	oncoprotein	10	0.556	7.463	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
83	NR2C1	interactor	7	0.810	0.904	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
84	NR2C2	suppressor	8	0.762	1.561	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
85	NUP155	interactor	3	0.667	0.333	Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
86	NUP214	oncoprotein	8	0.524	4.277	dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
87	PARK2	suppressor	11	0.333	19.352	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
88	PNMA1	oncoprotein	2	1.000	0	PNMA (PF14893, IPR026523): PNMA
89	PPARD	oncoprotein	7	0.867	0.571	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
90	PPARG	suppressor	20	0.333	70.047	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
91	PPP2CA	suppressor	8	0.500	10.000	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
92	PPP2R1A	oncoprotein	8	0.536	6.892	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
93	PTPA	suppressor	6	0.400	5.317	PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein
94	RANBP2	oncoprotein	8	0.429	6.176	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
95	RARA	oncoprotein	14	0.538	12.699	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
96	RBBP4	oncoprotein	18	0.353	54.206	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
97	REST	oncoprotein	6	0.733	0.933	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Presenilin (PF01080, IPR001108): Presenilin RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
98	REV3L	interactor	3	0.667	1.000	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666) DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
99	RFX5	oncoprotein	7	0.571	6.067	RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
100	RFXANK	interactor	7	0.533	4.292	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
101	RFXAP	interactor	5	0.600	3.400	RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
102	RINT1	suppressor	1	0	0	RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family
103	RUNX2	suppressor	7	0.810	1.012	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Runt (PF00853, IPR013524): Runt domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
104	RXRA	oncoprotein	19	0.471	36.477	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
105	SENP1	protein found in more fusions	7	0.333	5.267	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
106	SF1	protein found in more fusions	8	0.619	3.952	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
107	SFN	suppressor	13	0.545	15.993	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
108	SIN3A	oncoprotein	21	0.371	64.168	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
109	SIRT1	suppressor	17	0.333	47.194	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
110	SMAD3	oncoprotein	27	0.268	135.905	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
111	SP1	protein found in more fusions	32	0.256	193.502	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
112	SRF	interactor	9	0.821	0.967	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
113	SS18L1	oncoprotein	4	1.000	0	DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313) SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
114	STAT1	suppressor	11	0.444	17.155	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
115	SUV39H1	protein found in more fusions	15	0.407	30.494	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain
116	SYK	suppressor	6	0.600	1.186	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
117	TBL1XR1	oncoprotein	11	0.618	5.447	LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
118	TP53BP1	suppressor	6	0.400	3.963	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
119	UBE2I	interactor	40	0.171	402.640	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120	YWHAB	interactor	14	0.615	13.213	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
121	YWHAE	oncoprotein	13	0.603	17.962	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
122	YWHAG	protein found in more fusions	17	0.533	29.399	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
123	YWHAH	protein found in more fusions	12	0.764	5.706	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
124	YWHAQ	interactor	18	0.458	40.848	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
125	YWHAZ	protein found in more fusions	19	0.451	48.227	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
126	YY1	protein found in more fusions	12	0.382	12.623	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
127	ZBTB16	suppressor	20	0.427	56.725	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
128	ZBTB7B	interactor	6	0.700	0.500	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GAGA (PF09237, IPR015318): GAGA factor SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
129	ZEB2	oncoprotein	7	0.524	2.971	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain Rubredoxin (PF00301, IPR024935): Rubredoxin zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
130	ZNF354A	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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