1 |
HDAC4 | parental protein | 130 | 0.072 | 10784.326 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
2 |
ACTA1 | interactor | 3 | 0.667 | 0.333 | Actin (PF00022, IPR004000, SM00268): Actin |
3 |
AHRR | suppressor | 4 | 0.833 | 0.400 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold |
4 |
ANKRA2 | interactor | 9 | 0.417 | 13.111 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
5 |
APP | protein found in more fusions | 26 | 0.190 | 173.331 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
6 |
AR | oncoprotein | 22 | 0.371 | 56.901 | Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
7 |
ATF2 | oncoprotein | 15 | 0.330 | 33.920 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type |
8 |
ATF3 | suppressor | 13 | 0.455 | 20.845 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor |
9 |
ATRX | oncoprotein | 1 | 0 | 0 | DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) |
10 |
ATXN1 | protein found in more fusions | 9 | 0.393 | 13.667 | AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term |
11 |
BCL6 | oncoprotein | 15 | 0.429 | 20.939 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger |
12 |
BCOR | oncoprotein | 9 | 0.714 | 2.756 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain |
13 |
BCORL1 | suppressor | 4 | 0.833 | 0.200 | Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain |
14 |
BRMS1 | suppressor | 9 | 0.536 | 7.614 | Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family Sds3 (PF08598, IPR013907): Sds3-like |
15 |
CACNA1C | interactor | 2 | 1.000 | 0 | Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain Ion_trans (PF00520, IPR005821): Ion transport protein Rer1 (PF03248, IPR004932): Rer1 family ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18 DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated |
16 |
CAMK1 | interactor | 6 | 0.467 | 3.858 | Pkinase (PF00069, IPR000719): Protein kinase domain Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase |
17 |
CAMK2D | oncoprotein | 3 | 1.000 | 0 | CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain Pkinase (PF00069, IPR000719): Protein kinase domain |
18 |
CAMK4 | interactor | 1 | 0 | 0 | DUF1103 (PF06513, IPR009484): Repeat of unknown function (DUF1103) Pkinase (PF00069, IPR000719): Protein kinase domain |
19 |
CCDC136 | suppressor | 2 | 1.000 | 0 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Sec34 (PF04136, IPR007265): Sec34-like family Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding FlxA (PF14282, IPR025577): FlxA-like protein PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal |
20 |
CDK5 | oncoprotein | 6 | 0.700 | 1.400 | Pkinase (PF00069, IPR000719): Protein kinase domain |
21 |
CDKN1A | suppressor | 14 | 0.308 | 42.367 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
22 |
CDR2 | interactor | 2 | 0 | 0 | DivIC (PF04977, IPR007060): Septum formation initiator SlyX (PF04102, IPR007236): SlyX Striatin (PF08232, IPR013258): Striatin family BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) |
23 |
CEBPD | suppressor | 4 | 0.500 | 0.360 | bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 |
24 |
CIITA | oncoprotein | 8 | 0.464 | 9.202 | NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
25 |
CSRP3 | interactor | 1 | 0 | 0 | LIM (PF00412, IPR001781, SM00132): LIM domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS |
26 |
CTBP1 | protein found in more fusions | 20 | 0.310 | 71.823 | 2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D |
27 |
CTNNB1 | oncoprotein | 25 | 0.263 | 116.757 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
28 |
CUL7 | protein found in more fusions | 19 | 0.301 | 73.211 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
29 |
DNAJB5 | interactor | 1 | 0 | 0 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
30 |
DNAJB6 | interactor | 3 | 1.000 | 0 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain |
31 |
DNAJB8 | interactor | 1 | 0 | 0 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain |
32 |
EFEMP2 | interactor | 2 | 1.000 | 0 | EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Adipogenin (PF15202, IPR027938): Adipogenin |
33 |
ELAVL1 | oncoprotein | 21 | 0.195 | 99.302 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
34 |
ESCO2 | interactor | 2 | 1.000 | 0 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase |
35 |
ESR1 | suppressor | 32 | 0.286 | 180.888 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
36 |
FOXP3 | suppressor | 9 | 0.306 | 14.898 | Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
37 |
GATA1 | oncoprotein | 6 | 0.733 | 0.829 | GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain |
38 |
GATA3 | oncoprotein | 5 | 0.600 | 1.778 | GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain |
39 |
GCM1 | interactor | 6 | 0.533 | 3.817 | DUF1272 (PF06906, IPR010696): Protein of unknown function (DUF1272) GCM (PF03615, IPR003902): GCM motif protein |
40 |
GNB1 | interactor | 4 | 0.667 | 0.440 | Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
41 |
GOLGA2 | interactor | 5 | 0.800 | 0.800 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5 |
42 |
