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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HCN1 (from a repository: Mon Dec 5 10:05:22 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins0 (0.00 %)
The number (and %) of the tumor suppressors1 (20.00 %)
Total number of binary PPIs (saturation %)9 (90.00 %)
The number (and %) of affected PPIs5 (55.56 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.400
Assortativity coefficient-0.6325
The network average Clustering coefficient0.600
The number (and %) of a zero Clustering coefficients1 (20.00 %)
The number (and %) of a zero Betweenness Centrality3 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HCN1 All fusions
: BX537747;
Proteins found in more fusions NEDD4L (see 3 fusions); HCN1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HCN1parental protein50.3337.000DUF1759 (PF03564, IPR005312): Protein of unknown function (DUF1759)
Hamartin (PF04388, IPR007483): Hamartin protein
Ion_trans (PF00520, IPR005821): Ion transport protein
Ion_trans_N (PF08412, IPR013621): Ion transport protein N-terminal
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
2 HCN2interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ion_trans_N (PF08412, IPR013621): Ion transport protein N-terminal
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
3 HCN3interactor21.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ion_trans_N (PF08412, IPR013621): Ion transport protein N-terminal
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
4 HCN4interactor30.6671.000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Ion_trans (PF00520, IPR005821): Ion transport protein
Ion_trans_N (PF08412, IPR013621): Ion transport protein N-terminal
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
5 NEDD4Lsuppressor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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