GSK3B | suppressor | 12 | 0.436 | 13.826 | Pkinase (PF00069, IPR000719): Protein kinase domain |
43 |
HDAC3 | suppressor | 46 | 0.194 | 483.585 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
44 |
HDAC5 | protein found in more fusions | 59 | 0.155 | 971.846 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
45 |
HDAC7 | protein found in more fusions | 32 | 0.305 | 170.679 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO |
46 |
HDAC9 | interactor | 19 | 0.229 | 65.517 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein |
47 |
HIC1 | suppressor | 8 | 0.619 | 2.578 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
48 |
HIF1A | suppressor | 12 | 0.606 | 6.890 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 |
49 |
HNF4A | suppressor | 13 | 0.515 | 11.430 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
50 |
IFRD1 | interactor | 4 | 0.667 | 0.333 | IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region |
51 |
IKZF1 | suppressor | 14 | 0.577 | 12.049 | Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
52 |
IKZF2 | suppressor | 7 | 0.867 | 0.556 | ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
53 |
IKZF3 | suppressor | 12 | 0.491 | 16.394 | C1_2 (PF03107, IPR004146): C1 domain Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_7 (PF15269): Zinc-finger |
54 |
IKZF4 | interactor | 10 | 0.611 | 5.775 | ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease |
55 |
JDP2 | suppressor | 5 | 0.500 | 0.687 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor |
56 |
KDM5B | interactor | 7 | 0.667 | 1.875 | ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Rubredoxin (PF00301, IPR024935): Rubredoxin zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein |
57 |
KRT31 | interactor | 3 | 0.667 | 0.500 | Filament (PF00038, IPR001664): Intermediate filament protein |
58 |
KRT38 | interactor | 1 | 0 | 0 | Filament (PF00038, IPR001664): Intermediate filament protein |
59 |
KRT40 | interactor | 3 | 0.667 | 1.000 | Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184) |
60 |
LCOR | interactor | 6 | 0.600 | 2.263 | DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553) |
61 |
LDOC1 | oncoprotein | 4 | 0.667 | 0.286 | DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939) |
62 |
LZTR1 | oncoprotein | 3 | 1.000 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3 Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif |
63 |
MAP1S | interactor | 1 | 0 | 0 | Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain |
64 |
MAPK1 | oncoprotein | 19 | 0.307 | 57.384 | Pkinase (PF00069, IPR000719): Protein kinase domain |
65 |
MAPK3 | oncoprotein | 10 | 0.444 | 11.950 | Pkinase (PF00069, IPR000719): Protein kinase domain |
66 |
MARK3 | protein found in more fusions | 11 | 0.933 | 0.786 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
67 |
MECOM | oncoprotein | 8 | 0.571 | 4.357 | SET (PF00856, IPR001214, SM00317): SET domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger |
68 |
MEF2A | oncoprotein | 10 | 0.533 | 13.143 | TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat |
69 |
MEF2C | oncoprotein | 10 | 0.444 | 12.054 | SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat |
70 |
MEF2D | oncoprotein | 7 | 0.571 | 2.999 | DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat |
71 |
MIF4GD | interactor | 2 | 1.000 | 0 | MIF4G (PF02854, IPR003890, SM00543): MIF4G domain |
72 |
MORC2 | interactor | 1 | 0 | 0 | Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit zf-CW (PF07496, IPR011124): CW-type Zinc Finger EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin |
73 |
MTUS2 | suppressor | 2 | 0 | 0 | DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496) RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat FAM184 (PF15665): Family with sequence similarity 184, A and B |
74 |
NACC1 | interactor | 9 | 0.321 | 11.700 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain |
75 |
NCOR1 | oncoprotein | 28 | 0.365 | 110.089 | BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region |
76 |
NCOR2 | oncoprotein | 28 | 0.368 | 112.023 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) |
77 |
NFATC1 | oncoprotein | 8 | 0.571 | 5.683 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
78 |
NFKB1 | suppressor | 19 | 0.392 | 49.088 | Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
79 |
NFKBIA | oncoprotein | 10 | 0.622 | 7.615 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
80 |
NFKBIE | oncoprotein | 5 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
81 |
NPPB | interactor | 2 | 1.000 | 0 | ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide |
82 |
NR1H2 | oncoprotein | 10 | 0.556 | 7.463 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
83 |
NR2C1 | interactor | 7 | 0.810 | 0.904 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
84 |
NR2C2 | suppressor | 8 | 0.762 | 1.561 | Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
85 |
NUP155 | interactor | 3 | 0.667 | 0.333 | Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like |
86 |
NUP214 | oncoprotein | 8 | 0.524 | 4.277 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 |
87 |
PARK2 | suppressor | 11 | 0.333 | 19.352 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
88 |
PNMA1 | oncoprotein | 2 | 1.000 | 0 | PNMA (PF14893, IPR026523): PNMA |
89 |
PPARD | oncoprotein | 7 | 0.867 | 0.571 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
90 |
PPARG | suppressor | 20 | 0.333 | 70.047 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region |
91 |
PPP2CA | suppressor | 8 | 0.500 | 10.000 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
92 |
PPP2R1A | oncoprotein | 8 | 0.536 | 6.892 | TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
93 |
PTPA | suppressor | 6 | 0.400 | 5.317 | PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein |
94 |
RANBP2 | oncoprotein | 8 | 0.429 | 6.176 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
95 |
RARA | oncoprotein | 14 | 0.538 | 12.699 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
96 |
RBBP4 | oncoprotein | 18 | 0.353 | 54.206 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex |
97 |
REST | oncoprotein | 6 | 0.733 | 0.933 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Presenilin (PF01080, IPR001108): Presenilin RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain |
98 |
REV3L | interactor | 3 | 0.667 | 1.000 | DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666) DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683) |
99 |
RFX5 | oncoprotein | 7 | 0.571 | 6.067 | RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain |
100 |
RFXANK | interactor | 7 | 0.533 | 4.292 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
101 |
RFXAP | interactor | 5 | 0.600 | 3.400 | RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain |
102 |
RINT1 | suppressor | 1 | 0 | 0 | RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family |
103 |
RUNX2 | suppressor | 7 | 0.810 | 1.012 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Runt (PF00853, IPR013524): Runt domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722) |
104 |
RXRA | oncoprotein | 19 | 0.471 | 36.477 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1 |
105 |
SENP1 | protein found in more fusions | 7 | 0.333 | 5.267 | Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
106 |
SF1 | protein found in more fusions | 8 | 0.619 | 3.952 | UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain |
107 |
SFN | suppressor | 13 | 0.545 | 15.993 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
108 |
SIN3A | oncoprotein | 21 | 0.371 | 64.168 | Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein |
109 |
SIRT1 | suppressor | 17 | 0.333 | 47.194 | DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain |
110 |
SMAD3 | oncoprotein | 27 | 0.268 | 135.905 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
111 |
SP1 | protein found in more fusions | 32 | 0.256 | 193.502 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
112 |
SRF | interactor | 9 | 0.821 | 0.967 | SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) |
113 |
SS18L1 | oncoprotein | 4 | 1.000 | 0 | DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313) SSXT (PF05030, IPR007726): SSXT protein (N-terminal region) |
114 |
STAT1 | suppressor | 11 | 0.444 | 17.155 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
115 |
SUV39H1 | protein found in more fusions | 15 | 0.407 | 30.494 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain |
116 |
SYK | suppressor | 6 | 0.600 | 1.186 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
117 |
TBL1XR1 | oncoprotein | 11 | 0.618 | 5.447 | LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
118 |
TP53BP1 | suppressor | 6 | 0.400 | 3.963 | 53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
119 |
UBE2I | interactor | 40 | 0.171 | 402.640 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
120 |
YWHAB | interactor | 14 | 0.615 | 13.213 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
121 |
YWHAE | oncoprotein | 13 | 0.603 | 17.962 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
122 |
YWHAG | protein found in more fusions | 17 | 0.533 | 29.399 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
123 |
YWHAH | protein found in more fusions | 12 | 0.764 | 5.706 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
124 |
YWHAQ | interactor | 18 | 0.458 | 40.848 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
125 |
YWHAZ | protein found in more fusions | 19 | 0.451 | 48.227 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
126 |
YY1 | protein found in more fusions | 12 | 0.382 | 12.623 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
127 |
ZBTB16 | suppressor | 20 | 0.427 | 56.725 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger |
128 |
ZBTB7B | interactor | 6 | 0.700 | 0.500 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GAGA (PF09237, IPR015318): GAGA factor SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
129 |
ZEB2 | oncoprotein | 7 | 0.524 | 2.971 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain Rubredoxin (PF00301, IPR024935): Rubredoxin zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger |
130 |
ZNF354A | interactor | 1 | 0 | 0 | KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |